Nearly everyone is overtired or overworked from time to time. Such instances of temporary fatigue usually have an identifiable cause and a likely remedy.

Unrelenting exhaustion, on the other hand, lasts longer, is more profound and isn't relieved by rest. It's a nearly constant state of weariness that develops over time and reduces your energy, motivation and concentration. Fatigue at this level impacts your emotional and psychological well-being, too.

From Mayo Clinic to your inbox

Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health.

To provide you with the most relevant and helpful information, and understand which information is beneficial, we may combine your email and website usage information with other information we have about you. If you are a Mayo Clinic patient, this could include protected health information. If we combine this information with your protected health information, we will treat all of that information as protected health information and will only use or disclose that information as set forth in our notice of privacy practices. You may opt-out of email communications at any time by clicking on the unsubscribe link in the e-mail.

Dec. 02, 2020

See also

  1. 6 tips to manage rheumatoid arthritis symptoms
  2. Acetyl-L-carnitine: Can it relieve MS fatigue?
  3. Acromegaly
  4. Acute bronchitis: Is it contagious?
  5. Acute hepatitis C infection
  6. Acute kidney failure
  7. Acute lymphocytic leukemia
  8. Acute myelogenous leukemia
  9. Acute sinusitis
  10. Acute sinusitis: Do over-the-counter treatments help?
  11. Addison's disease
  12. Adjuvant therapy for cancer
  13. Adrenal fatigue: What causes it?
  14. Alcoholic hepatitis
  15. Ambien: Is dependence a concern?
  16. Amputation and diabetes
  17. Amyloidosis
  18. Anaphylaxis
  19. Anaphylaxis: First aid
  20. Anemia
  21. Angina
  22. Anorexia nervosa
  23. Anthrax
  24. Antidepressant withdrawal: Is there such a thing?
  25. Antidepressants and alcohol: What's the concern?
  26. Antidepressants and weight gain: What causes it?
  27. Antidepressants: Can they stop working?
  28. Antidepressants for children and teens
  29. Antidepressants: Side effects
  30. Antidepressants: Selecting one that's right for you
  31. Antidepressants: Which cause the fewest sexual side effects?
  32. Anxiety disorders
  33. Aortic calcification: An early sign of heart valve problems?
  34. Aortic valve regurgitation
  35. Aortic valve stenosis
  36. Aplastic anemia
  37. ARDS
  38. Arteriovenous fistula
  39. Artificial sweeteners: Any effect on blood sugar?
  40. Ascariasis
  41. Aspergillosis
  42. Atrial septal defect (ASD)
  43. Atrioventricular canal defect
  44. Atypical antidepressants
  45. Atypical cells: Are they cancer?
  46. Autoimmune hepatitis
  47. Automated external defibrillators: Do you need an AED?
  48. Base tan? Bad idea
  49. Bedtime routines: Not just for babies
  50. Biopsy procedures
  51. Bipolar disorder and alcoholism: Are they related?
  52. Bipolar disorder
  53. Bipolar in children
  54. Bipolar medications and weight gain
  55. Bipolar treatment: I vs. II
  56. Blastocystis hominis
  57. Infographic: Blood Cancer Awareness
  58. Blood Cancers and Disorders
  59. Blood clots during menstruation: A concern?
  60. Blood glucose meters
  61. Blood glucose monitors
  62. Blood sugar levels can fluctuate for many reasons
  63. Blood sugar testing: Why, when and how
  64. Blood tests for heart disease
  65. Mitral valve clip to treat mitral regurgitation: Bob's story
  66. Bone and joint problems associated with diabetes
  67. Bone cancer
