1. Sept. 21, 2023

    Breast-conserving surgery is a safe and effective treatment option for women with multiple ipsilateral breast cancer

    Research from Mayo Clinic finds breast-conserving surgery yields a low five-year recurrence rate for women with multiple ipsilateral breast cancer.

  2. Sept. 07, 2023

    A more accurate lung nodule biopsy: Combining shape-sensing bronchoscopy with mobile 3D imaging

    CT-to-body divergence is a challenge in lung cancer diagnosis via bronchoscopy. By combining mobile 3D imaging with shape-sensing robotic-assisted bronchoscopy, Mayo Clinic researchers achieve tool-in-lesion in 96.7% of[...]

  3. Aug. 19, 2023

    Scientific and clinical advances aid in diagnosis, staging and treatment of cholangiocarcinoma

    Sumera I. Ilyas, M.B.B.S., and colleagues highlight key areas of research that are helping clinicians better understand and treat cholangiocarcinoma.

  4. Aug. 19, 2023

    Examining interobserver agreement among endoscopists grading morphology and predicting histopathology of colorectal lesions in patients with inflammatory bowel disease

    Results show low interobserver agreement and low accuracy among endoscopists determining Paris and modified Paris classifications, lesion borders, and histopathology predictions.

  5. Aug. 10, 2023

    Optimal cutaneous lymphoma care: A multidisciplinary, comprehensive approach

    CTCL can be a difficult disease to diagnose. Working with a comprehensive, multidisciplinary care team from the first indication of this lymphoma can help patients get optimized care planning.

  6. Aug. 03, 2023

    Fluorescence-guided surgical advancements for patients with ovarian cancer

    In a 2022 study, Mayo Clinic researchers reported advanced tumor detection and resection in epithelial ovarian cancer using fluorescence-guided surgery. Applying this technique for ovarian cancer opens up more options f[...]

  7. July 28, 2023

    BEST model for cancer distress management

    Oncopsychology focuses on helping to manage the distress of serious conditions such as cancer in order to improve health outcomes. Mayo Clinic experts are taking gold standard methods and applying them in real-world, cl[...]

  8. July 14, 2023

    Preclinical modeling for radiation-induced hyposalivation

    Radiation-induced hyposalivation is one of the most challenging side effects for patients with head and neck cancer. Mayo Clinic researchers have developed a preclinical, murine model testing salivary stem cell transpla[...]

  9. June 30, 2023

    Onconephrology: An emerging, multidisciplinary field

    Advancements in cancer treatment have illuminated the need to understand the short- and long-term impacts on patients' kidneys. The emerging field of onconephrology provides a more comprehensive approach to cancer care.[...]

  10. May 26, 2023

    Time savings of 76% using deep learning automation in head and neck cancer

    In collaboration with Google Health, researchers at Mayo Clinic have trained a deep learning model in autosegmentation for head and neck cancer, garnering 76% time savings.

  11. May 13, 2023

    Challenging search for ovarian cancer early detection assay appears hopeful

    In a clinical pilot study, an 11-MDM ovarian cancer panel, developed at Mayo Clinic, distinguished cancer and noncancer in plasma and identified all five early-stage, high-grade serous ovarian cancers included.

  12. April 27, 2023

    Lung cancer care advancements in the American Southwest

    Mayo Clinic experts have transformed clinical care for patients with lung cancer. With more screening options and less invasive surgical options, patients with lung cancer can have improved outcomes.

  13. April 27, 2023

    CAR-T cell therapy clinical trials and outpatient options

    CAR-T cell therapy is a breakthrough immunotherapy for a growing number of indications. Learn how Mayo Clinic physician Saad J. Kenderian, M.B., Ch.B., is advancing the field through clinical research.

  14. April 25, 2023

    Thyroid preservation in differentiated thyroid cancer

    New guidelines advocate for hemithyroidectomy as a viable option for treating some thyroid cancers.

  15. April 22, 2023

    Spinal oncology surgery focuses on preserving quality of life

    Mayo Clinic increasingly uses a minimally invasive or a "mini open" approach for resecting spinal tumors. The procedure requires a multidisciplinary team and the latest technology.

  16. April 11, 2023

    Sacrectomy: Treating a challenging tumor

    Mayo Clinic orthopedic spine surgeons take on a challenging surgery for sacral tumors in which complete, also called en bloc, removal of the entire cancer provides the best oncologic outcome.

  17. March 31, 2023

    Mayo Clinic pancreatic cancer research is changing the paradigm for neoadjuvant therapy

    Mayo Clinic physician-scientists are advancing care options for patients with pancreatic cancer. Research and practice experts have found that PET imaging can help measu[...]

  18. March 31, 2023

    Surgical advancements drive improved survival for patients with melanoma

    Tina J. Hieken, M.D., answers questions about advancements in care for patients with melanoma. From comprehensive care teams to translation research, she discusses how surgery plays a role in melanoma care plans.

  19. March 24, 2023

    Pediatric brain tumor research: Enhancing treatment and quality of life

    Multidisciplinary teams are overcoming challenges and making discoveries in the laboratory and clinic. The efforts include finding new drugs and delivery methods and enhanced radiation protocols.

  20. March 24, 2023

    State-of-the-art molecular diagnostics for brain tumor care

    Mayo Clinic uses comprehensive molecular and genetic testing to refine brain tumor diagnoses. A multidisciplinary team helps ensure individualized tumor treatment.

  21. March 03, 2023

    Implementation of transperineal biopsy clinic

    The transperineal approach involves passing needles through the perineum versus the rectum, which significantly lowers the risk of infection and improves precision.

  22. Jan. 28, 2023

    Clonal hematopoiesis clinic stratifies risk for patients with cancer

    Clonal hematopoiesis of indeterminant potential (CHIP) increases risk of blood cancers. Mayo Clinic experts screen for CHIP through a specialized clin[...]

  23. Dec. 15, 2022

    Colorectal cancer screening tailored to each patient's needs

    With the advent of less invasive colorectal cancer screening options, more care teams are tailoring screening to each patient's needs. The best screening is the one with which a patient will follow through.

  24. Dec. 15, 2022

    Addressing the rising incidence of early-onset colorectal cancer

    Mayo Clinic gastroenterologist Frank A. Sinicrope, M.D., analyzes current evidence related to the phenotype and diagnosis of early-onset colorectal cancer and strategies to address the increasing incidence of this disea[...]

