Mayo Clinic's approach

A team of doctors and staff in a discussion. Mayo Clinic heart transplant team

A team of doctors and other staff work together and discuss care for people who may need a heart transplant.

Multidisciplinary team approach

At Mayo Clinic, doctors trained in heart disease (cardiologists), heart and lung surgery (cardiac and thoracic surgeons), infectious disease management, mental health conditions (psychiatrists), and other specialties collaborate as a multidisciplinary team to provide you with coordinated, comprehensive care. Doctors work together with health care professionals in many areas to evaluate you, perform your heart transplant and coordinate follow-up care.

Image of health care professionals in many medical specialties. Care team roles

Health care professionals trained in many medical specialties work together as a team to ensure favorable outcomes from your heart transplant.

Pediatric cardiologists, pediatric heart surgeons and other specialists work together to evaluate and treat children who may need heart transplants at Mayo Clinic's campus in Minnesota. At Mayo Clinic's campus in Arizona, cardiologists partner with Phoenix Children's Hospital to treat teenagers and young adults with congenital heart disease.

Multiorgan transplant experience

Mayo Clinic doctors and surgeons have experience evaluating and treating people with complex conditions who may need multiorgan transplants. Surgeons have experience performing multiorgan transplant procedures, and doctors trained in a wide array of specialties work together as a team in Mayo Clinic's Transplant Center to treat people who may need multiorgan transplants.

Amyloidosis expertise

Mayo doctors have extensive experience and expertise evaluating and treating people with amyloidosis.

Amyloidosis is a rare disease that occurs when an abnormal protein, called amyloid, builds up in multiple organs, including the heart, liver and kidneys, and can affect their function.

If amyloidosis has seriously affected your heart, you may be eligible for a heart transplant, or you may need a heart-liver transplant or a heart-kidney transplant. Your Mayo doctors and treatment team will evaluate your condition and determine if a heart transplant or other treatment may be most appropriate for your condition. Doctors at Mayo Clinic have experience treating amyloidosis with many treatments, including heart transplant for people who are eligible.

Individualized approach

Mayo Clinic doctors take the time to get to know you and work with you to provide exactly the care you need. Your doctors and transplant team will work with you and discuss your individual needs, desires and lifestyle to determine the most appropriate treatment for you.

Depending on your individual condition and needs, your doctors and transplant team may recommend a heart transplant or other therapies appropriate to your specific situation, such as a ventricular assist device.

Two doctors having a discussion. Mayo Clinic doctors collaborate to provide care

Mayo doctors collaborate as a team to care for people who may need a heart transplant.

Common recommendations and treatment at all Mayo Clinic locations

Mayo Clinic Transplant Center staff at campuses in Arizona, Florida and Minnesota work together to evaluate and treat people who may need heart transplants. Mayo Clinic offers common recommendations, evaluation processes, treatment, post-surgical care and follow-up care for heart transplant candidates at each of Mayo Clinic's campuses. Mayo Clinic staff coordinates care between the three sites as required.

You might be evaluated for a heart transplant at one Mayo Clinic location, but then have a heart transplant at another location if it's in your best interest. If you have your evaluation and transplant surgery at different locations, Mayo staff from both locations collaborates as a team to provide you with comprehensive care throughout the transplant process.

Research and innovation

Mayo Clinic researchers in the Transplant Center conduct ongoing studies and clinical trials in improving surgical procedures, improving outcomes and caring for people who need transplants. Researchers also study alternative therapies for people who might be able to use an alternative to a heart transplant. They also work on novel areas of research, such as exploring ways to personalize treatments for patients by using biomarkers and genetics to individualize therapy.

Mayo researchers in the Heart Transplant Research Program study challenges associated with heart transplantation and are working to understand the major causes of graft failure and find new ways to prolong survival.

The Mayo Clinic experience and patient stories

Our patients tell us that the quality of their interactions, our attention to detail and the efficiency of their visits mean health care like they've never experienced. See the stories of satisfied Mayo Clinic patients.

