1. July 20, 2021

    Study supports the use of plaque imaging in the evaluation of patients with acute retinal artery occlusion

    Researchers found that patients with retinal artery occlusion (RAO) had higher prevalence of intraplaque hemorrhage (IPH). The presence of IPH was independently associated with ipsilateral RAO.

  2. July 20, 2021

    Disease expression and familial transmission in Fuchs' endothelial dystrophy

    The Fuchs' endothelial corneal dystrophy (FECD) phenotype commonly occurs in individuals who do not harbor CTG18.1 expansion but are part of families with CTG18.1 expansion.

  3. July 20, 2021

    Genomic sequencing shows promise in elucidating genetic causes of strabismus

    Next-generation genome sequencing approaches hold great promise in identifying rare variants associated with strabismus and elucidating the genetic causes of the disorder.

  4. April 20, 2021

    Standardized prescribing guidelines reduce frequency and quantity of opioids prescribed

    Development of standardized opioid prescribing guidelines and discussion of postsurgical pain management reduced the overprescribing of opioids without increasing refill rates.

  5. April 20, 2021

    Studies support Scheimpflug tomography's efficacy in predicting the prognosis of FECD

    Studies confirm that the presence of even one or two map features increased the probability of Fuchs' endothelial corneal dystrophy (FECD) progression independent of central corneal thickness.

  6. April 20, 2021

    Fibrin hydrogels provide safe, degradable scaffolds for subretinal implantation

    Researchers report that an animal study demonstrates complete degradation of a surgically implanted fibrin scaffold within the subretinal space.

  7. March 20, 2021

    Retinoblastoma: Specialized neuroradiology for optimal care

    Mayo Clinic's experienced specialists work to preserve the child's life, eye and sight.

  8. March 11, 2021

    Regenerative approaches to improving corneal transplantation

    Mayo Clinic offers two partial-thickness corneal transplants for patients with diseased endothelial cells. Advancements in transplantation surgery make it possible to improve eyesight without removing the full thickness[...]

  9. May 01, 2020

    Stanniocalcin-1 may have therapeutic potential for retinopathy of prematurity

    Current therapies for retinopathy of prematurity (ROP), a leading cause of blindness in preterm infants, have side effects. This study looks at the role of STC-1 in the OIR stress response.

  10. May 01, 2020

    Intravitreal anti-VEGF pharmacotherapy safe for treatment of diabetic macular edema

    Study offers further evidence of a relatively safe systemic risk profile for intravitreal anti-VEGF pharmacotherapy used for the treatment of patients with decreased vision secondary to center-involving DME.

  11. May 01, 2020

    Gene expression: Missplicing in corneal endothelium differs in patients with TCF4 TNR expansion

    Insights gained may serve as a platform to develop productive approaches to therapy across the spectrum of TNR diseases.

  12. Sept. 14, 2019

    Use of intraocular lenses relatively safe for treatment of cataracts in infants ages 7 to 24 months old

    The Toddler Aphakia and Pseudophakia Study (TAPS) evaluated concerns about adverse events, re-operations and refractive changes in infants who receive intraocular lens implantation for cataract.

  13. Sept. 14, 2019

    Study finds most conjunctival tumors benign with low risk of malignant transformation

    While most conjunctival tumors are benign with low risk of malignant transformation, researchers recommend subspecialty referrals in the setting of changing appearance or worrisome features.

  14. Sept. 14, 2019

    Study supports increased risk of ischemic stroke in the peri-CRAO period

    Research supports that there is an increased risk of stroke around the time of central retinal artery occlusion (CRAO), especially if an embolic etiology of CRAO is diagnosed.

  15. July 16, 2019

    PedEyeQ assesses quality of life in children with eye conditions

    PedEyeQ comprehensive questionnaires can be used to assess two broad areas, eye-related quality of life and functional vision, in children of any age with any eye condition.

  16. July 16, 2019

    Study identifies clinical phenotype, visual outcomes of MOG-IgG antibody optic neuritis

    Research supports that MOG-IgG positivity should be suspected if optic disk edema is moderate to severe at onset or if MRI shows optic nerve sheath involvement.

  17. July 16, 2019

    Biopsy recommended for patients with clinical characteristics of IgG4-ROD

    Researchers recommend biopsy for patients who do not follow the usual clinical course of Graves' orbitopathy or have clinical characteristics of immunoglobulin G4-related ophthalmic disease (IgG4-ROD).

