News Jan. 17, 2020 Single-site robotic adrenalectomy at Mayo Clinic Single-site technology allows for adrenalectomy to be safely performed through a single 2.5-cm incision that accommodates the camera, an assist port and two working hands. Jan. 17, 2020 Managing skeletal issues in transgender and gender-nonconforming individuals A working model supports that, assuming compliance with hormone therapy, the skeleton should be relatively well protected in both transgender women and transgender men. Jan. 17, 2020 Hypophosphatasia: Clinical updates and therapeutic advances Most commonly utilized medications for osteoporosis may further impair skeletal mineralization and should be avoided in patients with hypophosphatasia (HPP). Mayo specialists discuss current HPP research and treatment. Jan. 17, 2020 Importance of pre-pregnancy care for women with diabetes: A case from the endocrine teaching clinics Aoife M. Egan, M.B., B.Ch., Ph.D., and Adrian Vella, M.D., discuss the care program for a patient with type 1 diabetes mellitus who wished to become pregnant. Oct. 22, 2019 11C-choline PET/CT for parathyroid imaging Benefits of carbon-11-choline (11C-choline) positron emission tomography/computerized tomography (PET/CT) over traditional imaging in the treatment of parathyroid adenomas include greater speed and accuracy a[...] Oct. 22, 2019 Endocrinologist-directed multidisciplinary hospital nutrition support service Mayo Clinic's Nutrition Support Service provides recommendations about whether patients require nutrition support and, if so, which route — gastric or jejunal tube feeding or parenteral nutrition — is optima[...] Oct. 22, 2019 Using fluorescence angiography to predict and prevent hypoparathyroidism after thyroid surgery Indocyanine green fluorescence angiography provides real-time data to help identify parathyroid glands and assess blood flow and viability during thyroid surgery. Oct. 22, 2019 The Mayo Clinic Pediatric Fertility Preservation Program The Mayo Clinic Pediatric Fertility Preservation Program offers both ovarian and testicular tissue cryopreservation to children under Institutional Review Board-approved research protocols. Oct. 22, 2019 ENPP1 variants associated with autosomal recessive hypophosphatemic rickets type 2: A case from the endocrine teaching clinics Anupam Kotwal, M.B.B.S., and Robert A. Wermers, M.D., discuss a case that adds to the body of knowledge about autosomal recessive hypophosphatemic rickets (ARHR) type 2 in adults. Oct. 22, 2019 Familial partial lipodystrophy — one size does not fit all: Cases from the endocrine teaching clinic Kristen M. Gonzales, M.D., and Vinaya Simha, M.B.B.S., M.D., discuss the genotypic and phenotypic diversity of familial partial lipodystrophy and associated metabolic abnormalities and comorbidities, plus standard manag[...] Dec. 15, 2018 Importance of prompt treatment for severe hypercortisolism secondary to ectopic Cushing syndrome: Cases from the endocrine teaching clinics Irina Bancos, M.D., and Tiffany M. Cortes, M.D., discuss cases of ectopic Cushing syndrome and the importance of prompt recognition, diagnosis and treatment: If complete resection of the ACTH-secreting neuroendocrine tu[...] Dec. 15, 2018 The Mayo Clinic thyroid cancer survivorship program A program designed for patients with well-differentiated thyroid cancer who have completed curative-intent treatment provides an individualized survivorship care plan that documents treatment, cancer staging, thyroid ho[...] Dec. 15, 2018 Hypertriglyceridemic pancreatitis Research indicates it is reasonable to target fasting serum triglyceride below 500 mg/dL to prevent hypertriglyceridemic pancreatitis. Strict adherence to a diet low in saturated fat and refined carbohydrates is likely [...] Sept. 15, 2018 Ethanol ablation for the treatment of cystic and predominantly cystic thyroid nodules Research indicates that a minimally invasive treatment option, such as percutaneous ethanol injection under ultrasound guidance, generally should be considered for the treatment of symptomatic benign cystic or predomina[...] Sept. 15, 2018 Steroid cell tumor of the ovary causing renin-mediated hypertension: A case from the endocrine teaching clinics Endocrinologists Oksana Hamidi, D.O., and Todd B. Nippoldt, M.D., discuss the diagnosis and