Most of the time fatigue can be traced to one or more lifestyle issues, such as poor sleep habits or lack of exercise. Fatigue can be caused by a medicine or linked to depression. Sometimes fatigue is a symptom of an illness that needs treatment.

Lifestyle factors

Fatigue may be related to:

  1. Alcohol or drug use
  2. Eating poorly
  3. Medicines, such as ones used to treat allergies or coughs
  4. Not enough sleep
  5. Too little physical activity
  6. Too much physical activity

Conditions

Exhaustion that doesn't let up might be a sign of:

  1. Adrenal insufficiency
  2. Amyotrophic lateral sclerosis (ALS)
  3. Anemia — a condition in which the body doesn't get oxygen due to a lack of healthy red blood cells
  4. Anxiety disorders
  5. Cancer
  6. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
  7. Chronic infection or inflammation
  8. Chronic kidney disease
  9. COPD — (chronic obstructive pulmonary disease) — the blanket term for a group of diseases, including emphysema, that block airflow from the lungs.
  10. Coronavirus disease 2019 (COVID-19)
  11. Depression (major depressive disorder)
  12. Diabetes
  13. Fibromyalgia
  14. Grief
  15. Heart disease
  16. Heart failure — a condition in which the heart doesn't pump blood as well as it should.
  17. Hepatitis A
  18. Hepatitis B
  19. Hepatitis C
  20. HIV/AIDS
  21. Hyperthyroidism (overactive thyroid)
  22. Hypothyroidism (underactive thyroid)
  23. Inflammatory bowel disease (IBD)
  24. Liver disease
  25. Low vitamin D
  26. Lupus
  27. Medicines and treatments, such as chemotherapy, radiation therapy, pain medicines, heart medicines and antidepressants
  28. Mononucleosis
  29. Multiple sclerosis
  30. Obesity
  31. Parkinson's disease
  32. Physical or emotional abuse
  33. Polymyalgia rheumatica
  34. Pregnancy
  35. Rheumatoid arthritis
  36. Sleep apnea — a condition in which breathing stops and starts many times during sleep.
  37. Stress.
  38. Traumatic brain injury

Causes shown here are commonly associated with this symptom. Work with your doctor or other health care professional for an accurate diagnosis.

From Mayo Clinic to your inbox

Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. Click here for an email preview.

We use the data you provide to deliver you the content you requested. To provide you with the most relevant and helpful information, we may combine your email and website data with other information we have about you. If you are a Mayo Clinic patient, we will only use your protected health information as outlined in our Notice of Privacy Practices. You may opt out of email communications at any time by clicking on the unsubscribe link in the email.

