Biographical summary
Rory L. Smoot, M.D., is a hepatobiliary and pancreas surgeon specializing in the treatment bile duct cancer (cholangiocarcinoma), pancreatic cancer and other pancreatic and hepatobiliary diseases. He is the vice-chair of Research for the Department of Surgery at Mayo Clinic in Rochester, Minnesota. Dr. Smoot partners with patients to provide respectful and attentive care to their individual health needs, ensuring their desired health outcomes are prioritized in clinical choices.
His clinical focus includes:
    - Surgical treatment for benign and malignant diseases of the pancreas, liver, gallbladder, and bile ducts.
- Surgical treatment for cholangiocarcinoma, metastatic cancer to the liver and other abdominal organs.
- Surgical treatment for abdominal and retroperitoneal sarcomas.
- Surgical treatment of splenic conditions.
- Surgical treatment of gastric and small bowel tumors.
Dr. Smoot earned his medical degree from Mayo Medical School in Rochester, Minnesota. He completed his general surgery residency at the Mayo School of Graduate Medical Education in Rochester, MN. After residency, he continued his training at the University of Toronto, completing a fellowship in hepatobiliary surgery. 
Dr. Smoot earned an Early-Stage Investigator qualification and is dedicated to advancing treatment for hepatobiliary and pancreas diseases. His research focuses on novel therapeutic strategies for cholangiocarcinoma, new therapies to augment liver regeneration and treatment for hepatobiliary malignancies. He authors expert content and publishes in high-impact scientific journals. His cancer research has been funded by the Department of Defense Career Development Award and the Regenerative Medicine Minnesota Foundation grant.
        Conditions treated
        Procedures performed
        Interests
- Benign Conditions of the Liver and Bile Ducts (Hemangioma, Bile duct injury, Polycystic liver disease, Cystadenoma, Adenoma)
- Malignant Conditions of the Liver and Bile Ducts (Cholangiocarcinoma, Hepatocellular carcinoma, Gallbladder cancer, Metastatic colon cancer, Other metastatic tumors)
- Benign Conditions of the Pancreas (IPMN, Mucinous neoplasm, Neuroendocrine tumors)
- Malignant Conditions of the Pancreas (Pancreas cancer, Metastatic tumors to the pancreas)
- Other abdominal and retroperitoneal tumors (Sarcoma, Carcinoid, Gastric cancer, GIST, Small bowel cancer)
Mayo Clinic locations
        Education
- 2014Fellow - Hepatobiliary Surgery FellowshipUniversity of Toronto 
- 2012ResidentSurgery, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine 
- 2012ResidentMayo School of Graduate Medical Education, Mayo Clinic College of Medicine 
- 2010Clinical InvestigatorMayo School of Graduate Medical Education, Mayo Clinic College of Medicine 
- 2010ResidentClinician Investigator, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine 
- 2005MDMayo Medical School, Mayo Clinic College of Medicine 
- 2003Research ScholarHoward Hughes Medical Institute 
- 2000BA - Biology (with honors)University of Kansas 
Activities and honors
Certifications
- 2013General SurgeryAmerican Board of Surgery 
Awards and honors
- 2018Poster of DistinctionSociety of Surgical Oncology 
- 2017Center for Cell Signaling in Gastroenterology New Named InvestigatorMayo 
- 2011Howard K. Gray Travel AwardSurgical Residency Program, Department of Surgery 
- 2010Dr. Kaare K. Nygaard Travel AwardSurgical Residency Program, Department of Surgery 
- 2009Balfour AwardBalfour Research Symposium, Mayo Clinic College of Medicine and Science, Department of Education Administration 
- 2009Inlow AwardSurgical Residency Program, Department of Surgery 
- 2007Dr. Kaare K. Nygaard Travel AwardSurgical Residency Program, Department of Surgery 
- 2006Silver Retractor AwardSilver Retractor 
- 2004Medical Student Prize for Excellence in NeurologyAmerican Academy of Neurology 
- 2003Continuing Education FellowshipHoward Hughes Medical Institute 
- 2000Gooding ScholarMayo Medical School, Mayo Clinic College of Medicine and Science, Department of Education Administration 
Professional memberships
- 2024 - presentGrant ReviewerPrimary Sclerosing Cholangitis (PSC) Support 
- 2024 - presentExternal Grant ReviewerBelgian Foundation Against Cancer 
- 2024 - presentMember, Research Transformation Discovery-Practice PillarResearch, Mayo Group Practices 
- 2024 - presentMember, Research Transformation Clinical Impact PillarResearch, Mayo Group Practices 
- 2024 - presentExternal Grant ReviewerSwiss National Science Foundation 
- 2023 - presentMember, Advisory CommitteeNHLBI Sponsored R38 - Mayo Clinic "Stimulating Access to Research in Residency" (StARR) program 
- 2022 - presentExecutive Committee Member, NIDDK-funded Digestive Disease Research Core CenterMayo Clinic 
- 2021 - presentSteering Committee MemberMayo Clinic Center for Biomedical Discovery 
- 2021 - presentMemberAmerican Association of Cancer Research 
- 2020 - presentCo-Chair, Surgical Peer Review Research CommitteeDepartment of Surgery 
- 2020 - presentMemberInternational Liver Cancer Association 
- 2019 - presentMember, Executive CommitteeDepartment of Surgery 
- 2018 - presentMemberAmerican Association for the Study of Liver Diseases 
- 2016 - presentMember, Membership CommitteeAmerican Hepato-Pancreato-Biliary Association 
- 2015 - 2018Subject Matter ExpertMayo Clinic EHR/RCM Convergence Project/Plummer Project 
- 2014 - 2018Member, Program Sub-Committee - HepatobiliarySociety for Surgery of the Alimentary Tract 
- 2014 - presentMemberThe Priestley Society 
- 2010 - presentMemberAmerican Hepato-Pancreato-Biliary Association 
- 2010 - 2012Member, Membership CommitteeAssociation for Academic Surgery 
- 2009 - 2023MemberSociety for Surgery of the Alimentary Tract 
- 2009 - 2022MemberAssociation for Academic Surgery 
Publications
Research activities