Mayo Clinic's approach

A team of doctors and staff in a discussion. Mayo Clinic heart transplant team

A team of doctors and other staff work together and discuss care for people who may need a heart transplant.

Multidisciplinary team approach

At Mayo Clinic, doctors trained in heart disease (cardiologists), heart and lung surgery (cardiac and thoracic surgeons), infectious disease management, mental health conditions (psychiatrists), and other specialties collaborate as a multidisciplinary team to provide you with coordinated, comprehensive care. Doctors work together with health care professionals in many areas to evaluate you, perform your heart transplant and coordinate follow-up care.

Image of health care professionals in many medical specialties. Care team roles

Health care professionals trained in many medical specialties work together as a team to ensure favorable outcomes from your heart transplant.

Pediatric cardiologists, pediatric heart surgeons and other specialists work together to evaluate and treat children who may need heart transplants at Mayo Clinic's campus in Minnesota. At Mayo Clinic's campus in Arizona, cardiologists partner with Phoenix Children's Hospital to treat teenagers and young adults with congenital heart disease.

Multiorgan transplant experience

Mayo Clinic doctors and surgeons have experience evaluating and treating people with complex conditions who may need multiorgan transplants. Surgeons have experience performing multiorgan transplant procedures, and doctors trained in a wide array of specialties work together as a team in Mayo Clinic's Transplant Center to treat people who may need multiorgan transplants.

Amyloidosis expertise

Mayo doctors have extensive experience and expertise evaluating and treating people with amyloidosis.

Amyloidosis is a rare disease that occurs when an abnormal protein, called amyloid, builds up in multiple organs, including the heart, liver and kidneys, and can affect their function.

If amyloidosis has seriously affected your heart, you may be eligible for a heart transplant, or you may need a heart-liver transplant or a heart-kidney transplant. Your Mayo doctors and treatment team will evaluate your condition and determine if a heart transplant or other treatment may be most appropriate for your condition. Doctors at Mayo Clinic have experience treating amyloidosis with many treatments, including heart transplant for people who are eligible.

Individualized approach

Mayo Clinic doctors take the time to get to know you and work with you to provide exactly the care you need. Your doctors and transplant team will work with you and discuss your individual needs, desires and lifestyle to determine the most appropriate treatment for you.

Depending on your individual condition and needs, your doctors and transplant team may recommend a heart transplant or other therapies appropriate to your specific situation, such as a ventricular assist device.

Two doctors having a discussion. Mayo Clinic doctors collaborate to provide care

Mayo doctors collaborate as a team to care for people who may need a heart transplant.

Common recommendations and treatment at all Mayo Clinic locations

Mayo Clinic Transplant Center staff at campuses in Arizona, Florida and Minnesota work together to evaluate and treat people who may need heart transplants. Mayo Clinic offers common recommendations, evaluation processes, treatment, post-surgical care and follow-up care for heart transplant candidates at each of Mayo Clinic's campuses. Mayo Clinic staff coordinates care between the three sites as required.

You might be evaluated for a heart transplant at one Mayo Clinic location, but then have a heart transplant at another location if it's in your best interest. If you have your evaluation and transplant surgery at different locations, Mayo staff from both locations collaborates as a team to provide you with comprehensive care throughout the transplant process.

Research and innovation

Mayo Clinic researchers in the Transplant Center conduct ongoing studies and clinical trials in improving surgical procedures, improving outcomes and caring for people who need transplants. Researchers also study alternative therapies for people who might be able to use an alternative to a heart transplant. They also work on novel areas of research, such as exploring ways to personalize treatments for patients by using biomarkers and genetics to individualize therapy.

Mayo researchers in the Heart Transplant Research Program study challenges associated with heart transplantation and are working to understand the major causes of graft failure and find new ways to prolong survival.

The Mayo Clinic experience and patient stories

Our patients tell us that the quality of their interactions, our attention to detail and the efficiency of their visits mean health care like they've never experienced. See the stories of satisfied Mayo Clinic patients.

