News March 12, 2022 Mobile platform obtains quantitative measurements of exophthalmos with variability similar to Hertel exophthalmometry A simple-to-use mobile application yields reliable, accurate measurements in a timely, efficient manner — and may be a suitable alternative when Hertel exophthalmometry is not available for measurement of globe po[...] March 12, 2022 Many ophthalmic irAEs can be treated without discontinuation of life-prolonging immunotherapy Ophthalmic immune-related adverse events (irAEs) associated with using immune checkpoint inhibitors (ICIs) are rare, but ophthalmologists need to recognize irAEs and un[...] March 12, 2022 Optic effect on peripheral retinal illumination holds implications for negative dysphotopsia Mayo Clinic researchers used ray-tracing analysis to compare the influence of 6.0 mm and 7.0 mm intraocular lens optic diameters on illumination of the peripheral retina. Jan. 07, 2022 Data and communication support individualized pediatric retinoblastoma program Evidence-based practices and communication with families are key to pediatric retinoblastoma care. Mayo Clinic physicians work collaboratively with one another, the patient's family and global data to advance retinoblas[...] Oct. 01, 2021 Netarsudil significantly reduces intraocular pressure in patients with primary open-angle glaucoma Mayo Clinic researchers have identified the mechanism of action for intraocular pressure (IOP) reduction by netarsudil in patients with primary open-angle glaucoma or ocular hypertension. Oct. 01, 2021 IPL-MGX improves dry eye symptoms more than MGX alone in treating ocular rosacea with dry eye Mayo Clinic offers intense pulsed light combined with meibomian gland expression to treat ocular rosacea and meibomian gland disease with dry eye symptoms successfully. Oct. 01, 2021 Patients may receive cataract surgery if diabetic macular edema is managed pre- and post-surgery A retrospective study indicates that patients with active diabetic macular edema and visually significant cataract can consider cataract surgery while maintaining an effective perioperative intravitreal anti-vascular en[...] July 20, 2021 Study supports the use of plaque imaging in the evaluation of patients with acute retinal artery occlusion Researchers found that patients with retinal artery occlusion (RAO) had higher prevalence of intraplaque hemorrhage (IPH). The presence of IPH was independently associated with ipsilateral RAO. July 20, 2021 Disease expression and familial transmission in Fuchs' endothelial dystrophy The Fuchs' endothelial corneal dystrophy (FECD) phenotype commonly occurs in individuals who do not harbor CTG18.1 expansion but are part of families with CTG18.1 expansion. July 20, 2021 Genomic sequencing shows promise in elucidating genetic causes of strabismus Next-generation genome sequencing approaches hold great promise in identifying rare variants associated with strabismus and elucidating the genetic causes of the disorder. April 20, 2021 Standardized prescribing guidelines reduce frequency and quantity of opioids prescribed Development of standardized opioid prescribing guidelines and discussion of postsurgical pain management reduced the overprescribing of opioids without increasing refill rates. April 20, 2021 Studies support Scheimpflug tomography's efficacy in predicting the prognosis of FECD Studies confirm that the presence of even one or two map features increased the probability of Fuchs' endothelial corneal dystrophy (FECD) progression independent of central corneal thickness. April 20, 2021 Fibrin hydrogels provide safe, degradable scaffolds for subretinal implantation Researchers report that an animal study demonstrates complete degradation of a surgically implanted fibrin scaffold within the subretinal space. March 20, 2021 Retinoblastoma: Specialized neuroradiology for optimal care Mayo Clinic's experienced specialists work to preserve the child's life, eye and sight. March 11, 2021 Regenerative approaches to improving corneal transplantation Mayo Clinic offers two partial-thickness corneal transplants for patients with diseased endothelial cells. Advancements in transplantation surgery make it possible to improve eyesight without removing the full thickness[...] May 01, 2020 Stanniocalcin-1 may have therapeutic potential for retinopathy of prematurity Current therapies for retinopathy of prematurity (ROP), a leading cause of blindness in preterm infants, have side effects. This study looks at the role of STC-1 in the OIR stress response. May 01, 2020 Intravitreal anti-VEGF pharmacotherapy safe for treatment of diabetic macular edema Study offers further evidence of a relatively safe systemic risk profile for intravitreal anti-VEGF pharmacotherapy used for the treatment of patients with decreased vision secondary to center-involving DME. May 01, 2020 Gene expression: Missplicing in corneal endothelium differs in patients with TCF4 TNR expansion Insights gained may serve as a platform to develop productive approaches to therapy across the spectrum of TNR diseases. Sept. 14, 2019 Use of intraocular lenses relatively safe for treatment of cataracts in infants ages 7 to 24 months old The Toddler Aphakia and Pseudophakia Study (TAPS) evaluated concerns about adverse events, re-operations and refractive changes in infants who receive intraocular