  25. Dec. 13, 2022

    Lymph node dissection during radical cystectomy for patients with nonmuscle-invasive bladder cancer

    A recent study found that patients with NMIBC who are undergoing radical cystectomy also should receive a lymph node dissection.

  26. Dec. 08, 2022

    Weekly dose of erlotinib shows decreased duodenal polyp burden and side effects for patients with FAP

    Mayo Clinic researchers reported decreased duodenal polyp burden for patients with FAP, as well as more manageable adverse effects. This is a great improvement in preventing cancer for these patients.

  27. Nov. 30, 2022

    Kidney-sparing therapy for low-grade upper tract urothelial cancer

    In a multicenter phase 3 study, researchers identified a kidney-sparing therapy for patients with a rare urologic cancer. Mayo Clinic experts enhanced the mitomycin-containing reverse thermal gel for safety and fewer ad[...]

  28. Nov. 10, 2022

    Support patients' return to sexual health following cancer treatment

    Communicating with patients and providing support for their sexual health concerns following cancer treatment is important for their overall recovery and quality of life.

  29. Nov. 03, 2022

    Hepatic artery infusion pump chemotherapy spares livers and saves lives

    Mayo Clinic in Minnesota has begun treating liver metastases using hepatic artery infusion pump chemotherapy. This intensified, targeted chemotherapy provides potentially curative options for patients where they did not[...]

  30. Oct. 27, 2022

    Improved overall survival for Hodgkin lymphoma with brentuximab vedotin

    Hematology researchers at Mayo Clinic have found that brentuximab vedotin plus standard chemotherapy improves overall survival with comparable side effects and toxicities for patients with Hodgkin lymphoma.

  31. Oct. 20, 2022

    Cancer vaccines illuminate more personalized treatment and prevention strategies

    Researchers at Mayo Clinic are studying the use of vaccines to treat and prevent cancer. With vaccines in various stages of clinical and preclinical research, personalized treatment options using vaccines are on the hor[...]

  32. Oct. 14, 2022

    Treating pediatric patients with primary and recurrent rhabdomyosarcoma

    Through a clinical trial, Mayo Clinic treats pediatric patients with primary and recurrent rhabdomyosarcoma, offering a cutting-edge treatment option for relapsed disease.

  33. Oct. 13, 2022

    De-escalated therapy improves quality of life following oropharynx cancer treatment

    The Head and Neck Cancer Center at Mayo Clinic provides a unique multidisciplinary approach for oropharynx cancer. This efficient team approach brings patients into clinical trials and new therapies faster.

  34. Oct. 06, 2022

    High-quality, advanced cancer care conducted at home

    Mayo Clinic in Florida is extending its Advanced Care at Home model to include cancer. Using an on-site command center, patients receive high acuity care in the comfort of their homes.

  35. Oct. 01, 2022

    Multispecialty team provides rapid, individualized care for pediatric brain tumors

    The Pediatric Brain Tumor Clinic focuses on children's needs while offering Mayo Clinic's deep expertise. Patients have access to the latest treatments and technology.

  36. Oct. 01, 2022

    Fertility preservation for children with brain tumors

    Mayo Clinic's Pediatric Fertility Preservation Program provides unique services to children with brain tumors. Neuro-oncologists determine when this option is appropriate to offer.

  37. Sept. 30, 2022

    Hysterectomy for endometrial cancer shifts significantly toward outpatient approach

    Hysterectomy for endometrial cancer has shifted from the inpatient setting to minimally invasive surgery in the outpatient setting according to a study published in International Journal of Gynecological Cancer.

  38. Sept. 29, 2022

    Oncolytic virus optimizes CAR-T cell therapy for solid tumors

    Mayo Clinic researchers have found that loading CAR-T cells with an oncolytic virus not only assists in killing solid tumors but in persistence of T cells as memory cells in the body.

  39. Sept. 22, 2022

    CAR-T cell therapy for lymphoma and other blood cancers at Mayo Clinic in Jacksonville, Florida

    Mayo Clinic experts are certified to manage CAR-T cell therapy and are advancing the field. Mohamed A. Kharfan Dabaja, M.D., M.B.A., answers questions about the application and research of this therapy.

  40. Sept. 22, 2022

    Thyroid cancer Q&A: The unique needs of adolescents and young adults

    Thyroid cancer is one of the most common cancers diagnosed in adolescents and young adults (AYAs). Mayo Clinic endocrinologist M. Regina Castro, M.D., discusses the unique considerations for AYAs with thyroid cancer.

  41. Aug. 12, 2022

    AI-assisted colonoscopies reduce miss rate by 50 percent

    In a multicenter, multicountry study, Mayo Clinic Gastroenterology and Hepatology joined a global collaboration to analyze the use of artificial intelligence (AI) in colorectal cancer screening. AI support reduced adeno[...]

  42. Aug. 12, 2022

    Chemotherapy robot enhances safety and patient interaction

    In March 2022, Mayo Clinic began using the first chemotherapy robot in Minnesota. The machine uses a system of checks and balances to ensure enhanced safety for staff and patients alike.

  43. July 30, 2022

    Role for cytoreduction surgery in metastatic adrenocortical carcinoma, new study

    Mayo Clinic participates in a retrospective multi-institutional study evaluating cytoreduction surgery of the primary tumor in patients with metastatic ACC.

  44. July 16, 2022

    Racial disparities discovered among genomic sequencing data

    Mayo Clinic researchers have found gaps in the genomic data included in The Cancer Genome Atlas. This is one of the first steps toward developing equitable individualized cancer care for all.

  45. July 16, 2022

    CAR-T cell therapy imaging, advancements and future directions

    CAR-T cell therapy has emerged as a safe and effective immunotherapy option for patients with some diseases. Researchers are learning ways to make CAR-T cell therapy more effective and available for more indications.

  46. June 30, 2022

    Cancer care and research that uses comprehensive data sets: Leadership in Cancer series (Part 3 of 3)

    Cheryl L. Willman, M.D., began her role leading Mayo Clinic Comprehensive Cancer Center in 2021. Using big data and analytics, she plans to continue advancements in cancer care and research.

