Mayo Clinic's approach

Mayo Clinic experts have extensive experience using bone marrow transplants to treat a variety of conditions, including cancers. Mayo Clinic offers bone marrow transplants for adults and children using their own cells (autologous transplant), cells from a donor (allogeneic transplant) or cells from an umbilical cord (cord blood transplant).

People who choose Mayo Clinic for their care receive comprehensive, compassionate and personalized attention from health care providers and staff who are committed to providing exactly the care they need. In addition, several support groups are offered at Mayo Clinic's campuses in Arizona, Florida and Minnesota.

Teamwork

At Mayo Clinic, health care providers who specialize in blood diseases (hematologists) form a multidisciplinary team with other experts to provide personalized, whole-person care to adults and children undergoing bone marrow transplants.

Image for Bone Marrow transplant

Your transplant team may include hematologists, cancer specialists (oncologists), mental health specialists (psychologists and psychiatrists), a bone marrow transplant scheduling coordinator, transfusion medicine nurses, trained and specialized nurses, physician assistants, social workers, a nurse coordinator, a clinical nurse specialist, a dietitian, pharmacists, a chaplain and a child life specialist for children undergoing bone marrow transplant.

Children and adolescents undergoing bone marrow transplants receive care at the Children's Center at Mayo Clinic's campus in Minnesota. At Mayo Clinic's campus in Arizona, pediatric experts collaborate with the Phoenix Children's Hospital to provide care to young patients. Together the two oversee a single bone marrow transplant program for children. Pediatric patients receive care from Mayo Clinic specialists in Florida through a partnership with Nemours Children's Specialty Care and Wolfson Children's Hospital.

Image of Mayo Clinic doctors and staff working together Working together

Mayo Clinic health care providers and staff collaborate to provide you with exactly the care you need.

Experience

Mayo Clinic specialists have extensive experience performing bone marrow transplants for adults and children with a variety of cancerous and noncancerous diseases. Each year, around 850 people undergo bone marrow transplants at Mayo Clinic.

The first bone marrow transplant at Mayo Clinic occurred in 1963. Bone marrow transplant procedures are performed by Mayo Clinic specialists in Arizona, Florida and Minnesota.

The long history of bone marrow transplants performed at Mayo Clinic means that health care providers are prepared with the knowledge and resources to provide you with expert, personalized care.

Image of staff providing compassionate care Providing compassionate care

Mayo Clinic experts draw on their extensive experience to provide personalized care to people considering bone marrow transplant.

Bringing research advances to patient care

Mayo Clinic scientists are involved in cutting-edge research that allows them to apply the latest advances to patient care.

Innovations include:

  • Haploidentical transplant. This type of transplant uses stem cells from donors who aren't perfect matches. Research is helping to bring understanding about how to reduce the risk of complications and improve recovery for people whose stem cell donors aren't perfect matches.
  • Reduced-intensity conditioning. Using lower doses of chemotherapy and radiation before a transplant may allow older people and those who aren't healthy enough for conditioning to undergo bone marrow transplants.
  • Cord blood transplant. This type of transplant is done using stored and frozen umbilical cord blood. There are fewer stem cells in cord blood, but those stem cells can grow more blood cells than can those collected from bone marrow. Using cells from cord blood reduces the risk of graft-versus-host disease (GVHD). Researchers are identifying the best ways to use cord blood for bone marrow transplants and finding new ways to track these cells after transplant.
  • Expanding indications for bone marrow transplant. Researchers are studying ways to use this treatment for a wider variety of conditions, including complicated and rare diseases.
  • New medication options. Mayo Clinic researchers study medications and treatments for people who have had bone marrow transplants, including new medications to help people stay healthy after a bone marrow transplant.
  • Reduced time in the hospital. At Mayo Clinic, some bone marrow transplants are performed as hospital-based outpatient procedures, which reduces the amount of time spent in the hospital.

Nationally recognized expertise

Mayo Clinic bone marrow transplant specialists are respected for their knowledge, experience and expertise.

Mayo Clinic in Rochester, Minnesota, and Mayo Clinic in Phoenix/Scottsdale, Arizona, are ranked among the Best Hospitals for cancer by U.S. News & World Report. Mayo Clinic in Jacksonville, Florida, is ranked highly performing for cancer by U.S. News & World Report.