treatment of a 37-year-old woman with a steroid cell tumor — an exceedingly rare sex cord-stromal tumor of the ovary. Sept. 15, 2018 Artificial pancreas: The journey continues Continuous glucose monitoring that provides real-time measurements every five minutes, insulin pumps and insulin analogs, and accelerated computing speed combine to deliver an artificial pancreas capable of 24/7 modulat[...] Sept. 15, 2018 Adrenocortical cancer presenting as postmenopausal bleeding: A case from the endocrine teaching clinics Irina Bancos, M.D., and Nana Esi N. Kittah, M.B., Ch.B., discuss the case of a woman who was diagnosed with Lynch syndrome, evaluated for a right adrenal mass and treated for adrenal cortical carcinoma. Sept. 15, 2018 Association of yoga exercises and vertebral compression fractures Between 2001 and 2014, nearly 30,000 visits to U.S. emergency rooms were related to yoga-associated injuries, with 13 percent of injuries occurring in adults age 65 years or older. Sept. 15, 2018 Radiofrequency ablation therapy for large benign thyroid nodules Studies confirm that ultrasound-guided thyroid nodule radiofrequency ablation (RFA) is a safe, effective outpatient treatment for patients with symptomatic or steadily growing benign, large, predominantly solid thyroid [...] Sept. 14, 2018 Incidentally discovered adrenal masses and subclinical Cushing syndrome A clinical trial helps researchers better understand differences in steroid production in patients with subclinical Cushing syndrome, and tie in measured abnormalities with cortisol-induced metabolic changes. Sept. 14, 2018 Hypoglycemia — Role for the selective arterial calcium stimulation test Use of endoscopic ultrasound, the selective arterial calcium stimulation test (SACST) or both allows specialists to localize or regionalize virtually all insulinomas preoperatively. Once factitious disease has been excl[...] Sept. 14, 2018 Recurrent primary hyperparathyroidism in a patient with multiple endocrine neoplasia, type 1: A case from the endocrine teaching clinics Recurrent primary hyperparathyroidism (PHPT) is the most common clinical manifestation of patients with multiple endocrine neoplasia, type 1 (MEN1). Naykky M. Singh Ospina, M.D., Robert A. Wermers, M.D., and William F. [...] Sept. 14, 2018 Immune checkpoint inhibitors and thyroid dysfunction: A case from the endocrine teaching clinics Danae A. Delivanis, M.D., and Mabel Ryder, M.D., explore the use of immune checkpoint inhibitors for patients with advanced, radioiodine refractory thyroid cancer in this case from the endocrine teaching clinics. Sept. 14, 2018 An unusual cause of a pituitary mass: A case from the endocrine teaching clinics Therapeutic and surgical treatment of patients with pituitary metastasis should be individualized based on presenting symptoms, imaging characteristics, treatment goals and patient preferences. Irina Bancos, M.D., and A[...] June 13, 2018 Weight regain after bariatric surgery Mayo specialists discuss treatment options available to help patients prevent weight gain after weight-loss surgery, including behavioral intervention, medications and transoral outlet reduction endoscopy. June 12, 2018 Thyroid storm: A case from the endocrine teaching clinics Diane Donegan, M.B., B.Ch., and Marius N. Stan, M.D., discuss diagnosis and treatment of thyroid storm, including aggressive nonsurgical management of hyperthyroidism, use of extracorporeal membrane oxygenation for card[...] June 12, 2018 Ratio of 25(OH)D-to-24,25(OH)2D: A new test to confirm 24-hydroxylase (CYP24A1) deficiency as the cause of hypercalcemia Researchers found that the ratio of 25(OH)D-to-24,25(OH)2D is necessary to estimate the calculation of vitamin D 24-hydroxylase enzyme activity to confirm 24-hydroxylase (CYP24A1) deficiency as the c[...] June 09, 2018 A flushing disorder: A case from the endocrine teaching clinics Shrikant U. Tamhane, M.B.B.S., and William F. Young Jr., M.D., discuss the case of a patient with flushing disorder. After normal laboratory tests, ultrasound showed a suspicious nodule in the patient's midright thyroid[...] June 09, 2018 An inconspicuous pheochromocytoma: A case from the endocrine teaching clinics Neurofibromatosis 1 (NF1) has a high prevalence of asymptomatic pheochromocytoma; hypertension is the most common