  1. HeidtFrankieWParentsfeatured.jpg

    A new heart, new hope for a newborn

    Travis Heidt was holding his son, Franklin, for the first time. "It was a very joyous time and also an overwhelming time," says the first-time parent. He was unsure of how to hold Franklin, unsure of how to care for him. But Travis knew that he and his wife, Morgan, would figure it out. They had a beautiful boy. He and Morgan had created a family. "The second that he came out, something changed inside…

  2. RippySydneyFeatured_edited.jpg

    Celebrating 10-years with a new heart - just like her big sister

    Linsey Rippy was 16 weeks pregnant with her second child when she learned her daughter, Madi, had dilated cardiomyopathy. She was just two-and-a-half years old. “Our hospital in the Twin Cities ran every genetic test on Madi, but nothing came up,” Linsey said. “She’d had a virus a few weeks before, so they figured that’s what caused her to develop the condition.” Doctors also figured that meant there was little risk of the baby Linsey…

  3. Transplant patient says thanks 'with all my old heart and new one'

    Ernie Hernandez was battling congestive heart failure when he learned his liver was failing, too. On Oct. 26, he found answers to both issues with the first combined heart and liver transplant in Arizona. Ernie Hernandez was used to the hot Arizona sun. He was born and raised in Phoenix and worked as a contractor [...]

  4. 10 years, 2 brothers, 2 transplants: the Wilson brothers' story

    The Wilson brothers' connection goes deeper than the average siblings. They both were in serious need of a heart transplant. The brothers now have new hearts, a new perspective on life, and a new purpose. On the surface, John and Mark Wilson are model brothers. Growing up, the two would playfully pick on each other [...]

  5. Joelle's journey to a new heart

    Cardiomyopathy is a medical term for a number of genetic and nongenetic diseases involving the heart muscle that adversely affect the heart's mechanical pumping function and its electrical system. It can occur in people of all ages, races or genders, and it is a frequent cause of sudden cardiac arrest and sudden cardiac death. For [...]

Expertise and rankings

A team of doctors and staff in a discussion. Mayo Clinic heart transplant team

Doctors work together with doctors and staff in many specialties to provide heart transplant care.

Cardiovascular disease experience

Mayo Clinic cardiologists and cardiac and thoracic surgeons have extensive experience diagnosing and treating people with heart failure and other cardiovascular diseases. Doctors and surgeons care for more than 100,000 people who have cardiovascular disease each year. Mayo Clinic's campuses in Arizona, Florida and Minnesota each offer a Heart Failure Clinic staffed by a team of cardiologists and other specialists trained in evaluating and treating heart failure.

Surgical expertise

Mayo Clinic heart transplant surgeons have performed hundreds of procedures using state-of-the-art technology since the heart transplant program began in 1988.

Heart transplant outcomes compare favorably with the national average. Learn more about Mayo Clinic's heart transplant volumes and outcomes.

Two surgeons in a discussion in an operating room. Mayo Clinic heart surgeons

Mayo Clinic heart surgeons work together to provide care for people who need heart transplants.

Heart transplant patient experience

Independent patient experience surveys indicate that a high number of Mayo Clinic patients who are being cared for by the heart transplant team are very satisfied with their care and would recommend the practice to others.

Nationally recognized expertise

Mayo Clinic in Rochester, Minnesota, Mayo Clinic in Phoenix/Scottsdale, Arizona, and Mayo Clinic in Jacksonville, Florida, are ranked among the Best Hospitals for heart and heart surgery by U.S. News & World Report. Mayo Clinic Children's Center in Rochester is ranked the No. 1 hospital in Minnesota, and the five-state region of Iowa, Minnesota, North Dakota, South Dakota and Wisconsin, according to U.S. News & World Report's 2022–2023 "Best Children's Hospitals" rankings.

With Mayo Clinic's emphasis on collaborative care, specialists at each of the campuses — Minnesota, Arizona and Florida — interact very closely with colleagues at the other campuses and the Mayo Clinic Health System.

Volumes and outcomes


Mayo Clinic doctors' experience and integrated team approach result in transplant outcomes that compare favorably with national averages. Teams work with transplant recipients before, during and after surgery to ensure the greatest likelihood of superior results.

Volumes and statistics are maintained separately for the three Mayo Clinic locations. Taken together or separately, transplant recipients at Mayo Clinic enjoy excellent results.

Learn more about Mayo Clinic's heart transplant volumes and outcomes.