  47. June 30, 2022

    Cancer care leadership takes a comprehensive approach: Leadership in Cancer series (Part 1 of 3)

    Cheryl L. Willman, M.D., began her role leading Mayo Clinic Comprehensive Cancer Center in 2021. Her background and expertise are leading the Cancer Center toward an even more comprehensive approach.

  48. June 30, 2022

    Health equity in cancer care using comprehensive tools and resources: Leadership in Cancer series (Part 2 of 3)

    Cheryl L. Willman, M.D., began her role leading Mayo Clinic Comprehensive Cancer Center in 2021. She focuses on health equity in cancer care using a comprehensive approach with bidirectional engagement.

  49. June 24, 2022

    Leadership role in NCI effort to advance glioblastoma treatments

    Mayo Clinic is a key participant in a nationwide program that aims to bring new glioblastoma therapeutics into clinical trials. The effort represents a new approach to experimental therapies.

  50. June 21, 2022

    Q&A: Caring for patients with genetic mutations predisposed to ovarian cancer

    A Mayo Clinic Obstetrics and Gynecology physician assistant responds to frequent questions from medical professionals about working with patients found to have a hereditary ovarian cancer risk gene.

  51. June 17, 2022

    Use of comprehensive multigene panel testing for patients with HBC

    Data from Mayo Clinic's INTERCEPT trial suggests that germline testing should be considered in all patients with hepatobiliary cancer (HBC).

  52. June 16, 2022

    For 1 in 6 patients with pancreatic cancer, pathogenic germline variants are present

    In a prospective, multisite study, 15.2% of patients with pancreatic cancer were found to have a genetic predisposition to this deadly disease.

  53. June 09, 2022

    Artificial intelligence informs solutions for gastric cancer challenges

    For gastric cancer, most patients are currently treated with surgery and chemotherapy. This new 32-gene signature can further stratify patients' diagnoses for a more tailored treatment plan.

  54. April 30, 2022

    mRNA transfection improves CTL response in immunotherapy

    In a 2022 study, Mayo Clinic researchers found that by transfecting cytotoxic CD8+ T cells with mRNA of natural killer cells they can improve response in patients previously not responding to immunotherapy.

  55. April 26, 2022

    Comprehensive colorectal screening for closing the gap in racial disparities

    Mayo Clinic physicians have found that comprehensive screening and intervention programs for colorectal cancer can close the care gap and potentially eliminate racial disparities for both incidence and mortality.

  56. April 26, 2022

    Poor antibody response for COVID vaccine in patients with cancer

    Mayo Clinic physicians evaluated the humoral response to the COVID vaccine in patients with cancer and found a decreased humoral response for patients receiving treatment.

  57. March 30, 2022

    Next-generation sequencing for colorectal cancer detects germline predisposition for 1 in 6 patients

    A prospective, multisite study found 1 in 6 patients with colorectal cancer had a germline predisposition and more than half of those would not have been detected following national guidelines.

  58. March 30, 2022

    Potential novel treatments for advanced-stage lung cancer

    Mayo Clinic participates in multiple neoadjuvant immunotherapy trials to better assess response rates and enhance operability in patients with advanced-stage lung cancer.

  59. March 01, 2022

    Amputation for bone sarcoma associated with socioeconomic disparities

    A 2021 study found socioeconomic factors to be associated with higher risk of amputation in patients with bone sarcomas. This disparity was evident regardless of health insurance status.

  60. Feb. 07, 2022

    Mayo Clinic Comprehensive Cancer Center researchers identify promising drug to treat gastrointestinal cancers

    PHOENIX ― Gastrointestinal cancers are some of the most commonly diagnosed cancers, and they continue to be associated with poor survival outcomes. The drug adagrasib specifically targets the KRASG12C gene mutation that is[...]

  61. Feb. 04, 2022

    Understanding and addressing the rehabilitation needs of patients with cancer

    Electronic health record-facilitated cancer symptom control trial tests new approaches to identify and assess which patients need rehabilitation services and how to efficiently deliver appropriate care.

  62. Jan. 18, 2022

    Direct oral anticoagulants significantly decrease recurrent venous thrombosis for adult cancer patients, Mayo Clinic study finds

    ROCHESTER, Minn. — Direct oral anticoagulants should be considered the standard of care to treat adult patients with cancer-associated thrombosis, according to a new, ongoing study by Mayo Clinic researchers. Thrombosis is[...]

  63. Jan. 07, 2022

    Coordinated care for innovative treatment of pediatric leukemia

    Mayo Clinic Children's Center offers thorough, accurate diagnoses coupled with individualized therapies provided by highly trained and experienced care teams for patients with pediatric leukemia.

  64. Jan. 07, 2022

    Multidisciplinary sickle cell program includes curative bone marrow transplant

    A pediatric hematologist/oncologist and trained bone marrow transplant physician at Mayo Clinic in Rochester, Minnesota, describes the program's collaborative approach and her unique role in pediatric sickle cell care.

  65. Jan. 07, 2022

    Pediatric sarcoma program focused on long-term quality of life

    Mayo Clinic's pediatric sarcoma program provides the latest therapies, collaborative tumor boards and resources for adolescents and young adults to enhance long-term quality of life for pediatric patients.

  66. Jan. 07, 2022

    Data and communication support individualized pediatric retinoblastoma program

    Evidence-based practices and communication with families are key to pediatric retinoblastoma care. Mayo Clinic physicians work collaboratively with one another, the patient's family and global data to advance retinoblas[...]

  67. Dec. 22, 2021

    HIPEC and cytoreductive surgery do not improve outcomes over cytoreductive surgery alone in patients with platinum-sensitive recurrent ovarian cancer

    Secondary cytoreductive surgery (CRS) plus HIPEC followed by carboplatin cycles didn't demonstrate greater benefit compared with CRS followed by carboplatin cycles for patients with platinum-sensitive recurrent ovarian [...]

  68. Dec. 20, 2021

    Improving implementation of best practice guidelines for colorectal cancer screening

    A web-based survey tool to assess factors shaping clinician beliefs and behaviors surrounding average-risk colorectal cancer screening strategies provides valid and consistent information about respondents.

  69. Nov. 25, 2021

    COVID-19 upends neuro-oncology worldwide

    The first global study of how the pandemic affected neuro-oncology found both negative and positive aspects. Basic and clinical research declined, but telemedicine was popular among practitioners and patients.

