Rectal cancer is a kind of cancer that starts as a growth of cells in the rectum. The rectum is the last several inches of the large intestine. It starts at the end of the final segment of the colon and ends when it reaches the short, narrow passage known as the anus.

Cancer inside the rectum and cancer inside the colon are often referred to together as colorectal cancer.

While rectal and colon cancers are similar in many ways, their treatments are quite different. This is mainly because the rectum is barely separated from other organs and structures. It sits in a tight space that can make surgery to remove rectal cancer complex.

Rectal cancer treatment usually involves surgery to remove the cancer. Other treatments may include chemotherapy, radiation or a combination of the two. Targeted therapy and immunotherapy also may be used.


Rectal cancer may not cause symptoms early on. Symptoms of rectal cancer usually happen when the disease is advanced.

Signs and symptoms of rectal cancer include:

  • A change in bowel habits, such as diarrhea, constipation or a more-frequent need to pass stool.
  • A feeling that the bowel doesn't empty completely.
  • Abdominal pain.
  • Dark maroon or bright red blood in stool.
  • Narrow stool.
  • Weight loss that happens without trying.
  • Weakness or fatigue.

When to see a doctor

Make an appointment with your doctor or other healthcare professional if you have any symptoms that worry you.

Get the latest colon cancer help and advice from Mayo Clinic delivered in your inbox.

Sign up for free and receive the latest on colon cancer treatment, care and management.

To provide you with the most relevant and helpful information, and understand which information is beneficial, we may combine your email and website usage information with other information we have about you. If you are a Mayo Clinic patient, this could include protected health information. If we combine this information with your protected health information, we will treat all of that information as protected health information and will only use or disclose that information as set forth in our notice of privacy practices. You may opt-out of email communications at any time by clicking on the unsubscribe link in the e-mail.


The exact cause of most rectal cancers isn't known.

Rectal cancer happens when cells in the rectum develop changes in their DNA. A cell's DNA holds the instructions that tell a cell what to do. In healthy cells, the DNA gives instructions to grow and multiply at a set rate. The instructions tell the cells to die at a set time. In cancer cells, the DNA changes give different instructions. The changes tell the cancer cells to make many more cells quickly. Cancer cells can keep living when healthy cells would die. This causes too many cells.

The cancer cells might form a mass called a tumor. The tumor can grow to invade and destroy healthy body tissue. In time, cancer cells can break away and spread to other parts of the body. When cancer spreads, it's called metastatic cancer.

Risk factors

Factors that may increase the risk of rectal cancer are the same as those that increase the risk of colon cancer. Colorectal cancer risk factors include:

  • A personal history of colorectal cancer or polyps. Your risk of colorectal cancer is higher if you've already had rectal cancer, colon cancer or adenomatous polyps.
  • Black race. Black people in the United States have a greater risk of colorectal cancer than do people of other races.
  • Diabetes. People with type 2 diabetes may have an increased risk of colorectal cancer.
  • Drinking alcohol. Heavy drinking increases the risk of colorectal cancer.
  • A diet low in vegetables. Colorectal cancer may be related to a diet low in vegetables and high in red meat.
  • Family history of colorectal cancer. You're more likely to develop colorectal cancer if you have a parent, sibling or child with colon or rectal cancer.
  • Inflammatory bowel disease. Chronic inflammatory diseases of the colon and rectum, such as ulcerative colitis and Crohn's disease, increase your risk of colorectal cancer.
  • Inherited syndromes that increase colorectal cancer risk. In some families, DNA changes passed from parents to children may increase the risk of colorectal cancer. These changes are involved in only a small percentage of rectal cancers. Inherited syndromes may include familial adenomatous polyposis, also known as FAP, and Lynch syndrome. Genetic testing can detect these and other, rarer inherited colorectal cancer syndromes.
  • Obesity. People who are obese have an increased risk of colorectal cancer compared with people considered to be at a healthy weight.
  • Older age. Colorectal cancer can be diagnosed at any age, but most people with this type of cancer are older than 50. The rates of colorectal cancer in people younger than 50 have been increasing, but healthcare professionals aren't sure why.
  • Radiation therapy for previous cancer. Radiation therapy directed at the abdomen to treat previous cancers may increase the risk of colorectal cancer.
  • Smoking. People who smoke may have an increased risk of colorectal cancer.
  • Too little exercise. If you're inactive, you're more likely to develop colorectal cancer. Getting regular physical activity may reduce your risk of cancer.


