Departments and specialties

Mayo Clinic has one of the largest and most experienced practices in the United States, with campuses in Arizona, Florida and Minnesota. Staff skilled in dozens of specialties work together to ensure quality care and successful recovery.

Research

The lifesaving potential of bioartificial livers

Researchers are developing a bioartificial liver.

Click here for an infographic to learn more

Mayo Clinic scientists, doctors and surgeons develop liver transplant insights and innovations that make transplants safer and available to more people. They are actively involved in conducting laboratory studies, clinical trials and other research on every aspect of conditions related to liver transplants.

Here are a few examples:

  • Bioartificial liver. This innovation helps patients cope as they await a donor liver. Developed by Mayo Clinic doctors and researchers, new bioartificial livers use living cells from pig livers to filter a patient's blood in a process similar to that of kidney dialysis. The device is being tested before it becomes available in clinics and hospitals.
  • Magnetic resonance elastography. This innovative technology was developed by Mayo Clinic doctors and researchers as a noninvasive way to test for liver scarring. Someday it may reduce the need for liver biopsies in people with liver disease.
  • Immunosuppressive medications. This research examines the effect of antibody-mediated injury in liver-kidney transplants and how doing a multiorgan transplant may actually result in better outcomes.
  • Maximizing organ donors. Transplant physicians found that people with liver cancer have the same beneficial outcomes using organs donated by patients who died of cardiac death rather than brain death.
  • Cell therapies for liver disease. This research offers potential new treatments for several liver diseases and may improve the success of liver transplantation.
  • Triage system. Mayo Clinic researchers originally proposed, designed and tested the Model for End-Stage Liver Disease (MELD). This system prioritizes people waiting for a transplant based on the severity of their condition and how urgently they may need a transplant.

Read more about the many liver transplant research studies supported by the Transplant Research Center.

Publications

See a list of publications by Mayo Clinic doctors on liver transplant on PubMed, a service of the National Library of Medicine.

Research Profiles

Liver transplant care at Mayo Clinic

Sept. 24, 2016
References
  1. Feldman M, et al. Liver transplantation. In: Sleisenger & Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 10th ed. Philadelphia, Pa.: Saunders; 2016. https://www.clinicalkey.com. Accessed June 13, 2016.
  2. Liver transplant. American Liver Foundation. http://www.liverfoundation.org/abouttheliver/info/transplant/. Accessed June 13, 2016.
  3. What I need to know about liver transplantation. National Institute for Diabetes and Digestive and Kidney Diseases. http://digestive.niddk.nih.gov/ddiseases/pubs/livertransplant_ez/. Accessed June 13, 2016.
  4. Questions & answers for transplant candidates about MELD and PELD. United Network for Organ Sharing. http://www.unos.org/docs/MELD_PELD. Accessed May 28, 2014.
  5. Liver Kaplan-Meier patient survival rates for transplants performed: 1997-2004. Organ Procurement and Transplantation Network. https://optn.transplant.hrsa.gov/data/view-data-reports/national-data/#. Accessed May 28, 2016.
  6. Selecting a hospital. United Network for Organ Sharing http://www.transplantliving.org/before-the-transplant/getting-on-the-list/selecting-a-hospital/. Accessed June 13, 2016.
  7. Dove LM, et al. Liver transplantation in adults: Patient selection and pretransplantation evaluation. http://www.uptodate.com/home. Accessed June 13, 2016.
  8. Bambha K, et al. Model for End-stage Liver Disease (MELD). http://www.uptodate.com/home. Accessed June 13, 2016.
  9. Cotler S. Living donor liver transplantation. http://www.uptodate.com/home. Accessed June 13, 2016.
  10. Partnering with your transplant team: The patient's guide to transplantation. United Network for Organ Sharing. https://www.unos.org/wp-content/uploads/unos/WEPNTK.pdf. Accessed March 11, 2016.
  11. Kim WR, et al. OPTN/SRTR 2014 annual data report: Liver. American Journal of Transplantation. 2016;16:11.
  12. Barbara Woodward Lips Patient Education Center. Liver transplant. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2013.
  13. Glorioso JM, et al. Pivotal preclinical trial of the spheroid reservoir bioartificial liver. Journal of Hepatology. 2015;63:388.
  14. Yu Y, et al. Cell therapies for liver diseases. Liver Transplantation. 2012;18:9.
  15. Taner T, et al. Decreased chronic cellular and antibody-mediated injury in the kidney following simultaneous liver-kidney transplantation. Kidney International. 2016;89:909.
  16. De Assuncao TM, et al. Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes. Laboratory Investigation. 2015;95:684.
  17. Croome KP, et al. The use of donation after cardiac death allografts does not increase recurrence of hepatocellular carcinoma. American Journal of Transplantation. 2015;15:2704.
  18. Tincani G, et al. Operative risks of domino liver transplantation for the familial amyloid polyneuropathy liver donor and recipient: A double analysis. American Journal of Transplantation. 2011;11:750.
  19. Kitchens WH. Domino liver transplantation: Indications, techniques, and outcomes. Transplantation Reviews. 2011;25:167.
  20. Scientific Registry of Transplant Recipients. http://www.srtr.org/default.aspx. Accessed April 11, 2016.
  21. Heimbach JK (expert opinion). Mayo Clinic, Rochester, Minn. July 19, 2016.