What are common side effects of Neurontin? How can I manage side effects?
Gabapentin (Neurontin, Gralise, Horizant) is a medicine originally designed to manage some types of epileptic seizures. It's also used to relieve pain for some conditions, such as shingles. Dizziness and drowsiness are common side effects of gabapentin. Some other possible side effects include weight gain and trouble with movement.
Some gabapentin side effects, such as feeling drowsy, are more likely to occur when you start taking the medicine. These side effects may go away as your body adjusts. Avoid driving, operating machinery or other activities that could be dangerous if you're dizzy, drowsy or not steady.
Side effects sometimes occur because of a combination of medicines you're taking. Gabapentin doesn't generally interact with other medicines. But antacids that contain aluminum or magnesium can affect the way your body absorbs gabapentin. To avoid this issue, be sure to take gabapentin and antacids at least two hours apart.
Stopping gabapentin suddenly may increase your risk of seizures. Talk with your healthcare team before you stop taking the medicine.
A concern about some antiseizure medicines, including gabapentin, is that they might cause an increased risk of suicidal thoughts and behavior.
Some studies have found an increase in suicidal behaviors in people taking antiseizure medicines. But the research is unclear about whether the medicine increases this risk. Be sure to talk with your healthcare professional or mental health professional right away if you're having thoughts of harming yourself or suicide.
Let your healthcare professional know if you have questions about gabapentin side effects or if your side effects aren't going away.
July 23, 2025
- Gabapentin. Epilepsy Foundation. https://www.epilepsy.com/tools-resources/seizure-medication-list/gabapentin. Accessed May 21, 20205.
- Neurontin (prescribing information). Pfizer; 2021. http://labeling.pfizer.com/ShowLabeling.aspx?id=630. Accessed May 21, 2025.
- Porwal MH, et al. An analysis of suicidal and self-injurious behavior reports with antiseizure medications in the FDA adverse event database. Epilepsy Research. 2024; doi:10.1016/j.eplepsyres.2024.107382.
- Yuen ASC, et al. Use of gabapentinoid treatment and the risk of self-harm: Population based self-controlled case series study. 2025; doi:10.1136/bmj-2024-081627.
- Medical review (expert opinion). Mayo Clinic. May 21, 2025.
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