Aortic valve regurgitation
In aortic valve regurgitation, the aortic valve doesn't close properly, causing blood to leak backward from the aorta into the left ventricle.
Aortic valve regurgitation — or aortic regurgitation — is a condition that occurs when your heart's aortic valve doesn't close tightly. Aortic valve regurgitation allows some of the blood that was pumped out of your heart's main pumping chamber (left ventricle) to leak back into it.
The leakage may prevent your heart from efficiently pumping blood to the rest of your body. As a result, you may feel fatigued and short of breath.
Aortic valve regurgitation can develop suddenly or over decades. Once aortic valve regurgitation becomes severe, surgery is often required to repair or replace the aortic valve.
Aortic valve regurgitation care at Mayo Clinic
Most often, aortic valve regurgitation develops gradually, and your heart compensates for the problem. You may have no signs or symptoms for years, and you may even be unaware that you have the condition.
However, as aortic valve regurgitation worsens, signs and symptoms may include:
- Fatigue and weakness, especially when you increase your activity level
- Shortness of breath with exercise or when you lie down
- Swollen ankles and feet
- Chest pain (angina), discomfort or tightness, often increasing during exercise
- Lightheadedness or fainting
- Irregular pulse (arrhythmia)
- Heart murmur
- Sensations of a rapid, fluttering heartbeat (palpitations)
When to see a doctor
Contact your doctor right away if signs and symptoms of aortic valve regurgitation develop. Sometimes the first indications of aortic valve regurgitation are those of its major complication, heart failure. See your doctor if you have fatigue, shortness of breath, and swollen ankles and feet, which are common symptoms of heart failure.
Chambers and valves of the heart
A normal heart has two upper and two lower chambers. The upper chambers — the right and left atria — receive incoming blood. The lower chambers — the more muscular right and left ventricles — pump blood out of your heart. The heart valves, which keep blood flowing in the right direction, are gates at the chamber openings (for the tricuspid and mitral valves) and exits (for the pulmonary and aortic valves). (for the tricuspid and mitral valves) and exits (for the pulmonary and aortic valves). (for the tricuspid and mitral valves) and exits (for the pulmonary and aortic valves).
Your heart has four valves that keep blood flowing in the correct direction. These valves include the mitral valve, tricuspid valve, pulmonary valve and aortic valve. Each valve has flaps (cusps or leaflets) that open and close once during each heartbeat. Sometimes, the valves don't open or close properly, disrupting the blood flow through your heart and potentially impairing the ability to pump blood to your body.
In aortic valve regurgitation, the valve between the lower left heart chamber (left ventricle) and the main artery that leads to the body (aorta) doesn't close properly, which causes some blood to leak backward into the left ventricle. This forces the left ventricle to hold more blood, possibly causing it to enlarge and thicken.
At first, left ventricle enlargement helps because it maintains adequate blood flow with more force. But eventually these changes weaken the left ventricle — and your heart overall.
Any condition that damages a valve can cause regurgitation. Causes of aortic valve regurgitation include:
Congenital heart valve disease. You may have been born with an aortic valve that has only two cusps (bicuspid valve) or fused cusps rather than the normal three separate cusps. In some cases a valve may only have one cusp (unicuspid) or four cusps (quadricuspid), but this is less common.
These congenital heart defects put you at risk of developing aortic valve regurgitation at some time in your life. If you have a parent or sibling with a bicuspid valve, it increases the risk that you may have a bicuspid valve, but it can also occur if you don't have a family history of a bicuspid aortic valve.
- Age-related changes to the heart. Calcium deposits can build up on the aortic valve over time, causing the aortic valve's cusps to stiffen. This can cause the aortic valve to become narrow, and it may also not close properly.
- Endocarditis. The aortic valve may be damaged by endocarditis — an infection inside your heart that involves heart valves.
- Rheumatic fever. Rheumatic fever — a complication of strep throat and once a common childhood illness in the United States — can damage the aortic valve. Rheumatic fever is still prevalent in developing countries but rare in the United States. Some older adults in the United States were exposed to rheumatic fever as children, although they may not have developed rheumatic heart disease.
- Other diseases. Other rare conditions can enlarge the aorta and aortic valve and lead to regurgitation, including Marfan syndrome, a connective tissue disease. Some autoimmune conditions, such as lupus, also can lead to aortic valve regurgitation.
- Trauma. Damage to the aorta near the site of the aortic valve, such as damage from injury to your chest or from a tear in the aorta, also can cause backward flow of blood through the valve.
Risk factors of aortic valve regurgitation include:
- Older age
- Certain heart conditions present at birth (congenital heart disease)
- History of infections that can affect the heart
- Certain conditions that can affect the heart, such as Marfan syndrome
- Other heart valve conditions, such as aortic valve stenosis
- High blood pressure
Aortic valve regurgitation can cause complications, including:
- Heart failure
- Infections that affect the heart, such as endocarditis
- Heart rhythm abnormalities
For any heart condition, see your doctor regularly so he or she can monitor you and possibly catch aortic valve regurgitation or other heart condition before it develops or in the early stages, when it's more easily treatable. If you have been diagnosed with a leaking aortic valve (aortic valve regurgitation) or a tight aortic valve (aortic valve stenosis), you'll probably require regular echocardiograms to be sure the aortic valve regurgitation doesn't become severe.
Also, be aware of conditions that contribute to developing aortic valve regurgitation, including:
- Rheumatic fever. If you have a severe sore throat, see a doctor. Untreated strep throat can lead to rheumatic fever. Fortunately, strep throat is easily treated with antibiotics.
- High blood pressure. Check your blood pressure regularly. Make sure it's well-controlled to prevent aortic regurgitation.
Aug. 07, 2020