Ophthalmology

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. Association Between Endothelial Cell Density and Corneal Swelling in Post-Penetrating Keratoplasty Scleral Contact Lens Wear

   Rochester, Minn.

   The purpose of this study is to model the relationship between corneal swelling and cell density and determine how this relationship differs by contact lens type.

2. Evaluation of Strabismus and Diplopia

   Rochester, Minn.

   Purpose and specific aims

   1. To compare two diplopia scoring methods to the established gold standard

   2. To evaluate the test-retest reliability of the diplopia scoring methods

   3. To evaluate health-related quality of life in patients with strabismus with and without diplopia

3. A Study to Evaluate the Effectiveness of Critical Flicker Fusion in Distinguishing Different Causes of Altered Vision

   Rochester, Minn.

   The purpose of this study is to evaluate the effectiveness of the critical flicker fusion device in distinguishing different kinds of optic neuropathy and visual perception.

4. A Study to Evaluate Using Interactive Video Games in Treating Adults with Amblyopia

   Rochester, Minn.

   The purpose of this study is to establish whether or not interactive video game play provides a means of treating amblyopia in adults.

5. A Study of the Effects of Pneumatic Vitreolysis on Macular Hole

   Rochester, Minn.

   The purpose of this study is to determine the proportion with VMT release and MH closure and to assess factors associated with success.  Eyes with vitreomacular traction (VMT) and full-thickness macular holes (MH) will be enrolled into a non-randomized cohort treated with pneumatic vitreolysis (PVL).

6. Outcomes of Descemet Membrane Endothelial Keratoplasty

   Rochester, Minn.

   The goal of this study is to determine optical and visual function through 5 years after Descemet membrane endothelial keratoplasty (DMEK). The study will also determine graft health (corneal endothelial cell loss) and survival through 5 years after DMEK, and factors associated with these outcomes, as well as assess the relationship between optical and anatomical corneal rehabilitation after DMEK.

7. Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 in Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)

   Rochester, Minn.

   This study will determine the effect of QPI-1007 on visual function in subjects with recent-onset NAION and assess the safety and tolerability of intravitreal injections of QPI-1007 in this population. This study will also evaluate the structural changes in the retina following administration of QPI-1007.

8. Exparel Injection for Postoperative Orbital Pain

   Rochester, Minn.

   After surgery to remove the eye, either by enucleation or evisceration, patients have variable levels of pain for several postoperative days. Some patients have almost no discomfort while others require significant amounts of oral narcotics and report pain of 10 out of 10 on a numerical rating scale. The current operative standard is to infiltrate the eye socket with 0.5% bupivacaine during surgery leading to several hours of postoperative analgesia. In 2011, Pacira Pharmaceuticals released a bupivacaine liposomal injectable suspension (Exparel, 1.3%) which offers sustained release of bupivacaine giving postoperative pain control for up to 72 hours. This medication has been used in numerous surgeries including inguinal hernia repair, hemorrhoidectomy, bunionectomy, breast reconstruction, and orthopedic surgery, and the literature reports improved pain control, decreased use of oral opioids, and increased patient satisfaction. There are no reports of the use of Exparel in the ophthalmic literature. The investigators propose a randomized, controlled trial to compare the postoperative pain control offered by sustained release bupivacaine to that offered by standard plain bupivacaine after enucleation or evisceration.

9. A Study of the Effects of Pneumatic Vitreolysis on Vitreomacular Traction

   Rochester, Minn.

   The purpose of this study is to determine if pneumatic vitreolysis (PVL) is effective in releasing VMT.  Eyes with idiopathic symptomatic vitreomacular traction (VMT) without a macular hole will be randomly assigned to 0.3-mL intraocular gas (C3F8) injection or sham injection.

10. A Study to Evaluate the Use of Nivolumab and Pomalidomide Combination for Relapsed/Refractory Primary Central Nervous System Lymphoma and Primary Vitreoretinal Lymphoma

    Jacksonville, Fla., Rochester, Minn.

    The purpose of this study is to evaluate the side effects and best dose of pomalidomide when given together with dexamethasone in treating patients with primary central nervous system lymphoma that has come back (relapsed) or does not respond to treatment (refractory) or intraocular lymphoma that is newly diagnosed, relapsed or refractory. Pomalidomide may stimulate the immune system to kill cancer cells. Drugs used in chemotherapy, such as dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells, stopping them from dividing, or by stopping them from spreading. Giving pomalidomide together with dexamethasone may kill more cancer cells.