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研究

Mayo Clinic doctors and researchers are actively studying and refining proton therapy techniques. They conduct clinical trials to improve treatment outcomes and understand the benefits of proton therapy for various cancers.

Cancer research is conducted in coordination with Mayo Clinic Comprehensive Cancer Center. Mayo Clinic Comprehensive Cancer Center receives funding from the National Cancer Institute and is designated as a comprehensive cancer center. This designation recognizes the institution's scientific excellence and multidisciplinary resources focused on cancer prevention, diagnosis and treatment.

Publications

See a list of publications about proton therapy by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

Research Profiles

April 29, 2026
  1. Frank SJ, et al., eds. Principles of proton beam therapy. In: Proton Therapy. Elsevier; 2021. https://www.clinicalkey.com. Accessed June 3, 2025.
  2. Mitin T. Radiation therapy techniques in cancer treatment. https://www.uptodate.com/contents/search. Accessed June 3, 2025.
  3. Dmochowski RR, et al., eds. Radiation therapy for prostate cancer. In: Campbell-Walsh-Wein Urology. 13th ed. Elsevier; 2026. https://www.clinicalkey.com. Accessed June 3, 2025.
  4. Proton therapy. RadiologyInfo.org. https://www.radiologyinfo.org/en/info.cfm?pg=protonthera. Accessed June 3, 2025.
  5. DiBase SJ, et al. External beam radiation therapy for localized prostate cancer. https://www.uptodate.com/contents/search. Accessed June 3, 2025.
  6. Proton beam therapy. RT Answers. https://www.rtanswers.org/cancer-types/brain-tumors/treatment-types/proton-beam-therapy. Accessed June 3, 2025.
  7. What to expect. RT Answers. https://www.rtanswers.org/what-is-radiation-therapy/what-to-expect. Accessed June 3, 2025.
  8. External beam radiation therapy for cancer. National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/types/radiation-therapy/external-beam. Accessed June 3, 2025.
  9. Find a proton therapy center near you. The National Association for Proton Therapy. https://proton-therapy.org/findacenter. Accessed June 3, 2025.
  10. Salem PP, et al. Proton radiation therapy: A systematic review of treatment-related side effects and toxicities. International Journal of Molecular Sciences. 2024; doi:10.3390/ijms252010969.
  11. Yang JT, et al. Randomized phase II trial of proton craniospinal irradiation versus photon involved-field radiotherapy for patients with solid tumor leptomeningeal metastasis. Journal of Clinical Oncology. 2022; doi:10.1200/JCO.22.01148.
  12. What is proton therapy? The National Association for Proton Therapy. https://proton-therapy.org/faq. Accessed March 25, 2026.
  13. Health Education & Content Services. An introduction to radiation treatment. Mayo Clinic; 2026.
  14. Medical review (expert opinion). Mayo Clinic. April 4, 2026.