  68. Bradycardia
  69. Mitral valve overview
  70. Explaining multiple sclerosis
  71. How kidneys work
  72. Jack Long — Live Long, Beat Strong to Find a Cure
  73. A leaky tricuspid valve
  74. Leaky Valve Cone Procedure
  75. Parathyroid
  76. Screenings of newborns and athletes for genetic heart disease
  77. Video: Septal myectomy and apical myectomy
  78. Treating Long QT Patients Who Have Asthma
  79. Treating Pericarditis
  80. When a fainting episode might suggest a LQTS diagnosis
  81. Bronchitis
  82. Brucellosis
  83. Brugada syndrome
  84. Caffeine: Does it affect blood sugar?
  85. Calcium supplements: A risk factor for heart attack?
  86. Can chicken soup cure a cold?
  87. Can vitamins help prevent a heart attack?
  88. Cancer
  89. Cancer
  90. Cancer blood tests
  91. Myths about cancer causes
  92. Infographic: Cancer Clinical Trials Offer Many Benefits
  93. Cancer diagnosis: 11 tips for coping
  94. Cancer-related fatigue
  95. Cancer Managing Symptoms
  96. Cancer pain: Relief is possible
  97. Cancer risk: What the numbers mean
  98. Cancer surgery
  99. Cancer survival rate
  100. Cancer survivors: Care for your body after treatment
  101. Cancer survivors: Late effects of cancer treatment
  102. Cancer survivors: Managing your emotions after cancer treatment
  103. Cancer survivors: Reconnecting with loved ones after treatment
  104. Cancer treatment decisions: 5 steps to help you decide
  105. Cancer treatment myths
  106. Cancer Vaccine Research
  107. Can't sleep? Try daytime exercise
  108. Cardiac asthma: What causes it?
  109. Infographic: Cardiac sarcoidosis: A heart under attack
  110. Cardiomyopathy
  111. Castleman disease
  112. Celiac disease
  113. Celiac disease diet: How do I get enough grains?
  114. Chelation therapy for heart disease: Does it work?
  115. Chemo brain
  116. Chemotherapy side effects: A cause of heart disease?
  117. Chicken soup: Can it treat a cold?
  118. Cholangiocarcinoma (bile duct cancer)
  119. Cholera
  120. Chronic fatigue syndrome
  121. Chronic kidney disease
  122. Chronic lymphocytic leukemia
  123. Chronic myelogenous leukemia
  124. Chronic sinusitis
  125. Churg-Strauss syndrome
  126. Cirrhosis
  127. What is cirrhosis? A Mayo Clinic expert explains
  128. Cirrhosis FAQs
  129. Clinical depression: What does that mean?
  130. Coconut oil: Can it cure hypothyroidism?
  131. Coffee after dinner? Make it decaf
  132. Cold and flu viruses: How long can they live outside the body?
  133. Cold or allergy: Which is it?
  134. Cold remedies
  135. Cold symptoms: Does drinking milk increase phlegm?
  136. Colon cancer
  137. Colon Cancer Family Registry
  138. Colon cancer screening: At what age can you stop?
  139. Colon cancer screening
  140. Colorectal Cancer
  141. Common cold
  142. Concussion
  143. Concussion in children
  144. Concussion Recovery
  145. Concussion Telemedicine
  146. Anxiety and diet
  147. Coronary artery spasm: Cause for concern?
  148. Craving and chewing ice: A sign of anemia?
  149. Crohn's Crisis
  150. Crohn's disease
  151. What is Crohn's disease? A Mayo Clinic expert explains
  152. Crohn's disease symptom: Is fatigue common?
  153. Crohn's or Colitis
  154. Curcumin: Can it slow cancer growth?
  155. Cushing syndrome
  156. Cyclospora infection
  157. Cyclothymia (cyclothymic disorder)
  158. Daily aspirin therapy
  159. Demyelinating disease: What can you do about it?
  160. Depression and anxiety: Can I have both?
  161. Depression, anxiety and exercise
  162. Depression: Diagnosis is key
  163. Depression in women: Understanding the gender gap
