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Rory L. Smoot, M.D.

  1. Hepatobiliary and Pancreas Surgeon
  2. Surgical Oncologist


  1. Rochester, Minnesota




Rory L. Smoot, M.D., is a hepatobiliary and pancreas surgeon specializing in the treatment bile duct cancer (cholangiocarcinoma), pancreatic cancer and other pancreatic and hepatobiliary diseases. He is the vice-chair of Research for the Department of Surgery at Mayo Clinic in Rochester, Minnesota. Dr. Smoot partners with patients to provide respectful and attentive care to their individual health needs, ensuring their desired health outcomes are prioritized in clinical choices.

His clinical focus includes:

  • Surgical treatment for benign and malignant diseases of the pancreas, liver, gallbladder, and bile ducts.
  • Surgical treatment for cholangiocarcinoma, metastatic cancer to the liver and other abdominal organs.
  • Surgical treatment for abdominal and retroperitoneal sarcomas.
  • Surgical treatment of splenic conditions.
  • Surgical treatment of gastric and small bowel tumors.

Dr. Smoot earned his medical degree from Mayo Medical School in Rochester, Minnesota. He completed his general surgery residency at the Mayo School of Graduate Medical Education in Rochester, MN. After residency, he continued his training at the University of Toronto, completing a fellowship in hepatobiliary surgery.

Dr. Smoot earned an Early-Stage Investigator qualification and is dedicated to advancing treatment for hepatobiliary and pancreas diseases. His research focuses on novel therapeutic strategies for cholangiocarcinoma, new therapies to augment liver regeneration and treatment for hepatobiliary malignancies. He authors expert content and publishes in high-impact scientific journals. His cancer research has been funded by the Department of Defense Career Development Award and the Regenerative Medicine Minnesota Foundation grant.

  1. Ampullary cancer
  2. Appendix cancer
  3. Bile duct cyst
  4. Bile duct injury
  5. Bile duct stone
  6. Bile duct stricture
  7. Biliary obstruction
  8. Carcinoid tumor
  9. Cholangiocarcinoma
  10. Duodenal cancer
  11. Enlarged spleen
  12. Gallbladder cancer
  13. Gallbladder polyp
  14. Gastrointestinal stromal tumors
  15. Hepatocellular carcinoma
  16. Hilar cholangiocarcinoma
  17. Immune thrombocytopenia
  18. IPMN
  19. Liver cancer
  20. Liver cyst
  21. Liver hemangioma
  22. Liver tumor
  23. Pancreatic cancer
  24. Pancreatic cyst
  25. Pancreatic neuroendocrine tumor
  26. Pancreatitis
  27. Peritoneal cancer
  28. Polycystic liver disease
  29. Recurrent cancer
  30. Retroperitoneal sarcoma
  31. Sarcoma
  32. Small bowel cancer
  33. Soft tissue sarcoma
  34. Stage 4 colorectal cancer
  35. Stomach cancer
  1. Bile duct resection
  2. Bile duct stone removal
  3. Cancer treatment
  4. Cholecystectomy
  5. Cryoablation for cancer
  6. Gastrectomy
  7. Hepatobiliary disease evaluation
  8. Hepatobiliary disease postoperative care
  9. Irreversible electroporation
  10. Laparoscopic surgery
  11. Liver cyst fenestration
  12. Liver cyst removal
  13. Liver resection
  14. Liver tumor ablation
  15. Microwave ablation for cancer
  16. Minimally invasive intestinal surgery
  17. Minimally invasive liver surgery
  18. Minimally invasive pancreas surgery
  19. Minimally invasive surgery
  20. Pancreatectomy
  21. Pancreatic enucleation
  22. Paracentesis
  23. Portal hypertension management
  24. Radiofrequency ablation for cancer
  25. Small bowel resection
  26. Soft tissue sarcoma surgery
  27. Soft tissue tumor ablation
  28. Splenectomy
  29. Whipple procedure
  • Benign Conditions of the Liver and Bile Ducts (Hemangioma, Bile duct injury, Polycystic liver disease, Cystadenoma, Adenoma)
  • Malignant Conditions of the Liver and Bile Ducts (Cholangiocarcinoma, Hepatocellular carcinoma, Gallbladder cancer, Metastatic colon cancer, Other metastatic tumors)
  • Benign Conditions of the Pancreas (IPMN, Mucinous neoplasm, Neuroendocrine tumors)
  • Malignant Conditions of the Pancreas (Pancreas cancer, Metastatic tumors to the pancreas)
  • Other abdominal and retroperitoneal tumors (Sarcoma, Carcinoid, Gastric cancer, GIST, Small bowel cancer)
  1. 2014
    Fellow - Hepatobiliary Surgery FellowshipUniversity of Toronto
  2. 2012
    ResidentSurgery, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  3. 2012
    ResidentMayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  4. 2010
    Clinical InvestigatorMayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  5. 2010
    ResidentClinician Investigator, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  6. 2005
    MDMayo Medical School, Mayo Clinic College of Medicine
  7. 2003
    Research ScholarHoward Hughes Medical Institute
  8. 2000
    BA - Biology (with honors)University of Kansas


