Ophthalmology

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. Association Between Endothelial Cell Density and Corneal Swelling in Post-Penetrating Keratoplasty Scleral Contact Lens Wear

   Rochester, Minn.

   The purpose of this study is to model the relationship between corneal swelling and cell density and determine how this relationship differs by contact lens type.

2. A Study to Evaluate Fogging in Scleral Contact Lens

   Rochester, Minn.

   The purpose of this study is to quantify potential decreases in visual acuity experienced by patients who experience mid-day fogging during scleral lens wear, compare severity of subjectively reported fogging with clinical findings, and to explore the relationship between scleral lens fitting parameters and mid-day fogging.

3. A Study Assessing the Effectiveness and Safety of Intravitreal Injections of 440 ug DE-109 Sirolimus for the Treatment of Active, Non-Infectious Uveitis of the Posterior Segment of the Eye

   Rochester, Minn.

   The purpose of this study is to assess the effectiveness and safety of DE-109 440 µg every 2 months in subjects with active, non-infectious uveitis of the posterior segment of the eye (NIU-PS). There is a 6-month, single-arm, open-label period after completion of the 6-month double- masked, controlled period allows the evaluation of the efficacy and safety of intravitreal injection of DE-109 440 µg every 2 months for longer duration than appropriate for a placebo or sham control.

4. A Study to Evaluate Advanced Ultrasound Techniques for Diagnosis of Giant Cell Arteritis

   Rochester, Minn.

   The purpose of this study is to evaluate shear wave data and vascular lumen size determined by Contrast-Enhanced Ultrasound (CEUS) in patients undergoing temporal artery biopsy, to determine the sensitivity and specificity of Shear Wave Elastography (SWE) and CEUS for the diagnosis of temporal arteritis, and to determine the impact of pre-operative ultrasound guided mapping on operative time required for temporal artery biopsy.

    

5. Outcomes of Descemet Membrane Endothelial Keratoplasty

   Rochester, Minn.

   The goal of this study is to determine optical and visual function through 5 years after Descemet membrane endothelial keratoplasty (DMEK). The study will also determine graft health (corneal endothelial cell loss) and survival through 5 years after DMEK, and factors associated with these outcomes, as well as assess the relationship between optical and anatomical corneal rehabilitation after DMEK.

6. A Study to Evaluate the Effectiveness of Critical Flicker Fusion in Distinguishing Different Causes of Altered Vision

   Rochester, Minn.

   The purpose of this study is to evaluate the effectiveness of the critical flicker fusion device in distinguishing different kinds of optic neuropathy and visual perception.

7. A Study of the Effects of Pneumatic Vitreolysis on Macular Hole

   Rochester, Minn.

   The purpose of this study is to determine the proportion with VMT release and MH closure and to assess factors associated with success.  Eyes with vitreomacular traction (VMT) and full-thickness macular holes (MH) will be enrolled into a non-randomized cohort treated with pneumatic vitreolysis (PVL).

8. A Study to Evaluate a Color Test for Patients with Optic Nerve Diseases

   Rochester, Minn.

   The purpose of this study is to evaluate the clinical utility of a quantitative test to measure how color saturation appears in patients with diseases of the optive nerve.

9. A Study to Evaluate Using Interactive Video Games in Treating Adults with Amblyopia

   Rochester, Minn.

   The purpose of this study is to establish whether or not interactive video game play provides a means of treating amblyopia in adults.

10. A Study to Assess Screening for Diabetic Retinopathy Using Retinal Camera in Family Medicine Clinic

    Jacksonville, Fla.

    The purpose of this study is to evaluate the ability of appropriately-trained family physicians to screen for and identify Diabetic Retinopathy using retinal camera and, secondarily, to describe patients’ perception of the convenience and cost-effectiveness of retinal imaging.