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    Britiny's team

    Britiny Schultz Britiny Schultz can't wait for fall. A huge football fan, she's looking forward to cheering on her favorite teams. It's something many fans take for granted — not Britiny. She's able to keep cheering, thanks to her doctors at Mayo Clinic and the incredible gift of life from not just one, but two organ donors. Britiny and her nieces and nephews The South Dakota native says she closely follows two teams: "The Bison…

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    Heart transplant patient finding motivation through competition, music and the Mayo Clinic community

    Mark Forbess playing the piano in the Mayo atrium The fall It was Good Friday 2023. Mark Forbess was just leaving Mayo Clinic in Florida after his first appointment as a new patient at the heart failure program, when everything went black. "I found myself on the pavement in front of Mayo Clinic," says Mark. "I was emerging from unconsciousness. Everything was dark. I opened my eyes to see that my face was pressed onto…

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    In a first, Mayo Clinic treats cardiology patient with phage therapy

    Mark Ulland, a Mayo Clinic patient, recently received a lifesaving combination of phage therapy followed by a heart transplant. It is the first time Mayo Clinic has ever used phages to treat a cardiology patient. It is also the first time in years that Mark has felt hopeful. "I'm extremely grateful," Mark says. "I feel blessed. I'm getting stronger every day." Mark's long journey back to health began when his heart was failing, and the…

  4. Jeff-and-Trish-Robinson-16-x-9--1024x576.jpg

    Heart Transplant Innovation: New 'heart in a box' technology provides gift of life to Arizona man, as couple prepares to celebrate 50-year anniversary

    Jeff and Trish Robinson Heart Transplant Innovation: Breakthrough technology known as "heart in a box" is giving hope to thousands of people in need of heart transplants. Traditionally, donor hearts were retrieved from patients who were declared brain dead, but their heart remained beating. "Heart in a box" allows for donation after circulatory death (DCD), where the heart has stopped beating. The new system is expected to widen the donor pool, thus getting more donor…

Expertise and rankings

A team of doctors and staff in a discussion. Mayo Clinic heart transplant team

Doctors work together with doctors and staff in many specialties to provide heart transplant care.

Cardiovascular disease experience

Mayo Clinic cardiologists and cardiac and thoracic surgeons have extensive experience diagnosing and treating people with heart failure and other cardiovascular diseases. Doctors and surgeons care for more than 100,000 people who have cardiovascular disease each year. Mayo Clinic's campuses in Arizona, Florida and Minnesota each offer a Heart Failure Clinic staffed by a team of cardiologists and other specialists trained in evaluating and treating heart failure.

Surgical expertise

Mayo Clinic heart transplant surgeons have performed hundreds of procedures using state-of-the-art technology since the heart transplant program began in 1988.

Heart transplant outcomes compare favorably with the national average. Learn more about Mayo Clinic's heart transplant volumes and outcomes.

Two surgeons in a discussion in an operating room. Mayo Clinic heart surgeons

Mayo Clinic heart surgeons work together to provide care for people who need heart transplants.

Heart transplant patient experience

Independent patient experience surveys indicate that a high number of Mayo Clinic patients who are being cared for by the heart transplant team are very satisfied with their care and would recommend the practice to others.

Nationally recognized expertise

Mayo Clinic in Rochester, Minnesota, Mayo Clinic in Phoenix/Scottsdale, Arizona, and Mayo Clinic in Jacksonville, Florida, are ranked among the Best Hospitals for heart and heart surgery by U.S. News & World Report. Mayo Clinic Children's Center in Rochester is ranked the No. 1 hospital in Minnesota, and the five-state region of Iowa, Minnesota, North Dakota, South Dakota and Wisconsin, according to U.S. News & World Report's 2023-2024 "Best Children's Hospitals" rankings.

With Mayo Clinic's emphasis on collaborative care, specialists at each of the campuses — Minnesota, Arizona and Florida — interact very closely with colleagues at the other campuses and the Mayo Clinic Health System.

Volumes and outcomes


Mayo Clinic doctors' experience and integrated team approach result in transplant outcomes that compare favorably with national averages. Teams work with transplant recipients before, during and after surgery to ensure the greatest likelihood of superior results.

Volumes and statistics are maintained separately for the three Mayo Clinic locations. Taken together or separately, transplant recipients at Mayo Clinic enjoy excellent results.

