Departments and specialties

Mayo Clinic has one of the largest and most experienced practices in the United States, with campuses in Arizona, Florida and Minnesota. Staff skilled in dozens of specialties work together to ensure quality care and successful recovery.

Doctors who perform this procedure

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Displaying 1-4 out of 4 doctors available

  1. Rich W. Byrne, M.D.

    Rich W. Byrne, M.D.

    1. Neurosurgeon
    1. Jacksonville, FL
    Areas of focus:

    Brain tumor surgery, Craniotomy, Minimally invasive surgery, Endoscopic procedure, Minimally invasive neurosurgery, Tra...nssphenoidal surgery, Keyhole craniotomy, Skull base surgery, Brain tumor, Brain metastasis, Meningioma, Epilepsy, Glioblastoma, Pituitary tumor, Acoustic neuroma, Glioma, Esthesioneuroblastoma, Chondrosarcoma, Craniopharyngioma, CSF leak, Astrocytoma, Chordoma, Oligodendroglioma, Brain cancer, Oligoastrocytoma, Skull base tumor, Glioma-associated epilepsy, Brain tumor-associated epilepsy

  2. Kaisorn L. Chaichana, M.D.

    Kaisorn L. Chaichana, M.D.

    1. Neurosurgeon
    1. Jacksonville, FL
    Areas of focus:

    Brain tumor surgery, Awake brain surgery, Craniotomy, Brain stereotactic radiosurgery, Pituitary tumor surgery, Minimal...ly invasive surgery, Stereotactic radiosurgery, Endoscopic procedure, Minimally invasive neurosurgery, Transsphenoidal surgery, Gamma knife surgery, Radiation therapy, Keyhole craniotomy, Endoscopic skull base surgery, Laser ablation, Skull base surgery, Laser interstitial thermotherapy, Brain tumor, Spinal cord tumor, Brain metastasis, Meningioma, Glioblastoma, Pituitary tumor, Acoustic neuroma, Glioma, Esthesioneuroblastoma, Chondrosarcoma, Ependymoma, Craniopharyngioma, CSF leak, Astrocytoma, Chordoma, Oligodendroglioma, Brain cancer, Oligoastrocytoma, Skull base tumor, Schwannoma, Glioma-associated epilepsy, Brain tumor-associated epilepsy

  3. Jan T. Hachmann, M.S.

    Jan T. Hachmann, M.S.

    1. Neurosurgeon
    1. Jacksonville, FL
    Areas of focus:

    Epilepsy surgery, Brain tumor surgery, Awake brain surgery, Craniotomy, Brain stereotactic radiosurgery, Pituitary tumo...r surgery, Minimally invasive surgery, Stereotactic radiosurgery, Endoscopic procedure, Minimally invasive neurosurgery, Transsphenoidal surgery, Gamma knife surgery, Radiation therapy, Spine tumor surgery, Keyhole craniotomy, Endoscopic skull base surgery, Laser ablation, Skull base surgery, Laser interstitial thermotherapy, Brain tumor, Spinal cord tumor, Brain metastasis, Meningioma, Epilepsy, Glioblastoma, Pituitary tumor, Acoustic neuroma, Glioma, Chondrosarcoma, Ependymoma, Craniopharyngioma, CSF leak, Astrocytoma, Chordoma, Oligodendroglioma, Brain cancer, Oligoastrocytoma, Skull base tumor, Schwannoma, Glioma-associated epilepsy, Brain tumor-associated epilepsy

  4. Alfredo Quinones-Hinojosa, M.D.

    Alfredo Quinones-Hinojosa, M.D.

    1. Neurosurgeon
    1. Jacksonville, FL
    Areas of focus:

    Brain tumor surgery, Awake brain surgery, Craniotomy, Pituitary tumor surgery, Minimally invasive surgery, Stereotactic... radiosurgery, Endoscopic procedure, Minimally invasive neurosurgery, Transsphenoidal surgery, Radiation therapy, Spine tumor surgery, Keyhole craniotomy, Endoscopic skull base surgery, Skull base surgery, Brain tumor, Spinal cord tumor, Brain metastasis, Meningioma, Epilepsy, Glioblastoma, Pituitary tumor, Acoustic neuroma, Glioma, Chondrosarcoma, Ependymoma, Craniopharyngioma, CSF leak, Astrocytoma, Chordoma, Oligodendroglioma, Brain cancer, Oligoastrocytoma, Skull base tumor, Schwannoma, Glioma-associated epilepsy, Brain tumor-associated epilepsy

Research

Doctors and surgeons trained in nervous system conditions, also known as neurologists and neurosurgeons, are working to improve care for people having keyhole craniotomy surgery. Researchers for the Brain Tumor Program study better ways to diagnose and treat all brain tumors. One area of study includes developing brain-mapping techniques for hard-to-reach tumors.