  18. April 13, 2019

    Risk of primary open-angle glaucoma increases after vitreoretinal surgery

    Research supports an increased risk of late-onset, primary open-angle glaucoma (POAG) after vitrectomy and vitrectomy with scleral buckling, but not after scleral buckling alone. Researchers recommend more-frequent moni[...]

  19. April 13, 2019

    New method classifies FECD severity: Tomographic evaluation of corneas for subclinical edema

    A new method of classifying Fuchs' endothelial corneal dystrophy (FECD) severity employs Scheimpflug tomography for preoperative assessment of corneas for the presence of subclinical edema.

  20. April 13, 2019

    Optimal timing for intervention in congenital nasolacrimal duct obstruction

    A study of infants with congenital nasolacrimal duct obstruction (CNLDO) suggests that surgical intervention may be most appropriate in an early and narrow time frame: between ages 9 and 15 months.

  21. Feb. 01, 2019

    Patients with central retinal artery occlusion require embolic work-ups

    Research published in Mayo Clinic Proceedings indicates symptomatic stroke, TIA or amaurosis fugax is common around the time of central retinal artery occlusion. Researchers recommend urgent embolic work-ups for those p[...]

  22. Sept. 21, 2018

    Surgical treatment impacts health-related quality of life for patients with glaucoma

    Patients with glaucoma report poor health-related quality of life due to worse diplopia, lower mean deviation on visual field testing in either eye, decreased visual acuity in either eye, younger age, and previous glauc[...]

  23. Sept. 21, 2018

    Ocular manifestations in post-transplant lymphoproliferative disorder: A case report

    Mayo subspecialists collaborated for successful treatment of an 8-year-old boy. After orthotopic heart transplantation, the boy exhibited bilateral ocular involvement in post-transplant lymphoproliferative disorder with[...]

  24. Sept. 21, 2018

    SCOPE research tracks increased use, performance of scleral lenses

    The Scleral Lenses in Current Ophthalmic Practice: An Evaluation (SCOPE) study group works to provide a better understanding of the role and performance of scleral lenses in clinical practice.

  25. Aug. 21, 2018

    Optic disk edema in GFAP meningoencephalitis may mimic papilledema

    Mayo specialists recommend testing cerebrospinal fluid glial fibrillary acidic protein (GFAP) autoantibodies in patients with unexplained meningoencephalitis. Their optic disk edema is more likely due to an inflammatory[...]

  26. Aug. 18, 2018

    Fibrin hydrogels provide a scaffold for transplantation of RPE monolayers

    Research suggests that fibrin hydrogels may provide a long-lived scaffold for the differentiation of retinal pigment epithelium (RPE) from stem cells that can then be degraded under controlled circumstances after delive[...]

  27. Aug. 17, 2018

    Incidence of pseudophakic intraocular lens exchange increases with incidence of cataract surgery

    Emerging indications of intraocular lens exchange, including unplanned refractive error and uveitis-glaucoma-hyphema syndrome from square-edged haptics in the ciliary sulcus, reflect changes in lens design and increasin[...]

  28. April 14, 2018

    Evidence supports association between CSC and exogenous glucocorticoid use

    Central serous chorioretinopathy (CSC) is uncommonly mentioned by nonophthalmologists as a side effect of steroid use. A review suggests significant association: Both exogenous and endogenous glucocorticoids are implica[...]

  29. April 13, 2018

    Psychological factors may impact quality of life after strabismus surgery

    Depressive symptoms, double vision and facial anomalies may impact patient-reported outcome measures after strabismus surgery. Research confirms the need to consider and address psychological factors and personality par[...]

  30. April 13, 2018

    Research confirms the clinical characteristics of ocular sarcoidosis

    In a population-based study of the clinical characteristics of ocular involvement of sarcoidosis, eye symptoms were the first presentation that led to the diagnosis of systemic sarcoidosis in more than half of the patie[...]

  31. Oct. 13, 2017

    Incidence of idiopathic intracranial hypertension parallels rising rate of obesity

    Obesity is a major risk factor for idiopathic intracranial hypertension (IIH). Research indicates that the incidence rates of obesity and IIH have increased steadily and in parallel since 1990.

  32. Oct. 13, 2017

    Pediatric Neuro-Ophthalmology, Third Edition, available

    Published by Springer-Verlag New York, the textbook contains 823 pages that detail the current diagnostic management and treatment of neuro-ophthalmological diseases in children.