  164. Depression (major depressive disorder)
  165. Depression: Provide support, encouragement
  166. Depression: Supporting a family member or friend
  167. Dermatomyositis
  168. Diabetes
  169. Diabetes and dental care
  170. Diabetes and depression: Coping with the two conditions
  171. Diabetes and exercise: When to monitor your blood sugar
  172. Diabetes and fasting: Can I fast during Ramadan?
  173. Diabetes and foot care
  174. Diabetes and Heat
  175. What is type 1 diabetes? A Mayo Clinic expert explains
  176. 10 ways to avoid diabetes complications
  177. Diabetes diet: Should I avoid sweet fruits?
  178. Diabetes diet: Create your healthy-eating plan
  179. Diabetes foods: Can I substitute honey for sugar?
  180. Diabetes and liver
  181. Diabetes management: How lifestyle, daily routine affect blood sugar
  182. Diabetes: Eating out
  183. Diabetes nutrition: Sweets
  184. Diabetes prevention: 5 tips for taking control
  185. Type 1 diabetes FAQs
  186. Diabetes symptoms
  187. Diabetes treatment: Can cinnamon lower blood sugar?
  188. Medications for type 2 diabetes
  189. Using insulin
  190. Diabetic coma
  191. Diabetic ketoacidosis
  192. Cancer-related diarrhea
  193. Dilated cardiomyopathy
  194. Does stress make rheumatoid arthritis worse?
  195. Does zinc work for colds?
  196. Drinking after hepatitis C cure: Is it safe?
  197. Drummer Beats Heart Disease
  198. Dumping syndrome
  199. Early HIV symptoms: What are they?
  200. Ease rheumatoid arthritis pain when grocery shopping
  201. Eating during cancer treatment: Tips to make food tastier
  202. Ebstein anomaly
  203. ED Drugs for Pulmonary Hypertension
  204. Emerging treatments for multiple sclerosis
  205. Encephalitis
  206. Endocarditis
  207. Endometriosis
  208. Endometriosis: Risk factor for ovarian cancer?
  209. Enlarged liver
  210. Enlarged spleen (splenomegaly)
  211. Esophageal cancer
  212. Infographic: Esophageal Cancer
  213. Esophageal Cancer
  214. Ewing sarcoma
  215. Exercise and multiple sclerosis
  216. Fasting diet: Can it improve my heart health?
  217. Fibromyalgia
  218. Fibromyalgia and acupuncture
  219. Fibromyalgia: Linked to other health problems?
  220. Fibromyalgia and Neurontin
  221. Fibromyalgia or not?
  222. Flu masks
  223. Flu Shot Prevents Heart Attack
  224. Flu shots
  225. Flu shots and heart disease
  226. Flu: When to see a doctor?
  227. Flu vaccine: Safe for people with egg allergy?
  228. Gaucher disease
  229. Generalized anxiety disorder
  230. Genetics and Cardiomyopathy
  231. GI Stents
  232. Giardia infection (giardiasis)
  233. Glomerulonephritis
  234. GLP-1 agonists: Diabetes drugs and weight loss
  235. Glycemic index: A helpful tool for diabetes?
  236. Grand mal seizure
  237. Granulomatosis with polyangiitis
  238. Grass-fed beef
  239. Graves' disease
  240. H1N1 flu (swine flu)
  241. Hairy cell leukemia
  242. Hangovers
  243. Hashimoto's disease
  244. Have a cold? Common sense rules
  245. Have a cold? Fight back with humidity
  246. Have a cold? Fight it with fluids
  247. Healthy eating: One step at a time
  248. Healthy Heart for Life!
  249. Heart arrhythmia
  250. Heart attack
  251. Heart attack prevention: Should I avoid secondhand smoke?
  252. Heart attack symptoms
  253. Heart Attack Timing
  254. Heart cancer: Is there such a thing?
  255. Heart disease
  256. Heart disease in women: Understand symptoms and risk factors
  257. Heart failure
  258. Heart failure and sex: Is it safe?
  259. Heart-healthy diet: 8 steps to prevent heart disease
  260. Heat exhaustion
  261. Heavy periods: Can folic acid help?