Some areas studied by Mayo Clinic researchers include:

  • The potential advantages of different types of craniotomies, including pterional keyhole craniotomy and supraorbital keyhole craniotomy.
  • Techniques used in awake brain mapping for better outcomes after a craniotomy.
  • The safety and potential risks of a craniotomy, along with the risk of delaying the procedure.

Publications

See a list of publications about brain MRI by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

July 19, 2025
  1. Thakur JD, et al. Critical appraisal of minimally invasive keyhole surgery for intracranial meningioma in a large case series. PLOS One. 2022; doi:10.1371/journal.pone.0264053.
  2. Avery RA, et al. Supraorbital and mini-pterional keyhole craniotomies for brain tumors in 204 cases. Journal of Neurosurgery. 2021; doi:10.3171/2020.7.JNS201274.
  3. Brown J, et al. Minimally invasive keyhole craniotomies for microsurgical clipping of intracranial aneurysms: a clinical study and analysis. Neurosurgical Review. 2024; doi:10.1007/s10143-024-02531-9.
  4. Eun J, et al. Outcomes and complications of cerebral aneurysms operated on by eyebrow incision according to aneurysm type and location. BMC Surgery. 2023; doi:10.1186/s12893-023-01942-7.
  5. Mai MD, et al. Clinical outcomes and complications of eyelid versus eyebrow supraorbital keyhole approaches: a systematic review and meta-analysis. Neurosurgical Focus. 2024; doi:10.3171/2024.2.FOCUS23610.
  6. Flint PW, et al., eds. Surgery of the anterior and middle cranial base. In: Cummings Otolaryngology: Head & Neck Surgery. 7th ed. Elsevier; 2021. https://www.clinicalkey.com. Accessed June 16, 2025.
  7. Jandial R. Supraorbital (keyhole) craniotomy with optional orbital osteotomy. In: Core Techniques in Operative Neurosurgery. 2nd ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed June 16, 2025.
  8. Perneczky A, et al. Endoscope-assisted brain surgery: Part 1 — Evolution, basic concept, and current technique. Neurosurgery. 1998; doi:10.1097/00006123-199802000-00001.
  9. Reisch R, et al. The keyhole concept in neurosurgery. World Neurosurgery. 2013; doi:10.1016/j.wneu.2012.02.024.
  10. Ong V, et al. The pterional keyhole craniotomy approach: A historical perspective. World Neurosurgery. 2023; doi:10.1016/j.wneu.2023.07.012.
  11. Bertani R, et al. Minimally invasive craniotomies for lesions of the anterior and middle fossa. Neurosurgical Review. 2022; doi:10.1007/s10143-022-01850-z.
  12. Avery MB, et al. Supraorbital and mini-pterional keyhole craniotomies for brain tumors: A clinical and anatomical comparison of indications and outcomes in 204 cases. Journal of Neurosurgery. 2022; doi:10.3171/2021.6.JNS21759.
  13. Hu W, et al. Computed tomography study of the retrosigmoid craniotomy keyhole approach using surface landmarks. International Journal of Clinical Practice. 2023; doi:10.1155/2023/5407912.
  14. Vijay A, et al., eds. Combined multiportal "pull-through" keyhole craniotomy. In: Integrated Management of Complex Intracranial Lesions: Open, Endoscopic, and Keyhole Techniques. Cambridge University Press. 2021.
  15. Surgery for adult brain and spinal cord tumors. American Cancer Society. https://www.cancer.org/cancer/types/brain-spinal-cord-tumors-adults/treating/surgery.html?utm_source=chatgpt.com. Accessed June 17, 2025.
  16. Parab A, et al. Endoscopic keyhole retromastoid approach in neurosurgical practice: Ant-Man's view of the neurosurgical marvel. World Neurosurgery. 2019; doi:10.1016/j.wneu.2019.02.203.
  17. Yang PF, et al. Keyhole corticoamygdalohippocampectomy for mesial temporal lobe epilepsy. Neuropsychiatry. 2017; DOI 10.1007/s10143-015-0657-8.
  18. Health Education & Content Services. Craniotomy. Mayo Clinic; 2023.

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