Adrenal fatigue is a term applied to a collection of nonspecific symptoms, such as body aches, fatigue, nervousness, sleep disturbances and digestive problems. The term often shows up in popular health books and on alternative medicine websites, but it isn't an accepted medical diagnosis.
Your adrenal glands produce a variety of hormones that are essential to life. The medical term adrenal insufficiency (Addison's disease) refers to inadequate production of one or more of these hormones as a result of an underlying disease.
Signs and symptoms of adrenal insufficiency may include:
- Body aches
- Unexplained weight loss
- Low blood pressure
- Loss of body hair
- Skin discoloration (hyperpigmentation)
Adrenal insufficiency can be diagnosed by blood tests and special stimulation tests that show inadequate levels of adrenal hormones.
Proponents of the adrenal fatigue diagnosis claim this is a mild form of adrenal insufficiency caused by chronic stress. The unproven theory behind adrenal fatigue is that your adrenal glands are unable to keep pace with the demands of perpetual fight-or-flight arousal. As a result, they can't produce quite enough of the hormones you need to feel good. Existing blood tests, according to this theory, aren't sensitive enough to detect such a small decline in adrenal function — but your body is.
It's frustrating to have persistent symptoms your doctor can't readily explain. But accepting a medically unrecognized diagnosis from an unqualified practitioner could be worse. Unproven remedies for so-called adrenal fatigue may leave you feeling sicker, while the real cause — such as depression or fibromyalgia — continues to take its toll.
April 12, 2017
See more Expert Answers
- Nieman LK. Clinical manifestation of adrenal insufficiency in adults. http://www.uptodate.com/home. Accessed March 13, 2017.
- Nieman LK. Diagnosis of adrenal insufficiency in adults. http://www.uptodate.com/home. Accessed March 13, 2017.
- Myth vs fact: Adrenal fatigue. Hormone Health Network. http://www.hormone.org/hormones-and-health/myth-vs-fact/adrenal-fatigue. Accessed March 13, 2017.
- Nippoldt TB (expert opinion). Mayo Clinic, Rochester, Minn. March 13, 2017.
- Cadegiani FA, et al. Adrenal fatigue does not exist: A systematic review. BMC Endocrine Disorders. 2016;16:48.
- Adrenal insufficiency and Addison's disease. National Institute of Diabetes and Digestive and Kidney Diseases. https://www.niddk.nih.gov/health-information/endocrine-diseases/adrenal-insufficiency-addisons-disease. Accessed March 13, 2017.
- Freeman J. Adrenal fatigue — An interview with Todd Nippoldt. Mayo Clinic Women's HealthSource. 2010;14:6.