  33. Oct. 13, 2017

    Risk of serious complications increases for older adult patients treated with dacryocystorhinostomy for acquired nasolacrimal duct obstruction

    Research indicates that in patients age 80 and older, the rate of symptom resolution after dacryocystorhinostomy was significantly lower and the risk of serious complications was higher than that of younger patients.

  34. Oct. 13, 2017

    Optical coherence tomography shows promise for the noninvasive detection of elevated intracranial pressure

    Optical coherence tomography could change current neurosurgical practice by sparing children with elevated intracranial pressure the stress and risks of invasive monitoring. Ophthalmologists may play a more determinativ[...]

  35. July 15, 2017

    Patients with Fuchs' endothelial corneal dystrophy exhibit a unique signature of missplicing events in TCF4

    Research shows that changes in gene function through alternate splicing induced by a trinucleotide repeat expansion in the TCF4 gene can be a valid pathogenic mechanism in most patients with Fuchs' endothelial corneal d[...]

  36. July 15, 2017

    Intraoperative use of GenTeal gel linked to subconjunctival necrotizing granulomata

    A study of patients who developed postoperative subconjunctival necrotizing granulomata after ophthalmologic surgical procedures involving large conjunctival incisions indicates an association between intraoperative use[...]

  37. July 15, 2017

    Posterior corneal profile changes impact Fuchs' endothelial corneal dystrophy, endothelial keratoplasty and intraocular lens implantation

    In eyes with Fuchs' endothelial corneal dystrophy (FECD), the posterior cornea is flatter and more spherical than normal, resulting in less negative power and loss of normal posterior surface toricity — changes th[...]

  38. April 15, 2017

    The causes of acquired 3rd nerve palsy

    A study using Rochester Epidemiology Project (REP) records demonstrates a higher incidence of microvascular and a lower incidence of aneurysmal third nerve palsies than previously reported in nonpopulation-based studies[...]

  39. April 15, 2017

    Ophthalmology moves toward a culture of safety

    Building a culture of safety requires acknowledgment of the high-risk nature of eye team activities, commitment to consistently safe operations, a blame-free environment, and collaboration across ranks and disciplines t[...]

  40. April 15, 2017

    Diplopia underrecognized in patients with medically and surgically treated glaucoma

    Research indicates that use of a standardized self-assessment of diplopia and strabismus in patients with glaucoma both before and after surgery encourages providers to broach the topic of diplopia with patients in rout[...]

  41. Nov. 01, 2016

    Eye in the Storm

    A clinician and investigators with Ophthalmology at Mayo Clinic in Rochester, Minnesota, team to learn how toxic RNA short-circuits corneal cells.

  42. Oct. 15, 2016

    KATP channel opener cromakalim lowers IOP in human and mouse models

    Research evaluating the intraocular pressure (IOP) lowering ability of ATP-sensitive potassium channel opener cromakalim in human and murine models indicates that cromakalim can significantly lower IOP in human and anim[...]

  43. Oct. 15, 2016

    Visual acuity continues to improve after DSEK for Fuchs' endothelial corneal dystrophy

    For patients in a prospective study, best spectacle-corrected visual acuity continued to improve between one and five years after Descemet stripping endothelial keratoplasty (DSEK), accompanied by improvements in cornea[...]

  44. Oct. 15, 2016

    Research identifies characteristics of convergence insufficiency in adults

    Researchers used a medical record retrieval system to describe the clinical characteristics of convergence insufficiency (CI) in a population-based cohort of adults 19 years of age and older, diagnosed over a 20-year pe[...]

  45. July 16, 2016

    Bevacizumab with dexamethasone implant improves visual acuity and macular morphology in eyes with DME

    A study of eyes with persistent diabetic macular edema after multiple anti-vascular endothelial growth factor injections indicates that a dexamethasone implant combined with bevacizumab improves visual acuity and macula[...]

  46. July 16, 2016

    Intense pulsed light for treatment of dry eye disease

    A retrospective study confirms that intense pulsed light (IPL) and meibomian gland expression (MGX) treatment can improve dry eye symptoms and offers a reasonable option for patients who have not shown improvement with [...]

  47. July 16, 2016

    Intraoperative torsional forced duction test assesses obliques' tightness and laxity

    The torsional forced duction test enables more-precise quantitative assessment of superior oblique (SO) and inferior oblique (IO) tightness and laxity, and is useful for intraoperative surgical planning.