  70. Nov. 20, 2021

    Mayo Clinic Cancer Center launches program for adolescents and young adults

    Mayo Clinic Cancer Center offers unique resources to support adolescents and young adults — those diagnosed between ages 15 and 39 — on their journeys with cancer.

  71. Nov. 20, 2021

    Liver transplantation for colorectal liver metastases at Mayo Clinic in Jacksonville, Florida

    Mayo Clinic in Jacksonville, Florida, is one of only a few centers in the U.S. offering liver transplant as a treatment option for highly selected patients with colorectal liver metastases.

  72. Nov. 20, 2021

    A collaborative approach using liver transplant for perihilar cholangiocarcinoma treatment

    Julie K. Heimbach, M.D., a transplant surgeon at Mayo Clinic in Rochester, Minnesota, discusses neoadjuvant chemotherapy and liver transplantation in the treatment of perihilar cholangiocarcinoma.

  73. Nov. 19, 2021

    Creation of a biomarker-augmented metastases score

    Adding biomarkers Bcl-2 interacting mediator of cell death (BIM) and survivin to previously created clinical metastases scores may improve the prediction of cancer-specific survival.

  74. Nov. 15, 2021

    Mayo Clinic Comprehensive Cancer Center launches consumer blog for patients, families and caregivers

    ROCHESTER, Minn. — Mayo Clinic Cancer Center has launched a new blog for people with cancer, as well as their families and caregivers. This blog offers practical information to educate patients and communities served by Ma[...]

  75. Oct. 29, 2021

    Mayo Clinic offers unique CLL testing and care

    Mayo Clinic offers patients diagnosed with chronic lymphocytic leukemia (CLL) nonstandard, specialized testing — tools to help them understand their prognoses and alleviate anxiety.

  76. Oct. 08, 2021

    A modern approach to endometrial cancer care: molecular risk stratification, targeted therapy and team science

    The field of endometrial cancer is evolving rapidly, moving toward molecular risk stratification and targeted therapy using a team science approach. A Mayo Clinic gynecologic oncologist and a medical oncologist explain.[...]

  77. Sept. 01, 2021

    Uterine microbe found to have disease-causing behavior in endometrial cancer

    Research supports that a microbe particularly associated with endometrial cancer is capable of pathogenic behavior and stimulated by one of the main risk factors for the disease — estrogen exposure.

  78. Aug. 20, 2021

    Genetic tumor testing for more-precise treatment of glioma

    Mayo Clinic's cerebral spinal fluid biomarker tests use next-generation sequencing to evaluate mutations and rearrangements in 187 genes, for optimal tumor management.

  79. July 31, 2021

    Establishing the pulmonary oncologic toxicity clinic to care for patients with lung toxicity

    Mayo Clinic Pulmonary and Critical Care Medicine is establishing a pulmonary oncologic toxicity clinic to care for patients with lung toxicity from chemotherapy, radiation and immunotherapy.

  80. July 16, 2021

    Immune checkpoint-induced hypoparathyroidism: A case from the endocrine teaching clinics

    Immune checkpoint inhibitor (ICI) drugs have revolutionized cancer therapy. Mayo Clinic endocrinologists discuss the case of a 76-year-old male with widespread metastatic melanoma who presented with weakness, anorexia a[...]

  81. July 01, 2021

    Recent findings and future directions in non-Hodgkin's lymphoma therapy

    Immune blockade therapy isn't nearly as effective as a sole treatment for non-Hodgkin's lymphomas compared with Hodgkin's lymphoma. Mayo Clinic researchers see potential for this therapy in combination with others.

  82. June 26, 2021

    Appropriate evidence-based triage is vital to outcomes in advanced epithelial ovarian cancer

    Two studies indicate the importance of triaging patients with advanced epithelial ovarian cancer by frailty and sarcopenia status for best survival and fewer complications.

  83. June 26, 2021

    Sentinel lymph node biopsy decreases lymphedema for patients with endometrial cancer

    Unlike use of lymphadenectomy, with a 49.4% rate of lower extremity lymphedema, using sentinel lymph node biopsy to stage patients with endometrial cancer led to a 26.0% rate of this type of lymphedema.

  84. June 18, 2021

    Assessing the performance of methylated DNA markers in blood for detection of pancreatic ductal adenocarcinoma

    A blood test combining methylated DNA markers with carbohydrate antigen 19-9 detects pancreatic ductal adenocarcinoma with high accuracy.

  85. June 11, 2021

    Where we are with gastric and esophageal cancers

    A Mayo Clinic medical oncologist answers questions about diagnosis and screening and discusses treatment advances in recent years for gastric and esophageal cancers.

  86. May 22, 2021

    Study assesses cost-effectiveness of pembrolizumab for treatment of bacillus Calmette-Guerin-unresponsive bladder carcinoma in situ

    Research confirms that pembrolizumab at current pricing is not cost-effective for patients with bladder cancer that has proved unresponsive to bacillus Calmette-Guerin (BCG) treatment.

  87. May 22, 2021

    Development of urosymphyseal fistula in posterior urethral stenosis

    Research supports that patients who develop posterior urethral stenosis and urosymphyseal fistula following salvage radiation after prostatectomy can achieve a durable restoration of quality of life.

  88. May 18, 2021

    New therapies offer improved quality of life for patients who need laryngectomy

    Surgical options for those who need laryngectomy to date have not satisfied all patients. An otolaryngologist at Mayo Clinic in Arizona talks about his work on alternatives: larynx transplant and 3D-printed prosthetic l[...]

  89. May 07, 2021

    Novel proton therapy technique shows promise with resistant cancer cells

    Mayo Clinic investigators believe a novel proton therapy delivery technique may bring fundamental change to radiation oncology treatment paradigms, especially for hard-to-treat cancers.

  90. May 04, 2021

    Development of new surgical procedures and predictors of outcome for patients with advanced pancreatic cancer

    Outcomes from two Mayo Clinic retrospective studies support new surgical procedures and predictors of outcome for patients with advanced pancreatic cancer.

  91. April 23, 2021

    Microscopic papillary thyroid carcinoma: elevated incidence, reasonable interventions

    Thyroid cancer rates have increased, prompted by higher screening rates and improvements. A Mayo Clinic endocrinologist discusses options of watchful waiting or treatment when thyroid nodules are small.

