The cause of headaches can be difficult to determine. The provider will question you about your headaches and do a physical exam.

Your provider may perform imaging tests to help determine the cause of your headache, including:

  • CT scan. CT scans use a computer to create cross-sectional images of the brain and head (including the sinuses) by combining images from an X-ray unit that rotates around the body.
  • Magnetic resonance imaging (MRI). With Magnetic resonance imaging (MRI), a magnetic field and radio waves are used to create cross-sectional images of the structures within the brain.


Most people who assume they have sinus headaches actually have migraines or tension-type headaches.

Migraines and chronic or recurrent headaches may be treated with prescription medication that is either taken every day to reduce or prevent headaches or taken at the onset of a headache to prevent it from getting worse.

To treat these types of headaches, your provider may recommend:

  • Pain relievers available without a prescription. Migraines and other types of headaches may be treated with medications available without a prescription, such as acetaminophen (Tylenol, others), naproxen sodium (Aleve) and ibuprofen (Advil, Motrin IB, others).
  • Triptans. Many people with migraine attacks use triptans to relieve pain. Triptans work by blocking pain pathways in the brain, but promote constriction of blood vessels and should be avoided if you have a history of heart disease or stroke.

    Medications include sumatriptan (Imitrex, Tosymra, others), rizatriptan (Maxalt), almotriptan, naratriptan (Amerge), zolmitriptan (Zomig), frovatriptan (Frova) and eletriptan (Relpax). Triptans are available as tablets, nasal sprays and injections.

    A single-tablet combination of sumatriptan and naproxen sodium (Treximet) has proved to be more effective in relieving migraine symptoms than either medication on its own.

  • Ergots. Ergotamine and caffeine combination drugs (Migergot) are less effective than triptans. Ergots seem to be most effective in those whose pain lasts for more than 72 hours.

    Ergotamine may cause worsened nausea and vomiting related to your migraines and other side effects, and it may also lead to medication overuse headaches.

    Dihydroergotamine (D.H.E. 45, Migranal) is an ergot derivative that is more effective and has fewer side effects than ergotamine. It's available as a nasal spray and in injection form. This medication may cause fewer side effects than ergotamine and is less likely to lead to medication-overuse headaches.

    Ergots, including dihydroergotamine, promote constriction of blood vessels and should be avoided if you have a history of heart disease or stroke.

  • Lasmiditan (Reyvow). This newer oral tablet is approved for the treatment of migraine with or without aura. It blocks pain pathways, similar to a triptan medication, but it does not appear to constrict blood vessels.
  • CGRP antagonists. Ubrogepant (Ubrelvy) and rimegepant (Nurtec ODT) are oral calcitonin gene-related peptide (CGRP) receptor antagonists approved for the treatment of acute migraine with or without aura in adults.
  • CGRP monoclonal antibodies. Erenumab-aooe (Aimovig), fremanezumab-vfrm (Ajovy), galcanezumab-gnlm (Emgality) and eptinezumab-jjmr (Vyepti) are newer drugs approved by the Food and Drug Administration to treat migraines. They're given monthly or quarterly by injection.
  • Anti-nausea medications. Because migraines are often accompanied by nausea, with or without vomiting, medication for nausea is appropriate and is usually combined with other medications. Frequently prescribed medications include chlorpromazine, metoclopramide (Reglan, Gimoti) and prochlorperazine (Compro, Procomp).
  • Glucocorticoids. A glucocorticoid such as dexamethasone (Hemady) may be used in conjunction with other medications to improve pain relief. Because of the risk of steroid toxicity, glucocorticoids shouldn't be used frequently.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.

Preparing for your appointment

You're likely to start by seeing your provider. You may be referred to a neurologist who specializes in headaches and migraines.

Here's some information to help you get ready for your appointment and to know what to expect from your provider.

What you can do

  • Be aware of pre-appointment restrictions. When you make the appointment, ask if there's anything you need to do in advance, such as restricting your diet.
  • Write down any symptoms you're experiencing, including any that may seem unrelated to the reason for which you scheduled the appointment.
  • Write down key personal information, including major stresses or recent life changes.
  • Make a list of all medications, vitamins and supplements you're taking.
  • Take a family member or friend along, if possible. Someone who accompanies you can help you remember what your provider tells you.
  • Write down questions to ask your provider.

Preparing questions will help you make the most of your time with your provider. For sinus headaches, some basic questions to ask include:

  • What is likely causing my symptoms or condition?
  • Are there other possible causes for my symptoms or condition?
  • What tests do I need?
  • Is my condition likely temporary or chronic?
  • What is the best course of action?
  • What are the alternatives to the primary approach you're suggesting?
  • I have these other health conditions. How can I best manage them together?
  • Are there any restrictions I need to follow?
  • Should I see a specialist?
  • Is there a generic alternative to the medicine you're prescribing?
  • Are there brochures or other printed materials I can take with me? What websites do you recommend?

Don't hesitate to ask any other questions you may have.

What to expect from your doctor

Your provider is likely to ask you questions, such as:

  • When did you first experience your headache, and what was it like?
  • Has your headache been continuous or occasional?
  • Has anyone in your immediate family had migraines?
  • What seems to improve your headaches?
  • What appears to worsen your headaches?

May 17, 2022

  1. Jayawardena ADL, et al. Headaches and facial pain in rhinology. American Journal of Rhinology & Allergy. 2018; doi:10.2500/ajra.2018.32.4501.
  2. Sinusitis. The Merck Manual Professional Version. https://www.merckmanuals.com/professional/ear,-nose,-and-throat-disorders/nose-and-paranasal-sinus-disorders/sinusitis?redirectid=737?ruleredirectid=30&qt=sinus%20headache&sc=&alt=sh . Accessed Feb. 27, 2022.
  3. Kaniecki R. Sinus, disabling tension-type, and temporomandibular joint headaches. Current Opinion in Neurology. 2021; doi:10.1097/WCO.0000000000000918.
  4. Sinus infection (sinusitis). Centers for Disease Control and Prevention. https://www.cdc.gov/antibiotic-use/sinus-infection.html. Accessed Feb. 27, 2022.
  5. Wootton RJ, et al. Evaluation of headache in adults. https://www.uptodate.com/contents/search. Accessed Feb. 27, 2022.
  6. Sinus headaches. American Academy of Otolaryngology — Head and Neck Surgery. https://www.enthealth.org/conditions/sinus-headaches/. Accessed Feb. 27, 2022.
  7. Headache information page. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/Disorders/All-Disorders/Headache-Information-Page. Accessed Feb. 27, 2022.
  8. Schwedt TJ, et al. Acute treatment of migraine in adults. https://www.uptodate.com/contents/search. Accessed Feb. 27, 2022.
  9. Schwedt TJ, et al. Preventive treatment of episodic migraine in adults. https://www.uptodate.com/contents/search. Accessed Feb. 27, 2022.
  10. Headache: Hope through research. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Hope-Through-Research/Headache-Hope-Through-Research. Feb. 27, 2022.
  11. Cutrer FM. Exercise (exertional) headache. https://www.uptodate.com/contents/search. Accessed Feb. 13, 2022.


Show the heart some love!

Help us advance cardiovascular medicine.