symptom. Endocrinologists Todd B. Nippoldt, M.D., and Anu Sharma, M.B.B.S., discuss a case and recommenda[...] June 09, 2018 Diagnostic approach to disorders of extraskeletal bone formation Clinical diagnosis of genetic forms of heterotopic ossification is supported by associated features of the specific conditions and molecular confirmation of involvement of known genes. May 25, 2018 Thyroid eye disease clinic — The Mayo Clinic Model At Mayo Clinic, patients with Graves' orbitopathy (GO) are seen by an endocrinologist, ophthalmologist and ENT surgeon. The multidisciplinary team works to minimize or eliminate postoperative eye misalignment and double[...] May 25, 2018 Functioning gonadotroph macroadenoma causing ovarian hyperstimulation: A case from the endocrine teaching clinics Endocrinologists Haleigh A. James, M.D., and Todd B. Nippoldt, M.D., discuss a case that illustrates the clinical course of a functioning gonadotroph adenoma — a rare pituitary tumor that secretes biologically act[...] May 25, 2018 Senescent cells: Promising anti-aging targets for health span extension and the treatment of osteoporosis Cellular senescence, a cell fate that involves an irreversible state of replicative arrest induced by stress, has emerged as a promising fundamental aging mechanism that could be targeted to treat multiple diseases of a[...] May 22, 2018 An emerging connection between circadian rhythm disruption and type 2 diabetes mellitus Researchers explore the molecular and physiological mechanisms responsible for circadian disruption-associated risk of type 2 diabetes mellitus (T2DM), which hold potential for contributing to development of novel thera[...] May 22, 2018 Novel therapeutic approach for ectopic Cushing syndrome: A case from the endocrine teaching clinics Endocrinologists Irina Bancos, M.D., and Jad Sfeir, M.D., discuss the case of a woman with corticotropin (ACTH)-dependent Cushing syndrome. Treatment involved a minimally invasive procedure targeting the lung lesion usi[...] April 21, 2018 A missed parathyroid adenoma: A case from the endocrine teaching clinics A case from the endocrine teaching clinics affirms that ectopic parathyroid tissue should be considered in patients with persistent primary hyperparathyroidism. - Resource Center for Medical Professionals including clin[...] Oct. 02, 2017 Researchers review risks, recommendations for weight gain management in midlife women ROCHESTER, Minn. ? A review of the weight gain risks and challenges faced by women in midlife has led Mayo Clinic researchers to a series of recommendations for this patient population. The findings are published in this m[...] July 11, 2017 Hypoparathyroidism: Causes, presentation and advances in treatment Approval of the recombinant human parathyroid hormone rhPTH(1-84), currently an expensive drug, for treatment of hypoparathyroidism has stimulated research into new treatment modalities and development of PTH analogues.[...] April 11, 2017 Metformin revisited Metformin continues to dominate as an oral therapeutic agent for type 2 diabetes mellitus (T2DM), both as monotherapy and in combination with other medications. Yet after 50 years, its mechanism of action isn't fully un[...] Feb. 25, 2017 Weight gain in women at midlife: Unique issues in management and the role of menopausal hormone therapy Menopausal hormone therapy (MHT) is the most effective treatment for menopausal vasomotor symptoms, but it cannot be recommended as a therapy to help women at midlife lose weight. Dec. 03, 2016 Preventing type 2 diabetes mellitus: Insights from genetic studies To date there are approximately 65 common genetic variants reproducibly associated with type 2 diabetes mellitus. The greatest risk is associated with variation in the gene TCF7L2. Sept. 07, 2016 Addressing the challenges of transgender health care The Mayo Clinic Transgender and Intersex Specialty Care Clinic provides tips for addressing the mental health, hormonal and surgical needs of transgender patients and those with differences of sexual development, or int[...] Sept. 07, 2016 Intragastric balloon: A re-emerging approach for obesity The intragastric balloon aids weight loss in patients with mild to moderate obesity, but lifestyle changes including behavior modification, exercise and a healthy diet are crucial