  48. April 15, 2016

    Trabeculectomy-related complications not related to mitomycin

    Researchers studying Rochester Epidemiology Project data on patients with glaucoma treated with trabeculectomy found the complication rate was unchanged during the 25-year study period, regardless of changes in mitomyci[...]

  49. April 12, 2016

    Onset of corneal abnormalities in Fuchs' dystrophy begins early in the course of the disease

    Improved understanding of the onset of corneal changes in Fuchs' dystrophy may help identify patients who will benefit from intervention before any changes in the host tissue that affect outcomes become irreversible.

  50. Oct. 31, 2015

    MYD88 L265P mutation may provide a new marker for diagnosis of vitreoretinal lymphoma

    Research indicates that MYD88 L265P constitutive activating mutations are present in at least some cases of the diffuse large B-cell lymphoma form of vitreoretinal lymphoma.

  51. Oct. 30, 2015

    RNA toxicity and missplicing identified in patients with Fuchs' endothelial corneal dystrophy

    The genetic mechanism of Fuchs' endothelial corneal dystrophy (FECD) is the same as the genetic mechanism in myotonic dystrophy type 1, a severe neuromuscular degeneration. It's possible that other common genetic diseas[...]

  52. Oct. 30, 2015

    Rituximab offers no benefit over placebo to patients with active or moderate-to-severe Graves' orbitopathy

    Results from a double-masked, randomized controlled trial indicate that rituximab offers no additional benefit over placebo to patients with active and moderate-to-severe Graves' orbitopathy (GO) and carries non-negligi[...]

  53. July 11, 2015

    Fixation is the primary driver of dissociated vertical divergence

    Research shows that peripheral binocular luminance disparity modulates dissociated vertical divergence (DVD) at the cortical level primarily when superimposed upon fixation. DVD develops when fixation evokes facultative[...]

  54. July 11, 2015

    Regenerative Medicine Biotrust provides hope for patients with Best disease

    Mayo's Regenerative Medicine Biotrust converted skin samples into bioengineered stem cells and then converted those cells into functioning retinal pigment epithelial cells, allowing researchers to test potential options[...]

  55. July 11, 2015

    Patients report better vision-related quality of life after endothelial keratoplasty

    Endothelial keratoplasty offers corneal surgeons simpler postoperative management, including lack of suture removal and suture-associated complications, a predictable postoperative refractive error, and a tectonically s[...]

  56. April 11, 2015

    Reimbursement policy creates a conflict of interest for patients and physicians

    Research indicates that some surgeons have made a significant change in the delivery of ptosis and blepharoplasty surgical services after the bundling of payment for these two procedures by the CMS.

  57. April 11, 2015

    Intraocular pressure should be monitored in eyes receiving ranibizumab

    Although uncommon, sustained intraocular pressure increase after intravitreal ranibizumab injections is possible. Treating ophthalmologists should check pre-injection IOP at each patient visit.

  58. April 11, 2015

    Combination therapy offers rapid improvements in vision and CST in patients with macular edema due to RVOs

    Compared with bevacizumab monotherapy, the combination of bevacizumab with a dexamethasone implant leads to more rapid improvements in vision and CST in patients with macular edema due to RVOs, while requiring fewer bev[...]

  59. Nov. 06, 2014

    Disease-causing mutations exhibit disparate effects on the localization of bestrophin-1

    Recent studies of the mechanisms underlying the bestrophinopathies indicate that four degenerative retinal diseases are associated with disparate effects on bestrophin-1 localization, but not oligomerization. Stem cell [...]

  60. Nov. 06, 2014

    Use of antidepressant medications and the incidence of cataract surgery

    A retrospective, population-based study indicates that cataract surgery in people age 50 years or older was significantly associated with an increased use of selective serotonin reuptake inhibitors, the most commonly pr[...]

  61. Nov. 06, 2014

    Trinucleotide repeat in TCF4 responsible for Fuchs' endothelial corneal dystrophy

    Researchers at Mayo Clinic have identified the specific genetic defect in the TCF4 gene — the expansion of the TGC repeat — that appears to be responsible for Fuchs' endothelial corneal dystrophy (FECD).

  62. Aug. 07, 2014

    Rat IVC model allows researchers to study the role of intracranial pressure modulation in optic neuropathies

    In the rat intraventricular cannula model, intracranial pressure can be manually reduced or increased over an extended period of time to study the role of intracranial pressure in optic nerve pathology.

