David J. Cangemi, M.D.

David J. Cangemi, M.D., is a board-certified gastroenterologist in the Division of Gastroenterology and Hepatology at Mayo Clinic in Jacksonville, Florida, where he specializes in gastrointestinal motility disorders and disorders of gut — brain interaction. He provides care for patients who are experiencing complex gastrointestinal symptoms such as gastroparesis, functional dyspepsia, irritable bowel syndrome, chronic abdominal pain, bloating, nausea, and vomiting. Dr. Cangemi's expertise includes evaluating and managing conditions that affect how the digestive tract moves and senses, particularly when traditional gastrointestinal testing has not identified a clear cause.

Dr. Cangemi's clinical practice emphasizes a careful, individualized approach to diagnosis and treatment. He performs a range of diagnostic procedures to assess gastrointestinal motility and function, including esophageal and anorectal manometry, impedance pH monitoring, gastric emptying studies, gastrointestinal transit studies, colonoscopy, and upper endoscopy. His approach integrates these advanced diagnostic tools with a nuanced understanding of gut — brain communication to help patients achieve meaningful improvement in symptoms and quality of life.

In addition to his clinical work, Dr. Cangemi conducts ongoing research focused on understanding the mechanisms of functional dyspepsia and developing innovative treatments for disorders of gut — brain interaction. His research includes prospective studies assessing intestinal permeability in functional dyspepsia and exploring virtual reality as a novel therapy for symptom management. This translational work reflects his commitment to improving outcomes for patients with conditions that are often underrecognized, difficult to diagnose, and challenging to treat.

Dr. Cangemi received his medical degree from Florida State University College of Medicine in Tallahassee, Florida. He completed his internal medicine residency at the Mayo School of Graduate Medical Education in Jacksonville, Florida, followed by gastroenterology fellowship training at the University of Texas Southwestern Medical Center in Dallas, Texas, and an advanced fellowship in motility and functional gastrointestinal disorders at Massachusetts General Hospital in Boston, Massachusetts. He is board-certified in both internal medicine and gastroenterology by the American Board of Internal Medicine.

"Gastrointestinal motility disorders and disorders of gut — brain interaction frequently impair patients' quality of life and can sometimes be difficult to diagnose and manage," says Dr. Cangemi. "I work to understand the mechanisms behind each patient's symptoms and translate that understanding into an individualized, evidence-based treatment plan aimed to improve symptoms and quality of life." Outside of his medical practice, Dr. Cangemi enjoys playing golf, traveling, and supporting the Jacksonville Jaguars.