  262. Hemochromatosis
  263. Hemolytic uremic syndrome (HUS)
  264. Hemophilia
  265. Hepatitis A
  266. Hepatitis B
  267. Hepatitis C
  268. Hepatitis C: How common is sexual transmission?
  269. Hepatitis C: What happens in end-stage liver disease?
  270. Herbal treatment for anxiety: Is it effective?
  271. Hiatal hernia
  272. High-dose flu vaccines: How are they different from other flu vaccines?
  273. High-dose vitamin C: Can it kill cancer cells?
  274. Hirschsprung's disease
  275. HIV/AIDS
  276. Hodgkin's lymphoma (Hodgkin's disease)
  277. Hodgkin's vs. non-Hodgkin's lymphoma: What's the difference?
  278. Holiday Heart
  279. How do I reduce fatigue from rheumatoid arthritis?
  280. How plant-based food helps fight cancer
  281. Humidifier care 101
  282. Humidifiers
  283. Huntington's disease
  284. Hypercalcemia
  285. Hyperglycemia in diabetes
  286. Hyperinsulinemia: Is it diabetes?
  287. Hyperparathyroidism
  288. Hyperthyroidism (overactive thyroid)
  289. Hypertrophic cardiomyopathy
  290. Infographic: Hypertrophic Cardiomyopathy
  291. Hyponatremia
  292. Hypoparathyroidism
  293. Hypopituitarism
  294. Hypothermia
  295. Hypothyroidism: Can calcium supplements interfere with treatment?
  296. Hypothyroidism diet
  297. Hypothyroidism and joint pain?
  298. Hypothyroidism: Should I take iodine supplements?
  299. Hypothyroidism symptoms: Can hypothyroidism cause eye problems?
  300. Hypothyroidism (underactive thyroid)
  301. Inflammatory bowel disease (IBD)
  302. Inflammatory bowel disease FAQs
  303. Influenza (flu)
  304. Infographic: Innovative Rectal Cancer Treatments
  305. Insomnia
  306. Insomnia: How do I stay asleep?
  307. Insomnia treatment: Cognitive behavioral therapy instead of sleeping pills
  308. Insulin and weight gain
  309. Intervention: Help a loved one overcome addiction
  310. Iron deficiency anemia
  311. Is depression a factor in rheumatoid arthritis?
  312. Is fibromyalgia hereditary?
  313. Jet lag disorder
  314. Kidney cancer
  315. Kidney Cancer
  316. Infographic: Kidney Cancer
  317. What is kidney cancer? An expert explains
  318. Kidney cancer FAQs
  319. What is kidney disease? An expert explains
  320. Kidney disease FAQs
  321. Lack of sleep: Can it make you sick?
  322. Late-night eating: OK if you have diabetes?
  323. LADA
  324. Lead poisoning
  325. Legionnaires' disease
  326. Leukemia
  327. Liver cancer
  328. Infographic: Liver Cancer
  329. What is liver cancer? An expert explains
  330. Liver cancer FAQs
  331. Infographic: Liver Transplant Bile Duct Cancer
  332. Liver transplant for hepatitis C
  333. Living better with rheumatoid arthritis
  334. Living with Lupus
  335. Long QT syndrome
  336. Low blood counts
  337. Low blood pressure (hypotension)
  338. Low blood sodium in older adults: A concern?
  339. Low-phosphorus diet: Helpful for kidney disease?
  340. Lupus
  341. Lupus: Can it cause hair loss?
  342. Lupus: Can it cause hives?
  343. Lyme disease
  344. Male depression: Understanding the issues
  345. Male hypogonadism
  346. Mangosteen juice: Can it relieve arthritis pain?
  347. MAOIs and diet: Is it necessary to restrict tyramine?
  348. Marijuana and depression
  349. Mayo Clinic Minute: Will there be a Lyme disease vaccine for humans?
  350. Measles Virus as a Cancer Fighter
  351. Membranous nephropathy
  352. Menorrhagia (heavy menstrual bleeding)
  353. Mental health: Overcoming the stigma of mental illness
  354. Mental health providers: Tips on finding one
  355. Mental illness
  356. Menus for heart-healthy eating
  357. Mitral valve prolapse
