Hand numbness can be caused by damage, irritation, or compression of one of the nerves or a branch of one of the nerves in your arm and wrist.
Diseases affecting the peripheral nerves, such as diabetes, also can cause numbness, although with diabetes, similar symptoms usually occur first in your feet.
Uncommonly, numbness may be caused by problems in your brain or spinal cord, although in such cases arm or hand weakness or loss of function also occurs. Numbness alone isn't usually associated with potentially life-threatening disorders, such as strokes or tumors.
Your doctor will need detailed information about your symptoms to diagnose the cause of your numbness. A variety of tests may be needed to confirm the cause before appropriate treatment can begin.
Possible causes of numbness in one or both of your hands include:
Brain and nervous system conditions
- Cervical spondylosis
- Guillain-Barre syndrome
- Paraneoplastic syndromes of the nervous system
- Peripheral neuropathy
- Spinal cord injury
- Stroke
Trauma or overuse injuries
- Brachial plexus injury
- Carpal tunnel syndrome
- Cubital tunnel syndrome
- Frostbite
Chronic conditions
- Alcohol use disorder
- Amyloidosis
- Diabetes
- Multiple sclerosis
- Raynaud's disease
- Sjogren's syndrome
Infectious diseases
- Lyme disease
- Syphilis
Treatment side effects
- Side effects of chemotherapy or HIV drugs
Other causes
- Ganglion cyst
- Vasculitis
- Vitamin B-12 deficiency
Causes shown here are commonly associated with this symptom. Work with your doctor or other health care professional for an accurate diagnosis.
June 12, 2021
- Numbness. Merck Manual Professional Version. https://www.merckmanuals.com/professional/neurologic-disorders/symptoms-of-neurologic-disorders/numbness#. Accessed April 16, 2021.
- Stroke: Hope through research. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Hope-Through-Research/Stroke-Hope-Through-Research. Accessed April 16, 2021.
- Signs and symptoms of adult brain and spinal cord tumors. American Cancer Society. https://www.cancer.org/cancer/brain-spinal-cord-tumors-adults/detection-diagnosis-staging/signs-and-symptoms.html. Accessed April 16, 2021.
- De Keyser F. Ganglion cysts of the wrist and hand. https://www.uptodate.com/contents/search. Accessed April 20, 2021.
- Raynaud's disease. National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/health-topics/topics/raynaud/. Accessed April 16, 2021.
- Numbness. National Multiple Sclerosis Society. http://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Numbness. Accessed April 16, 2021.
- Neuropathy (nerve damage). American Diabetes Association. http://www.diabetes.org/living-with-diabetes/complications/neuropathy/. Accessed April 16, 2021.
- Stabler SP. Vitamin B12 deficiency. New England Journal of Medicine. 2013; doi: 10.1056/NEJMcp1113996.
- Cervical spondylosis (arthritis of the neck). American Academy of Orthopaedic Surgeons. https://orthoinfo.aaos.org/en/diseases--conditions/cervical-spondylosis-arthritis-of-the-neck. Accessed Feb. 3, 2016.
- Ganglion (cyst) of the wrist. American Academy of Orthopaedic Surgeons. https://orthoinfo.aaos.org/en/diseases--conditions/ganglion-cyst-of-the-wrist-and-hand. Accessed April 20, 2021.
- Syrinx of the spinal cord or brain stem. Merck Manual Professional Version. https://www.merckmanuals.com/professional/neurologic-disorders/spinal-cord-disorders/syrinx-of-the-spinal-cord-or-brain-stem. Accessed April 20, 2021.
- Brachial plexus injuries information page. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/brachial_plexus/brachial_plexus.htm. Accessed April 19, 2021.
- Daroff RB, et al. Disorders of the peripheral nerves. In: Bradley's and Daroff's Neurology in Clinical Practice. 8th ed. Saunders Elsevier; 2022. https://www.clinicalkey.com. Accessed April 28, 2021.
- Briemberg HR, et al. Approach to the patient with sensory loss. https://www.uptodate.com/contents/search. Accessed April 16, 2021.
- Levin K. Cervical spondylitic myelopathy. https://www.uptodate.com/contents/search. Accessed April 20, 2021.
- Vriesendorp FJ. Guillain-Barré syndrome in adults: Clinical features and diagnosis. https://www.uptodate.com/contents/search. Accessed April 20, 2021.
- Baer AN. Clinical manifestations of Sjögren's syndrome: Extraglandular disease. https://www.uptodate.com/contents/search. Accessed April 19, 2021.
- Bowden JL, et al. The prevalence and magnitude of impaired cutaneous sensation across the hand in the chronic period post-stroke. PLoS ONE. 2014; doi: 10.1371/journal.pone.0104153. eCollection 2014.
- Ferri FF. Frostbite. In: Ferri's Clinical Advisor 2021. Elsevier; 2021. https://www.clinicalkey.com. Accessed April 28, 2021.