Most of the time fatigue can be traced to one or more of your habits or routines, particularly lack of exercise. It's also commonly related to depression. On occasion, fatigue is a symptom of other underlying conditions that require medical treatment.

Lifestyle factors

Taking an honest inventory of things that might be responsible for your fatigue is often the first step toward relief. Fatigue may be related to:

  1. Alcohol or drug use
  2. Excess physical activity
  3. Jet lag disorder
  4. Lack of physical activity
  5. Medications, such as antihistamines, cough medicines
  6. Not enough sleep
  7. Unhealthy eating habits


Unrelenting exhaustion may be a sign of a condition or an effect of the drugs or therapies used to treat it, such as:

  1. Acute liver failure
  2. Anemia
  3. Anxiety disorders
  4. Cancer
  5. Chronic fatigue syndrome
  6. Chronic infection or inflammation
  7. Chronic kidney disease
  8. Concussion
  9. COPD (chronic obstructive pulmonary disease) exacerbation — worsening of symptoms
  10. Coronavirus disease 2019 (COVID-19)
  11. Depression (major depressive disorder)
  12. Diabetes
  13. Emphysema
  14. Fibromyalgia
  15. Grief
  16. Heart disease
  17. Hyperthyroidism (overactive thyroid)
  18. Hypothyroidism (underactive thyroid)
  19. Inflammatory bowel disease (IBD)
  20. Medications and treatments, such as chemotherapy, radiation therapy, pain drugs, heart drugs and antidepressants
  21. Multiple sclerosis
  22. Obesity
  23. Pain that's persistent
  24. Sleep apnea
  25. Stress
  26. Traumatic brain injury

Causes shown here are commonly associated with this symptom. Work with your doctor or other health care professional for an accurate diagnosis.