  92. April 17, 2021

    Young-onset esophageal adenocarcinoma: Results from a population-based study

    Mayo Clinic research examining the incidence, stage distribution and survival outcomes associated with esophageal adenocarcinoma (EAC) in a large population-based study yields some surprising results about young-onset E[...]

  93. April 15, 2021

    Elucidating a rare pituitary cancer

    A Mayo Clinic study describes the challenges of diagnosing individuals with this cancer and outlines treatment options.

  94. April 13, 2021

    Tolerability, safety and deep response found in cevostamab phase 1 trial

    A midterm analysis of a multisite phase 1 study of cevostamab for relapsed or refractory multiple myeloma (RRMM) finds the drug safe and tolerable with deep response for study participants.

  95. April 09, 2021

    Patients with HPV(+)OPSCC complete aggressive de‐escalation of adjuvant therapy without increasing risk of cancer progression

    Research compares prior de‐escalation outcomes to a contemporary cohort of patients with human papillomavirus-associated oropharyngeal squamous cell carcinoma (HPV(+)OPSCC) who met criteria for de‐escalated radiation th[...]

  96. March 16, 2021

    Mayo Clinic-developed mass spectrometry assay improves detection of monoclonal proteins, advancing outcomes in hard-to-treat diseases

    A clinical biochemist and scientific team from Mayo Clinic created a new screening and monitoring tool for monoclonal protein disorders, advancing outcomes in hard-to-treat diseases.

  97. March 13, 2021

    Ide-cel, a BCMA-directed CAR-T cell therapy, shows favorable risk-benefit profile and response

    A phase 1 study finds low incidence of severe side effects and high response rate for ide-cel, an anti-BCMA CAR-T cell therapy for relapsed or refractory multiple myeloma.

  98. March 05, 2021

    mt-sDNA test shows high specificity for colorectal cancer screening in average-risk 45- to 49-year-olds

    The multitarget stool DNA (mt-sDNA) test showed more than 95% specificity in a cross-sectional study of 45- to 49-year-old patients at average risk for colorectal cancer.

  99. Feb. 13, 2021

    Screening strategies for prevalent esophageal adenocarcinoma may be different from those recommended for Barrett's esophagus

    Researchers find evidence that a second phenotype of esophageal adenocarcinoma is not associated with chronic gastroesophageal reflux and other Barrett's esophagus risk factors.

  100. Feb. 05, 2021

    High-risk nonmuscle invasive bladder cancer

    In a phase III clinical trial, 53% of patients with nonmuscle invasive bladder cancer (NMIBC) in the carcinoma in situ cohort had a complete response within three months of treatment.

  101. Jan. 23, 2021

    mSMART: A clear and simple guide for treating patients with multiple myeloma

    If you've ever wondered what Mayo Clinic would do to treat its multiple myeloma patients, guidelines called mSMART outline Mayo specialists' current treatment approach.

  102. Jan. 19, 2021

    Adrenal masses require full investigation at the time of discovery

    Researchers using Rochester Epidemiology Project data have identified a population-based proportion of malignant tumors and other information helpful when discussing management with a patient newly diagnosed with an adr[...]

  103. Jan. 16, 2021

    New minimally invasive vascularized lymph node transfer for lymphedema

    Single-port robotic omental harvest for the surgical treatment of lymphedema using a free lymph node transfer minimizes donor site morbidity and alleviates debilitating symptoms of lymphedema.

  104. Jan. 08, 2021

    Determining the best treatment course for patients with multiple myeloma

    A long-term strategy for management of multiple myeloma should include a risk-stratified approach as well as selecting the ideal combinations and sequencing the hematologist can determine for each patient's disease.

  105. Dec. 29, 2020

    Pemigatinib trial seeks to build on targeted advances in cholangiocarcinoma

    Tanios S. Bekaii-Saab, M.D., discusses the explosion of research leading to the approval of pemigatinib for patients with unresectable, previously treated advanced or metastatic cholangiocarcinoma with FGFR2 fusion or r[...]

  106. Dec. 22, 2020

    Making up for lost time in GI cancers

    Tanios S. Bekaii-Saab, M.D., discusses how the field of gastrointestinal (GI) cancers is gaining ground with regard to the development of targeted and immunotherapy agents.

  107. Dec. 18, 2020

    Broad-based testing increases detection of inherited germline variants in patients with cancer

    Universal germline genetic testing found that 13.3% of study participants harbored a pathogenic germline variant — 48% of which would not have been detected using standard guidelines.

  108. Dec. 17, 2020

    Pelvic exenteration: Radical but positive for carefully selected patients with pelvic cancer

    A Mayo Clinic gynecologic surgeon discusses how pelvic exenteration, though radical, can benefit carefully selected patients and how complications can be predicted.

  109. Nov. 20, 2020

    Improving quality of life for patients living with oropharyngeal cancer

    A Mayo Clinic study supports that compared with intensity-modulated radiation therapy, proton beam therapy is better tolerated by patients who've had expert transoral surgical resection of oropharyngeal cancer.

  110. Nov. 20, 2020

    Therapeutic sequencing improves outcomes for patients with progressive mCRPC

    Researchers investigated the long-term oncologic outcomes of three chemotherapy regimens in patients who had previously experienced disease progression after treatment with a novel androgen receptor inhibitor.

  111. Nov. 02, 2020

    Mayo Clinic study finds 1 in 8 patients with cancer harbor inherited genetic mutations

    The Interrogating Cancer Etiology Using Proactive Genetic Testing (INTERCEPT) study represents the largest known multicenter study of universal testing of patients with cancer.

  112. Oct. 30, 2020

    Breast radiotherapy team at Mayo Clinic adopts shortened courses to spare normal tissue

    Mayo Clinic helps patients with breast cancer by sparing normal tissue and reducing treatment time via newly adopted practice guidelines embracing short-course radiotherapy as a standard of care.

  113. Oct. 16, 2020

    Select thyroid clinical trials at Mayo Clinic

    Mayo Clinic researchers are investigating therapeutic use of radiofrequency ablation for small papillary thyroid carcinomas. A placebo-controlled interventional trial is testing a new therapy for patients with thyroid e[...]

  114. Oct. 09, 2020

    Consensus reached on initial treatment of acute graft-versus-host disease in patients who receive bone marrow transplant; nothing definitive yet for secondary treatment

    There are now two approved second line therapies for treatment of steroid-refractory GVHD ― one for acute GVHD and one for chronic GVHD.

