Hand numbness is usually caused by damage, irritation or compression of one of the nerves or a branch of one of the nerves in your arm and wrist.

Diseases affecting the peripheral nerves, such as diabetes, also can cause numbness, although with diabetes similar symptoms usually occur first in your feet.

In very uncommon instances, numbness can be caused by problems in your brain or spinal cord, although in such cases arm or hand weakness or loss of function also occurs. Numbness alone is only rarely associated with potentially life-threatening disorders, such as strokes or tumors.

Your doctor will need detailed information about your symptoms to diagnose the cause of your numbness. A variety of tests may be needed to confirm the cause before appropriate treatment can begin.

Possible causes of numbness in one or both of your hands include:

  1. Alcohol use disorder
  2. Amyloidosis
  3. Brachial plexus injury
  4. Carpal tunnel syndrome (cubital tunnel syndrome)
  5. Cervical spondylosis
  6. Ganglion cyst
  7. Guillain-Barre syndrome
  9. Lyme disease
  10. Multiple sclerosis
  11. Paraneoplastic syndromes of the nervous system
  12. Peripheral neuropathy
  13. Raynaud's disease
  14. Side effects of chemotherapy drugs
  15. Sjogren's syndrome
  16. Spinal cord injury
  17. Stroke
  18. Syphilis
  19. Type 2 diabetes
  20. Ulnar nerve compression
  21. Vasculitis
  22. Vitamin B-12 deficiency

Causes shown here are commonly associated with this symptom. Work with your doctor or other health care professional for an accurate diagnosis.

April 08, 2016