COVID-19 diagnostic testing is done to find out if you're currently infected with SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19).
The U.S. Food and Drug Administration (FDA) approved two types of tests for diagnosing COVID-19 — molecular and antigen:
- Molecular test. Also called a PCR test, this diagnostic test detects genetic material of the COVID-19 virus using a lab technique called polymerase chain reaction (PCR). A health care worker collects fluid from a nasal or throat swab or, less often, from saliva. Results may be available in minutes if analyzed on-site or in a few days if sent to an outside lab. Molecular tests are considered very accurate when properly performed by a health care professional, but the rapid test appears to miss some infections.
- Antigen test. This diagnostic test rapidly detects certain proteins that are part of the COVID-19 virus. Using a nasal or throat swab to get sample fluid, antigen tests can produce results in minutes. Because these tests are faster and less expensive than molecular tests are, some experts consider antigen tests more practical to use for large numbers of people. A positive antigen test result is considered very accurate, but there's an increased chance of false-negative results. So antigen tests aren't as sensitive as molecular tests are. Depending on the situation, your doctor may recommend a molecular test to confirm a negative antigen test result.
The availability of COVID-19 diagnostic testing and where to get tested may vary depending on where you live and the recommendations of your local public health officials.
Why it's done
In the U.S., your doctor may recommend a COVID-19 diagnostic test if:
- You have COVID-19 symptoms, such as fever, cough, tiredness or shortness of breath
- You've had close contact with someone who tests positive for the COVID-19 virus or is suspected of having the virus
- You're at high risk of complications if you become infected
Certain groups are considered high priority for diagnostic testing. These include people with COVID-19 signs and symptoms who:
- Work in a health care facility or as first responders
- Live or work in long-term care facilities, such as nursing homes, or other places where people are housed closely together, such as prisons or shelters
- Are being cared for in a hospital
Other people may be given priority for testing depending on local health department guidelines for monitoring COVID-19 in individual communities.
Some people who are infected with the COVID-19 virus may be asymptomatic, meaning they don't have any signs or symptoms. But they can still transmit the virus to others. As more COVID-19 tests become available, in some areas of the country testing is being expanded to include asymptomatic people. If people without symptoms have a positive test result, they should follow guidelines for self-isolation to help curb the spread of the virus.
There's a chance that your COVID-19 diagnostic test could return a false-negative result. This means that the test didn't detect the COVID-19 virus, even though you actually are infected with it. You risk unknowingly spreading the virus to others if you don't take proper precautions, such as following social distancing guidelines and wearing a face mask when appropriate.
The risk of false-negative test results depends on the type and sensitivity of the COVID-19 diagnostic test, thoroughness of the sample collection, and accuracy of the lab analysis. Be wary of any offers for at-home COVID-19 tests that the FDA has not cleared for use or that promise immediate results at home — they may give you a false result.
How you prepare
If you think you may have COVID-19, call your doctor's office to review your symptoms, if any, and ask about testing. Then your doctor and other staff can prepare for your visit, wear personal protective equipment, and give you instructions about where to go and how the test will be done. Plan to wear a face mask to and from the testing center, and have anyone who accompanies you wear one, too.
What you can expect
For a COVID-19 diagnostic test, you provide a sample of mucus from your nose or throat, or a sample of saliva. The sample needed for diagnostic testing may be collected at your doctor's office, a health care facility or a drive-up testing center.
- Nose or throat swab. The U.S. Centers for Disease Control and Prevention recommends a nasal swab, though a throat swab is acceptable. Your doctor or other health care professional inserts a thin, flexible stick with cotton at the tip into your nose or brushes the swab along the back of your throat to collect a sample of mucus. This may be somewhat uncomfortable. For the nasal sample, swabbing may occur in both nostrils to collect enough mucus for the test. The swab remains in place briefly before being gently rotated as it's pulled out. The sample gets sealed in a tube and sent to a lab for analysis.
- Saliva sample. Though not considered the best way to get a good sample, a saliva test may be done if discomfort is an issue with a nose or throat swab. You spit into a tube several times to provide a sample of your saliva to test. The tube is sealed before being sent to a lab for analysis.
If you have a productive cough, your doctor may collect a sputum sample, which contains secretions from the lungs, a part of the lower respiratory system. The virus is more concentrated in the nose and throat early in the course of the infection. But after more than five days of symptoms, the virus tends to be more concentrated in the lower respiratory system.
