Insulin and weight gain: Keep the pounds off

Insulin and weight gain often go hand in hand, but weight control is possible. If you need insulin therapy, here's how to minimize — or avoid — weight gain.

By Mayo Clinic Staff

People who take insulin often gain weight. Insulin is a hormone that regulates how the body absorbs sugar, also known as glucose. The weight gain can be frustrating because keeping a healthy weight is important to manage your diabetes. The good news is that you can maintain your weight while taking insulin.

The link between insulin and weight gain

When you take insulin, sugar can enter your cells. This makes the sugar levels in your blood go down. This is the goal of treatment.

But if you take in more calories than you need to keep a healthy weight, your cells will get more sugar than they need. This happens in people who don't have diabetes, too. How many calories you need depends on how active you are. Sugar that your cells don't need to use becomes fat.

Avoid weight gain while taking insulin

Eating healthy foods and being physically active most days of the week can help you not gain weight. The following tips can help you keep the pounds off:

  • Count calories. Eating and drinking fewer calories helps you prevent weight gain. Keep fruits, vegetables and whole grains in your refrigerator and pantry. Plan for every meal to have the right mix of starches, fruits and vegetables, proteins, and fats. Generally, recommended meals would consist of half nonstarchy vegetable, one-quarter protein and one-quarter a starch, such as rice, or a starchy vegetable, such as corn or peas.

    Shrink the sizes of your portions, don't take second helpings and drink water instead of high-calorie drinks. Talk to your health care provider, nurse or a dietitian about how to plan meals and where to find resources.

  • Don't skip meals. Don't try to cut calories by skipping meals. When you skip a meal, you're more likely to make unhealthy diet choices at the next mealtime because you're too hungry. Skipping meals can also cause low blood sugar levels if you don't adjust your insulin dose.
  • Be physically active. Physical activity burns calories. A recommended goal for most adults is at least 150 minutes a week (or 30 minutes five days a week) of moderately intense aerobic activity plus muscle-strengthening exercises at least two times a week. Aerobic activities can include walking, bicycling, water aerobics, dancing or gardening. Talk with your provider about activities and exercises that are right for you.

    Also, ask your provider how to handle exercise. Physical activity helps your body use insulin more efficiently. Depending on how much exercise you're planning on doing, you may need to cut back on your insulin dosage or have a snack. It's possible for your blood sugar to drop even hours after exercise.

  • Ask your provider about other diabetes medicines. Some diabetes medicines that help regulate blood sugar levels may help you lose weight and lower your insulin dosage. Examples of these medicines include metformin (Fortamet, Glumetza, others), exenatide (Byetta), liraglutide (Victoza, Saxenda), dulaglutide (Trulicity), sitagliptin (Januvia), saxagliptin (Onglyza), canagliflozin (Invokana), dapagliflozin (Farxiga), empagliflozin (Jardiance) and pramlintide (Symlin). Ask your provider if these or other medicines should be part of your diabetes treatment plan.
  • Take your insulin only as directed. Don't skip or reduce your insulin dosages to stop weight gain. Although you might lose pounds if you take less insulin than prescribed, the risks are serious. Without enough insulin, your blood sugar level will rise — and so will your risk of diabetes complications.

From Mayo Clinic to your inbox

Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. Click here for an email preview.

We use the data you provide to deliver you the content you requested. To provide you with the most relevant and helpful information, we may combine your email and website data with other information we have about you. If you are a Mayo Clinic patient, we will only use your protected health information as outlined in our Notice of Privacy Practices. You may opt out of email communications at any time by clicking on the unsubscribe link in the email.

