What are the vaccines’ side effects?

Poster for video

Why do the COVID-19 vaccines cause side effects?
Find out about the side effects of the COVID-19 vaccine and why you should get it.

Melanie Swift, M.D., COVID-19 Vaccine Allocation and Distribution, Mayo Clinic: When we get vaccinated, we often experience some side effects and the reason that we get side effects is that our immune system is revving up and reacting. Now when you get sick, the same thing happens and actually a lot of the symptoms from illnesses that we get like influenza and COVID, are actually caused not by the direct action of the virus, by our immune system, so our bodies react and that gives us these general symptoms like fever, achiness, headache.

When you take two doses of vaccine, the first vaccine is the first time for your body to see this particular protein, the spike protein that the vaccines produce and your body begins to develop an immune response. The second vaccine dose goes into your body, start to make that spike protein and your antibodies jump on it and rev up and your immune system responds.

The vaccine side effects that we've seen resolve within about 72 hours of taking the vaccine. At the most, those side effects can last up to a week. And we really have not seen long-term side effects from the vaccine beyond that. It is so important to get this vaccine when it's offered to you, even if you're healthy, even if you might not be at risk for complications from COVID yourself. You could catch it and transmit it to other people who are and our society really needs everyone to be vaccinated so that we can stop transmission.

Key takeaways


COVID-19 vaccines can cause mild side effects after the first or second dose, including:

  • Pain, redness or swelling where the shot was given
  • Fever
  • Fatigue
  • Headache
  • Muscle pain
  • Chills
  • Joint pain
  • Nausea and vomiting
  • Swollen lymph nodes

Most side effects happen within the first three days after vaccination and typically last only 1 to 2 days.

Serious side effects of the Janssen/Johnson & Johnson COVID-19 vaccine can occur within three weeks of vaccination and require emergency care. Possible symptoms include:

  • Shortness of breath
  • Persistent stomach pain
  • Severe or persistent headaches or blurred vision
  • Chest pain
  • Leg swelling
  • Easy bruising or tiny red spots on the skin beyond the injection site

Mild to moderate headaches and muscle aches are common in the first three days after vaccination and don’t require emergency care.

More about COVID-19 vaccine side effects