Bone cancer can begin in any bone in the body, but it most commonly affects the pelvis or the long bones in the arms and legs. Bone cancer is rare, making up less than 1 percent of all cancers. In fact, noncancerous bone tumors are much more common than cancerous ones.
The term "bone cancer" doesn't include cancers that begin elsewhere in the body and spread (metastasize) to the bone. Instead, those cancers are named for where they began, such as breast cancer that has metastasized to the bone.
Some types of bone cancer occur primarily in children, while others affect mostly adults. Surgical removal is the most common treatment, but chemotherapy and radiation therapy also may be utilized. The decision to use surgery, chemotherapy or radiation therapy is based on the type of bone cancer being treated.
Signs and symptoms of bone cancer include:
- Bone pain
- Swelling and tenderness near the affected area
- Weakened bone, leading to fracture
- Unintended weight loss
When to see a doctor
Make an appointment with your doctor if you or your child develops bone pain that:
- Comes and goes
- Becomes worse at night
- Isn't helped by over-the-counter pain relievers
The cause of most bone cancers is unknown. A small number of bone cancers have been linked to hereditary factors, while others are related to previous radiation exposure.
Types of bone cancer
Osteosarcoma, the most common type of bone cancer, often starts in the long bones — the legs or the arms — but it can occur in any bone.
Bone cancers are broken down into separate types based on the type of cell where the cancer began. The most common types of bone cancer include:
- Osteosarcoma. Osteosarcoma is the most common form of bone cancer. In this tumor, the cancerous cells produce bone. This variety of bone cancer occurs most often in children and young adults, in the bones of the leg or arm. In rare circumstances, osteosarcomas can arise outside of bones (extraskeletal osteosarcomas).
- Chondrosarcoma. Chondrosarcoma is the second most common form of bone cancer. In this tumor, the cancerous cells produce cartilage. Chondrosarcoma usually occurs in the pelvis, legs or arms in middle-aged and older adults.
- Ewing sarcoma. Ewing sarcoma tumors most commonly arise in the pelvis, legs or arms of children and young adults.
It's not clear what causes bone cancer, but doctors have found certain factors are associated with an increased risk, including:
- Inherited genetic syndromes. Certain rare genetic syndromes passed through families increase the risk of bone cancer, including Li-Fraumeni syndrome and hereditary retinoblastoma.
- Paget's disease of bone. Most commonly occurring in older adults, Paget's disease of bone can increase the risk of bone cancer developing later.
- Radiation therapy for cancer. Exposure to large doses of radiation, such as those given during radiation therapy for cancer, increases the risk of bone cancer in the future.
Bone cancer care at Mayo Clinic
March 10, 2020
- Bone cancer. National Cancer Institute. https://www.cancer.gov/types/bone/bone-fact-sheet. Accessed Dec. 26, 2017.
- Bone cancer. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed Dec. 28, 2017.
- Goldman L, et al., eds. Malignant tumors of bone, sarcomas and other soft tissue neoplasms. In: Goldman-Cecil Medicine. 25th ed. Philadelphia, Pa.: Saunders Elsevier; 2016. https://www.clinicalkey.com. Accessed Dec. 26, 2017.
- Questions and answers about bone cancer. Centers for Disease Control and Prevention. https://www.cdc.gov/nceh/radiation/phase2/mbone.pdf. Accessed Dec. 26, 2017.
- Ferri FF. Bone tumor, primary malignant. In: Ferri's Clinical Advisor 2018. Philadelphia, Pa.: Elsevier; 2018. https://www.clinicalkey.com. Accessed Dec. 26, 2017.
- Kliegman RM, et al. Neoplasms of bone. In: Nelson Textbook of Pediatrics. 20th ed. Philadelphia, Pa.: Elsevier; 2016. https://www.clinicalkey.com. Accessed Dec. 27, 2017.
- Azar FM, et al. Malignant tumors of bone. In: Campbell's Operative Orthopaedics. 13th ed. Philadelphia, Pa.: Elsevier; 2017. https://www.clinicalkey.com. Accessed Dec. 27, 2017.
- Hornicek FJ. Bone sarcomas: Preoperative evaluation, histologic classification and principles of surgical management. https://www.uptodate.com/contents/search. Accessed Dec. 27, 2017.
- Amin MB, et al., eds. Bone. In: AJCC Cancer Staging Manual. 8th ed. New York, N.Y.: Springer; 2017.
- Rose PS (expert opinion). Mayo Clinic, Rochester, Minn. Feb. 6, 2018.
- Taking time: Support for people with cancer. National Cancer Institute. https://www.cancer.gov/publications/patient-education/taking-time. Accessed Feb. 6, 2018.
- Mayo Clinic Cancer Center, Rochester, Minn. National Cancer Institute. http://www.cancer.gov/researchandfunding/extramural/cancercenters/find-a-cancer-center/mayoclinic. Accessed Jan. 23, 2018.
- COG research collaborations. Children's Oncology Group. https://childrensoncologygroup.org/index.php/research-collaborations. Accessed Jan. 23, 2018.