Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people. In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals, or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

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Mayo Clinic's campus in Phoenix/Scottsdale, Arizona

  1. 480-342-4800
  2. 8 a.m. to 5 p.m.
  3. Mountain time
  4. Monday through Friday
Mayo Clinic's campus in Jacksonville, Florida

  1. 904-953-7223
  2. 8 a.m. to 5 p.m.
  3. Mountain time
  4. Monday through Friday
Mayo Clinic's campus in Rochester, Minnesota

Central Appointment Office

  1. 507-284-5253
  2. 507-281-9786 (TDD service for hearing impaired)
  3. 7 a.m. to 6 p.m.
  4. Central time
  5. Monday through Friday

Mayo Clinic's bone marrow (stem cell) transplant team is recognized internationally for its expertise in comprehensive specialty treatment for people with blood and bone marrow diseases. Mayo Clinic is one of the largest providers of bone marrow transplants in the United States. It has performed nearly 10,000 stem cell transplants at its campuses in Arizona, Florida and Minnesota.

At Mayo Clinic, bone marrow transplant experts help adults and children with leukemia and other blood, plasma and bone marrow diseases. Your doctors will talk with you about all treatment options appropriate for you, including experimental treatments, and deliver care tailored to your needs.

Mayo Clinic bone marrow transplant experts are involved in patient care and research in the Mayo Clinic Cancer Center, designated by the National Cancer Institute as a comprehensive cancer center. The Mayo Clinic Cancer Center ranks in the top tier of cancer centers in the United States for Cancer research, treatment and education. Mayo Clinic Cancer Center is also a member of the National Comprehensive Cancer Network.

Mayo Clinic's experts focus on your needs, bringing to your situation the strength of their:

  • Experience. Specialists in bone marrow transplant and hematology at Mayo Clinic have extensive experience helping people with all types of diseases, including very rare ones. For example, they are leaders in the use of blood stem cell transplants to treat amyloidosis.

    Each year, more than 30,000 people with blood diseases are treated at Mayo Clinic, and more than 700 of them undergo bone marrow transplants. This experience means your doctors are prepared with the knowledge and resources to provide exactly the care you need.

  • Teamwork. At Mayo Clinic, bone marrow transplant physicians form a multidisciplinary team with experts from other areas to evaluate your condition and develop an individualized treatment plan. They work with doctors trained in blood diseases (hematologists), cancer (oncologists) and other specialties (for example, lung, heart and kidney specialists). Mayo Clinic staff efficiently coordinates care as needed between its campuses in Arizona, Florida and Minnesota.
  • Care focused on you. Mayo Clinic's bone marrow transplant specialists are focused on your needs and your family needs. Doctors, nurses, social workers and others provide whole-person care based on your goals and situation. For example, a bone marrow transplant may be conducted as a hospital-based outpatient procedure, which reduces the time you'll spend in the hospital.
  • Advanced technology. Mayo Clinic patients benefit from Mayo's nationally accredited on-site advanced cell processing laboratory to prepare cells for transplant. The Human Cellular Therapy Laboratory develops and produces safe cellular products for research and patient care. And Mayo Clinic is accredited by the National Marrow Donor Program as a specialized center for matched unrelated donor stem cell transplants.
  • Innovative research. Mayo Clinic researchers make bone marrow transplants safer and improve the lives of people who need them. Their innovative treatments harness the body's immune system, make use of new stem cell technologies and prevent complications such as graft versus host disease.

    Mayo Clinic bone marrow transplant physicians and hematologists work with other hospitals in the United States and internationally to conduct clinical trials. The close connection between clinical care and research at Mayo Clinic makes it possible for eligible patients to enroll in clinical trials, where they may receive new treatments.

    Mayo Clinic bone marrow transplant experts and hematologists are also involved in patient care and research in the Mayo Clinic Cancer Center. This center ranks in the top tier of cancer centers in the United States.

At Mayo Clinic's campus in Minnesota, children and adolescents with blood disorders receive care through the Children's Center. Children needing hospitalization receive care at Mayo Eugenio Litta Children's Hospital.

At Mayo Clinic's campus in Arizona, doctors trained in blood diseases and cancer (hematologists and oncologists) partner with Phoenix Children's Hospital to treat children who may need bone marrow transplants. Together the two hospitals oversee a single bone marrow transplant program for children.

At Mayo Clinic's campus in Florida, hematologists and oncologists partner with Nemours Children's Specialty Care and Wolfson Children's Hospital to treat children who may need bone marrow transplants.

