Diagnosis
If you have symptoms of coronavirus disease 2019 (COVID-19) or you've been exposed to the COVID-19 virus, contact your healthcare team. Let them know whether you've had close contact with anyone diagnosed with COVID-19.
In the United States, at-home COVID-19 tests are available. The U.S. Food and Drug Administration (FDA) approves or authorizes the tests. On the FDA website, you can find a list of the tests that are validated and their expiration dates. You also can check with your healthcare professional before buying a test if you have any concerns.
When taking a test at home, carefully read the directions that come with the test. Follow the instructions exactly to get as accurate a result as possible.
Here are some guidelines for when to take a COVID-19 test:
- If you have COVID-19 symptoms, test for the illness right away.
- If you were exposed to the COVID-19 virus but don't have symptoms, wait at least five days after exposure and then test.
- If you have symptoms and tested positive for COVID-19 within the last 30 days, you can test again. But if you were recently exposed to the coronavirus and don't have symptoms, you don't need to test.
Also, testing before an event or contact with people at high risk of serious illness helps prevent the spread of the virus that causes COVID-19.
COVID-19 tests use a sample taken from your nose or throat, or a sample of saliva.
Two types of tests can help diagnose COVID-19.
- Molecular tests. These tests look for genetic material from the COVID-19 virus. Polymerase chain reaction (PCR) tests are molecular tests. You also may see this type of test referred to as a nucleic acid amplification test (NAAT). PCR tests are more accurate than the other type of COVID-19 test, called an antigen test. PCR tests may be done at home. But they are much more likely to be done by a healthcare professional and processed in a lab.
- Antigen tests. These tests look for viral proteins called antigens. Antigen tests also may be called rapid COVID-19 tests or at-home COVID-19 tests. These tests are useful if you need a quick result. Antigen tests are reliable and accurate, but they are less accurate than PCR tests. This is especially true if you don't have symptoms. If you take an antigen test and the result shows that you do not have COVID-19, called a negative result, take another antigen test after 48 hours to get the most accurate result.
Understanding test results
If you have a positive result with a COVID-19 PCR or antigen test, you almost certainly have COVID-19. Another test isn't needed.
If you get a negative PCR test result, you most likely do not have COVID-19.
If you have a negative antigen test result, the FDA recommends that you repeat an antigen test two days after the first test. Whether or not you have symptoms, repeating the test helps get the correct diagnosis.
If you test positive, call a healthcare professional immediately to find out what options are available.
Preventing the spread of the COVID-19 virus while sick
To prevent the spread of the COVID-19 virus to others, stay home and apart from anyone you live with for as long as you have worsening symptoms. If you have a weakened immune system, you will likely need to isolate for longer. How long depends on your symptoms and personal health history. Your healthcare professional can advise you on what's best in your situation.
If you must be around others, a face mask helps lower the spread of this coronavirus. During this time, try not to share items such as cups or towels. Use a separate bathroom and bedroom. Getting more airflow in your home can help as well.
Once you're feeling better and haven't had a fever for a full 24 hours, and you haven't taken medicine for fever during that time, you can go back to being around others. If your fever returns or you start to feel worse, return to isolation until your symptoms improve and you are fever-free without medicine for 24 hours. But listen to the advice of your healthcare professional.
In the five days after isolation, to help prevent the spread of the COVID-19 virus, you can wear a mask, wash your hands, keep your distance from others, take a COVID-19 test and improve airflow.
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Treatment
Many people with COVID-19 recover with rest, plenty of fluids and care that manages symptoms. Medicine you can get without a prescription can help, such as:
- Fever reducers.
- Pain relievers, such as ibuprofen (Advil, Motrin IB, others) or acetaminophen (Tylenol, others).
- Cough syrup or medicine.
If you are at high risk of serious COVID-19 illness, your healthcare professional may suggest medicine to prevent mild illness from getting worse. These medicines can include nirmatrelvir-ritonavir (Paxlovid), remdesivir (Veklury) or molnupiravir (Lagevrio).
Nirmatrelvir-ritonavir and molnupiravir are taken by mouth as pills. Remdesivir is given through an IV.
If you're very ill, you may need to be treated in the hospital.
Treatment for serious COVID-19 illness
People who are in the hospital for COVID-19 treatment receive care based on their immune system response and the need for oxygen support.
Added oxygen may be given through a tube in the nose. Some people may need to have a tube placed in their airways to push air into the lungs. That's called mechanical ventilation. In very severe situations, a machine called extracorporeal membrane oxygenation (ECMO) can be used to mimic the function of the heart and lungs.
Medicines for severe COVID-19 may be remdesivir, baricitinib (Olumiant) or tocilizumab (Actemra), or a corticosteroid such as dexamethasone.
Baricitinib is a pill. Tocilizumab is given through an IV. Dexamethasone may be given either as a pill or through an IV.
Another treatment option may come from blood donated by people who have recovered from COVID-19. This treatment is called convalescent plasma. The blood is processed to remove blood cells, leaving behind a liquid called plasma that has immune system proteins called antibodies. Convalescent plasma with high antibody levels may be used to help people with weakened immune systems recover from COVID-19.
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Clinical trials
Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this disease.
Lifestyle and home remedies
If you have COVID-19, it's important to get plenty of rest, drink fluids and watch your symptoms. Medicines you can get without a prescription can help manage pain, fever or cough.
If you have COVID-19 and are staying separate from others, try to keep busy and help your body clear out the infection. These steps might help:
- Eat healthy meals.
- Get enough sleep.
- Try relaxation exercises.
- Do activities you enjoy.
- Connect with friends and family, such as with phone or video calls.
People who have COVID-19 or care for someone with the illness may feel new or worse symptoms of stress, depression and anxiety. If you or someone you know needs help with managing the stress of illness, isolation or caregiving, contact your healthcare professional. Consider asking for a referral to a mental health professional.
Preparing for your appointment
To be treated for COVID-19, you may start by seeing your primary healthcare professional. Or you may be referred immediately to a specialist trained in treating infectious diseases.
Here's some information to help you get ready for your appointment.
What you can do
When you make the appointment, ask if there's anything you need to do in advance. Make a list of:
- Your symptoms, including any that don't seem related to the reason for your appointment.
- Your recent travel, including any international travel.
- Key personal information, including major stresses, recent life changes and family medical history.
- All medicines, vitamins and other supplements you take, including the doses.
- Questions to ask your healthcare team.
Take a family member or friend along, if possible, to help you remember the information you're given.
Some basic questions to ask your healthcare team include:
- How likely is it that COVID-19 is causing my symptoms?
- What are other possible causes for my symptoms?
- What tests do I need?
- What course of action do you recommend?
- Are there restrictions I need to follow?
- Should I see a specialist?
What to expect from your doctor
Your healthcare professional is likely to ask you several questions, such as:
- When did your symptoms begin?
- Where have you traveled recently?
- Who have you been in close contact with?
- How bad are your symptoms?
Oct. 21, 2025