  115. Sept. 15, 2020

    New research indicates maintenance bacillus Calmette-Guerin is not cost-effective for all patients with intermediate- and high-risk nonmuscle invasive bladder cancer

    New research supports prioritizing bacillus Calmette-Guerin (BCG) for induction therapy during shortages and reserving maintenance BCG for patients at the highest risk of progression.

  116. Sept. 04, 2020

    Incidence and characteristics of therapy-related myeloid neoplasms after peptide receptor radionuclide therapy in patients with neuroendocrine tumors

    Drs. Sonbol and Halfdanarson share findings of their systematic review on the frequency of therapy-related myeloid neoplasm (t-MN) in patients with neuroendocrine tumors after PRRT.

  117. Aug. 28, 2020

    Identification of actionable alterations in colorectal cancer are leading to the development of novel treatment strategies

    Daniel H. Ahn, D.O., talks about the latest advancements and research in colorectal cancer treatment.

  118. Aug. 21, 2020

    Cardio-oncology — A marriage of cardiology & oncology

    With more cancer drug options and increased treatment success, patients with cancer are surviving in record numbers. To address negative side effects of therapies on the heart and vascular function, Mayo Clinic establis[...]

  119. Aug. 15, 2020

    Comparing modalities for detecting dysplasia in patients with IBD

    A one-year cross-sectional IBD surveillance colonoscopy cohort compares high-definition white light endoscopy and chromoendoscopy.

  120. Aug. 14, 2020

    This is not your mother's breast clinic

    Breast Clinic specialists discuss how the complexity of breast cancer treatment requires integration of multiple specialties to provide the expert care, seamless coordination and patient experience for which Mayo Clinic[...]

  121. Aug. 14, 2020

    Patients receiving lutetium Lu 177 dotatate radiation therapy may experience travel delays

    Radiation used in peptide receptor radionuclide therapy could be detected by sensitive radiation detectors at U.S. ports of entry, including international airports and border crossings.

  122. Aug. 14, 2020

    Glioblastoma: Seeking personalized care through radiomics

    Mayo Clinic is using radiomics to learn more about individuals' responses to glioblastoma treatment. Tumor volume can affect an individual's response to chemotherapy. Differences in the molecular mechanisms of tumors in[...]

  123. Aug. 08, 2020

    Second-line treatment options for hepatocellular carcinoma

    Tanios S. Bekaii-Saab, M.D., F.A.C.P., discusses the rapidly changing hepatocellular carcinoma treatment landscape and shares how he navigates first-line and second-line treatment options for these patients.

  124. Aug. 04, 2020

    Pediatric brain tumors: Rapid and focused care

    Patients referred to Mayo Clinic for pediatric brain tumor can often be seen the next day. A team of specialists works together, drawing on Mayo's broad expertise in neuro-oncology.

  125. July 01, 2020

    Oncology centers examine the aftermath of COVID-19 on clinical trials with Steven R. Alberts, M.D.

    Medical oncologist and interim chair of the Mayo Clinic Cancer Center, Dr. Alberts provides his perspective on how COVID-19 has affected clinical trials for cancer and what patients should know about receiving care duri[...]

  126. June 27, 2020

    Glioblastoma extracellular vesicles: Targeting the ill effects, using the good

    The mechanisms by which glioblastoma-derived extracellular vesicles promote tumor growth appear to be more complicated than previously thought. Mayo Clinic is working to exploit certain factors of extracellular vesicles[...]

  127. June 16, 2020

    Mayo Clinic, NASA team up to test AI algorithm on colorectal cancer

    A Center for Individualized Medicine algorithm shows potential in detecting spatio-temporal patterns of colorectal cancer progression from tumor snapshots to predict the cancer's evolutionary trajectory.

  128. June 13, 2020

    New approaches to immunotherapy for glioblastoma

    Mayo Clinic is advancing new applications of immunotherapy for glioblastoma, with a focus on more-potent and combination therapies for optimal effectiveness.

  129. May 13, 2020

    Esophageal cancer treatment amid COVID-19: Q&A with Shanda Blackmon, M.D., M.P.H.

    Thoracic surgeon Dr. Blackmon provides her perspective on how COVID-19 has affected esophageal cancer treatment and what patients should know about receiving care during this pandemic.

  130. May 09, 2020

    How COVID-19 could impact future practice: Q and A with Tanios S. Bekaii-Saab, M.D., F.A.C.P.

    Tanios S. Bekaii-Saab, M.D., FACP, medical oncologist at Mayo Clinic in Phoenix, Arizona, answers questions on how COVID-19 could impact the future practice of medicine.

  131. May 08, 2020

    Lung cancer care during COVID-19: Q&A with Shanda Blackmon, M.D., M.P.H.

    Thoracic surgeon Dr. Blackmon answers questions on how COVID-19 has affected lung cancer treatment, what patients should know about risks, and care and referral considerations.

  132. May 02, 2020

    Patient safety and care delivery remain the focus at Mayo Clinic Cancer Center: A special message from Robert R. McWilliams, M.D., practice chair, Mayo Clinic Cancer Center

    Continuing to provide lifesaving cancer treatment is a priority for Mayo Clinic. Following our primary value, "The needs of the patient come first," patients have continued to safely receive care for cancer at our locat[...]

  133. April 17, 2020

    Steroid profiling in the diagnosis of malignant adrenal masses: Cases from the endocrine teaching clinics

    Endocrinologists Shobana Athimulam, M.B.B.S., and Irina Bancos, M.D., discuss the diagnoses and next steps in management of two patients with malignant adrenal tumors.

  134. March 20, 2020

    Complex gynecological surgery for recurrent cancer: Navigating challenges when communicating with patients and their families

    Pelvic exenteration is used to treat cancer in the pelvic organs that has recurred after other treatment. Providers' empathy and understanding is vital to successful patient-centered care.

  135. March 20, 2020

    Alternative, innovative method of delivering chemotherapy shows promising results, retrospective review says

    Hyperthermic intraperitoneal chemotherapy (HIPEC) has been shown to decrease the risk of recurrence and improve the survival of patients with peritoneal-based malignancies, with minimal side effects.