The Mayo Clinic experience and patient stories

Our patients tell us that the quality of their interactions, our attention to detail and the efficiency of their visits mean health care like they've never experienced. See the stories of satisfied Mayo Clinic patients.

  1. Mayo Clinic Connect brings together 2 women with leukemia, 46 years apart

    Editor's note: The Mayo Clinic Connect volunteer mentor featured in this story has asked that her Connect handle — @LoriBMT — be used in place of her name. In 2019, 65-year-old @LoriBMT sat in a Mayo Clinic lab area awaiting her turn for blood work. She had been in the hospital for more than six weeks following a bone marrow transplant. @LoriBMT is a positive person, but after weeks of feeling tired and week, she…

  2. Lisa_Miller-featured.jpg

    A new lease on life thanks to research into rare neurodegenerative disease

    The changes were subtle at first. "Almost unnoticeable," says Lisa Miller, remembering the symptoms that seemed to appear suddenly in late 2017. At a friend's wedding, the Front Royal, Virginia, project engineer remembers falling out of her shoes. "My left heel kept coming out from my shoes," she says. She chalked it up to too much merriment. A few months later, a co-worker told Lisa her gait was off and that she was dragging her…

  3. Felicia-bell-featured.jpg

    Diversity in bone marrow transplantation gives gift of life to mom of five

    Family is everything to Felicia Curtis. The mom of five from Gainesville, Florida, knew she had to fight when she was diagnosed with non-Hodgkin's lymphoma in 2017, when she was 20 weeks pregnant with her youngest child. Over the next several months, Felicia underwent several rounds of chemotherapy to fight the cancer. Her son was born healthy at 33 weeks. The future was bright. But six months later, the cancer returned, and doctors said the…

  4. Arneson-featured.jpg

    "Divine design" gives multiple myeloma patient transplant, care at home

    Ann Arneson describes her journey to Mayo Clinic as “divine design.” Ann — a retired teacher, a leader in her church and ministry, mother, grandmother, and line dance enthusiast — is Mayo Clinic’s first bone marrow transplant patient to recover at home thanks to the new advanced care at home program. “I know that people and circumstances are not by chance, but for a purpose — part of a bigger plan,” says Ann. A brush…

  5. Innovative transplant offers hope for patient with rare autoimmune disorder, few options

    Faced with a condition that has no cure and few treatment options, Chris Ryals turned to Mayo Clinic in Florida for an answer. An innovative transplant essentially reversed his symptoms and gave him hope. As a career military man, Chris Ryals was used to being physically active. The Air Force master sergeant ran regularly, visited [...]

Expertise and rankings

Mayo Clinic specialist working together Experience you can count on

Mayo Clinic specialists work together, combining their knowledge and experience in caring for people undergoing bone marrow transplant to provide the most effective care. This experience and expertise earns Mayo Clinic health care providers respect from colleagues around the world.

Each year, Mayo Clinic specialists diagnose and treat thousands of people who have blood or bone marrow disease, many of whom benefit from bone marrow transplant. Mayo Clinic's Bone Marrow Transplant Program is among the largest in the country.

Mayo Clinic is recognized for excellence in bone marrow transplant by national and international groups:

Learn more about Mayo Clinic's quality rankings.

Volumes and outcomes

 

Mayo Clinic specialists' experience and integrated team approach results in transplant outcomes that compare favorably with national averages. Teams work with transplant recipients before, during and after surgery to ensure the greatest likelihood of superior results.

Volumes and outcomes are maintained separately for the three Mayo Clinic locations. Taken together or separately, transplant recipients at Mayo Clinic enjoy excellent results.

Eligibility

If your bone marrow stops working or doesn't produce healthy stem cells, you may benefit from a bone marrow transplant. Bone marrow transplants are used to treat people whose stem cells have been damaged by disease or the treatment of a disease, or as a way to have the donor's immune system fight a blood disorder, such as leukemia.

Experts will determine whether a bone marrow transplant may be safe and beneficial for you. Your treatment team will explain the benefits and risks of a bone marrow transplant.

Your treatment team will also evaluate you to determine whether a bone marrow transplant or an alternative therapy may be the most appropriate treatment option for your condition.

Learn more about bone marrow transplant eligibility at Mayo Clinic.