Learn more about Mayo Clinic's heart transplant volumes and outcomes.

Locations, travel and lodging

The Village at Mayo Clinic in Phoenix, Arizona, offers low-cost housing for transplant patients and their caregivers.

The Gabriel House of Care in Jacksonville, Florida, offers low-cost housing for transplant patients and their caregivers.

The Gift of Life Transplant House in Rochester, Minnesota, offers low-cost housing for transplant patients and their caregivers.

Mayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states.

For more information on visiting Mayo Clinic, choose your location below:

Costs and insurance

Mayo Clinic has dedicated transplant financial services representatives and social workers who can assist you with insurance and financial questions regarding your heart transplant.

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people.

In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. Many insurance companies require you to get preapproval authorization prior to transplant services.

Read more about heart transplant costs and insurance at Mayo Clinic.

More information about billing and insurance:

Mayo Clinic in Arizona, Florida and Minnesota

Mayo Clinic Health System

Clinical trials

Explore Mayo Clinic studies of tests and procedures to help prevent, detect, treat or manage conditions.

Jan. 19, 2024
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  2. Guglin M, et al. Evaluation for heart transplantation and LVAD implantation: JACC Council perspectives. Journal of the American College of Cardiology. 2020; doi:10.1016/j.jacc.2020.01.034.
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  4. Heart. Organ Procurement and Transplantation Network. Accessed Aug. 9, 2021.
  5. Getting a new heart: Information for patients about heart transplant. American Society of Transplantation. Accessed Aug. 9, 2021.
  6. Medicines to keep your new organ healthy. American Society of Transplantation. Accessed Aug. 9, 2021.
  7. Bhagra SK, et al. Cardiac transplantation: Indications, eligibility and current outcomes. Heart. 2019; doi:10.1136/heartjnl-2018-313103.
  8. Matching donors and recipients. Health Resources & Services Administration. Accessed Aug. 9, 2021.
  9. Freeman R, et al. Cardiac transplant postoperative management and care. Critical Care Nursing Quarterly. 2016; doi:10.1097/CNQ.0000000000000116.
  10. Neethling E, et al. Intraoperative and early postoperative management of heart transplantation: Anesthetic implications. Journal of Cardiothoracic and Vascular Anesthesia. 2020; doi:10.1053/j.jvca.2019.09.037.
  11. Yardley M, et al. Importance of physical capacity and the effects of exercise in heart transplant recipients. World Journal of Transplantation. 2018; doi:10.5500/wjt.v8.i1.1.
  12. Entwistle TR, et al. Modifying dietary patterns in cardiothoracic transplant patients to reduce cardiovascular risk: The AMEND-IT Trial. Clinical Transplantation. 2021; doi:10.1111/ctr.14186.
  13. Uithoven KE, et al. The role of cardiac rehabilitation in reducing major adverse cardiac events in heart transplantation patients. Journal of Cardiac Failure. 2020; doi:10.1016/j.cardfail.2020.01.011.
  14. Colvin M, et al. OPTN/SRTR 2019 Annual Data Report: Heart. American Journal of Transplantation. 2021; doi:10.1111/ajt.16492.
  15. Benefits of physical activity. Centers for Disease Control and Prevention. Accessed Aug. 16, 2021.
  16. Bui QM, et al. Psychosocial evaluation of candidates for heart transplant and ventricular assist devices. Circulation: Heart failure. 2019; doi:10.1161/CIRCHEARTFAILURE.119.006058.
  17. Total artificial heart. National Heart, Lung, and Blood Institute. Accessed Aug. 16, 2021.
  18. D'Addese L, et al. Pediatric heart transplantation in the current era. Current Opinion in Pediatrics. 2019; doi:10.1097/MOP.0000000000000805.
  19. Office of Patient Education. Nutrition guidelines for transplant recipients. Mayo Clinic; 2019.
  20. Dingli D (expert opinion). Mayo Clinic. Sept. 9, 2021.
  21. Organ facts and surgeries: Heart. Organ Procurement and Transplantation Network. Accessed Sept. 10, 2021.


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