In addition to the COVID-19 diagnostic test, your doctor may also test for other respiratory conditions, such as influenza, that have similar symptoms and could explain your illness.
Certain FDA-authorized COVID-19 test kits allow you to collect the sample at home and then send it to a lab to be tested, though a sample collected by a trained professional and sent to a certified lab is considered more reliable.
Supporting Your Child During COVID-19 Nasal Swab Testing
The purpose of this video is to prepare children for a COVID-19 nasal swab test, to help ease some of their potential fear and anxiety. When children are prepared to take a medical test, they become more cooperative and compliant, which creates a positive coping experience for them. This video has been made to be watched by children as young as 4 years old.
Jennifer Rodemeyer, Child Life Program Manager, Mayo Clinic: Hi, I'm Jennifer and I am a child life specialist at Mayo Clinic. My job is to help kids like you prepare for medical tests.
You may have heard there is a virus going around that can make people feel sick. A virus is a germ and it is so tiny you can't even see it.
Some people who get this virus can have a fever or a cough and may feel achy and tired, while some people can have this virus and not feel sick at all. People may get this virus from touching things. That's why it's important to wash your hands often with soap and water. The virus also can spread through a cough or a sneeze. So it's important to always cover your cough or sneeze.
Today, even though you may or may not be feeling sick, we will need to give you a test so we know how to best proceed with your medical care. This medical test will tell us if you have the virus.
When you go to take your test, the health care provider will wear special protective clothing. They wear this clothing to keep themselves and you safe from getting germs. They will wear a mask to cover their nose and mouth and a clear plastic shield to protect their eyes.
The most important thing you can do during your test is to sit perfectly still like a statue. To help make sure you don't move, your parent or caregiver will help keep you still and calm during your test. The health care provider needs to touch the inside of the back of your nose with a long, skinny Q-tip. To do this, you need to hold your chin up, then the health care provider will put the Q-tip in your nose for a short time to collect a sample.
While this happens you may feel like you want to push the Q-tip away, but it's really important to stay as still as possible so the health care provider can finish the test. The Q-tip will be in and out of your nose in a few seconds.
Some kids tell me that counting to 3 or taking a deep breath relaxes them before the test happens, and some tell me they like to hold on to their favorite stuffed animal or blanket. Maybe you have your own way to relax.
Remember that during the test, the most important thing to do is to keep your body perfectly still.
You may have many feelings seeing the health care provider wearing different clothing, but know this person is caring and wants to help you.
Thank you for helping us get this test done, so we know how to proceed with your medical care.
Some facilities have rapid tests for COVID-19 diagnostic testing. In that case, you may get your results in less than an hour or on the same day that you're tested. Other facilities may have to send the test sample to an outside lab for analysis. If they need to send out the sample, your results may not be available until a few days later.
Your COVID-19 diagnostic test result could be positive or negative.
- Positive result. This means you currently have an active infection with the virus that causes COVID-19. Take appropriate steps to care for yourself and avoid spreading the virus to others. Self-isolate until you meet all three of these conditions: Your symptoms have improved, and it's been three days since you've had a fever, and at least 10 days have passed since your symptoms first appeared. Some people, such as those with health conditions that lower their ability to fight disease (immunity), may need to stay in isolation longer, so follow your doctor's advice.
- Negative result. This means that you likely weren't infected with the COVID-19 virus. But a false-negative test result could happen depending on the timing and quality of the test sample. Even if you test negative, you could become infected in the future, so it's important to follow guidelines for social distancing, face mask use and hand-washing to avoid potential spread. Your doctor may recommend repeat testing if you continue to have symptoms.
If you test positive for the COVID-19 virus — or your doctor suspects that you have the virus but you don't have test results yet — you may be asked to participate in contact tracing. Contact tracing plays a key role in limiting the spread of infectious diseases. The sooner contact tracing starts, the more effective it is in limiting virus spread.
To begin, you provide a list of people you had close contact with during the time you may have been contagious. Public health workers then get in touch with those close contacts to let them know about the exposure and their potential for being infected. Your identity is protected during this exchange of information.
The contact tracing team provides information on what close contacts can do to minimize the risk of spreading the virus. Steps may include getting a COVID-19 test, staying at home in quarantine for 14 days after the exposure, learning about signs and symptoms, and taking other precautions.
Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this disease.