Experience in reduced-intensity conditioning Print Doctors use many conditioning therapies to prepare your bone marrow and immune system before infusion of the new stem cells. The process is intended to kill cancer cells and suppress your immune system before your bone marrow transplant. Reduced-intensity conditioning may be an option if you're receiving stem cells from a donor. In reduced-intensity conditioning, you are given lower doses or different types of chemotherapy or radiation for your conditioning treatment. Reduced-intensity conditioning kills some cancer cells and somewhat suppresses your immune system. The goal is to decrease the risk of transplant-related complications. Then the donor's cells are infused into your body. Donor cells replace cells in your bone marrow over time. Immune factors in the donor cells may then fight your cancer cells. This less intense conditioning option may be appropriate for people who aren't healthy enough for high-dose conditioning or people who are older. Your doctor will discuss with you which type of conditioning may be best for you, considering several factors, including your age, medical condition and health. Share your experience Share your Mayo Clinic transplant experience with others using social media. Facebook YouTube Twitter Mayo Clinic Health Community Sharing Mayo Clinic Request an Appointment at Mayo Clinic Dec. 04, 2020 Print Mayo Clinic in Rochester, Minn.,Mayo Clinic in Phoenix/Scottsdale, Ariz., and Mayo Clinic in Jacksonville, Fla., have been recognized among the top Cancer hospitals in the nation for 2020-2021 by U.S. News & World Report. Learn more about this top honor Bone Marrow Transplant ProgramDepartment homeSectionsRequest an appointmentOverviewTests & proceduresConditions treatedDoctorsDoctors by location and specialtyExpertise & rankingsLocations, travel & lodgingClinical trialsResearchThe Mayo Clinic experience & patient storiesCosts & insuranceNews from Mayo ClinicEligibilityVolumes and outcomesResources for medical professionalsContact us SectionsRequest an appointmentOverviewTests & proceduresConditions treatedDoctorsDoctors by location and specialtyExpertise & rankingsLocations, travel & lodgingClinical trialsResearchThe Mayo Clinic experience & patient storiesCosts & insuranceNews from Mayo ClinicEligibilityVolumes and outcomesResources for medical professionals ORG-20193492 Departments & Centers Medical Departments & Centers Bone Marrow Transplant Program