Dec. 02, 2020

See also

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  24. Antidepressant withdrawal: Is there such a thing?
  25. Antidepressants and alcohol: What's the concern?
  26. Antidepressants and weight gain: What causes it?
  27. Antidepressants: Can they stop working?
  28. Antidepressants for children and teens
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  30. Antidepressants: Selecting one that's right for you
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  39. Artificial sweeteners: Any effect on blood sugar?
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  42. Atrial septal defect (ASD)
  43. Atrioventricular canal defect
  44. Atypical antidepressants
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  65. Bone and joint problems associated with diabetes
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  70. 4 Ways to Prevent Heart Attack
  71. Ebstein Anomaly
  72. Ebstein Anomaly Part Two: Patient Frequently Asked Questions
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  80. Video: Leaky Valve Animation
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  85. Pulmonary Hypertension Treatment and Research
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  87. Screenings of newborns and athletes for genetic heart disease
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  108. Cancer-related fatigue
  109. Cancer pain: Relief is possible
  110. Cancer risk: What the numbers mean
  111. Cancer surgery
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  113. Cancer survivors: Care for your body after treatment
  114. Cancer survivors: Late effects of cancer treatment
  115. Cancer survivors: Managing your emotions after cancer treatment
  116. Cancer survivors: Reconnecting with loved ones after treatment
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  119. Cancer treatment for women: Possible sexual side effects
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  180. Depression: Diagnosis is key
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  189. Diabetes and depression: Coping with the two conditions
  190. Diabetes and exercise: When to monitor your blood sugar
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  193. Diabetes and Heat
  194. Diabetes and menopause
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  196. Diabetes and travel: Planning is key
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  198. 10 ways to avoid diabetes complications
  199. Diabetes diet: Should I avoid sweet fruits?
  200. Diabetes diet: Create your healthy-eating plan
  201. Diabetes: Does alcohol and tobacco use increase my risk?
  202. Diabetes foods: Can I substitute honey for sugar?
  203. Diabetes and liver
  204. Diabetes management: Does aspirin therapy prevent heart problems?
  205. Diabetes management: How lifestyle, daily routine affect blood sugar
  206. Diabetes: Eating out
  207. Diabetes nutrition: Sweets
  208. Diabetes prevention: 5 tips for taking control
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  210. Diabetes treatment: Can cinnamon lower blood sugar?
  211. Medications for type 2 diabetes
  212. Using insulin
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  214. Diabetic ketoacidosis
  215. Cancer-related diarrhea
  216. Dilated cardiomyopathy
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  218. Does zinc work for colds?
  219. Drinking after hepatitis C cure: Is it safe?
  220. Drummer Beats Heart Disease
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  223. Early HIV symptoms: What are they?
  224. Ease rheumatoid arthritis pain when grocery shopping
  225. Eastern equine encephalitis (EEE): What is it?
  226. Eating during cancer treatment: Tips to make food tastier
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  228. Echinacea: Is it effective for the common cold?
  229. ED Drugs for Pulmonary Hypertension
  230. Heart transplant to treat dilated cardiomyopathy: Elmo's story
  231. Emerging treatments for multiple sclerosis
  232. Encephalitis
  233. Endocarditis
  234. Endometriosis
  235. Endometriosis: Risk factor for ovarian cancer?
  236. Enlarged liver
  237. Enlarged spleen (splenomegaly)
  238. Esophageal cancer
  239. Infographic: Esophageal Cancer
  240. Estriol as a potential treatment option for multiple sclerosis (MS)
  241. Ewing sarcoma
  242. Exercise and multiple sclerosis
  243. External Drive: Charles' Artificial Heart
  244. Fasting diet: Can it improve my heart health?
  245. Fibromyalgia
  246. Fibromyalgia and acupuncture
  247. Fibromyalgia: Does exercise help or hurt?
  248. Fibromyalgia: Linked to other health problems?
  249. Fibromyalgia pain: Options for coping
  250. Fibromyalgia: Self-care tips
  251. Fibromyalgia and Neurontin
  252. Fibromyalgia or not?
  253. Fingolimod during pregnancy: Is it safe?
  254. Fish oil and depression
  255. Flu masks
  256. Flu Shot Prevents Heart Attack
  257. Flu shots
  258. Flu shots and heart disease
  259. Flu: When to see a doctor?
  260. Flu vaccine: Safe for people with egg allergy?
  261. Fluzone High-Dose: What distinguishes it from other flu vaccines?
  262. Foods and sleep
  263. Gaucher disease
  264. Generalized anxiety disorder
  265. Genetics and Cardiomyopathy
  266. GI Stents
  267. Giardia infection (giardiasis)
  268. Glomerulonephritis
  269. GLP-1 agonists: Diabetes drugs and weight loss
  270. Glycemic index: A helpful tool for diabetes?
  271. Grand mal seizure
  272. Granulomatosis with polyangiitis
  273. Grass-fed beef
  274. Graves' dermopathy: How is it treated?