Rectal cancer can lead to complications, including:

  • Bleeding in the rectum. Rectal cancer often causes bleeding in the rectum. Sometimes the amount of blood is worrying, and treatment might be needed to stop it right away.
  • Intestinal obstruction. Rectal cancer can grow to block the intestines. This prevents stool from leaving the body. Surgery to remove the cancer often relieves an obstruction. If you can't have surgery right away, you might need other treatments to ease the blockage.
  • Intestinal perforation. Rectal cancer may cause a tear in the intestines. Perforation typically requires surgery.


There's no sure way to prevent rectal cancer, but you can reduce your risk if you:

Ask about rectal cancer screening

Colorectal cancer screening reduces the risk of cancer by finding precancerous polyps in the colon and rectum that could turn into cancer. Ask your healthcare professional about when you should begin screening. Most medical organizations recommend starting screening around age 45. You may be screened earlier if you have risk factors for colorectal cancer.

Several screening options exist. Talk about your options with your healthcare professional. Together you can decide which tests are right for you.

Drink alcohol in moderation, if at all

If you choose to drink alcohol, do so in moderation. For healthy adults, that means up to one drink a day for women and up to two drinks a day for men.

Eat more fruits and vegetables

Choose a healthy diet with a variety of fruits and vegetables. Food sources of vitamins and nutrients are best. Avoid taking large doses of vitamins in pill form, as they may be harmful.

Exercise most days of the week

Aim for at least 30 minutes of exercise on most days of the week. If you haven't been active lately, ask your healthcare professional whether it's OK and start slowly.

Maintain a healthy weight

If your weight is healthy, work to maintain that weight. If you need to lose weight, ask a healthcare professional about healthy ways to lower your weight. Eat fewer calories and slowly increase the amount of exercise.

Stop smoking

Talk with your healthcare team about strategies and aids that can help you quit. Options include nicotine replacement products, medicines and support groups. If you've never smoked, don't start.

May 17, 2024

Living with rectal cancer?

Connect with others like you for support and answers to your questions in the Colorectal Cancer support group on Mayo Clinic Connect, a patient community.

Colorectal Cancer Discussions

Bummed: Colon cancer has metastasized to my liver!

44 Replies Mon, Jul 15, 2024

Stomach like a beer belly after colon cancer surgery

93 Replies Sat, Jul 13, 2024

See more discussions
  1. Elsevier Point of Care. Clinical Overview: Colorectal cancer. https://www.clinicalkey.com. Accessed Feb. 9, 2024.
  2. Rectal cancer. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1461. Accessed Feb. 9, 2024.
  3. Niederhuber JE, et al., eds. Cancer of the rectum. In: Abeloff's Clinical Oncology. 6th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed Feb. 9, 2024.
  4. Bleday R, et al. Surgical treatment of rectal cancer. https://www.uptodate.com/contents/search. Accessed Feb. 9, 2024.
  5. Rectal cancer treatment (PDQ) — Patient version. National Cancer Institute. https://www.cancer.gov/types/colorectal/patient/rectal-treatment-pdq. Accessed Feb. 9, 2024.
  6. Holman FA, et al. Results of a pooled analysis of IOERT containing multimodality treatment for locally recurrent rectal cancer: Results of 565 patients of two major treatment centers. European Journal of Surgical Oncology. 2017; doi:10.1016/j.ejso.2016.08.015.
  7. Holman FA, et al. Results of intraoperative electron beam radiotherapy containing multimodality treatment for locally unresectable T4 rectal cancer: A pooled analysis of the Mayo Clinic Rochester and Catharina Hospital Eindhoven. Journal of Gastrointestinal Oncology. 2016; doi:10.21037/jgo.2016.07.01.
  8. Elftmann TD, et al. Laparoscopic-assisted segmental colectomy: Surgical techniques. Mayo Clinic Proceedings. 1994; doi:10.1016/S0025-6196(12)61783-2.
  9. Merchea A, et al. Long-term oncologic outcomes of minimally invasive proctectomy for rectal adenocarcinoma. Journal of Gastrointestinal Surgery. 2018; doi:10.1007/s11605-018-3751-8.
  10. Warner KJ. Allscripts EPSi. Mayo Clinic. Feb. 10, 2020.
  11. Palliative care. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=3&id=1454. Accessed Feb. 9, 2024.