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Bone Marrow Transplant Program

Research

Stem cell researcher Stem cell researcher

Doctors at Mayo Clinic research stem cell innovations to improve care.

The Amazing Stem Cell

Stem cells are unlocking new potential for testing and treatment.

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Mayo Clinic scientists make bone marrow transplants safer and improve patients' lives. They conduct laboratory studies, clinical trials and other research on many aspects of transplantation. Mayo Clinic participates in the Blood and Marrow Transplant Clinical Trials Network. And Mayo scientists often collaborate with colleagues throughout the country and internationally, sharing their insights to improve care for people everywhere. Recent studies include:

  • Chronic graft-versus-host disease. Because of their long history with bone marrow transplant, Mayo researchers are well-positioned to study the long-term effect of serious complications, such as chronic graft-versus-host disease (GVHD), and how to treat them.
  • Heart rhythm problems during stem cell transplant. Heart rhythm problems (arrhythmias) are often a complication during stem cell transplant. Mayo researchers studied 983 people who underwent stem cell transplants to better understand who is more likely to experience this problem.
  • Stem cells in space. Mayo Clinic researchers have sent an experiment to the international space station to test whether stem cells grow better in microgravity.
  • Adult (fat-derived) stem cells for graft-versus-host disease (GVHD). Mayo Clinic human cell therapy experts are studying how stem cells derived from fat or stroma (mesenchymal stem cells) can be used to suppress immunity and enhance tissue repair in GVHD.

Read more about the many bone marrow transplant research studies supported by the Mayo Clinic Transplant Research Center and the Mayo Clinic Cancer Center.

Publications

See a list of publications by Mayo Clinic authors on PubMed, a service of the National Library of Medicine.

Research Profiles

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Clinical trialsThe Mayo Clinic experience & patient stories
Oct. 10, 2019
  1. National Marrow Donor Program. http://bethematch.org. Accessed Feb. 26, 2015.
  2. AskMayoExpert. Hematopoietic stem cell transplant. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2015.
  3. AskMayoExpert. Graft-versus-host disease. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
  4. Barbara Woodward Lips Patient Education Center. Allogeneic blood and marrow transplant (BMT). Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2010.
  5. Riggin EA. Allscripts EPSi. Mayo Clinic, Rochester, Minn. July 20, 2016.
  6. Lee SJ, et al. 5 year results of bmt ctn 0201: Unrelated donor bone marrow is associated with better psychological well-being and less burdensome chronic gvhd symptoms than peripheral blood. American Society of Hematology. Meeting abstract. https://ash.confex.com/ash/2015/webprogram/Paper80881.html. Accessed July 19, 2016.
  7. Adams RH (expert opinion). Mayo Clinic, Rochester, Minn. Aug. 15, 2016.
  8. Geerdes PA (expert opinion). Mayo Clinic, Rochester, Minn. Aug. 17, 2012.
  9. Reunited and it feels pretty good. In the Loop. July 28, 2015. http://intheloop.mayoclinic.org. Accessed July 19, 2016.
  10. Singla A, et al. Incidence of supraventricular arrhythmias during autologous peripheral blood stem cell transplantation. Biology of Blood and Marrow Transplantation. 2013;19:1233.
  11. Hoffman R, et al. Overview of hematopoietic stem cell transplantation. In: Hematology: Basic Principles and Practice. 6th ed. Philadelphia, Pa.: Saunders Elsevier; 2013. http://www.clinicalkey.com. Accessed July 19, 2016.
  12. Dispenzieri A. POEMS syndrome: 2012 update on diagnosis, risk-stratification and management. American Journal of Hematology. 2012;87:804.
  13. Yang ZZ, et al. T-cell-mediated antitumor immunity in B-cell non-Hodgkin lymphoma: Activation, suppression and exhaustion. Leukemia and Lymphoma. 2015;56:2498.
  14. Diseases treatable by transplants. National Marrow Donor Program. https://bethematch.org/transplant-basics/how-transplants-work/diseases-treatable-by-transplants/. Accessed July 20, 2016.
  15. Majhail NS, et al. Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation. Biology of Blood and Marrow Transplantation. 2012;18:348.
  16. Yawn BP, et al. Management of sickle cell disease: Summary of the 2014 evidence-based report by expert panel members. JAMA. 2014;312:1033.
  17. NCCN member institutions. National Comprehensive Cancer Network. https://www.nccn.org. Accessed July 20, 2016.
  18. Cordes S, et al. Autologous stem cell transplantation in immunoglobulin light chain amyloidosis with factor X deficiency. Blood Coagulation and Fibrinolysis. 2016;27:101.
  19. Colborn LK. Office of Access Management. Mayo Clinic, Rochester, Minn. Jan. 28, 2016.
  20. Gertz MA, et al. Autologous stem cell transplant in 716 patients with multiple myeloma: Low treatment-related mortality, feasibility of outpatient transplant, and effect of a multidisciplinary quality initiative. Mayo Clinic Proceedings. 2008;83:1131.
  21. O'Suoji C, et al. Rare pediatric non-Hodgkin lymphomas: A report from Children's Oncology Group Study ANHL 04B1. Pediatric Blood Cancer. 2016;63:794.
  22. Galardy PJ, et al. Targeting childhood, adolescent and young adult non-Hodgkin lymphoma: Therapeutic horizons. British Journal of Haematology. 2016;173:625.
  23. Slack JL, et al. Reduced toxicity conditioning and allogeneic stem cell transplantation in adults using fludarabine, carmustine, melphalan, and antithymocyte globulin: Outcomes depend on disease risk index but not age, comorbidity score, donor type, or human leukocyte antigen mismatch. Biology of Blood and Marrow Transplantation. 2013;19:1167.
  24. King AA, et al. Successful matched sibling donor marrow transplantation following reduced intensity conditioning in children with hemoglobinopathies. American Journal of Hematology. 2015;90:1093.
  25. Mayo Clinic to grow human cells in space: Testing stroke treatment. Mayo Clinic News Network. http://newsnetwork.mayoclinic.org. Accessed July 20, 2016.
  26. Muchtar E, et al. Autologous stem cell transplant for multiple myeloma patients 70 years or older. Bone Marrow Transplant. In press.
  27. Ansell SM. Targeting immune checkpoints in lymphoma. Current Opinion in Hematology. 2015;22:337.
  28. Hashmi S, et al. Survival aster mesenchymal stromal cell therapy in steroid-refractory acute graft-versus-host disease: Systematic review and meta-analysis. The Lancet Haematology. 2016;1:e45-52. https://www.clinicalkey.com. Accessed July 20, 2016.

Mayo Clinic in Minnesota and Mayo Clinic in Phoenix/Scottsdale, Ariz., have been recognized among the top Cancer hospitals in the nation for 2019-2020 by U.S. News & World Report.

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