Gastroesophageal junction and stomach
The area where the lower end of the esophagus meets the upper part of the stomach is called the gastroesophageal junction. Cancer of the gastroesophageal junction has become more common in recent decades.
Gastroesophageal junction cancer
Cancer of the gastroesophageal junction develops in the area where the esophagus joins the top part of the stomach.
Stomach cancer most commonly begins in the cells that line the inside of the stomach.
Stomach cancer usually begins in the mucus-producing cells that line the stomach. This type of cancer is called adenocarcinoma.
For the past several decades, rates of cancer in the main part of the stomach (stomach body) have been falling worldwide. During the same period, cancer in the area where the top part of the stomach (cardia) meets the lower end of the swallowing tube (esophagus) has become much more common. This area of the stomach is called the gastroesophageal junction.
Stomach cancer care at Mayo Clinic
Products & Services
Signs and symptoms of gastroesophageal junction cancer and stomach cancer may include:
- Feeling bloated after eating
- Feeling full after eating small amounts of food
- Severe, persistent heartburn
- Severe indigestion that is always present
- Unexplained, persistent nausea
- Stomach pain
- Persistent vomiting
- Unintentional weight loss
When to see a doctor
If you have signs and symptoms that worry you, make an appointment with your doctor. Your doctor will likely investigate more common causes of these signs and symptoms first.
Stomach and pyloric valve
Your stomach is a muscular sac about the size of a small melon that expands when you eat or drink to hold as much as a gallon of food or liquid. Once your stomach pulverizes the food, strong muscular contractions (peristaltic waves) push the food toward the pyloric valve, which leads to the upper portion of your small intestine (duodenum).
In general, cancer begins when an error (mutation) occurs in a cell's DNA. The mutation causes the cell to grow and divide at a rapid rate and to continue living when a normal cell would die. The accumulating cancerous cells form a tumor that can invade nearby structures. And cancer cells can break off from the tumor to spread throughout the body.
Gastroesophageal junction cancer is associated with having gastrointestinal reflux disease (GERD) and, less strongly, with obesity and smoking. GERD is a condition caused by frequent backflow of stomach acid into the esophagus.
There is a strong correlation between a diet high in smoked and salted foods and stomach cancer located in the main part of the stomach. As the use of refrigeration for preserving foods has increased around the world, the rates of stomach cancer have declined.
The main risk factors for gastroesophageal junction cancer are a history of GERD and obesity.
Factors that increase your risk of stomach cancer located in the stomach body include:
- A diet high in salty and smoked foods
- A diet low in fruits and vegetables
- Family history of stomach cancer
- Infection with Helicobacter pylori
- Long-term stomach inflammation
- Pernicious anemia
- Stomach polyps
It's not clear what causes gastroesophageal junction or stomach cancer, so there's no way to prevent it. But you can take steps to reduce your risk of gastroesophageal junction cancer and stomach cancer by making small changes to your everyday life. For instance, try to:
- Exercise. Regular exercise is associated with a reduced risk of stomach cancer. Try to fit physical activity into your day most days of the week.
- Eat more fruits and vegetables. Try to incorporate more fruits and vegetables into your diet each day. Choose a wide variety of colorful fruits and vegetables.
- Reduce the amount of salty and smoked foods you eat. Protect your stomach by limiting these foods.
- Stop smoking. If you smoke, quit. If you don't smoke, don't start. Smoking increases your risk of stomach cancer, as well as many other types of cancer. Quitting smoking can be very difficult, so ask your doctor for help.
- Ask your doctor about your risk of gastroesophageal junction or stomach cancer. Talk with your doctor if you have an increased risk of gastroesophageal junction cancer or stomach cancer. Together you may consider periodic endoscopy to look for signs of stomach cancer.