Diabetic retinopathy is best diagnosed with a comprehensive dilated eye exam. For this exam, drops placed in your eyes widen (dilate) your pupils to allow your doctor a better view inside your eyes. The drops can cause your close vision to blur until they wear off, several hours later.

During the exam, your eye doctor will look for abnormalities in the inside and outside parts of your eyes.

Fluorescein angiography

After your eyes are dilated, a dye is injected into a vein in your arm. Then pictures are taken as the dye circulates through your eyes' blood vessels. The images can pinpoint blood vessels that are closed, broken or leaking.

Optical coherence tomography (OCT)

With this test, pictures provide cross-sectional images of the retina that show the thickness of the retina. This will help determine how much fluid, if any, has leaked into retinal tissue. Later, optical coherence tomography (OCT) exams can be used to monitor how treatment is working.


Treatment, which depends largely on the type of diabetic retinopathy you have and how severe it is, is geared to slowing or stopping the progression.

Early diabetic retinopathy

If you have mild or moderate nonproliferative diabetic retinopathy, you might not need treatment right away. However, your eye doctor will closely monitor your eyes to determine when you might need treatment.

Work with your diabetes doctor (endocrinologist) to determine if there are ways to improve your diabetes management. When diabetic retinopathy is mild or moderate, good blood sugar control can usually slow the progression.

Advanced diabetic retinopathy

If you have proliferative diabetic retinopathy or macular edema, you'll need prompt treatment. Depending on the specific problems with your retina, options might include:

  • Injecting medications into the eye. These medications, called vascular endothelial growth factor inhibitors, are injected into the vitreous of the eye. They help stop growth of new blood vessels and decrease fluid buildup.

    Three drugs are approved by the U.S. Food and Drug Administration (FDA) for treatment of diabetic macular edema — faricimab-svoa (Vabysmo), ranibizumab (Lucentis) and aflibercept (Eylea). A fourth drug, bevacizumab (Avastin), can be used off-label for the treatment of diabetic macular edema.

    These drugs are injected using topical anesthesia. The injections can cause mild discomfort, such as burning, tearing or pain, for 24 hours after the injection. Possible side effects include a buildup of pressure in the eye and infection.

    These injections will need to be repeated. In some cases, the medication is used with photocoagulation.

  • Photocoagulation. This laser treatment, also known as focal laser treatment, can stop or slow the leakage of blood and fluid in the eye. During the procedure, leaks from abnormal blood vessels are treated with laser burns.

    Focal laser treatment is usually done in your doctor's office or eye clinic in a single session. If you had blurred vision from macular edema before surgery, the treatment might not return your vision to normal, but it's likely to reduce the chance of the macular edema worsening.

  • Panretinal photocoagulation. This laser treatment, also known as scatter laser treatment, can shrink the abnormal blood vessels. During the procedure, the areas of the retina away from the macula are treated with scattered laser burns. The burns cause the abnormal new blood vessels to shrink and scar.

    It's usually done in your doctor's office or eye clinic in two or more sessions. Your vision will be blurry for about a day after the procedure. Some loss of peripheral vision or night vision after the procedure is possible.

  • Vitrectomy. This procedure uses a tiny incision in your eye to remove blood from the middle of the eye (vitreous) as well as scar tissue that's tugging on the retina. It's done in a surgery center or hospital using local or general anesthesia.

While treatment can slow or stop the progression of diabetic retinopathy, it's not a cure. Because diabetes is a lifelong condition, future retinal damage and vision loss are still possible.

Even after treatment for diabetic retinopathy, you'll need regular eye exams. At some point, you might need additional treatment.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.

Alternative medicine

Several alternative therapies have suggested some benefits for people with diabetic retinopathy, but more research is needed to understand whether these treatments are effective and safe.

Let your doctor know if you take herbs or supplements. They can interact with other medications or cause complications in surgery, such as excessive bleeding.

It's vital not to delay standard treatments to try unproven therapies. Early treatment is the best way to prevent vision loss.

Coping and support

The thought that you might lose your sight can be frightening, and you may benefit from talking to a therapist or finding a support group. Ask your doctor for referrals.