for maintaining weight loss once the de[...] May 07, 2016 Bariatric surgery in adolescents Adolescents with a BMI ≥ 35 kg/m2 and a severe comorbidity, or a BMI ≥ 40 kg/m2 with more minor comorbidities, may be candidates for bariatric surgery. April 08, 2016 Assessment of bone strength in vivo in humans: A novel diagnostic tool for osteoporosis VirtuOst technology uses clinical computerized tomography scans obtained for any purpose to obtain noninvasive measures of bone strength at the spine or hip using finite element analysis (FEA). Nov. 25, 2015 New tools to predict fracture risk Bone mass and quality decline with age, leading to compromised strength and increased fracture risk. Trabecular bone score (TBS) uses standard dual energy X-ray absorptiometry to measure how well-structured the trabecul[...] Nov. 25, 2015 Postural orthostatic tachycardia syndrome and chronic fatigue in adolescents: Working toward recovery Mayo's Pediatric Pain Rehabilitation Center offers a program for teens with postural orthostatic tachycardia syndrome (POTS) that helps participants focus on increasing function, tapering off pain medications, and build[...] Nov. 25, 2015 Evaluating the efficacy of intervertebral disk regeneration with stem cells in animals More than 90 percent of people older than 50 experience intervertebral disk (IVD) degeneration. In animal studies, stem cell transplantation to the disk has shown promise in decelerating or arresting the degenerative pr[...] Sept. 01, 2015 Lipodystrophy syndromes: New treatment, newer questions Advances of understanding of the molecular mechanisms of fat loss and its treatment also provide valuable insight into adipose tissue biology and the pathophysiology of other common obesity-related metabolic disorders. May 29, 2015 The role of focused parathyroidectomy Focused parathyroidectomy entails an image-guided exploration of a single parathyroid adenoma with the use of intraoperative parathyroid hormone monitoring to define a biochemical cure. Smaller incisions often result in[...] March 28, 2015 Primary aldosteronism: The role of adrenal venous sampling For patients with primary aldosteronism who want to pursue surgical treatment rather than pharmacological therapy, adrenal venous sampling (AVS) is the key diagnostic step. At experienced centers, the complication rate [...] March 05, 2015 Retroperitoneoscopic adrenalectomy: A useful surgical approach in select patients Retroperitoneoscopic adrenalectomy (RPA) allows direct access to the retroperitoneum and adrenal gland without the need for intra-abdominal organ mobilization. RPA involves placing the patient in prone position. The adr[...] Jan. 31, 2015 Advances in endoscopic pituitary surgery Use of an expanded endoscopic approach allows surgeons to visualize difficult-to-see regions in the sella and enhances the opportunity for a complete pituitary tumor resection. Oct. 23, 2014 Hypophosphatasia Hypophosphatasia (HPP) is an inborn error of metabolism that manifests with a broad range of symptoms and severity. In general, the younger the patient's age at diagnosis, the more severe the disease. Sept. 10, 2014 Ultrasound-guided percutaneous ethanol ablation of neck nodal metastases in patients with papillary thyroid carcinoma Cost-effective ultrasound-guided percutaneous ethanol ablation may be generally incorporated into the management of NNM in patients with advanced localized papillary thyroid cancer not amenable to conventional retreatme[...] April 24, 2014 The Thyroid Nodule Clinic The Thyroid Nodule Clinic provides a one-stop thyroid nodule evaluation that includes a focused clinical assessment, ultrasound evaluation and fine-needle aspiration — all typically performed within a single appoi[...] Skeletal health in adult patients with cancer Bone health monitoring is essential to cancer treatment - Bone health monitoring is essential to cancer treatment - The skeletal effects of cancer-associated bone loss have become more important due to improved patient [...] Future therapy for Graves' ophthalmology TSH receptor antagonists impact orbital fibroblast functions relevant to GO development - No uniformly effective therapy exists for Graves' ophthalmology. Insights into the important role of TSH receptor and TRAb in the[...] Medical Professionals Endocrinology News