lens implantation for cataract. Sept. 14, 2019 Study finds most conjunctival tumors benign with low risk of malignant transformation While most conjunctival tumors are benign with low risk of malignant transformation, researchers recommend subspecialty referrals in the setting of changing appearance or worrisome features. Sept. 14, 2019 Study supports increased risk of ischemic stroke in the peri-CRAO period Research supports that there is an increased risk of stroke around the time of central retinal artery occlusion (CRAO), especially if an embolic etiology of CRAO is diagnosed. July 16, 2019 PedEyeQ assesses quality of life in children with eye conditions PedEyeQ comprehensive questionnaires can be used to assess two broad areas, eye-related quality of life and functional vision, in children of any age with any eye condition. July 16, 2019 Study identifies clinical phenotype, visual outcomes of MOG-IgG antibody optic neuritis Research supports that MOG-IgG positivity should be suspected if optic disk edema is moderate to severe at onset or if MRI shows optic nerve sheath involvement. July 16, 2019 Biopsy recommended for patients with clinical characteristics of IgG4-ROD Researchers recommend biopsy for patients who do not follow the usual clinical course of Graves' orbitopathy or have clinical characteristics of immunoglobulin G4-related ophthalmic disease (IgG4-ROD). April 13, 2019 Risk of primary open-angle glaucoma increases after vitreoretinal surgery Research supports an increased risk of late-onset, primary open-angle glaucoma (POAG) after vitrectomy and vitrectomy with scleral buckling, but not after scleral buckling alone. Researchers recommend more-frequent moni[...] April 13, 2019 New method classifies FECD severity: Tomographic evaluation of corneas for subclinical edema A new method of classifying Fuchs' endothelial corneal dystrophy (FECD) severity employs Scheimpflug tomography for preoperative assessment of corneas for the presence of subclinical edema. April 13, 2019 Optimal timing for intervention in congenital nasolacrimal duct obstruction A study of infants with congenital nasolacrimal duct obstruction (CNLDO) suggests that surgical intervention may be most appropriate in an early and narrow time frame: between ages 9 and 15 months. Feb. 01, 2019 Patients with central retinal artery occlusion require embolic work-ups Research published in Mayo Clinic Proceedings indicates symptomatic stroke, TIA or amaurosis fugax is common around the time of central retinal artery occlusion. Researchers recommend urgent embolic work-ups for those p[...] Sept. 21, 2018 Surgical treatment impacts health-related quality of life for patients with glaucoma Patients with glaucoma report poor health-related quality of life due to worse diplopia, lower mean deviation on visual field testing in either eye, decreased visual acuity in either eye, younger age, and previous glauc[...] Sept. 21, 2018 Ocular manifestations in post-transplant lymphoproliferative disorder: A case report Mayo subspecialists collaborated for successful treatment of an 8-year-old boy. After orthotopic heart transplantation, the boy exhibited bilateral ocular involvement in post-transplant lymphoproliferative disorder with[...] Sept. 21, 2018 SCOPE research tracks increased use, performance of scleral lenses The Scleral Lenses in Current Ophthalmic Practice: An Evaluation (SCOPE) study group works to provide a better understanding of the role and performance of scleral lenses in clinical practice. Aug. 21, 2018 Optic disk edema in GFAP meningoencephalitis may mimic papilledema Mayo specialists recommend testing cerebrospinal fluid glial fibrillary acidic protein (GFAP) autoantibodies in patients with unexplained meningoencephalitis. Their optic disk edema is more likely due to an inflammatory[...] Aug. 18, 2018 Fibrin hydrogels provide a scaffold for transplantation of RPE monolayers Research suggests that fibrin hydrogels may provide a long-lived scaffold for the differentiation of retinal pigment epithelium (RPE) from stem cells that can then be degraded under controlled circumstances after delive[...] Aug. 17, 2018 Incidence of pseudophakic intraocular lens exchange increases with incidence of cataract surgery Emerging indications of intraocular lens exchange, including unplanned refractive error and uveitis-glaucoma-hyphema syndrome from square-edged haptics in the ciliary sulcus, reflect changes in lens design and increasin[...] April 14, 2018 Evidence supports association between CSC and exogenous glucocorticoid use Central serous chorioretinopathy (CSC) is uncommonly mentioned by nonophthalmologists as a side effect of steroid use. A review suggests significant association: Both exogenous and endogenous glucocorticoids are implica[...] April 13, 2018 Psychological factors may impact quality of life after strabismus surgery Depressive symptoms, double vision and facial anomalies may impact patient-reported outcome measures after strabismus surgery. Research confirms the need to consider and address psychological factors and personality par[...] April 13, 2018 Research confirms the clinical characteristics of ocular sarcoidosis In a population-based study of the clinical characteristics of ocular involvement of sarcoidosis, eye symptoms were the first presentation that led to the diagnosis of