Nearly everyone is overtired or overworked from time to time. Such instances of temporary fatigue usually have an identifiable cause and a likely remedy.

Unrelenting exhaustion, on the other hand, lasts longer, is more profound and isn't relieved by rest. It's a nearly constant state of weariness that develops over time and reduces your energy, motivation and concentration. Fatigue at this level impacts your emotional and psychological well-being, too.

Jan. 11, 2018

See also

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  2. Acetyl-L-carnitine: Can it relieve MS fatigue?
  3. Acromegaly
  4. Acute bronchitis: Is it contagious?
  5. Acute hepatitis C infection
  6. Acute kidney failure
  7. Acute lymphocytic leukemia
  8. Acute myelogenous leukemia
  9. Acute sinusitis
  10. Acute sinusitis: Do over-the-counter treatments help?
  11. Addison's disease
  12. Adjuvant therapy for cancer
  13. Adrenal fatigue: What causes it?
  14. Alcoholic hepatitis
  15. Alternative cancer treatments: 10 options to consider
  16. Ambien: Is dependence a concern?
  17. Amputation and diabetes
  18. Amyloidosis
  19. Anaphylaxis
  20. Anemia
  21. Angina
  22. Anorexia nervosa
  23. Anthrax
  24. Antidepressant withdrawal: Is there such a thing?
  25. Antidepressants and alcohol: What's the concern?
  26. Antidepressants and weight gain: What causes it?
  27. Antidepressants: Can they stop working?
  28. Antidepressants for children and teens
  29. Antidepressants: Side effects
  30. Antidepressants: Selecting one that's right for you
  31. Antidepressants: Which cause the fewest sexual side effects?
  32. Anxiety disorders
  33. Aortic calcification: An early sign of heart valve problems?
  34. Aortic valve regurgitation
  35. Aortic valve stenosis
  36. Aplastic anemia
  37. ARDS
  38. Arteriovenous fistula
  39. Artificial sweeteners: Any effect on blood sugar?
  40. Ascariasis
  41. Aspergillosis
  42. Atrial septal defect (ASD)
  43. Atrioventricular canal defect
  44. Atypical antidepressants
  45. Atypical cells: Are they cancer?
  46. Autoimmune hepatitis
  47. Automated external defibrillators: Do you need an AED?
  48. Base tan? Bad idea
  49. Bedtime routines: Not just for babies
  50. Biopsy procedures
  51. Bipolar disorder
  52. Bipolar disorder and alcoholism: Are they related?
  53. Bipolar in children
  54. Bipolar medications and weight gain
  55. Bipolar treatment: I vs. II
  56. Blastocystis hominis
  57. Infographic: Blood Cancer Awareness
  58. Blood clots during menstruation: A concern?
  59. Blood glucose meters
  60. Blood glucose monitors
  61. Blood sugar levels can fluctuate for many reasons
  62. Blood sugar testing: Why, when and how
  63. Blood tests for heart disease
  64. Mitral valve clip to treat mitral regurgitation: Bob's story
  65. Bone and joint problems associated with diabetes
  66. Bone cancer
  67. Bradycardia
  68. Mitral valve overview
  69. Explaining multiple sclerosis
  70. 4 Ways to Prevent Heart Attack
  71. Ebstein Anomaly
  72. Ebstein Anomaly Part Two: Patient Frequently Asked Questions
  73. Fact or Fiction? Debunking Exercise & Nutrition Myths for Preventing Heart Disease and Risk Factors
  74. Giant Cell Myocarditis
  75. Healthy Heart Numbers
  76. Heart disease in women
  77. Heart Failure
  78. How kidneys work
  79. Jack Long — Live Long, Beat Strong to Find a Cure
  80. Video: Leaky Valve Animation
  81. Leaky Valve Cone Procedure
  82. Mayo Clinic - Holiday Heart Attack and Stroke Risk
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  84. Pulmonary hypertension overview
  85. Pulmonary Hypertension Treatment and Research
  86. Relationship between Long QT Syndrome and SIDS
  87. Screenings of newborns and athletes for genetic heart disease
  88. Video: Septal myectomy and apical myectomy
  89. Sports Cardiology Program
  90. Treating Long QT Patients Who Have Asthma
  91. Treating Pericarditis
  92. When a fainting episode might suggest a LQTS diagnosis
  93. Bronchitis
  94. Brucellosis
  95. Brugada syndrome
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  97. Caffeine and depression: Is there a link?