  136. Feb. 28, 2020

    Enterprisewide expertise for spinal oncology care

    Mayo's spinal oncology specialists may employ proton beam therapy, carbon fiber implants or surgical alternatives ― such as decompression, stabilization, ablation technologies or cement augmentation ― to meet each patie[...]

  137. Feb. 22, 2020

    Percutaneous biopsy of suspicious upper tract lesions a safe diagnostic strategy

    A retrospective review of patients who received percutaneous image-guided core-needle biopsy for diagnosis of upper tact urothelial carcinoma supports that the process is safe and well tolerated by those patients.

  138. Feb. 22, 2020

    Optimal sequencing of commonly used medications for treatment of metastatic castration-resistant prostate cancer

    Research supports the use of docetaxel before enzalutamide or abiraterone as the primary first line therapy for metastatic castration-resistant prostate cancer.

  139. Feb. 14, 2020

    Detection of esophageal cancer via assay of novel methylated DNA markers in plasma

    In the largest plasma-based pilot of esophageal cancer biomarkers to date, Mayo Clinic researchers identified five methylated DNA markers (MDMs) that achieved high discrimination for cancer.

  140. Feb. 14, 2020

    Role of AI in detection and management of colorectal polyps and cancer

    Up to 25% of polyps can be missed during colonoscopy, due to factors such as withdrawal time, preparation quality and the endoscopist's ability to recognize flat polyps.

  141. Feb. 14, 2020

    Update on hereditary gastrointestinal cancers: Lynch syndrome and familial adenomatous polyposis syndromes

    A primer on Lynch syndrome, familial adenomatous polyposis (FAP) and attenuated FAP provides clinicians with tools to understand the genetic bases of these conditions and appropriate diagnosis and management.

  142. Feb. 14, 2020

    Prepless colon capsule technology: New research examines this less invasive approach to colorectal cancer screening

    Mayo gastroenterologists are collaborating in the first U.S. study evaluating the safety and compliance of a prepless capsule imaging system for colorectal cancer (CRC) screening.

  143. Jan. 31, 2020

    Mayo Clinic specialists team up to treat rhabdomyosarcoma

    Multidisciplinary teamwork, ongoing research and innovative treatments ― including hyperthermic intraperitoneal chemotherapy (HIPEC) and proton beam therapy ― may improve outcomes for pediatric patients with rhabdomyosa[...]

  144. Jan. 06, 2020

    Out of the shadows: Understanding endocrine cancers

    Mayo Clinic's Endocrine Malignancies Disease Group focuses on patients with less-common endocrine cancers, leading to an optimized approach to thyroid nodules and improved overall survival in anaplastic thyroid cancer.

  145. Dec. 10, 2019

    Researchers discover distinct pathways in lung adenocarcinoma

    Discovery of distinct pathways in lung adenocarcinoma may help improve targeted cancer therapies: Mayo Clinic Forefront cancer magazine.

  146. Dec. 10, 2019

    Tweaking protein may improve colorectal cancer outcomes

    Mayo Clinic researchers tweak a key protein to boost effectiveness of chemotherapy in colorectal cancer: Mayo Clinic Forefront cancer magazine.

  147. Dec. 10, 2019

    Scientists find autoimmune disease related to testicular cancer

    Scientists urge screening for paraneoplastic encephalitis autoimmune disease in patients with testicular cancer: Mayo Clinic Forefront cancer magazine.

  148. Dec. 10, 2019

    Mayo Clinic calls out need for aggressive glioblastoma treatment

    Aggressive cellular therapy, new drugs, surgery & clinical trials needed for glioblastoma brain tumor survival: Mayo Clinic Forefront cancer magazine.

  149. Oct. 26, 2019

    One of the largest male breast cancer studies to date illuminates state of treatment, prognosis and health disparities

    Mayo investigators have identified unique practice patterns and prognosis factors in male breast cancer, and associated health disparities. Studies indicate the incidence of breast cancer in males may be on the rise.

  150. Oct. 22, 2019

    Panel of methylated DNA markers provides improved accuracy in detecting advanced neoplasia and other lesions that may require resection

    Researchers identified and validated a panel of DNA methylation markers that can detect advanced neoplasia and help determine which cysts require surgery.

  151. Oct. 22, 2019

    Evaluating the safety and diagnostic accuracy of endoscopic fine-needle aspiration for detection of extravascular migratory metastases in the pancreas

    In a retrospective review, researchers demonstrated that cytology analysis of pancreatic samples collected by endoscopic ultrasound fine-needle aspiration (EUS-FNA) can detect extravascular migratory metastases often mi[...]

  152. Oct. 22, 2019

    Assessing the timeline, location and patterns of recurrence in patients achieving complete remission after radiofrequency ablation

    Researchers assessed the timeline, location and patterns of recurrence in patients who achieved remission after radiofrequency ablation in a multicenter cohort study.

  153. Sept. 24, 2019

    Soft tissue sarcoma: Technology and expertise to improve care

    Wound-healing complications are common after surgical resection for soft tissue sarcoma. Intraoperative fluorescence angiography assesses blood flow and tissue perfusion, allowing for the surgical removal of nonviable t[...]

  154. Aug. 27, 2019

    New analysis shows radical prostatectomy to be cost-effective management of prostate cancer

    A cost-effectiveness study indicates that the ProtecT trial actually supports the upfront treatment of more-aggressive prostate cancers and the surveillance of less aggressive prostate cancers.

  155. Aug. 01, 2019

    Blocking YAP May Aid in Treating Brain Cancer

    Researchers found that a drug known to inhibit yes-associated protein can reduce the growth of highly aggressive glioblastoma cells in animal and cell models and make glioblastoma cells more susceptible to radiation.

  156. June 21, 2019

    New data indicate percutaneous ablation may be an appropriate option for certain patients with renal masses

    A review of patients treated with partial nephrectomy, percutaneous radiofrequency ablation or percutaneous cryoablation for small renal masses found no clinical or statistical difference in five-year outcomes.

  157. June 18, 2019

    Study helps clarify role of T cells in follicular lymphoma

    Mayo Clinic researchers find that costimulatory receptors on T cells may be key in treating follicular lymphoma: Mayo Clinic Forefront cancer magazine.

  158. April 19, 2019

    Axi-cel treatment for B-cell lymphoma provides real-world outcomes comparable to ZUMA-1 trial data

    In a study of axicabtagene ciloleucel (axi-cel) CAR-T cell therapy for relapsed or refractory aggressive B-cell lymphoma, 30-day responses were comparable to the ZUMA-1 trial's best responses.