  275. Graves' disease
  276. H1N1 flu (swine flu)
  277. Hairy cell leukemia
  278. Hangover prevention: Do lighter colored drinks help?
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  280. Hashimoto's disease
  281. Have a cold? Common sense rules
  282. Have a cold? Fight back with humidity
  283. Have a cold? Fight it with fluids
  284. Healthy eating: One step at a time
  285. Healthy Heart for Life!
  286. Healthy heart for life: Avoiding heart disease
  287. Heart arrhythmia
  288. Heart attack
  289. Heart attack prevention: Should I avoid secondhand smoke?
  290. Heart attack symptoms
  291. Heart Attack Timing
  292. Heart cancer: Is there such a thing?
  293. Heart disease
  294. Heart disease in women: Understand symptoms and risk factors
  295. Heart failure
  296. Heart failure and sex: Is it safe?
  297. Heart-healthy diet: 8 steps to prevent heart disease
  298. Heat exhaustion
  299. Heavy periods: Can folic acid help?
  300. Hemochromatosis
  301. Hemolytic uremic syndrome (HUS)
  302. Hemophilia
  303. Hepatitis A
  304. Hepatitis B
  305. Hepatitis C
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  307. Hepatitis C: What happens in end-stage liver disease?
  308. Herbal treatment for anxiety: Is it effective?
  309. Hiatal hernia
  310. High-dose vitamin C: Can it kill cancer cells?
  311. Hirschsprung's disease
  312. HIV/AIDS
  313. Hodgkin's lymphoma (Hodgkin's disease)
  314. Hodgkin's vs. non-Hodgkin's lymphoma: What's the difference?
  315. Holiday Heart
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  317. How well do you wash your hands?
  318. Humidifier care 101
  319. Humidifiers
  320. Huntington's disease
  321. Hypercalcemia
  322. Hyperglycemia in diabetes
  323. Hyperinsulinemia: Is it diabetes?
  324. Hyperparathyroidism
  325. Hyperthyroidism (overactive thyroid)
  326. Hypertrophic cardiomyopathy
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  328. Hyponatremia
  329. Hypoparathyroidism
  330. Hypopituitarism
  331. Hypothermia
  332. Hypothyroidism: Can calcium supplements interfere with treatment?
  333. Hypothyroidism diet
  334. Hypothyroidism and joint pain?
  335. Hypothyroidism: Should I take iodine supplements?
  336. Hypothyroidism symptoms: Can hypothyroidism cause eye problems?
  337. Hypothyroidism (underactive thyroid)
  338. IBD and colon cancer: How often do you need screening?
  339. Inflammatory bowel disease (IBD)
  340. Influenza (flu)
  341. Infographic: Innovative Rectal Cancer Treatments
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  344. Insomnia treatment: Cognitive behavioral therapy instead of sleeping pills
  345. Insulin and weight gain
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  347. Intensive insulin therapy
  348. Intervention: Help a loved one overcome addiction
  349. Iron deficiency anemia
  350. Is antibacterial soap a do or a don't?
  351. Is depression a factor in rheumatoid arthritis?
  352. Is fibromyalgia hereditary?
  353. Is there a multiple sclerosis diet?
  354. Jet lag disorder
  355. Depression and diet
  356. Kidney cancer
  357. Kidney Cancer
  358. Infographic: Kidney Cancer
  359. Lack of sleep: Can it make you sick?
  360. Late-night eating: OK if you have diabetes?
  361. LADA
  362. Preventing lead exposure
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  364. Legionnaires' disease
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  381. Lupus: Can it cause hives?
  382. Lupus affects kidneys
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  385. Male hypogonadism
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  387. Managing depression in MS
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  389. Mangosteen juice: Can it relieve arthritis pain?
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  397. Mental health providers: Tips on finding one
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  401. Mindfulness practice: Can it reduce symptoms of MS?
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  403. Mitral valve regurgitation
  404. Mitral valve stenosis
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  443. Palindromic rheumatism: Precursor to rheumatoid arthritis?
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  446. Pectus Excavatum
  447. Pelvic inflammatory disease (PID)
  448. Pericarditis
  449. Peritonitis
  450. Persistent depressive disorder (dysthymia)
  451. Persistent post-concussive symptoms (Post-concussion syndrome)
  452. Personalized therapy for multiple sclerosis (MS)
  453. Plague
  454. Plugged ears: What is the remedy?
  455. Pneumonia
  456. Pneumonitis
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  458. Polycythemia vera
  459. Polymyalgia rheumatica
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  462. Polypill: Does it treat heart disease?
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  464. Postpartum thyroiditis
  465. Post-polio syndrome
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  476. Pulmonary edema
  477. Pulmonary fibrosis
  478. Pulmonary hypertension
  479. Pulmonary valve stenosis
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  487. Renal diet for vegetarians
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  489. Rhabdomyolysis
  490. Rheumatic fever
  491. Rheumatoid arthritis
  492. Rheumatoid Arthritis
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  494. Rheumatoid arthritis and exercise
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  496. Rheumatoid arthritis diet
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