Epilepsy Subspecialty Group Overview

Personalized care Personalized care

At Mayo Clinic, your doctor takes the time to listen to you and understand your needs.

Mayo Clinic neurologists trained in epilepsy and seizures have expertise and experience in evaluating and treating adults and children with epilepsy and seizures. Each year, Mayo Clinic teams evaluate and treat more than 7,000 people with epilepsy.

Neurologists work closely with doctors and staff trained in brain and nervous system surgery (neurosurgeons), radiology and nervous system conditions (neuroradiologists), mental health conditions and nervous system conditions (neuropsychologists), and other areas.

Your care team will evaluate the root cause of your seizures and talk with you about treatment options personalized for you.

Advanced diagnosis and treatment

Advancements in epilepsy diagnostics and treatment

Mayo Clinic physicians are also researchers and educators, so they are on the forefront of new diagnostic and treatment options. They have available to them a full range of diagnostic and treatment services so that you get the exact care you need.

Diagnostic tests include:

  • Electroencephalography (EEG) including video EEG and ambulatory EEG
  • Magnetic resonance imaging (MRI)
  • Neuropsychological evaluations
  • Positron emission tomography (PET)
  • SISCOM imaging

Treatments include:

  • Hormone therapy
  • Ketogenic diet
  • Standard and investigational drugs
  • Surgery (including awake brain surgery)
  • Vagus nerve stimulation
  • Responsive neurostimulation
  • Research trials with medications and devices
  • Community education

Seizures remain inadequately controlled in about a third of people with epilepsy. As a level 4 comprehensive epilepsy center, Mayo Clinic is positioned to identify the best treatment for people whose epilepsy doesn't respond to medications. These treatment options may include clinical trials, neurostimulation devices and, in some instances, surgery.

Mayo Clinic provides care to people with epilepsy and other health concerns, such as autoimmune conditions. Each person receives a comprehensive treatment plan tailored to specific needs, such as learning disabilities, behavioral issues, depression, and lifestyle and independence.


Doctors at Mayo Clinic study the causes of epilepsy and new approaches to diagnosing and treating it, including medications, deep brain stimulation, intraoperative functional brain mapping and minimally invasive laser surgery.

Mayo Clinic doctors developed an imaging technology that pinpoints seizure locations. Called subtraction ictal SPECT coregistered to MRI (SISCOM), this tool has been widely adopted and makes it possible for surgeons to remove the parts of the brain causing seizures while protecting healthy areas.

You may be eligible to participate in clinical trials testing investigational treatments for epilepsy, including investigational drugs, epilepsy genetics or deep brain stimulation.

Read more about epilepsy research.


See a list of publications by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

Sept. 25, 2020