If you've already lost vision, ask your doctor about low-vision products, such as magnifiers, and services that can make daily living easier.

Preparing for your appointment

The American Diabetes Association (ADA) recommends that people with type 1 diabetes have an eye exam within five years of being diagnosed. If you have type 2 diabetes, the American Diabetes Association (ADA) advises getting your initial eye exam at the time of your diagnosis.

If there's no evidence of retinopathy on your initial exam, the ADA recommends that people with diabetes get dilated and comprehensive eye exams at least every two years. If you have any level of retinopathy, you'll need eye exams at least annually. Ask your eye doctor what he or she recommends.

The ADA recommends that women with diabetes have an eye exam before becoming pregnant or during the first trimester of pregnancy and be closely followed during the pregnancy and up to one year after giving birth. Pregnancy can sometimes cause diabetic retinopathy to develop or worsen.

Here's some information to help you get ready for your eye appointment.

What you can do

  • Write a brief summary of your diabetes history, including when you were diagnosed; medications you have taken for diabetes, now and in the past; recent average blood sugar levels; and your last few hemoglobin A1C readings, if you know them.
  • List all medications, vitamins and other supplements you take, including dosages.
  • List your symptoms, if any. Include those that may seem unrelated to your eyes.
  • Ask a family member or friend to go with you, if possible. Someone who accompanies you can help remember the information you receive. Also, because your eyes will be dilated, a companion can drive you home.
  • List questions for your doctor.

For diabetic retinopathy, questions to ask your doctor include:

  • How is diabetes affecting my vision?
  • Do I need other tests?
  • Is this condition temporary or long lasting?
  • What treatments are available, and which do you recommend?
  • What side effects might I expect from treatment?
  • I have other health conditions. How can I best manage them together?
  • If I control my blood sugar, will my eye symptoms improve?
  • What do my blood sugar goals need to be to protect my eyes?
  • Can you recommend services for people with visual impairment?

Don't hesitate to ask other questions you have.

What to expect from your doctor

Your doctor is likely to ask you questions, including:

  • Do you have eye symptoms, such as blurred vision or floaters?
  • How long have you had symptoms?
  • In general, how well are you controlling your diabetes?
  • What was your last hemoglobin A1C?
  • Do you have other health conditions, such as high blood pressure or high cholesterol?
  • Have you had eye surgery?

Feb 21, 2023

  1. Diabetic retinopathy. National Eye Institute. https://www.nei.nih.gov/learn-about-eye-health/eye-conditions-and-diseases/diabetic-retinopathy. Accessed Feb. 19, 2021.
  2. AskMayoExpert. Diabetic retinopathy. Mayo Clinic, 2020.
  3. Fraser CE, et al. Diabetic retinopathy: Classification and clinical features. https://www.uptodate.com/contents/search. Accessed Feb. 22, 2021.
  4. Diabetic retinopathy. American Optometrics Association. https://www.aoa.org/healthy-eyes/eye-and-vision-conditions/diabetic-retinopathy?sso=y. Accessed Feb. 19, 2021.
  5. Fraser CE, et al. Diabetic retinopathy: Prevention and treatment. https://www.uptodate.com/contents/search. Accessed Feb. 22, 2021.
  6. The diabetes advisor: Eye exams for people with diabetes. American Diabetes Association. https://professional.diabetes.org/sites/professional.diabetes.org/files/media/Eyes_-_Eye_Tests_for_People_with_Diabetes.pdf. Accessed Feb. 25, 2021.
  7. Zhang HW, et al. Single herbal medicine for diabetic retinopathy (review). Cochrane Database of Systematic Reviews. 2018; doi:10.1002/14651858.CD007939.pub2.
  8. Nair AA, et al. Spotlight on faricimab in the treatment of wet age-related macular degeneration: Design, development and place in therapy. Drug Design, Development and Therapy. 2022; doi:10.2147/DDDT.S368963.
  9. Chodnicki KD (expert opinion). Mayo Clinic. Feb. 8, 2023.


One gift, 3X the impact

Join our Year-End Challenge and triple your gift to help shape the future of healthcare!