  1. 2013
    General SurgeryAmerican Board of Surgery

Awards and honors

  1. 2018
    Poster of Distinction - Yohanathan L, Sugihara T, Werneburg N, Sosa C, Vasmatzis G, Truty M, Gores G, Smoot R: The Src Family Kinase LCK Phosphorylates YAP and is Associated with Early Recurrence in Intrahepatic CholangiocarcinomaSociety of Surgical Oncology
  2. 2011
    Howard K. Gray Travel AwardHoward K. Gray Travel Award
  3. 2010
    Dr. Kaare K. Nygaard Travel AwardDr. Kaare K. Nygaar
  4. 2009
    Balfour AwardBalfour Research Symposium, Mayo Clinic College of Medicine and Science, Department of Education Administration
  5. 2009
    Inlow AwardInlow Award
  6. 2007
    Dr. Kaare K. Nygaard Travel AwardDr. Kaare K. Nygaar
  7. 2006
    Silver Retractor AwardSilver Retractor
  8. 2004
    Medical Student Prize for Excellence in NeurologyAmerican Academy of Neurology
  9. 2003
    Continuing Education FellowshipHoward Hughes Medical Institute
  10. 2000
    Gooding ScholarMayo Medical School, Mayo Clinic College of Medicine and Science, Department of Education Administration

Professional memberships

  1. 2022 - present
    Executive Committee MemberMayo Clinic
  2. 2021 - present
    Steering Committee MemberMayo Clinic Center for Biomedical Discovery
  3. 2020 - present
    Co-ChairSurgical Peer Review Research Committee, Department of Surgery
  4. 2019 - present
    MemberDepartment of Surgery Research Executive Committee
  5. 2016 - present
    CouncilorMinnesota Surgical Society
  6. 2016 - present
    MemberMembership Committee, American Hepato-Pancreato-Biliary Association
  7. 2015 - 2018
    Subject Matter ExpertMayo Clinic EHR/RCM Convergence Project/Plummer Project
  8. 2014 - 2018
    Committee MemberProgram Sub-Committee-Hepatobiliary, Society for Surgery of the Alimentary Tract
  9. 2014 - present
    MemberThe Priestley Society
  10. 2014 - present
    MemberMinnesota Surgical Society
  11. 2010 - present
    MemberAmerican Hepato-Pancreato-Biliary Association
  12. 2010 - 2012
    Committee MemberAssociation for Academic Surgery
  13. 2009 - present
    MemberSociety for Surgery of the Alimentary Tract
  14. 2009 - present
    MemberAssociation for Academic Surgery
  15. 2005 - present
    MemberAmerican College of Surgeons
  16. 2000 - 2013
    Student MemberAmerican Medical Association


Research activities

See a description of research activities.