Locations, travel and lodging

The Village at Mayo Clinic in Phoenix, Arizona, offers low-cost housing for transplant patients and their caregivers.

The Gabriel House of Care in Jacksonville, Florida, offers low-cost housing for transplant patients and their caregivers.

The Gift of Life Transplant House in Rochester, Minnesota, offers low-cost housing for transplant patients and their caregivers.

Mayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states.

For more information on visiting Mayo Clinic, choose your location below:

Costs and insurance

Bone marrow transplant costs and insurance information

Mayo Clinic has dedicated transplant financial services representatives and social workers who can assist you with insurance and financial questions regarding your transplant.

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people. In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. Many insurance companies require you to get preapproval authorization prior to transplant services.

Insurance information

Before your transplant, it's important that you work closely with your insurance company to understand your benefit plan. You'll be responsible for any of your transplant and medical care costs not covered by your insurance company.

You may want to ask your insurance company several questions regarding your transplant expenses, including:

  • What is the specific coverage of my plan? What are my deductibles, coinsurance, copayments, lifetime maximum amount and annual maximum amounts for both medical care and transplant services?
  • Does my plan have a preexisting or waiting period clause? If so, what is the time frame? Can this be waived?
  • Does my plan include pharmacy coverage? If so, will my plan cover my current medications and immunosuppressant medications?
  • Does my plan require any special approvals for evaluation or transplant? How long does the approval process take once submitted to insurance?
  • Does my plan cover my transportation and lodging expenses during my transplant care?
  • Does my current insurance require enrollment in Medicare when eligible?
  • Does my insurance follow Medicare Coordination of Benefits guidelines?
  • How will my current coverage change after enrolling in Medicare? Will my plan become a supplemental or secondary plan?

If your plan is a Medicare supplement, ask questions including:

  • Does my plan follow Medicare guidelines?
  • Does my plan cover Medicare Part A and B deductible and coinsurance?
  • Does my plan have a preexisting or waiting period? If so, what is the time frame?
  • Does my plan offer an option for Medicare Part D coverage?

Other expenses

Please plan for other expenses that may occur related to your transplant, which may include follow-up medical appointments, long-term medications, caregiver expenses, travel, parking, lodging and other expenses.

If you have an allogeneic bone marrow transplant, your donor's transplant-related medical care may be paid by your insurance company.

For international patients

Mayo Clinic has dedicated international patient account representatives who can assist you with questions regarding your costs and insurance. Read more about international financial services.

Case managers

Mayo Clinic financial staff will work closely with your case managers from your insurance company. Your case manager, who is assigned to you, is available to answer questions and calls related to your insurance costs.

More information about billing and insurance:

Mayo Clinic in Arizona, Florida and Minnesota

Mayo Clinic Health System

Clinical trials

Explore Mayo Clinic studies of tests and procedures to help prevent, detect, treat or manage conditions.