  98. Caffeine: Does it affect blood sugar?
  99. Calcium supplements: A risk factor for heart attack?
  100. Can chicken soup cure a cold?
  101. Infertility and endometriosis
  102. Can I still get endometriosis after menopause?
  103. Can vitamins help prevent a heart attack?
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  107. Infographic: Cancer Clinical Trials Offer Many Benefits
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  109. Cancer diagnosis? Advice for dealing with what comes next
  110. Cancer-related fatigue
  111. Cancer pain: Relief is possible
  112. Cancer risk: What the numbers mean
  113. Cancer surgery
  114. Cancer survival rate
  115. Cancer survivors: Care for your body after treatment
  116. Cancer survivors: Late effects of cancer treatment
  117. Cancer survivors: Managing your emotions after cancer treatment
  118. Cancer survivors: Reconnecting with loved ones after treatment
  119. Cancer treatment decisions: 5 steps to help you decide
  120. Cancer treatment for men: Possible sexual side effects
  121. Cancer treatment for women: Possible sexual side effects
  122. Cancer treatment myths
  123. Cancer Vaccine Research
  124. Cannabis for MS: Can it help treat symptoms?
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  127. Infographic: Cardiac sarcoidosis: A heart under attack
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  129. Caring for a loved one with diabetes
  130. Castleman disease
  131. Celiac disease
  132. Celiac disease: Can gluten be absorbed through the skin?
  133. Celiac disease diet: How do I get enough grains?
  134. Chagas disease
  135. Chelation therapy for heart disease: Does it work?
  136. Chemo brain
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  139. Cholangiocarcinoma (bile duct cancer)
  140. Cholera
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  151. Coffee after dinner? Make it decaf
  152. Cold and flu viruses: How long can they live outside the body?
  153. Cold or allergy: Which is it?
  154. Cold remedies
  155. Cold symptoms: Does drinking milk increase phlegm?
  156. Colon cancer
  157. Colon Cancer Family Registry
  158. Colon cancer screening: At what age can you stop?
  159. Colon cancer screening
  160. Common cold
  161. Concussion
  162. Concussion in children
  163. Concussion Recovery
  164. Concussion Telemedicine
  165. Control your portions, control your weight
  166. Anxiety and diet
  167. Coping with endometriosis pain
  168. Coping with side effects of hepatitis C drugs
  169. Coronary artery spasm: Cause for concern?
  170. Craving and chewing ice: A sign of anemia?
  171. Crohn's Crisis
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  173. Crohn's disease symptom: Is fatigue common?
  174. Crohn's or Colitis
  175. Cupping therapy: Can it relieve fibromyalgia pain?
  176. Curcumin: Can it slow cancer growth?
  177. Cushing syndrome
  178. Cyclospora infection
  179. Cyclothymia (cyclothymic disorder)
  180. Daily aspirin therapy
  181. Day-to-day with endometriosis: Challenge your expectations
  182. Demyelinating disease: What can you do about it?
  183. Depression and anxiety: Can I have both?
  184. Depression, anxiety and exercise
  185. Depression: Diagnosis is key
  186. Depression in women: Understanding the gender gap
  187. Depression (major depressive disorder)
  188. Depression: Provide support, encouragement
  189. Depression: Supporting a family member or friend
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  191. Diabetes
  192. Diabetes and Alzheimer's
  193. Diabetes and dental care
  194. Diabetes and depression: Coping with the two conditions
  195. Diabetes and exercise: When to monitor your blood sugar
  196. Diabetes and fasting: Can I fast during Ramadan?
  197. Diabetes and foot care
  198. Diabetes and Heat
  199. Diabetes and menopause
  200. Diabetes and summer: How to beat the heat
  201. Diabetes and travel: Planning is key
  202. Diabetes and electric blankets
  203. 10 ways to avoid diabetes complications
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  207. Diabetes foods: Can I substitute honey for sugar?