  159. March 20, 2019

    Researchers pursue new strategies for CAR-T cell therapy

    Mayo Clinic researchers find ways to reduce toxicity and improve response rates in CAR-T cell therapy: Mayo Clinic Forefront cancer magazine.

  160. Dec. 21, 2018

    Beating the beast: Mayo Clinic's pediatric urologists and their sarcoma team's mission to cure rhabdomyosarcoma

    Mayo pediatric radiologists construct 3D, color-coded models of the tumor and surrounding structures to assess the best potential therapies for each child and assist the surgical team with preoperative planning and refe[...]

  161. Sept. 18, 2018

    Liver transplant for PSC-associated cholangiocarcinoma

    Mayo Clinic is a pioneer of liver transplantation for cholangiocarcinoma in the setting of primary sclerosing cholangitis (PSC). The treatment involves adjuvant therapy before liver transplantation.

  162. Sept. 15, 2018

    Adrenocortical cancer presenting as postmenopausal bleeding: A case from the endocrine teaching clinics

    Irina Bancos, M.D., and Nana Esi N. Kittah, M.B., Ch.B., discuss the case of a woman who was diagnosed with Lynch syndrome, evaluated for a right adrenal mass and treated for adrenal cortical carcinoma.

  163. Sept. 01, 2018

    Onco-Epilepsy: More than tumor and seizures

    Research published in Mayo Clinic Proceedings indicates that onco-epilepsy, a combined approach to brain tumor management, may extend survival and improve patients' quality of life.

  164. April 14, 2018

    Laparoscopic gastrectomy for gastric cancer

    The minimally invasive procedure offers faster recovery, less blood loss and pain, and a return to eating and normal bowel function more quickly. The hospital stay is shorter and the patient is less likely to need a fee[...]

  165. April 13, 2018

    Assessing the risk of tumoremia after endoscopic ultrasound-guided fine-needle aspiration of pancreatic adenocarcinoma

    Although endoscopic ultrasound-guided fine-needle aspiration is thought to be safe, some experts question whether tumor manipulation during this procedure causes tumors to shed cells into the bloodstream.

  166. Feb. 27, 2018

    Inherited cancers clinic seeks to advance understanding, diagnosis and management of hereditary colorectal cancers

    Use of a simple questionnaire of personal and family history of cancer in outpatient settings helps improve the identification of high-risk patients and families, detect cancers earlier, and formulate more-effective ind[...]

  167. Feb. 20, 2018

    Targeted DNA next-generation sequencing aids the molecular assessment of pancreatic neuroendocrine tumors

    A recent Mayo Clinic study demonstrated that endoscopic ultrasound-acquired cytology-based tumor genotyping can reveal a spectrum of genetic variants, which may help guide biomarker-driven, individualized, targeted trea[...]

  168. Feb. 15, 2018

    Cytoreductive surgery and HIPEC offers effective treatment for selected patients with peritoneal carcinomatosis

    A retrospective study of intermediate-term outcomes for patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) indicates the treatment was most successful for patients with res[...]

  169. Feb. 09, 2018

    Care of the patient with lung cancer at Mayo Clinic: Mayo Clinic tumor board provides multidisciplinary expertise

    The multidisciplinary assembly provides up-to-date treatment options for patients with lung cancer, explores enrollment in clinical trials, and enhances cross-discipline education from the exchange of information and ex[...]

  170. Feb. 09, 2018

    Advances in lung cancer immunotherapy and management of immune-mediated adverse events

    A new study explores the combination of the intratumoral administration of the measles virus with systemic PD-L1 targeted immunotherapy using atezolizumab for second line therapy of non-small cell lung cancer.

  171. Jan. 20, 2018

    Noninvasive radiologic biomarkers to individualize lung cancer therapy

    Computer-Aided Nodule Assessment and Risk Yield (CANARY) image analysis software has shown promise in noninvasively predicting epithelial growth factor receptor (EGFR) status of adenocarcinoma of the lung, allowing for [...]

  172. Nov. 22, 2017

    The Fish Farm

    Zebrafish have become the model of choice in many medical laboratories. They breed more prolifically and hold more animals per research footprint compared with other vertebrates, and can be very resource-friendly.

  173. Nov. 17, 2017

    Interventions for cancer caregivers indicate potential for quality of life improvement

    Caregivers for patients with advanced cancer can experience higher levels of energy and activity, adaptation, and spiritual well-being when administered a psychosocial intervention designed to improve quality of life (Q[...]

  174. Nov. 01, 2017

    Starving Cancer

    Mayo researchers are studying genes that are highly expressed in cancerous tissue but not in normal tissue and examining the cause and effect of fatty acid synthase in the cancer cell to identify a process to starve can[...]

  175. March 24, 2017

    Cleaning Up Cancer

    Researchers use a variety of approaches to address two big challenges: strengthen the immune response to recognize and attack cancer; and keep the immune system on high alert, even as cancer cells struggle to reduce the[...]

  176. Dec. 18, 2016

    Stereotactic radiosurgery is best for some brain tumors

    Mayo Clinic Forefront magazine: Shift in practice may reserve whole-brain radiation for patients with extensive disease.

  177. Nov. 18, 2016

    Fertility preservation: Efforts to improve quality of life in children facing gonadotoxic therapy

    Recent advances in reproductive endocrinology allow cryopreservation of prepubertal boys' testicular tissue and girls' ovarian tissue before they begin cancer therapy known to impact fertility adversely.

  178. Sept. 26, 2016

    Battling Brain Cancers Through Genomics

    A study of the classification of genetic alterations common to gliomas indicates that molecular methods can do a better job than current methods of predicting which specific treatment course is necessary for each indivi[...]

  179. Sept. 05, 2013

    Cancer immunotherapy eradicates tumors from within

    Cancer immunotherapy cures tumor-burdened mice - Researchers used human DNA from melanoma cells delivered through the vector vesicular stomatitis virus to eradicate cancerous tumors in mice. Success is associated with t[...]

  180. Mayo Clinic urologists awarded governors proclamation recognizing Prostate Cancer Awareness Month in Minnesota

    Mayo Clinic urologists awarded governors proclamation recognizing Prostate Cancer Awareness Month in Minnesota