Services

Mayo Clinic's Bone Marrow Transplant Program provides consultations, evaluations and treatment for patients who would potentially benefit from a bone marrow transplant.

Mayo Clinic bone marrow transplant specialists work with a multidisciplinary team to determine the most appropriate treatment for you. They have expertise in many areas of bone marrow transplant, including those listed below. Not all services are available at each of Mayo Clinic's three campuses in Arizona, Florida and Minnesota. Please confirm when you call to request an appointment.

Mayo Clinic in Rochester, Minn., Mayo Clinic in Jacksonville, Fla., and Mayo Clinic in Scottsdale, Ariz., are ranked among the Best Hospitals for cancer by U.S. News & World Report.

The doctors of the Mayo Clinic Bone Marrow Transplant Program perform the following bone marrow (stem cell) tests and procedures related to bone marrow transplant. All services may not be available at each location. Please confirm when you call for an appointment.

Mayo Clinic bone marrow transplant physicians have extensive experience treating people with serious blood disease. You may come to Mayo Clinic on your own or with a referral from your doctor. Doctors will work with you to determine the most appropriate treatment for you.

Mayo Clinic provides transplant services for people with a wide range of cancerous and noncancerous diseases, including but not limited to those listed below. All services may not be available at each location. Please confirm when you call for an appointment.

Find conditions treated by this department:

Mayo Clinic has one of the largest and most experienced practices in the United States, with campuses in Arizona, Florida and Minnesota. Staff skilled in dozens of specialties work together to ensure quality care and successful recovery.

Find doctors and medical staff:

Arizona doctors by specialty

Bone marrow transplant

Allogeneic transplant
Adult autologous transplant
Multiple myeloma

Florida doctors by specialty

Blood and marrow transplant

Minnesota doctors by specialty

Adult bone marrow transplant
Pediatric bone marrow transplant

Each year, Mayo Clinic doctors diagnose and treat thousands of people who have blood or bone marrow disease, many of whom benefit from bone marrow transplant. Mayo Clinic is one of the largest providers of bone marrow transplants in the United States.

Mayo Clinic's bone marrow transplant teams in Arizona, Florida and Minnesota are leaders and innovators in a range of bone marrow transplant options:

Mayo Clinic specialists have been performing bone marrow transplants since 1963. They have completed nearly 10,000 successful transplants and contributed to the science of transplantation, making bone marrow transplant safer and improving the lives of people who need them.

Nationally recognized expertise

Mayo Clinic's blood and marrow transplant program is

Bone marrow transplant outcomes compare favorably with the national average.

Learn more about Mayo Clinic's quality rankings.

Mayo Clinic in Rochester, Minn., Mayo Clinic in Jacksonville, Fla., and Mayo Clinic in Scottsdale, Ariz., are ranked among the Best Hospitals for cancer by U.S. News & World Report.

The Village at Mayo Clinic in Phoenix, Arizona, offers low-cost housing for transplant patients and their caregivers.

The Gabriel House of Care in Jacksonville, Florida, offers low-cost housing for transplant patients and their caregivers.

The Gift of Life Transplant House in Rochester, Minnesota, offers low-cost housing for transplant patients and their caregivers.

Mayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states.

For more information on visiting Mayo Clinic, choose your location below:

Mayo Clinic scientists make bone marrow transplants safer and improve patients' lives. They conduct laboratory studies, clinical trials and other research on many aspects of transplantation. Mayo Clinic participates in the Blood and Marrow Transplant Clinical Trials Network. And Mayo scientists often collaborate with colleagues throughout the country and internationally, sharing their insights to improve care for people everywhere. Recent studies include:

  • Chronic graft-versus-host disease. Because of their long history with bone marrow transplant, Mayo researchers are well-positioned to study the long-term effect of serious complications, such as chronic graft-versus-host disease (GVHD), and how to treat them.
  • Heart rhythm problems during stem cell transplant. Heart rhythm problems (arrhythmias) are often a complication during stem cell transplant. Mayo researchers studied 983 people who underwent stem cell transplants to better understand who is more likely to experience this problem.
  • Stem cells in space. Mayo Clinic researchers have sent an experiment to the international space station to test whether stem cells grow better in microgravity.
  • Adult (fat-derived) stem cells for graft-versus-host disease (GVHD). Mayo Clinic human cell therapy experts are studying how stem cells derived from fat or stroma (mesenchymal stem cells) can be used to suppress immunity and enhance tissue repair in GVHD.