Sept. 01, 2022 See more In-depth

See also

  1. 10 ways to control high blood pressure without medication
  2. A1C test
  3. Alcohol: Does it affect blood pressure?
  4. Alpha blockers
  5. Amputation and diabetes: How to protect your feet
  6. Angiotensin II receptor blockers
  7. Angiotensin-converting enzyme (ACE) inhibitors
  8. Anxiety: A cause of high blood pressure?
  9. Artificial sweeteners: Any effect on blood sugar?
  10. Bardet-Biedl syndrome (BBS)
  11. Bariatric surgery
  12. Beta blockers
  13. Beta blockers: Do they cause weight gain?
  14. Beta blockers: How do they affect exercise?
  15. Biliopancreatic diversion with duodenal switch
  16. Biliopancreatic diversion with duodenal switch (BPD/DS)
  17. Blood glucose meter: How to choose
  18. Blood glucose monitors
  19. Blood pressure chart: What your reading means
  20. Blood pressure cuff: Does size matter?
  21. Blood pressure medication: Still necessary if I lose weight?
  22. Blood pressure medications: Can they raise my triglycerides?
  23. Blood pressure readings: Why higher at home?
  24. Blood pressure: Can it be higher in one arm?
  25. Blood pressure: Does it have a daily pattern?
  26. Blood pressure: Is it affected by cold weather?
  27. Blood sugar levels can fluctuate for many reasons
  28. Blood sugar testing: Why, when and how
  29. Bone and joint problems associated with diabetes
  30. Caffeine and hypertension
  31. Calcium channel blockers
  32. Calcium supplements: Do they interfere with blood pressure drugs?
  33. Can having vitamin D deficiency cause high blood pressure?
  34. Can whole-grain foods lower blood pressure?
  35. Central-acting agents
  36. Choosing blood pressure medicines
  37. COVID-19: Who's at higher risk of serious symptoms?
  38. Diabetes
  39. Diabetes and depression: Coping with the two conditions
  40. Diabetes and exercise: When to monitor your blood sugar
  41. Diabetes and heat
  42. Diabetes and liver
  43. Diabetes care: 10 ways to avoid complications
  44. Diabetes diet: Create your healthy-eating plan
  45. Diabetes diet: Should I avoid sweet fruits?
  46. Diabetes foods: Can I substitute honey for sugar?
  47. Diabetes management: How lifestyle, daily routine affect blood sugar
  48. Diabetes symptoms: When diabetes symptoms are a concern
  49. Diabetes treatment: Can cinnamon lower blood sugar?
  50. Diabetes treatment: Using insulin to manage blood sugar
  51. Diabetic Gastroparesis
  52. Diuretics
  53. Diuretics: A cause of low potassium?
  54. Erectile dysfunction and diabetes: Take control today
  55. Exercise: A drug-free approach to lowering high blood pressure
  56. Free blood pressure machines: Are they accurate?
  57. Gastric bypass (Roux-en-Y)
  58. Gastric Bypass Complications
  59. Gastric bypass diet: What to eat after the surgery
  60. Gastric Bypass Surgery: One Patient's Journey
  61. Get the most out of home blood pressure monitoring
  62. Glucose tolerance test
  63. Glycemic index: A helpful tool for diabetes?
  64. Guide to types of weight-loss surgery
  65. Hemochromatosis
  66. High blood pressure (hypertension)
  67. High blood pressure and cold remedies: Which are safe?
  68. High blood pressure and sex: Overcome the challenges
  69. High blood pressure dangers: Hypertension's effects on your body
  70. How to measure blood pressure using a manual monitor
  71. How to measure blood pressure using an automatic monitor
  72. Hypertension FAQs
  73. Hypertensive crisis: What are the symptoms?
  74. Isolated systolic hypertension: A health concern?
  75. Kidney disease FAQs
  76. L-arginine: Does it lower blood pressure?
  77. Late-night eating: OK if you have diabetes?
  78. Low-phosphorus diet: Helpful for kidney disease?
  79. Medications and supplements that can raise your blood pressure
  80. Menopause and high blood pressure: What's the connection?
  81. Pancreas transplant
  82. Pancreas transplant animation
  83. Picnic Problems: High Sodium
  84. Pulse pressure: An indicator of heart health?
  85. Reactive hypoglycemia: What can I do?
  86. Resperate: Can it help reduce blood pressure?
  87. Sleep deprivation: A cause of high blood pressure?
  88. Sleeve gastrectomy
  89. Statins: Are these cholesterol-lowering drugs right for you?
  90. Stress and high blood pressure: What's the connection?
  91. The dawn phenomenon: What can you do?
  92. Vasodilators
  93. Vegetarian diet: Can it help me control my diabetes?
  94. Weight Loss Surgery Options
  95. What is blood pressure?
  96. What is hypertension? A Mayo Clinic expert explains.
  97. White coat hypertension
  98. Wrist blood pressure monitors: Are they accurate?