  358. Mitral valve regurgitation
  359. Mitral valve stenosis
  360. Mixed connective tissue disease
  361. Monoamine oxidase inhibitors (MAOIs)
  362. Monoclonal antibody drugs
  363. Mononucleosis
  364. Mononucleosis: Can it recur?
  365. Mononucleosis and Epstein-Barr: What's the connection?
  366. Mort Crim and Cancer
  367. Mouth sores caused by cancer treatment: How to cope
  368. MRI: Is gadolinium safe for people with kidney problems?
  369. Multiple myeloma
  370. Infographic: Multiple Myeloma
  371. Multiple sclerosis
  372. Infographic: Multiple Sclerosis
  373. Multiple sclerosis: Can it cause seizures?
  374. What is multiple sclerosis? An expert explains
  375. Multiple sclerosis FAQs
  376. Multisystem inflammatory syndrome in children (MIS-C)
  377. Mumps
  378. Myelodysplastic syndromes
  379. Myelofibrosis
  380. Myelofibrosis
  381. Myocarditis
  382. Natural remedies for depression: Are they effective?
  383. Nervous breakdown: What does it mean?
  384. Neti pot: Can it clear your nose?
  385. New Hep C Treatment
  386. What is ulcerative colitis? A Mayo Clinic expert explains
  387. No appetite? How to get nutrition during cancer treatment
  388. Nonalcoholic fatty liver disease
  389. Non-Hodgkin's lymphoma
  390. Not tired? Don't go to bed
  391. NSAIDs: Do they increase my risk of heart attack and stroke?
  392. Nuts and your heart: Eating nuts for heart health
  393. He's the bravest kid I've ever seen
  394. Oil of oregano: Can it treat sinusitis?
  395. Omega-3 in fish
  396. Omega-6 fatty acids
  397. Living with an ostomy
  398. Pain and depression: Is there a link?
  399. Parvovirus infection
  400. Pectus excavatum
  401. Pectus excavatum
  402. Pelvic inflammatory disease (PID)
  403. Pericarditis
  404. Peritonitis
  405. Persistent depressive disorder (dysthymia)
  406. Persistent post-concussive symptoms (Post-concussion syndrome)
  407. Plague
  408. Plugged ears: What is the remedy?
  409. Pneumonia
  410. Pneumonitis
  411. Polio
  412. Polycythemia vera
  413. Polymyalgia rheumatica
  414. Polymyositis
  415. Polypill: Does it treat heart disease?
  416. Postpartum depression
  417. Post-polio syndrome
  418. Prediabetes
  419. Premenstrual dysphoric disorder
  420. Premenstrual syndrome (PMS)
  421. PrEP to prevent HIV
  422. Prescription sleeping pills: What's right for you?
  423. Primary biliary cholangitis
  424. Primary sclerosing cholangitis
  425. Protect your joints while housecleaning
  426. Protein: Heart-healthy sources
  427. Proton Beam Therapy
  428. Pulmonary atresia
  429. Pulmonary edema
  430. Pulmonary fibrosis
  431. Pulmonary hypertension
  432. Pulmonary valve stenosis
  433. Put fish on the menu
  434. Q fever
  435. Reactive hypoglycemia: What can I do?
  436. Reading food labels
  437. Rectal cancer
  438. Recurring strep throat: When is tonsillectomy useful?
  439. Red wine, antioxidants and resveratrol
  440. Renal diet for vegetarians
  441. Rethinking Rheumatoid Arthritis
  442. Rhabdomyolysis
  443. Rheumatic fever
  444. Rheumatoid arthritis
  445. Rheumatoid Arthritis
  446. Rheumatoid arthritis: Does pregnancy affect symptoms?
  447. Rheumatoid arthritis and exercise
  448. Rheumatoid arthritis: Vaccines
  449. Rheumatoid arthritis: Can it affect the eyes?
  450. Rheumatoid arthritis: Can it affect the lungs?
  451. Robotic heart surgery treats mitral regurgitation: Ed's story
  452. Rocky Mountain spotted fever
  453. Roseola
  454. Salt craving: A symptom of Addison's disease?
  455. Sarcoidosis
  456. Savella may help fatigue
  457. Selective serotonin reuptake inhibitors (SSRIs)