Read more about the many bone marrow transplant research studies supported by the Mayo Clinic Transplant Research Center and the Mayo Clinic Cancer Center.

Publications

See a list of publications by Mayo Clinic authors on PubMed, a service of the National Library of Medicine.

Our patients tell us that the quality of their interactions, our attention to detail and the efficiency of their visits mean health care like they've never experienced. See the stories of satisfied Mayo Clinic patients.

Bone marrow transplant costs and insurance information

Mayo Clinic has dedicated transplant financial services representatives and social workers who can assist you with insurance and financial questions regarding your transplant.

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people. In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. Many insurance companies require you to get preapproval authorization prior to transplant services.

Insurance information

Before your transplant, it's important that you work closely with your insurance company to understand your benefit plan. You'll be responsible for any of your transplant and medical care costs not covered by your insurance company.

You may want to ask your insurance company several questions regarding your transplant expenses, such as:

  • What is the specific coverage of my plan? What are my deductibles, coinsurance, copayments, lifetime maximum amount and annual maximum amounts for both medical care and transplant services?
  • Does my plan have a pre-existing or waiting period clause? If so, what is the time frame? Can this be waived?
  • Does my plan include pharmacy coverage? If so, will my plan cover my current medications and immunosuppressant medications?
  • Does my plan require any special approvals for evaluation or transplant? How long does the approval process take once submitted to insurance?
  • Does my current insurance require enrollment in Medicare when eligible?
  • Does my insurance follow Medicare Coordination of Benefits guidelines?
  • How will my current coverage change after enrolling in Medicare? Will my plan become a supplemental or secondary plan?

If your plan is a Medicare supplement, ask questions including:

  • Does my plan follow Medicare guidelines?
  • Does my plan cover Medicare Part A and B deductible and coinsurance?
  • Does my plan have a pre-existing or waiting period clause? If so, what is the time frame?
  • Does my plan offer an option for Medicare Part D coverage?

Other expenses

Please plan for other expenses that may occur related to your transplant. These may include, for example, follow-up medical appointments, long-term medications, caregiver expenses, travel, parking and lodging.

For international patients

Mayo Clinic has dedicated international patient account representatives who can assist you with questions regarding your costs and insurance. Read more about international financial services.

Case managers

Mayo Clinic financial staff will work closely with your case managers from your insurance company. Your case manager, who is assigned to you, is available to answer questions and calls related to your insurance costs.

People who meet certain criteria may be considered for bone marrow transplant. At Mayo Clinic, doctors will consider selected patients over 65 years of age, depending on their overall physical health.

People who need a bone marrow transplant may have any of several serious conditions, including:

Your doctor can explain your risk of complications from a bone marrow transplant. Together you can weigh the risks and benefits to decide whether a bone marrow transplant is safe and beneficial for you.

Your treatment team will also discuss whether a bone marrow transplant or an alternative therapy may be the most appropriate treatment option. Your care is tailored to your specific need.

Your care team members will evaluate whether you're a candidate for a bone marrow transplant. They may:

  • Review your medical history
  • Perform a physical examination
  • Conduct blood tests
  • Perform imaging tests, such as X-rays
  • Conduct tests to check your heart, lungs and other organ functions
  • Remove a small sample of bone marrow (biopsy) to evaluate your condition
  • Perform other tests to ensure you don't have any other serious conditions
  • Order a psychosocial evaluation

The evaluation may take several days or more.

Read about stem cell transplant. Also see a video about how a stem cell transplant works.

The first bone marrow transplant at Mayo Clinic occurred in 1963. Mayo's physicians have performed nearly 10,000 procedures since the program began in 1972.

Mayo Clinic doctors' experience and integrated team approach result in transplant outcomes that compare favorably with national averages. Teams work with transplant recipients before, during and after your transplant to ensure the greatest likelihood of superior results.

Volumes and statistics are maintained separately for each Mayo Clinic location. Taken together or separately, transplant patients at Mayo Clinic enjoy excellent results.

Each of the links below connects to an external site, Be the Match, which hosts transplant survival data gathered from institutions across the United States.

