Mayo Clinic's approach

At Mayo Clinic, top-ranked doctors and specialists from the Brain Tumor Program work together with Mayo Clinic doctors and surgeons trained in conditions of the nervous system (neurologists and neurosurgeons). Mayo Clinic's world-renowned neurosurgeons are trained in brain surgery and other areas and have experience performing craniotomies to treat a variety of brain conditions.

Mayo Clinic doctors and surgeons have experience diagnosing and treating conditions that may require keyhole craniotomy. These conditions include brain tumors, brain aneurysms, seizures, vascular malformations, bleeding in the brain, brain swelling and more.

Collaboration

Mayo Clinic healthcare professionals in neurology and neurosurgery work with a multidisciplinary team of experts in many specialties to provide comprehensive care for adults and children who need a craniotomy. They work with experts in brain and nervous system imaging (radiologists) and with experts who specialize in the ear, nose, throat. and head and neck (otolaryngologists). They also work with radiation oncology, pain medicine, and physical medicine and rehabilitation experts.

Specialists in Mayo Clinic's Brain Tumor Program offer personalized and comprehensive care to people with brain tumors.

Having all of this subspecialized expertise in a single place, focused on you, means that you're not just getting one opinion. Your care is discussed among the team. Your test results are available quickly. Appointments are scheduled in coordination, and the most highly specialized brain tumor surgeons in the world are all working together to determine what's best for you. What might take months to do elsewhere can typically happen in a matter of days at Mayo Clinic.

Technology and expertise

Mayo Clinic healthcare professionals in neurology, neurosurgery and pediatric neurosurgery are on the leading edge of treating brain conditions. Mayo Clinic is one of the few medical centers in the country to offer awake brain surgery. Mayo Clinic's innovative approaches also include robotics, intraoperative MRI, computer-assisted brain surgery and deep brain stimulation.

Mayo Clinic professionals use state-of-the-art facilities that include an intraoperative MRI suite, comprehensive intraoperative neuromonitoring and image-guided surgery.

Expertise and rankings

Experience

Mayo Clinic's highly specialized neurosurgical teams perform a large number of craniotomies, including keyhole craniotomies, each year. When integrated with ongoing research and education, this results in broad expertise in the imaging and treatment of diseases affecting people of all ages.

Mayo Clinic in Rochester, Minnesota, ranks among the Best Hospitals for neurology and neurosurgery and for cancer in the U.S. News & World Report rankings. Mayo Clinic Children's in Rochester is ranked the No. 1 hospital in Minnesota, and the five-state region of Iowa, Minnesota, North Dakota, South Dakota and Wisconsin, according to U.S. News & World Report's 2024–2025 "Best Children's Hospitals" rankings. With the emphasis on collaborative care, specialists interact very closely with their colleagues across all sites.

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Mayo Clinic in Arizona, Florida and Minnesota

Mayo Clinic Health System

July 19, 2025
  1. Thakur JD, et al. Critical appraisal of minimally invasive keyhole surgery for intracranial meningioma in a large case series. PLOS One. 2022; doi:10.1371/journal.pone.0264053.
  2. Avery RA, et al. Supraorbital and mini-pterional keyhole craniotomies for brain tumors in 204 cases. Journal of Neurosurgery. 2021; doi:10.3171/2020.7.JNS201274.
  3. Brown J, et al. Minimally invasive keyhole craniotomies for microsurgical clipping of intracranial aneurysms: a clinical study and analysis. Neurosurgical Review. 2024; doi:10.1007/s10143-024-02531-9.
  4. Eun J, et al. Outcomes and complications of cerebral aneurysms operated on by eyebrow incision according to aneurysm type and location. BMC Surgery. 2023; doi:10.1186/s12893-023-01942-7.
  5. Mai MD, et al. Clinical outcomes and complications of eyelid versus eyebrow supraorbital keyhole approaches: a systematic review and meta-analysis. Neurosurgical Focus. 2024; doi:10.3171/2024.2.FOCUS23610.
  6. Flint PW, et al., eds. Surgery of the anterior and middle cranial base. In: Cummings Otolaryngology: Head & Neck Surgery. 7th ed. Elsevier; 2021. https://www.clinicalkey.com. Accessed June 16, 2025.
  7. Jandial R. Supraorbital (keyhole) craniotomy with optional orbital osteotomy. In: Core Techniques in Operative Neurosurgery. 2nd ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed June 16, 2025.
  8. Perneczky A, et al. Endoscope-assisted brain surgery: Part 1 — Evolution, basic concept, and current technique. Neurosurgery. 1998; doi:10.1097/00006123-199802000-00001.
  9. Reisch R, et al. The keyhole concept in neurosurgery. World Neurosurgery. 2013; doi:10.1016/j.wneu.2012.02.024.
  10. Ong V, et al. The pterional keyhole craniotomy approach: A historical perspective. World Neurosurgery. 2023; doi:10.1016/j.wneu.2023.07.012.
  11. Bertani R, et al. Minimally invasive craniotomies for lesions of the anterior and middle fossa. Neurosurgical Review. 2022; doi:10.1007/s10143-022-01850-z.
  12. Avery MB, et al. Supraorbital and mini-pterional keyhole craniotomies for brain tumors: A clinical and anatomical comparison of indications and outcomes in 204 cases. Journal of Neurosurgery. 2022; doi:10.3171/2021.6.JNS21759.
  13. Hu W, et al. Computed tomography study of the retrosigmoid craniotomy keyhole approach using surface landmarks. International Journal of Clinical Practice. 2023; doi:10.1155/2023/5407912.
  14. Vijay A, et al., eds. Combined multiportal "pull-through" keyhole craniotomy. In: Integrated Management of Complex Intracranial Lesions: Open, Endoscopic, and Keyhole Techniques. Cambridge University Press. 2021.
  15. Surgery for adult brain and spinal cord tumors. American Cancer Society. https://www.cancer.org/cancer/types/brain-spinal-cord-tumors-adults/treating/surgery.html?utm_source=chatgpt.com. Accessed June 17, 2025.
  16. Parab A, et al. Endoscopic keyhole retromastoid approach in neurosurgical practice: Ant-Man's view of the neurosurgical marvel. World Neurosurgery. 2019; doi:10.1016/j.wneu.2019.02.203.
  17. Yang PF, et al. Keyhole corticoamygdalohippocampectomy for mesial temporal lobe epilepsy. Neuropsychiatry. 2017; DOI 10.1007/s10143-015-0657-8.
  18. Health Education & Content Services. Craniotomy. Mayo Clinic; 2023.

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