  208. Diabetes and liver
  209. Diabetes management: Does aspirin therapy prevent heart problems?
  210. Diabetes management: How lifestyle, daily routine affect blood sugar
  211. Diabetes: Eating out
  212. Diabetes nutrition: Sweets
  213. Diabetes prevention: 5 tips for taking control
  214. Diabetes symptoms
  215. Diabetes treatment: Can cinnamon lower blood sugar?
  216. Medications for type 2 diabetes
  217. Using insulin
  218. Diabetic coma
  219. Diabetic ketoacidosis
  220. Cancer-related diarrhea
  221. Dilated cardiomyopathy
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  223. Drinking after hepatitis C cure: Is it safe?
  224. Drummer Beats Heart Disease
  225. Dumping syndrome
  226. Early hepatitis C infection: How often does it become chronic?
  227. Early HIV symptoms: What are they?
  228. Eastern equine encephalitis (EEE): What is it?
  229. Eating during cancer treatment: Tips to make food tastier
  230. Ebstein anomaly
  231. Echinacea: Is it effective for the common cold?
  232. ED Drugs for Pulmonary Hypertension
  233. Heart transplant to treat dilated cardiomyopathy: Elmo's story
  234. Emerging treatments for multiple sclerosis
  235. Encephalitis
  236. Endocarditis
  237. Endometriosis
  238. Endometriosis risk factors
  239. Endometriosis causes: Theories about how endo starts
  240. Endometriosis: Risk factor for ovarian cancer?
  241. Endometriosis: Treatment options
  242. Testing for endometriosis
  243. Enlarged liver
  244. Enlarged spleen (splenomegaly)
  245. Esophageal cancer
  246. Infographic: Esophageal Cancer
  247. Estriol as a potential treatment option for multiple sclerosis (MS)
  248. Ewing sarcoma
  249. Exercise and multiple sclerosis
  250. External Drive: Charles' Artificial Heart
  251. Fasting diet: Can it improve my heart health?
  252. Fibromyalgia
  253. Fibromyalgia or not?
  254. Fibromyalgia and acupuncture
  255. Fibromyalgia: Does exercise help or hurt?
  256. Fibromyalgia: Linked to other health problems?
  257. Fibromyalgia pain: Options for coping
  258. Fibromyalgia: Self-care tips
  259. Fibromyalgia and Neurontin
  260. Finding balance: Tips to manage life with endometriosis
  261. Fingolimod during pregnancy: Is it safe?
  262. Fish oil and depression
  263. Flu masks
  264. Flu Shot Prevents Heart Attack
  265. Flu shots
  266. Flu shots and heart disease
  267. Flu: When to see a doctor?
  268. Flu vaccine: Safe for people with egg allergy?
  269. Fluzone High-Dose: What distinguishes it from other flu vaccines?
  270. Foods and sleep
  271. Gaucher disease
  272. Generalized anxiety disorder
  273. Genetics and Cardiomyopathy
  274. GI Stents
  275. Giardia infection (giardiasis)
  276. Glomerulonephritis
  277. GLP-1 agonists: Diabetes drugs and weight loss
  278. Glycemic index: A helpful tool for diabetes?
  279. Grand mal seizure
  280. Granulomatosis with polyangiitis
  281. Grass-fed beef
  282. Graves' dermopathy: How is it treated?
  283. Graves' disease
  284. Hairy cell leukemia
  285. Hangover prevention: Do lighter colored drinks help?
  286. Hangovers
  287. Hashimoto's disease
  288. Have a cold? Common sense rules
  289. Have a cold? Fight back with humidity
  290. Have a cold? Fight it with fluids
  291. Healthy eating: One step at a time
  292. Healthy Heart for Life!
  293. Healthy heart for life: Avoiding heart disease
  294. Heart arrhythmias
  295. Heart attack
  296. Heart attack prevention: Should I avoid secondhand smoke?
  297. Heart attack symptoms
  298. Heart Attack Timing
  299. Heart disease
  300. Heart disease in women: Understand symptoms and risk factors