Sections

Aug. 21, 2018
References
  1. National Marrow Donor Program. http://bethematch.org. Accessed Feb. 26, 2015.
  2. AskMayoExpert. Hematopoietic stem cell transplant. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2015.
  3. AskMayoExpert. Graft-versus-host disease. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
  4. Barbara Woodward Lips Patient Education Center. Allogeneic blood and marrow transplant (BMT). Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2010.
  5. Riggin EA. Allscripts EPSi. Mayo Clinic, Rochester, Minn. July 20, 2016.
  6. Lee SJ, et al. 5 year results of bmt ctn 0201: Unrelated donor bone marrow is associated with better psychological well-being and less burdensome chronic gvhd symptoms than peripheral blood. American Society of Hematology. Meeting abstract. https://ash.confex.com/ash/2015/webprogram/Paper80881.html. Accessed July 19, 2016.
  7. Adams RH (expert opinion). Mayo Clinic, Rochester, Minn. Aug. 15, 2016.
  8. Geerdes PA (expert opinion). Mayo Clinic, Rochester, Minn. Aug. 17, 2012.
  9. Reunited and it feels pretty good. In the Loop. July 28, 2015. http://intheloop.mayoclinic.org. Accessed July 19, 2016.
  10. Singla A, et al. Incidence of supraventricular arrhythmias during autologous peripheral blood stem cell transplantation. Biology of Blood and Marrow Transplantation. 2013;19:1233.
  11. Hoffman R, et al. Overview of hematopoietic stem cell transplantation. In: Hematology: Basic Principles and Practice. 6th ed. Philadelphia, Pa.: Saunders Elsevier; 2013. http://www.clinicalkey.com. Accessed July 19, 2016.
  12. Dispenzieri A. POEMS syndrome: 2012 update on diagnosis, risk-stratification and management. American Journal of Hematology. 2012;87:804.
  13. Yang ZZ, et al. T-cell-mediated antitumor immunity in B-cell non-Hodgkin lymphoma: Activation, suppression and exhaustion. Leukemia and Lymphoma. 2015;56:2498.
  14. Diseases treatable by transplants. National Marrow Donor Program. https://bethematch.org/transplant-basics/how-transplants-work/diseases-treatable-by-transplants/. Accessed July 20, 2016.
  15. Majhail NS, et al. Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation. Biology of Blood and Marrow Transplantation. 2012;18:348.
  16. Yawn BP, et al. Management of sickle cell disease: Summary of the 2014 evidence-based report by expert panel members. JAMA. 2014;312:1033.
  17. NCCN member institutions. National Comprehensive Cancer Network. https://www.nccn.org. Accessed July 20, 2016.
  18. Cordes S, et al. Autologous stem cell transplantation in immunoglobulin light chain amyloidosis with factor X deficiency. Blood Coagulation and Fibrinolysis. 2016;27:101.
  19. Colborn LK. Office of Access Management. Mayo Clinic, Rochester, Minn. Jan. 28, 2016.
  20. Gertz MA, et al. Autologous stem cell transplant in 716 patients with multiple myeloma: Low treatment-related mortality, feasibility of outpatient transplant, and effect of a multidisciplinary quality initiative. Mayo Clinic Proceedings. 2008;83:1131.
  21. O'Suoji C, et al. Rare pediatric non-Hodgkin lymphomas: A report from Children's Oncology Group Study ANHL 04B1. Pediatric Blood Cancer. 2016;63:794.
  22. Galardy PJ, et al. Targeting childhood, adolescent and young adult non-Hodgkin lymphoma: Therapeutic horizons. British Journal of Haematology. 2016;173:625.
  23. Slack JL, et al. Reduced toxicity conditioning and allogeneic stem cell transplantation in adults using fludarabine, carmustine, melphalan, and antithymocyte globulin: Outcomes depend on disease risk index but not age, comorbidity score, donor type, or human leukocyte antigen mismatch. Biology of Blood and Marrow Transplantation. 2013;19:1167.
  24. King AA, et al. Successful matched sibling donor marrow transplantation following reduced intensity conditioning in children with hemoglobinopathies. American Journal of Hematology. 2015;90:1093.
  25. Mayo Clinic to grow human cells in space: Testing stroke treatment. Mayo Clinic News Network. http://newsnetwork.mayoclinic.org. Accessed July 20, 2016.
  26. Muchtar E, et al. Autologous stem cell transplant for multiple myeloma patients 70 years or older. Bone Marrow Transplant. In press.
  27. Ansell SM. Targeting immune checkpoints in lymphoma. Current Opinion in Hematology. 2015;22:337.
  28. Hashmi S, et al. Survival aster mesenchymal stromal cell therapy in steroid-refractory acute graft-versus-host disease: Systematic review and meta-analysis. The Lancet Haematology. 2016;1:e45-52. https://www.clinicalkey.com. Accessed July 20, 2016.