July 20, 2022
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  2. Hoffman R, et al. Overview and choice of donor of hematopoietic stem cell transplantation. In: Hematology: Basic Principles and Practice. 7th ed. Elsevier; 2018. https://www.clinicalkey.com. Accessed Jan. 28, 2022.
  3. Blood-forming stem cell transplants. National Cancer Institute. http://www.cancer.gov/about-cancer/treatment/types/stem-cell-transplant/stem-cell-fact-sheet. Accessed Jan. 28, 2022.
  4. Majhail NS. How to perform hematopoietic stem cell transplantation. JACC CardioOncology. 2021; doi:10.1016/j.jaccao.2021.09.012.
  5. Diseases treatable by transplants. National Marrow Donor Program. https://bethematch.org/transplant-basics/how-transplants-work/diseases-treatable-by-transplants/. Accessed Jan. 27, 2022.
  6. AskMayoExpert. Cutaneous graft-versus-host disease (adult). Mayo Clinic; 2021.
  7. Blood and marrow stem cell transplantation. Leukemia & Lymphoma Society. https://www.lls.org/resource-center/download-or-order-free-publications. Accessed Jan. 28, 2022.
  8. Chao NJ. Survival, quality-of-life and late complications after hematopoietic cell transplantation in adults. https://www.uptodate.com/contents/search. Accessed Feb. 10, 2022.
  9. Blood and bone marrow transplant. National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health-topics/blood-and-bone-marrow-transplant. Accessed Jan. 28, 2022.
  10. D'Souza A, et al. Current use of and trends in hematopoietic cell transplantation in the United States. Biology of Blood and Marrow Transplantation. 2020; doi:10.1016/j.bbmt.2020.04.013.
  11. Hematopoietic stem cell transplantation. Merck Manual Professional Version. https://www.merckmanuals.com/professional/immunology-allergic-disorders/transplantation/hematopoietic-stem-cell-transplantation#. Accessed Feb. 10, 2022.
  12. Blood and marrow transplant (BMT): An introduction to allogeneic BMT. Leukemia & Lymphoma Society. https://www.lls.org/resource-center/download-or-order-free-publications. Accessed Jan. 28, 2022.
  13. Participating clinical centers. Primary Immune Deficiency Treatment Consortium. https://www.rarediseasesnetwork.org/cms/pidtc/Learn-More/Participating-Clinical-Centers. Accessed Feb. 18, 2022.
  14. Full membership institutions. Pediatric Transplantation and Cellular Therapy Consortium. http://www.pbmtc.org/about/members/full. Accessed Feb. 18, 2022.
  15. Participating institutions. ECOG-ACRIN Cancer Research Group. https://ecog-acrin.org/participating-institutions. Accessed Feb. 18, 2022.
  16. Mills SD, et al. Bone-marrow transplant in an identical twin. JAMA. 1964; doi:10.1001/jama.1964.03060380005001.
  17. Rashidi A, et al. Outcomes of haploidentical vs matched sibling transplantation for acute myeloid leukemia in first complete remission. Blood Advances. 2019; doi:10.1182/bloodadvances.2019000050.
  18. Ahmed S, et al. Lower graft-versus-host disease and relapse risk in post-transplant cyclophosphamide-based haploidentical versus matched sibling donor reduced-intensity conditioning transplant for Hodgkin Lymphoma. Biology of Blood and Marrow Transplantation. 2019; doi:10.1016/j.bbmt.2019.05.025.
  19. Jain T, et al. Choosing a reduced-intensity conditioning regimen for allogeneic stem cell transplantation, fludarabine/busulfan versus fludarabine melphalan: A systematic review and meta-analysis. Biology of Blood and Marrow Transplantation. 2019; doi:10.1016/j.bbmt.2018.11.016.
  20. Chen YB, et al. Plerixafor alone for the mobilization and transplantation of HLA-matched sibling donor hematopoietic stem cells. Blood Advances. 2019; doi:10.1182/bloodadvances.2018027599.
  21. Ballen KK, et al. Hospital length of stay in the first 100 days after allogeneic hematopoietic cell transplantation for acute leukemia in remission: Comparison among alternative graft sources. Biology of Blood and Marrow Transplantation. 2014; doi:10.1016/j.bbmt.2014.07.021.
  22. Sweeney SK, et al. Tracking embryonic hematopoietic stem cells to the bone marrow: Nanoparticle options to evaluate transplantation efficiency. Stem Cell Research & Therapy. 2018; doi:10.1186/s13287-018-0944-8.
  23. Kumar A, et al. Antithymocyte globulin for graft-versus-host disease prophylaxis: An updated systematic review and meta-analysis. Bone Marrow Transplantation. 2019; doi:10.1038/s41409-018-0393-0.
  24. Graff TM, et al. Safety of outpatient autologous hematopoietic cell transplantation for multiple myeloma and lymphoma. Bone Marrow Transplant. 2015; doi:10.1038/bmt.2015.46.
  25. Braswell Pickering EA. Allscripts EPSi. Mayo Clinic. March 1, 2022.
  26. Search for a FACT accredited organization. Foundation for the Accreditation of Cellular Therapy (FACT). http://accredited.factwebsite.org/. Accessed Feb. 18, 2022.
  27. Transplant center search results. Be The Match. https://bethematch.org/tcdirectory/search/advanced/#mayo/-/-/false/-. Accessed Feb. 18, 2022.
  28. Participating transplant centers. Center for International Blood and Marrow Transplant Research. https://www.cibmtr.org/About/WhoWeAre/Centers/Pages/index.aspx?country=us&state=Minnesota. Accessed Feb. 18, 2022.
  29. Locations. Children's Oncology Group. https://childrensoncologygroup.org/index.php/locations/. Accessed Feb. 18, 2022.

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