Feb. 20, 2026

See also

  1. ​Self-care for fatty liver disease (MASLD)
  2. 6 tips to manage rheumatoid arthritis symptoms
  3. A leaky tricuspid valve
  4. Acute lymphocytic leukemia
  5. Acute sinusitis
  6. Acute sinusitis: Do over-the-counter treatments help?
  7. Addison's disease
  8. Adenocarcinoma: How this type of cancer affects prognosis
  9. Amyloidosis
  10. Anaphylaxis: First aid
  11. Anemia
  12. Angina
  13. Anorexia nervosa
  14. Anthrax
  15. Antidepressants and weight gain: What causes it?
  16. Antidepressants: Can they stop working?
  17. Anxiety and diet
  18. Anxiety disorders
  19. Aortic calcification: An early sign of heart valve problems?
  20. Aortic valve regurgitation
  21. Aortic valve stenosis
  22. ARDS
  23. Artificial sweeteners: Any effect on blood sugar?
  24. Ascariasis
  25. Aspergillosis
  26. At-home colon cancer tests
  27. Atrial septal defect (ASD)
  28. Atypical antidepressants
  29. Biliary tract cancer: Should I get a second opinion?
  30. Bipolar disorder
  31. Bipolar disorder and alcoholism: Are they related?
  32. Bipolar disorder in children: Is it possible?
  33. Blastocystis hominis
  34. Blood sugar testing: Why, when and how
  35. Blood tests for heart disease
  36. Bone cancer
  37. Brain tumor
  38. Can vitamins help prevent a heart attack?
  39. Cancer blood tests: Lab tests used in cancer diagnosis
  40. Cancer causes: Popular myths about the causes of cancer
  41. Cancer fatigue: Why it occurs and how to cope
  42. Cancer pain: Relief is possible
  43. Cancer survival rate: What it means for your prognosis
  44. Cardiac asthma: What causes it?
  45. Celiac disease
  46. Chelation therapy for heart disease: Does it work?
  47. Chemo brain
  48. Chronic kidney disease
  49. Chronic kidney disease: Is a clinical trial right for me?
  50. Chronic sinusitis
  51. Churg-Strauss syndrome
  52. Coconut oil: Can it cure hypothyroidism?
  53. Cold symptoms: Does drinking milk increase phlegm?
  54. Colon Cancer Family Registry
  55. Colon cancer prevention: What you can do
  56. Common cold
  57. Concussion
  58. Concussion in children
  59. Craving and chewing ice: A sign of anemia?
  60. Crohn's Crisis
  61. Crohn's disease and the gut microbiome
  62. Cutaneous B-cell lymphoma
  63. Dermatomyositis
  64. Diabetes and depression: Coping with the two conditions
  65. Diabetes and exercise: When to monitor your blood sugar
  66. Diabetes and heat
  67. Diabetes care: 10 ways to avoid complications
  68. Diabetes diet: Should I avoid sweet fruits?
  69. Diabetes foods: Can I substitute honey for sugar?
  70. Diabetes management: How lifestyle, daily routine affect blood sugar
  71. Diabetes treatment: Medications for type 2 diabetes
  72. Diabetes treatment: Using insulin to manage blood sugar
  73. Diabetic ketoacidosis
  74. Dilated cardiomyopathy
  75. Do zinc supplements shorten colds?
  76. Does stress make rheumatoid arthritis worse?
  77. Drummer Beats Heart Disease
  78. Dumping syndrome
  79. Early HIV symptoms: What are they?
  80. Ebstein anomaly
  81. ED Drugs for Pulmonary Hypertension
  82. Effectively managing chronic kidney disease
  83. Endometriosis FAQs
  84. Enlarged spleen (splenomegaly)
  85. Esophageal cancer
  86. Ewing sarcoma
  87. Explaining multiple sclerosis
  88. Fatty liver disease (MASLD) diet
  89. Fertility preservation: Understand your options before cancer treatment
  90. Fibromyalgia
  91. Flu shot: Your best bet for avoiding influenza
  92. Flu shots: Especially important if you have heart disease
  93. Flu vaccine: Safe for people with egg allergy?
  94. Follicular lymphoma
  95. Gaucher disease
  96. Genetics and Cardiomyopathy
  97. GI Stents
  98. Glycemic index: A helpful tool for diabetes?
  99. Grass-fed beef
  100. Hairy cell leukemia
  101. Healthy Heart for Life!
  102. Heart attack
  103. Heart attack prevention: Should I avoid secondhand smoke?
  104. Heart attack symptoms: Know what's a medical emergency
  105. Heart Attack Timing
  106. Heart disease
  107. Heart disease in women: Understand symptoms and risk factors
  108. Heart failure
  109. Heart failure action plan
  110. Heat exhaustion
  111. Heavy periods: Can folic acid help?
  112. Hepatitis B and Hepatitis C: What's the difference?
  113. Hepatitis C
  114. Hepatitis C screening
  115. Hepatitis C: What happens in end-stage liver disease?
  116. Herbal treatment for anxiety: Is it effective?
  117. High-dose flu vaccines: How are they different from other flu vaccines?
  118. High-dose vitamin C: Can it kill cancer cells?
  119. Hirschsprung's disease
  120. Hodgkin lymphoma (Hodgkin disease)
  121. Hodgkin vs. non-Hodgkin lymphoma: What's the difference?
  122. How do I reduce fatigue from rheumatoid arthritis?
  123. How kidneys work
  124. Hypercalcemia
  125. Hyperthyroidism (overactive thyroid)
  126. Hypertrophic cardiomyopathy
  127. Hyponatremia
  128. Hypoparathyroidism
  129. Hypopituitarism
