Clinical Trials Below are current clinical trials.43 studies in Ophthalmology (open studies only). Filter this list of studies by location, status and more. A Study Assessing the Effectiveness and Safety of Intravitreal Injections of 440 ug DE-109 Sirolimus for the Treatment of Active, Non-Infectious Uveitis of the Posterior Segment of the Eye Rochester, Minn. The purpose of this study is to assess the effectiveness and safety of DE-109 440 µg every 2 months in subjects with active, non-infectious uveitis of the posterior segment of the eye (NIU-PS). There is a 6-month, single-arm, open-label period after completion of the 6-month double- masked, controlled period allows the evaluation of the efficacy and safety of intravitreal injection of DE-109 440 µg every 2 months for longer duration than appropriate for a placebo or sham control. Association Between Endothelial Cell Density and Corneal Swelling in Post-Penetrating Keratoplasty Scleral Contact Lens Wear Rochester, Minn. The purpose of this study is to model the relationship between corneal swelling and cell density and determine how this relationship differs by contact lens type. A Study to Evaluate Using Interactive Video Games in Treating Adults with Amblyopia Rochester, Minn. The purpose of this study is to establish whether or not interactive video game play provides a means of treating amblyopia in adults. A Study of the Effects of Pneumatic Vitreolysis on Macular Hole Rochester, Minn. The purpose of this study is to determine the proportion with VMT release and MH closure and to assess factors associated with success. Eyes with vitreomacular traction (VMT) and full-thickness macular holes (MH) will be enrolled into a non-randomized cohort treated with pneumatic vitreolysis (PVL). A Study to Evaluate the Effectiveness of Critical Flicker Fusion in Distinguishing Different Causes of Altered Vision Rochester, Minn. The purpose of this study is to evaluate the effectiveness of the critical flicker fusion device in distinguishing different kinds of optic neuropathy and visual perception. Outcomes of Descemet Membrane Endothelial Keratoplasty Rochester, Minn. The goal of this study is to determine optical and visual function through 5 years after Descemet membrane endothelial keratoplasty (DMEK). The study will also determine graft health (corneal endothelial cell loss) and survival through 5 years after DMEK, and factors associated with these outcomes, as well as assess the relationship between optical and anatomical corneal rehabilitation after DMEK. A Study to Evaluate the Use of Nivolumab and Pomalidomide Combination for Relapsed/Refractory Primary Central Nervous System Lymphoma and Primary Vitreoretinal Lymphoma Rochester, Minn., Jacksonville, Fla. The purpose of this study is to evaluate the side effects and best dose of pomalidomide when given together with dexamethasone in treating patients with primary central nervous system lymphoma that has come back (relapsed) or does not respond to treatment (refractory) or intraocular lymphoma that is newly diagnosed, relapsed or refractory. Pomalidomide may stimulate the immune system to kill cancer cells. Drugs used in chemotherapy, such as dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells, stopping them from dividing, or by stopping them from spreading. Giving pomalidomide together with dexamethasone may kill more cancer cells. Glaucoma Biomarkers Rochester, Minn. Glaucoma is a major cause of blindness. The inability to predict a patient's IOP response to medications is a critical barrier for the clinician to consistently provide highly effective IOP-based treatments. Current trial-and error approaches to glaucoma management are inefficient and have not addressed this barrier as there are no predictive factors for drug response. Our long-term goal is to improve outcomes by identifying biomarkers and environmental factors that profile a patient at risk for glaucoma by age-of-onset, rate of disease progression, "poor response" to treatment, and large IOP fluctuation. Our purpose of this research project is to address this critical barrier by focusing on physiological factors that predict IOP response to drugs. Exparel Injection for Postoperative Orbital Pain Rochester, Minn. After surgery to remove the eye, either by enucleation or evisceration, patients have variable levels of pain for several postoperative days. Some patients have almost no discomfort while others require significant amounts of oral narcotics and report pain of 10 out of 10 on a numerical rating scale. The current operative standard is to infiltrate the eye socket with 0.5% bupivacaine during surgery leading to several hours of postoperative analgesia. In 2011, Pacira Pharmaceuticals released a bupivacaine liposomal injectable suspension (Exparel, 1.3%) which offers sustained release of bupivacaine giving postoperative pain control for up to 72 hours. This medication has been used in numerous surgeries including inguinal hernia repair, hemorrhoidectomy, bunionectomy, breast reconstruction, and orthopedic surgery, and the literature reports improved pain control, decreased use of oral opioids, and increased patient satisfaction. There are no reports of the use of Exparel in the ophthalmic literature. The investigators propose a randomized, controlled trial to compare the postoperative pain control offered by sustained release bupivacaine to that offered by standard plain bupivacaine after enucleation or evisceration. A Study of the Effects of Pneumatic Vitreolysis on Vitreomacular Traction Rochester, Minn. The purpose of this study is to determine if pneumatic vitreolysis (PVL) is effective in releasing VMT. Eyes with idiopathic symptomatic vitreomacular traction (VMT) without a macular hole will be randomly assigned to 0.3-mL intraocular gas (C3F8) injection or sham injection. 1 2 3 4 5 Next Medical Professionals Ophthalmology Clinical Trials