  63. Aug. 07, 2014

    Study to explore the prevalence of angle-closure glaucoma and appropriate laser peripheral iridotomy in Caucasian populations

    Because angle-closure glaucoma has been considered uncommon among non-Asian ethnic groups, ophthalmologists may underuse gonioscopy during routine eye exams for Caucasians. A new study screens 5,000 volunteer Caucasian [...]

  64. Aug. 07, 2014

    PEDIG translates research to evidence-based care for patients at Mayo Clinic

    The Pediatric Eye Disease Investigator Group uses evidence-based care to advance the treatment of children with amblyopia. PEDIG has also developed a more rigorous approach to assessing clinical parameters and provides [...]

  65. May 01, 2014

    Incidence and probability of progression to blindness due to open-angle glaucoma decreases dramatically

    New diagnostic and progression analysis tools and new therapies for intraocular pressure reduction have benefited individual patients. A Rochester Epidemiology Project-based study explores their effects on the rates of [...]

  66. May 01, 2014

    Retrospective study identifies incidence and demographics of new-onset strabismus in adults

    Research using Rochester Epidemiology Project data to explore the incidence and demographics of new-onset strabismus and its types in adults shows ocular misalignment among adults differs significantly from pediatric st[...]

  67. May 01, 2014

    Fluoroquinolones do not increase patients' risk of rhegmatogenous retinal detachment

    In a retrospective study, researchers did not identify any increased risk of retinal detachment or acute retinal tears in patients who used oral fluoroquinolone prescriptions. Fluoroquinolones are one of the most common[...]

  68. Nov. 15, 2013

    Children with congenital esotropia are at increased risk of developing mental illness

    Children with congenital esotropia are more likely to develop mental illness - Rochester Epidemiology Project research indicates that children diagnosed with CET are more likely to have mental illness diagnoses by their[...]

  69. Sept. 05, 2013

    Immunosuppressive agents may enhance corticosteroid treatments for uveitis

    Immunosuppressive medications may aid management of uveitis - Corticosteroids and topical cyclosporine drugs are approved for use in ocular inflammatory diseases. Patients with uveitis who require long-term corticostero[...]

  70. Sept. 05, 2013

    Cancer immunotherapy eradicates tumors from within

    Cancer immunotherapy cures tumor-burdened mice - Researchers used human DNA from melanoma cells delivered through the vector vesicular stomatitis virus to eradicate cancerous tumors in mice. Success is associated with t[...]

  71. Sept. 05, 2012

    Study shows no significant correlation between EVP and elevated IOP in patients with open-angle glaucoma

    EVP is not the primary cause of high IOP in patients with open-angle glaucoma - Researchers seeking a clearer understanding of EVP's contribution to the elevation of IOP in patients with open-angle glaucoma found that a[...]

  72. Sept. 05, 2012

    Aflibercept shows promise as a game-changer for patients with age-related macular degeneration

    Aflibercept promises excellent visual outcomes for patients with exudative AMD - A review of clinical trial results indicates that monthly and bimonthly aflibercept treatments were noninferior to monthly ranibizumab at [...]

  73. Sept. 05, 2012

    Blepharoptosis repair improves patients' quality of life

    Patients with blepharoplasty report statistically significant improvement of quality of life - Researchers used both the vision-specific NEI VFQ-25 and a generic health-related instrument, the EQ-5D, to examine the effe[...]

  74. Sept. 05, 2012

    Macular hole repair does not require face-down positioning

    Older patients benefit from macular hole surgery without face-down positioning - Surgery with broad ILM peeling, 20 percent sulfur hexafluoride gas and no face-down positioning may be effective in the treatment of idiop[...]

  75. Sept. 05, 2012

    Anti-VEGF therapy for age-related macular degeneration yields improved acuity for eyes with VMID

    Patients with VMID are not necessarily treatment resistant for AMD - A study that reviewed patients with vitreomacular interface disease (VMID) undergoing treatment for exudative age-related macular degeneration (AMD) f[...]

  76. Sept. 05, 2012

    Patients with Fuchs endothelial dystrophy experience residual corneal haze after DSEK

    Residual haze partially improves after DSEK for Fuchs dystrophy - A study of eyes with Fuchs dystrophy indicates that visual function after Descemet stripping with endothelial keratoplasty is affected by residual haze i[...]

  77. incidence-of-cataract-surgery-continues-to-increase-steadily


  78. Adults with nonparalytic forms of strabismus face increased risk of mental illness

    Adults with nonparalytic forms of strabismus face increased risk of mental illness