  301. Heart failure
  302. Heart failure and sex: Is it safe?
  303. Heart-healthy diet: 8 steps to prevent heart disease
  304. Heat exhaustion
  305. Heavy periods: Can folic acid help?
  306. Hemochromatosis
  307. Hemolytic uremic syndrome (HUS)
  308. Hemophilia
  309. Hepatitis A
  310. Hepatitis B
  311. Hepatitis C
  312. Hepatitis C: How common is sexual transmission?
  313. Hepatitis C: What happens in end-stage liver disease?
  314. Herbal treatment for anxiety: Is it effective?
  315. Hiatal hernia
  316. High-dose vitamin C: Can it kill cancer cells?
  317. Hirschsprung's disease
  318. HIV/AIDS
  319. Hodgkin's lymphoma (Hodgkin's disease)
  320. Hodgkin's vs. non-Hodgkin's lymphoma: What's the difference?
  321. Holiday Heart
  322. Honey: An effective cough remedy?
  323. How does diet affect endometriosis?
  324. How well do you wash your hands?
  325. Humidifier care 101
  326. Humidifiers
  327. Huntington's disease
  328. Hypercalcemia
  329. Hyperglycemia in diabetes
  330. Hyperinsulinemia: Is it diabetes?
  331. Hyperparathyroidism
  332. Hyperthyroidism
  333. Hypertrophic cardiomyopathy
  334. Infographic: Hypertrophic Cardiomyopathy
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  336. Hypoparathyroidism
  337. Hypopituitarism
  338. Hypothermia
  339. Hypothyroidism: Can calcium supplements interfere with treatment?
  340. Hypothyroidism diet
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  342. Hypothyroidism: Should I take iodine supplements?
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  344. Hypothyroidism
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  346. Inflammatory bowel disease (IBD)
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  348. Infographic: Innovative Rectal Cancer Treatments
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  351. Insomnia treatment: Cognitive behavioral therapy instead of sleeping pills
  352. Insulin and weight gain
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  354. Intensive insulin therapy
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  356. Iron deficiency anemia
  357. Is antibacterial soap a do or a don't?
  358. Is depression a factor in rheumatoid arthritis?
  359. Is fibromyalgia hereditary?
  360. Is there a multiple sclerosis diet?
  361. Jet lag disorder
  362. Depression and diet
  363. Kidney cancer
  364. Kidney Cancer
  365. Infographic: Kidney Cancer
  366. Lack of sleep: Can it make you sick?
  367. Late-night eating: OK if you have diabetes?
  368. LADA
  369. Preventing lead exposure
  370. Lead poisoning
  371. Legionnaires' disease
  372. Leukemia
  373. Lexapro side effects: Is breast tenderness common?
  374. Liver cancer
  375. Infographic: Liver Cancer
  376. Infographic: Liver Transplant Bile Duct Cancer
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  379. Living with Lupus
  380. Long QT syndrome
  381. Long-term safety of natalizumab for treating multiple sclerosis
  382. Low blood counts
  383. Low blood pressure (hypotension)
  384. Low blood sodium in older adults: A concern?
  385. Low-phosphorus diet: Helpful for kidney disease?
  386. Lupus
  387. Lupus: Can it cause hair loss?
  388. Lupus: Can it cause hives?
  389. Lupus affects kidneys
  390. Lyme disease
  391. Male depression: Understanding the issues
  392. Male hypogonadism
  393. Managing anxiety in MS: What works?
  394. Managing depression in MS
  395. Diabetes and carbs
  396. Managing your self-esteem when you have endometriosis
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  398. MAOIs and diet: Is it necessary to restrict tyramine?