systemic sarcoidosis in more than half of the patie[...] Oct. 13, 2017 Incidence of idiopathic intracranial hypertension parallels rising rate of obesity Obesity is a major risk factor for idiopathic intracranial hypertension (IIH). Research indicates that the incidence rates of obesity and IIH have increased steadily and in parallel since 1990. Oct. 13, 2017 Risk of serious complications increases for older adult patients treated with dacryocystorhinostomy for acquired nasolacrimal duct obstruction Research indicates that in patients age 80 and older, the rate of symptom resolution after dacryocystorhinostomy was significantly lower and the risk of serious complications was higher than that of younger patients. April 15, 2017 The causes of acquired 3rd nerve palsy A study using Rochester Epidemiology Project (REP) records demonstrates a higher incidence of microvascular and a lower incidence of aneurysmal third nerve palsies than previously reported in nonpopulation-based studies[...] Nov. 01, 2016 Eye in the Storm A clinician and investigators with Ophthalmology at Mayo Clinic in Rochester, Minnesota, team to learn how toxic RNA short-circuits corneal cells. Oct. 15, 2016 Research identifies characteristics of convergence insufficiency in adults Researchers used a medical record retrieval system to describe the clinical characteristics of convergence insufficiency (CI) in a population-based cohort of adults 19 years of age and older, diagnosed over a 20-year pe[...] July 16, 2016 Intense pulsed light for treatment of dry eye disease A retrospective study confirms that intense pulsed light (IPL) and meibomian gland expression (MGX) treatment can improve dry eye symptoms and offers a reasonable option for patients who have not shown improvement with [...] April 12, 2016 Adults with nonparalytic forms of strabismus face increased risk of mental illness Research based on Rochester Epidemiology Project data indicates that adults with divergence insufficiency or small-angle hypertropia may be at increased risk of mental illness and its comorbidities. Oct. 30, 2015 RNA toxicity and missplicing identified in patients with Fuchs' endothelial corneal dystrophy The genetic mechanism of Fuchs' endothelial corneal dystrophy (FECD) is the same as the genetic mechanism in myotonic dystrophy type 1, a severe neuromuscular degeneration. It's possible that other common genetic diseas[...] Oct. 30, 2015 Rituximab offers no benefit over placebo to patients with active or moderate-to-severe Graves' orbitopathy Results from a double-masked, randomized controlled trial indicate that rituximab offers no additional benefit over placebo to patients with active and moderate-to-severe Graves' orbitopathy (GO) and carries non-negligi[...] April 11, 2015 Combination therapy offers rapid improvements in vision and CST in patients with macular edema due to RVOs Compared with bevacizumab monotherapy, the combination of bevacizumab with a dexamethasone implant leads to more rapid improvements in vision and CST in patients with macular edema due to RVOs, while requiring fewer bev[...] Nov. 06, 2014 Disease-causing mutations exhibit disparate effects on the localization of bestrophin-1 Recent studies of the mechanisms underlying the bestrophinopathies indicate that four degenerative retinal diseases are associated with disparate effects on bestrophin-1 localization, but not oligomerization. Stem cell [...] Aug. 07, 2014 Rat IVC model allows researchers to study the role of intracranial pressure modulation in optic neuropathies In the rat intraventricular cannula model, intracranial pressure can be manually reduced or increased over an extended period of time to study the role of intracranial pressure in optic nerve pathology. Aug. 07, 2014 PEDIG translates research to evidence-based care for patients at Mayo Clinic The Pediatric Eye Disease Investigator Group uses evidence-based care to advance the treatment of children with amblyopia. PEDIG has also developed a more rigorous approach to assessing clinical parameters and provides [...] May 01, 2014 Incidence and probability of progression to blindness due to open-angle glaucoma decreases dramatically New diagnostic and progression analysis tools and new therapies for intraocular pressure reduction have benefited individual patients. A Rochester Epidemiology Project-based study explores their effects on the rates of [...] May 01, 2014 Fluoroquinolones do not increase patients' risk of rhegmatogenous retinal detachment In a retrospective study, researchers did not identify any increased risk of retinal detachment or acute retinal tears in patients who used oral fluoroquinolone prescriptions. Fluoroquinolones are one of the most common[...] Sept. 05, 2013 Cancer immunotherapy eradicates tumors from within Cancer immunotherapy cures tumor-burdened mice - Researchers used human DNA from melanoma cells delivered through the vector vesicular stomatitis virus to eradicate cancerous tumors in mice. Success is associated with t[...] Sept. 05, 2012 Macular hole repair does not require face-down positioning Older patients benefit from macular hole surgery without face-down positioning - Surgery with broad ILM peeling, 20 percent sulfur hexafluoride gas and no face-down positioning may be effective in the treatment of idiop[...] Medical Professionals Ophthalmology News