  458. Self-care for the flu
  459. Self-Image During Cancer
  460. Serotonin and norepinephrine reuptake inhibitors (SNRIs)
  461. Infographic: Shedding light on dangerous faints
  462. Shingles
  463. Shingles and alcohol
  464. Shingles vaccine: Can I transmit the vaccine virus to others?
  465. Shingles vaccine: Should I get it?
  466. Sick sinus syndrome
  467. Silent heart attack
  468. Sinus headaches
  469. Sinus infection and toothache: Any connection?
  470. Sjogren's syndrome
  471. Sjogren's syndrome: Can it cause recurrent UTIs?
  472. Skip booze for better sleep
  473. Blood sugar testing
  474. Radiation simulation
  475. Small cell, large cell cancer: What this means
  476. Small vessel disease
  477. Smallpox
  478. Somatic symptom disorder
  479. Soy: Does it worsen hypothyroidism?
  480. Stomach cancer
  481. Infographic: Stomach Cancer
  482. What is stomach cancer? A Mayo Clinic expert explains
  483. Stomach cancer FAQs
  484. Heart disease prevention
  485. Strep throat
  486. Strep throat in young children: A common diagnosis?
  487. Stuffy nose? Try saline spray
  488. Sudden cardiac arrest
  489. Sudden death in young people: Heart problems often blamed
  490. Sunburn
  491. Sunburn treatment: Do I need medical attention?
  492. Takayasu's arteritis
  493. Tanning: Does a base tan prevent sunburn?
  494. Teen depression
  495. Test anxiety: Can it be treated?
  496. Thalassemia
  497. Thalidomide: Research advances in cancer and other conditions
  498. The dawn phenomenon: What can you do?
  499. Thyroid disease: Can it affect a person's mood?
  500. Tips to make your mornings easier
  501. Toxic hepatitis
  502. Toxoplasmosis
  503. Treatment-resistant depression
  504. Tricuspid atresia
  505. Tricuspid valve regurgitation
  506. Tricyclic antidepressants and tetracyclic antidepressants
  507. Tuberculosis
  508. Tumor vs. cyst: What's the difference?
  509. Type 1 diabetes
  510. Type 1 diabetes in children
  511. Type 2 diabetes
  512. Type 2 diabetes in children
  513. Typhoid fever
  514. Ulcerative colitis
  515. Ulcerative colitis flare-ups: 5 tips to manage them
  516. Valerian: A safe and effective herbal sleep aid?
  517. Valley fever
  518. Vasculitis
  519. Vegetarian diet: Can it help me control my diabetes?
  520. Ventricular septal defect (VSD)
  521. Vicks VapoRub: An effective nasal decongestant?
  522. Video: Heart and circulatory system
  523. How cancer spreads
  524. How diabetes affects your blood sugar
  525. Mitral valve regurgitation
  526. PICC line placement
  527. Video-kidney cancer patient-tattoo
  528. Viral hemorrhagic fevers
  529. Vitamin B-12 and depression
  530. Vitamin C: Can it prevent colds?
  531. Vitamin D and MS: Any connection?
  532. Vitamin deficiency anemia
  533. Vitamins for MS: Do supplements make a difference?
  534. Von Willebrand disease
  535. Walking pneumonia
  536. Warm-mist versus cool-mist humidifier: Which is better for a cold?
  537. Watch an interview with Fernando C Fervenza MD PhD
  538. West Nile virus
  539. Heart failure action plan
  540. What is meant by the term "heart age"?
  541. What's the difference between H1N1 flu and influenza A?
  542. When cancer returns: How to cope with cancer recurrence
  543. Whiplash
  544. Whipple's disease
  545. Whooping cough
  546. Whooping cough
  547. Why isn't there a hepatitis C vaccine?
  548. Wilson's disease
  549. Wilson's syndrome: An accepted medical diagnosis?
  550. Infographic: Women and Heart Disease
  551. Effectively managing chronic kidney disease
  552. Do zinc supplements shorten colds?