Diagnosis

To diagnose precocious puberty, the doctor will:

  • Review your child's and your family's medical history
  • Do a physical exam
  • Run blood tests to measure hormone levels

X-rays of your child's hand and wrist also are important for diagnosing precocious puberty. These X-rays can help the doctor determine your child's bone age, which shows if the bones are growing too quickly.

Determining the type of precocious puberty

Your child's doctor will also need to find out which type of precocious puberty your child has. To do so, he or she will perform a test called a gonadotropin-releasing hormone (GnRH) stimulation test.

In this test, the doctor will take a blood sample, and then give your child a shot containing the GnRH hormone. More blood samples are then taken over a certain period of time to check how hormones in your child's body react. In children with central precocious puberty, the GnRH hormone will cause other hormone levels to rise. In children with peripheral precocious puberty, other hormone levels stay the same.

Additional testing for central precocious puberty

  • Magnetic resonance imaging (MRI). A brain MRI is usually done for children who have central precocious puberty to see if any brain abnormalities are causing the early start of puberty.
  • Thyroid testing. The doctor may also test your child's thyroid if he or she shows any signs of slow thyroid function (hypothyroidism), such as fatigue, sluggishness, increased sensitivity to cold, constipation, a drop in school performance or pale, dry skin.

Additional testing for peripheral precocious puberty

Other tests also are necessary for children with peripheral precocious puberty to find the cause of their condition. For example, the doctor may run additional blood tests to check other hormone levels or, in girls, he or she may do an ultrasound to check for an ovarian cyst or tumor.

Treatment

The primary goal of treatment is to enable your child to grow to a normal adult height.

Treatment for precocious puberty depends on the cause. However, in some cases, there is no identifiable cause for precocious puberty. In this instance, your child may not need treatment depending on his or her age and how rapidly puberty is progressing. Your child's doctor may want to monitor your child for several months to see how he or she is developing.

Treating central precocious puberty

Most children with central precocious puberty, in which there's no underlying medical condition, can be effectively treated with medication. This treatment, called GnRH analogue therapy, usually includes a monthly injection of a medication, such as leuprolide acetate (Lupron Depot), or triptorelin (Trelstar, Triptodur Kit), which delays further development. Some newer formulations can be given at longer intervals.

The child continues to receive this medication until he or she reaches the normal age of puberty. On average, 16 months after he or she stops receiving the medication, the process of puberty begins again.

Another treatment option for central precocious puberty is a histrelin implant (Vantas), which lasts for up to a year. This treatment is effective for central precocious puberty without the pain and inconvenience of regular injections, but it does require a minor surgical procedure. The implant is placed under your child's skin through an incision in the inner area of the upper arm. After a year, the implant is removed and, if necessary, replaced with a new implant.

Treating an underlying medical condition

If another medical condition is causing your child's precocious puberty, treatment of that condition is necessary to stop the progress of puberty. For example, if a child has a tumor that's producing hormones and causing precocious puberty, puberty usually will stop when the tumor is surgically removed.

Coping and support

Children who begin puberty early may feel different from their peers. Although there are few studies on the emotional effects of precocious puberty, it's possible that feeling different can cause social and emotional problems, including early sexual experimenting. As a parent, you also may have trouble dealing with your child's early development.

If you, your child or other members of your family are having difficulty coping, seek counseling. Psychological counseling can help your family better understand and handle the emotions, issues and challenges that accompany precocious puberty. If you have questions or would like guidance on how to find a qualified counselor, talk with a member of your health care team.

Preparing for your appointment

You're likely to start by seeing your child's pediatrician or a family doctor. Or you may be referred immediately to a doctor who specializes in the treatment of hormone-related conditions in children (pediatric endocrinologist).

Here's some information to help you get ready for your appointment and know what to expect from your child's doctor.

What you can do

  • Be aware of any pre-appointment restrictions. When you make the appointment, ask if there's anything you need to do in advance, such as restrict your child's diet.
  • Write down your child's symptoms, including any that may seem unrelated to the reason for which you scheduled the appointment.
  • Write down key personal information, including any major stresses or recent life changes.
  • Make a list of all medications, vitamins or supplements that your child takes or that others in the home take — because your child may have had access to them.
  • Make a list of family members' heights, especially if any of them are short as adults.
  • Write down your family medical history, and note if any family members have had precocious puberty or endocrine problems.
  • Bring a copy of your child's growth curve record if you are visiting a new doctor who doesn't have access to your child's medical record.
  • Write down questions to ask your child's doctor.

List questions for your child's doctor to help make the most of your time together. For precocious puberty, some basic questions to ask your doctor include:

  • What is likely causing my child's symptoms or condition?
  • Are there other possible causes for my child's symptoms or condition?
  • What tests does my child need?
  • Is this condition likely temporary or chronic?
  • What's the best treatment?
  • When should treatment begin, and how long will it last?
  • What are the alternatives to the primary approach you're suggesting?
  • My child has other health conditions. How can we best manage them together?
  • Are there restrictions my child needs to follow?
  • Should my child see a specialist?
  • Is there a generic alternative to the medicine you're prescribing?
  • Are there brochures or other printed material I can take home? What websites do you recommend?

Don't hesitate to ask any other questions you have.

What to expect from your doctor

Your doctor is likely to ask you a number of questions about:

  • Your family medical history, in particular, family members' heights and any history of endocrine disorders or tumors
  • The age at which puberty began for siblings and parents
  • Family racial composition
April 05, 2019
References
  1. Kliegman RM, et al. Disorders of puberty. In: Nelson Textbook of Pediatrics. 20th ed. Philadelphia, Pa.: Elsevier; 2016. https://www.clinicalkey.com. Accessed March 7, 2019.
  2. Ferri FF. Precocious puberty. In: Ferri's Clinical Advisor 2019. Philadelphia, Pa.: Elsevier; 2019. https://www.clinicalkey.com. Accessed Feb. 20, 2019.
  3. AskMayoExpert. Precocious puberty. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2018.
  4. Zitelli BJ, et al. Pediatric endocrinology. In: Pediatric Physical Diagnosis. Philadelphia, Pa.: Elsevier; 2018. https://www.clinicalkey.com. Accessed March 7, 2019.
  5. Harrington J, et al. Definition, etiology, and evaluation of precocious puberty. https://www.uptodate.com/contents/search. Accessed March 7, 2019.
  6. Precocious puberty. Merck Manual Professional Version. http://www.merckmanuals.com/professional/pediatrics/endocrine-disorders-in-children/precocious-puberty. Accessed March 7, 2019.
  7. Harrington J, et al. Treatment of precocious puberty. https://www.uptodate.com/contents/search. Accessed March 7, 2019.
  8. Elsevier Point of Care. Clinical Overview: Precocious puberty. https://clinicalkey.com. Accessed March 7, 2019.