Locations, travel and lodging

The Village at Mayo Clinic in Phoenix, Arizona, offers low-cost housing for transplant patients and their caregivers.

The Gabriel House of Care in Jacksonville, Florida, offers low-cost housing for transplant patients and their caregivers.

The Gift of Life Transplant House in Rochester, Minnesota, offers low-cost housing for transplant patients and their caregivers.

Mayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states.

For more information on visiting Mayo Clinic, choose your location below:

Costs and insurance

Mayo Clinic has dedicated transplant financial services representatives and social workers who can assist you with insurance and financial questions regarding your heart transplant.

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people.

In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. Many insurance companies require you to get preapproval authorization prior to transplant services.

Read more about heart transplant costs and insurance at Mayo Clinic.

More information about billing and insurance:

Mayo Clinic in Arizona, Florida and Minnesota

Mayo Clinic Health System

Clinical trials

Explore Mayo Clinic studies of tests and procedures to help prevent, detect, treat or manage conditions.

May 11, 2022
  1. Heart transplant. National Heart, Lung, and Blood Institute. Accessed Aug. 9, 2021.
  2. Guglin M, et al. Evaluation for heart transplantation and LVAD implantation: JACC Council perspectives. Journal of the American College of Cardiology. 2020; doi:10.1016/j.jacc.2020.01.034.
  3. Heart transplant. American Heart Association. Accessed Aug. 9, 2021.
  4. Heart. Organ Procurement and Transplantation Network. Accessed Aug. 9, 2021.
  5. Getting a new heart: Information for patients about heart transplant. American Society of Transplantation. Accessed Aug. 9, 2021.
  6. Medicines to keep your new organ healthy. American Society of Transplantation. Accessed Aug. 9, 2021.
  7. Bhagra SK, et al. Cardiac transplantation: Indications, eligibility and current outcomes. Heart. 2019; doi:10.1136/heartjnl-2018-313103.
  8. Matching donors and recipients. Health Resources & Services Administration. Accessed Aug. 9, 2021.
  9. Freeman R, et al. Cardiac transplant postoperative management and care. Critical Care Nursing Quarterly. 2016; doi:10.1097/CNQ.0000000000000116.
  10. Neethling E, et al. Intraoperative and early postoperative management of heart transplantation: Anesthetic implications. Journal of Cardiothoracic and Vascular Anesthesia. 2020; doi:10.1053/j.jvca.2019.09.037.
  11. Yardley M, et al. Importance of physical capacity and the effects of exercise in heart transplant recipients. World Journal of Transplantation. 2018; doi:10.5500/wjt.v8.i1.1.
  12. Entwistle TR, et al. Modifying dietary patterns in cardiothoracic transplant patients to reduce cardiovascular risk: The AMEND-IT Trial. Clinical Transplantation. 2021; doi:10.1111/ctr.14186.
  13. Uithoven KE, et al. The role of cardiac rehabilitation in reducing major adverse cardiac events in heart transplantation patients. Journal of Cardiac Failure. 2020; doi:10.1016/j.cardfail.2020.01.011.
  14. Colvin M, et al. OPTN/SRTR 2019 Annual Data Report: Heart. American Journal of Transplantation. 2021; doi:10.1111/ajt.16492.
  15. Benefits of physical activity. Centers for Disease Control and Prevention. Accessed Aug. 16, 2021.
  16. Bui QM, et al. Psychosocial evaluation of candidates for heart transplant and ventricular assist devices. Circulation: Heart failure. 2019; doi:10.1161/CIRCHEARTFAILURE.119.006058.
  17. Total artificial heart. National Heart, Lung, and Blood Institute. Accessed Aug. 16, 2021.
  18. D'Addese L, et al. Pediatric heart transplantation in the current era. Current Opinion in Pediatrics. 2019; doi:10.1097/MOP.0000000000000805.
  19. Office of Patient Education. Nutrition guidelines for transplant recipients. Mayo Clinic; 2019.
  20. Dingli D (expert opinion). Mayo Clinic. Sept. 9, 2021.
  21. Organ facts and surgeries: Heart. Organ Procurement and Transplantation Network. Accessed Sept. 10, 2021.


News from Mayo Clinic

Products & Services