Tuberous sclerosis (TWO-bur-uhs skluh-ROH-sis), also called tuberous sclerosis complex, is an uncommon genetic disorder that causes noncancerous (benign) tumors — unexpected overgrowths of normal tissue — to develop in many parts of the body. Signs and symptoms vary widely, depending on where the growths develop and how severely a person is affected.

Tuberous sclerosis is often detected during infancy or childhood. Some people with tuberous sclerosis have such mild signs and symptoms that the condition isn't diagnosed until adulthood, or it goes undiagnosed. Others experience serious disabilities.

Although there is no cure for tuberous sclerosis, and the course or severity of the disorder can't be predicted, treatments are available to manage symptoms.


Tuberous sclerosis symptoms are caused by noncancerous growths (benign tumors), in parts of the body, most commonly in the brain, eyes, kidneys, heart, lungs and skin, although any part of the body can be affected. Symptoms can range from mild to severe, depending on the size or location of the overgrowth.

Although the signs and symptoms are unique for each person with tuberous sclerosis, they can include:

  • Skin abnormalities. Most people with tuberous sclerosis have patches of light-colored skin, or they may develop small, harmless areas of thickened, smooth skin or reddish bumps under or around the nails. Facial growths that begin in childhood and resemble acne also are common.
  • Seizures. Growths in the brain may be associated with seizures, which can be the first symptom of tuberous sclerosis. In small children, a common type of seizure called infantile spasm shows up as repetitive spasms of the head and legs.
  • Cognitive disabilities. Tuberous sclerosis can be associated with developmental delays and sometimes intellectual disability or learning disabilities. Mental health disorders, such as autism spectrum disorder or attention-deficit/hyperactivity disorder (ADHD), also can occur.
  • Behavioral problems. Common behavioral problems may include hyperactivity, self-injury or aggression, or issues with social and emotional adjustment.
  • Kidney problems. Most people with tuberous sclerosis develop noncancerous growths on their kidneys, and they may develop more growths as they age.
  • Heart issues. Growths in the heart, if present, are usually largest at birth and shrink as the child gets older.
  • Lung problems. Growths that develop in the lungs may cause coughing or shortness of breath, especially with physical activity or exercise. These benign lung tumors occur more often in women than in men.
  • Eye abnormalities. Growths can appear as white patches on the light-sensitive tissue at the back of the eye (retina). These noncancerous growths don't always interfere with vision.

When to see a doctor

Signs and symptoms of tuberous sclerosis may be noticed at birth. Or the first signs and symptoms may become evident during childhood or even years later in adulthood.

Contact your child's doctor if you're concerned about your child's development or you notice any of the signs or symptoms of tuberous sclerosis described above.


Signs and symptoms of tuberous sclerosis may be noticed at birth. Or the first signs and symptoms may become evident during childhood or even years later in adulthood.

Contact your child's doctor if you're concerned about your child's development or you notice any of the signs or symptoms of tuberous sclerosis described above.

Risk factors

Tuberous sclerosis can be the result of either:

  • A random cell division error. About two-thirds of people who have tuberous sclerosis have a new mutation in either the TSC1 or TSC2 gene — the genes associated with tuberous sclerosis — and do not have a family history of tuberous sclerosis.
  • Inheritance. About one-third of people who have tuberous sclerosis inherit an altered TSC1 or TSC2 gene from a parent who has the disorder.

If you have tuberous sclerosis, you have up to a 50 percent chance of passing the condition to your biological children. Severity of the condition may vary. A parent with tuberous sclerosis may have a child who has a milder or more severe form of the disorder.


Depending on where the noncancerous growths (benign tumors), develop and their size, they can cause severe or life-threatening complications in people with tuberous sclerosis. Here are some examples of complications:

  • Excess fluid in and around the brain. One type of brain growth can block the flow of cerebral spinal fluid within the brain. This blockage can cause the buildup of fluid in the cavities (ventricles) deep within the brain, a condition called hydrocephalus. Various signs and symptoms include an unexpectedly large head size, nausea, headaches and behavior changes.
  • Heart complications. Growths in the heart, usually in infants, can block blood flow or cause problems with heart rhythm (dysrhythmia).
  • Kidney damage. Growths in the kidney can be large and cause potentially serious — even life-threatening — kidney problems. Growths in the kidney can cause high blood pressure or bleeding or lead to kidney failure. Rarely, kidney growths can become cancerous.
  • Lung failure. Growths in the lungs can lead to a collapsed lung or fluid around the lungs that interferes with lung function.
  • Increased risk of cancerous (malignant) tumors. Tuberous sclerosis is associated with an increased risk of developing malignant tumors in the kidneys and brain.
  • Vison damage. Growths in the eye can interfere with vision if they block too much of the retina, though this is rare.

The Mayo Clinic experience and patient stories

Our patients tell us that the quality of their interactions, our attention to detail and the efficiency of their visits mean health care like they've never experienced. See the stories of satisfied Mayo Clinic patients.

  1. Surgery to Get Rid of Seizures Gives Brad Lewis New Freedom

    For 14 years, Brad Lewis never knew quite what to expect when he woke up in the morning. A rare genetic disorder, tuberous sclerosis, caused a variety of health problems. But the one that disrupted his life the most was epilepsy. At one point, Brad was having as many as 80 seizures a day. ?Seizures [...]

Oct. 25, 2017
  1. Tuberous sclerosis.National Organization for Rare Disorders. https://rarediseases.org/rare-diseases/tuberous-sclerosis/. Accessed Sept. 18, 2017.
  2. National Library of Medicine. Tuberous sclerosis complex. Genetics Home Reference. https://ghr.nlm.nih.gov/condition/tuberous-sclerosis-complex. Accessed Sept. 18, 2017.
  3. Tuberous sclerosis information page. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/Disorders/All-Disorders/Tuberous-Sclerosis-Information-Page. Accessed Sept. 18, 2017.
  4. Tuberous sclerosis (TS). Merck Manual Professional Version. http://www.merckmanuals.com/professional/pediatrics/neurocutaneous-syndromes/tuberous-sclerosis-ts. Accessed Sept. 18, 2017.
  5. Owens J, et al. Tuberous sclerosis complex: Genetics, clinical features, and diagnosis. https://www.uptodate.com/contents/search. Accessed Sept. 18, 2017.
  6. Bodensteiner JB, et al. Tuberous sclerosis complex: Management and prognosis. https://www.uptodate.com/contents/search. Accessed Sept. 18, 2017.
  7. Parents/caregivers: Living with tuberous sclerosis complex. Tuberous Sclerosis Alliance. http://www.tsalliance.org/individuals-families/parentscaregivers/. Accessed Sept. 18, 2017.
  8. Hand JL (expert opinion). Mayo Clinic, Rochester, Minn. Oct. 3, 2017.