  130. Hypothermia
  131. Hypothyroidism (underactive thyroid)
  132. Hypothyroidism and joint pain?
  133. Hypothyroidism: Can calcium supplements interfere with treatment?
  134. Influenza (flu)
  135. Infographic: Multiple Myeloma
  136. Infographic: Pancreatic Neuroendocrine Tumors
  137. Insomnia: How do I stay asleep?
  138. Insulin and weight gain: Keep the pounds off
  139. Is there a special diet for Crohn's disease?
  140. Jack Long — Live LONG - Beat STRONG to find a cure
  141. Jet lag disorder
  142. Kidney Cancer
  143. Kidney cancer FAQs
  144. Kidney disease FAQs
  145. Lack of sleep: Can it make you sick?
  146. LADA
  147. Lead poisoning
  148. Listeria infection
  149. Liver cancer
  150. Liver disease: How medications can harm the liver
  151. Long Term Brain Cancer Survivor
  152. Low blood cell counts: Side effects of cancer treatment
  153. Low blood sodium in older adults: A concern?
  154. Low-phosphorus diet: Helpful for kidney disease?
  155. Lyme disease
  156. Lymphoma FAQs
  157. Male depression: Understanding the issues
  158. Male hypogonadism
  159. Mayo Clinic Minute: Will there be a Lyme disease vaccine for humans?
  160. Medications for liver failure
  161. Medicines that treat ulcerative colitis
  162. Mental health providers: Tips on finding one
  163. Mental health: Overcoming the stigma of mental illness
  164. Mental illness
  165. Metastatic castration-resistant prostate cancer (mCRPC)
  166. Mitral valve overview
  167. Mitral valve regurgitation
  168. Multiple myeloma
  169. Multiple sclerosis FAQs
  170. Multisystem inflammatory syndrome in children (MIS-C)
  171. Mumps
  172. Myelodysplastic syndromes
  173. Natural remedies for depression: Are they effective?
  174. Neti pot: Can it clear my nose?
  175. Non-Hodgkin lymphoma
  176. NSAIDs: Do they increase my risk of heart attack and stroke?
  177. Omega-6 fatty acids
  178. Palliative care for biliary tract cancer
  179. Pancreatic neuroendocrine tumors
  180. Parvovirus infection
  181. Pericarditis
  182. Peripheral T-cell lymphoma
  183. Peritoneal carcinomatosis
  184. Peritonitis
  185. Petroleum jelly: Safe for a dry nose?
  186. PICC line placement
  187. Pineal gland tumor
  188. Pituitary tumors and adenomas
  189. Plague
  190. Polio
  191. Polypill: Does it treat heart disease?
  192. Postpartum depression
  193. Premenstrual dysphoric disorder
  194. Prescription sleeping pills: What's right for you?
  195. Prostate cancer recurrence
  196. Pulmonary atresia
  197. Pulmonary atresia with intact ventricular septum
  198. Pulmonary hypertension
  199. Pulmonary valve stenosis
  200. Reactive hypoglycemia: What can I do?
  201. Rectal cancer
  202. Red wine and resveratrol: Good for your heart?
  203. Rhabdomyolysis
  204. Rheumatoid arthritis
  205. Rheumatoid arthritis: Can it affect the lungs?
  206. Rheumatoid arthritis: Does pregnancy affect symptoms?
  207. Robotic heart surgery treats mitral regurgitation: Ed's story
  208. Sarcoidosis
  209. Self-care for the flu
  210. Shingles
  211. Shingles vaccine: Can I transmit the vaccine virus to others?
  212. Shingles vaccine: Should I get it?
  213. Sick sinus syndrome
  214. Silent heart attack
  215. Sinus headaches
  216. Sinus infection and toothache: Any connection?
  217. Small lymphocytic lymphoma
  218. Smallpox
  219. Test anxiety: Can it be treated?
  220. Thalassemia
  221. The dawn phenomenon: What can you do?
  222. The gut microbiome and its role in ulcerative colitis
  223. Thyroid disease: Can it affect a person's mood?
  224. Thyroid peroxidase antibody test: What is it?
  225. Tips for recovering after an ulcerative colitis flare-up
  226. Tips to make your mornings easier
  227. Treating Pericarditis
  228. Treatment options for biliary tract cancer
  229. Tricuspid valve regurgitation
  230. Tuberculosis
  231. Type 1 diabetes FAQs
  232. Type 1 diabetes in children
  233. Type 2 diabetes
  234. Typhoid fever
  235. Ulcerative colitis vs. Crohn's disease
  236. Understanding complement 3 glomerulopathy (C3G)
  237. VEXAS syndrome
  238. Video: Heart and circulatory system
  239. Video: Septal myectomy and apical myectomy
  240. Viral hepatitis
  241. Vitamin B-12 and depression
  242. Vitamin deficiency anemia
  243. Vitamins for MS: Do supplements make a difference?
  244. Von Willebrand disease
  245. Walking pneumonia
  246. What is biliary tract cancer?
  247. What is cirrhosis? A Mayo Clinic expert explains
  248. What is Crohn's disease? A Mayo Clinic expert explains
  249. What is kidney cancer? An expert explains
  250. What is kidney disease? An expert explains
  251. What is stomach cancer? A Mayo Clinic expert explains
  252. What is type 1 diabetes? A Mayo Clinic expert explains
  253. What is ulcerative colitis? A Mayo Clinic expert explains
  254. White stool: Should I be concerned?
  255. Whooping cough
  256. Whooping cough
  257. Why isn't there a hepatitis C vaccine?