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  400. Mayo Clinic Minute: The facts about three flu vaccine myths
  401. Mayo Clinic Minute: Why you need your flu shot now
  402. Mayo Clinic Minute: Will there be a Lyme disease vaccine for humans?
  403. Measles Virus as a Cancer Fighter
  404. Membranous nephropathy
  405. Menorrhagia
  406. Mental health: Overcoming the stigma of mental illness
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  408. Mental illness
  409. Menus for heart-healthy eating
  410. Mild depression: Are antidepressants effective?
  411. Mindfulness practice: Can it reduce symptoms of MS?
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  413. Mitral valve regurgitation
  414. Mitral valve stenosis
  415. Mixed connective tissue disease
  416. Monoamine oxidase inhibitors (MAOIs)
  417. Monoclonal antibody drugs
  418. Mononucleosis
  419. Mononucleosis: Can it recur?
  420. Mononucleosis and Epstein-Barr: What's the connection?
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  422. Mouth sores caused by cancer treatment: How to cope
  423. MRI: Is gadolinium safe for people with kidney problems?
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  426. Multiple sclerosis
  427. Infographic: Multiple Sclerosis
  428. Multiple sclerosis: Can it cause seizures?
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  430. Myelodysplastic syndromes
  431. Myelofibrosis
  432. Myelofibrosis
  433. Myocarditis
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  435. Nervous breakdown: What does it mean?
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  437. Neti pot solution: Can I make my own?
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  444. Nuts and your heart: Eating nuts for heart health
  445. He's the bravest kid I've ever seen
  446. Oil of oregano: Can it treat sinusitis?
  447. Omega-3 in fish
  448. Omega-6 fatty acids
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  450. Living with an ostomy
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  452. Palindromic rheumatism: Precursor to rheumatoid arthritis?
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  455. Pectus Excavatum
  456. Pelvic inflammatory disease (PID)
  457. Pericarditis
  458. Peritonitis
  459. Persistent depressive disorder (dysthymia)
  460. Personalized therapy for multiple sclerosis (MS)
  461. Plague
  462. Plugged ears: What is the remedy?
  463. Pneumonia
  464. Pneumonitis
  465. Polio
  466. Polycythemia vera
  467. Polymyalgia rheumatica
  468. Polymyositis
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  470. Polypill: Does it treat heart disease?
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  472. Postpartum depression
  473. Postpartum thyroiditis
  474. Post-polio syndrome
  475. Prediabetes
  476. Premenstrual dysphoric disorder
  477. Premenstrual syndrome (PMS)
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  481. Primary sclerosing cholangitis
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  485. Pulmonary fibrosis
  486. Pulmonary hypertension
  487. Pulmonary valve stenosis
  488. Put fish on the menu
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  490. Reactive hypoglycemia: What can I do?
  491. Reading food labels
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  496. Reducing stress to manage endometriosis
  497. Renal diet for vegetarians
  498. Rethinking Rheumatoid Arthritis
  499. Rhabdomyolysis
  500. Rheumatic fever
  501. Rheumatoid arthritis
  502. Rheumatoid Arthritis
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  519. Self-Image During Cancer
  520. Serotonin and norepinephrine reuptake inhibitors (SNRIs)
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  530. Sinus headaches
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  538. Small cell, large cell cancer: What this means
  539. Small vessel disease
  540. Smallpox
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  550. Stuffy nose? Try saline spray
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  556. Takayasu's arteritis
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  560. Thalassemia
  561. Thalidomide: Research advances in cancer and other conditions
  562. Infographic: The blueprints to your heart
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  565. Tips for cutting costs of blood glucose test strips
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  567. Toxoplasmosis
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  570. Tricuspid valve regurgitation
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  576. Type 2 diabetes
  577. Type 2 diabetes in children
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  581. Use these tips to help children prevent diabetes
  582. Valerian: A safe and effective herbal sleep aid?
  583. Valley fever
  584. Vasculitis
  585. Vegetarian diet: Can it help me control my diabetes?
  586. Ventricular septal defect
  587. Vicks VapoRub: An effective nasal decongestant?
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  591. Mitral valve regurgitation
  592. PICC line placement
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  596. Vitamin C: Can it prevent colds?
  597. Vitamin D and MS: Any connection?
  598. Vitamin deficiency anemia
  599. Vitamins for MS: Do supplements make a difference?
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  601. Walking pneumonia
  602. Warm-mist versus cool-mist humidifier: Which is better for a cold?
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  605. Heart failure action plan
  606. What is meant by the term "heart age"?
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  608. When cancer returns: How to cope with cancer recurrence
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  610. Whipple's disease
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  614. Wilson's disease
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  616. Infographic: Women and Heart Disease
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