Tests and procedures used to diagnose pancreatic neuroendocrine tumors include:

  • Blood tests. Blood tests may reveal excess hormones or other signs of a pancreatic neuroendocrine tumor.
  • Urine tests. Analysis of your urine may reveal breakdown products that result when your body processes hormones.
  • Imaging tests. Imaging tests help your doctor look for abnormalities in your pancreas. Tests may include ultrasound, CT and MRI.

    Imaging might also be done with nuclear medicine tests, which involve injecting a radioactive tracer into your body. The tracer sticks to pancreatic neuroendocrine tumors so that they show clearly on the images, which may be created with positron emission tomography (PET) that's combined with CT or MRI.

  • Creating images of your pancreas from the inside of your body. During an endoscopic ultrasound, a thin tube with a camera on the tip is passed down your throat and into your stomach and small intestine. A special ultrasound tool is used to create pictures of your pancreas. Special tools can be passed through the tube to collect a tissue sample (biopsy).
  • Surgery to collect a sample of cells for testing. In some cases, your doctor may recommend minimally invasive surgery to obtain a tissue sample for testing (biopsy). During laparoscopy, the surgeon makes several small incisions in your abdomen, through which special tools and a tiny camera are inserted. The surgeon then looks for signs of cancer and may collect a tissue sample.
  • Collecting cells from other areas for testing. If cancer has spread to your liver, lymph nodes or other locations, a needle may be used to collect cells for analysis.


Advanced treatments add more options for treating pNETs.

Treatment for a pancreatic neuroendocrine tumor varies based on the types of cells involved in your cancer, the extent and characteristics of your cancer, your preferences, and your overall health.

Options may include:

  • Surgery. If the pancreatic neuroendocrine tumor is confined to the pancreas, treatment usually includes surgery. For cancers that occurs in the tail of the pancreas, surgery may involve removing the tail of the pancreas (distal pancreatectomy), leaving the head portion intact.

    Cancers that affect the head of the pancreas may require a Whipple procedure (pancreaticoduodenectomy), which involves removing the cancer and part or most of your pancreas.

  • Peptide receptor radionuclide therapy (PRRT). PRRT combines a drug that targets cancer cells with a small amount of a radioactive substance that's injected into a vein. The medication sticks to the pancreatic neuroendocrine tumor cells hiding in the body. Over days to weeks, the medication delivers radiation directly to the cancer cells, causing them to die.

    One PRRT, lutetium Lu 177 dotatate (Lutathera), is used to treat advanced cancers.

  • Targeted therapy. Targeted therapy uses medications that attack vulnerabilities in the cancer cells. Targeted therapy is used to treat certain advanced or recurrent pancreatic neuroendocrine tumors.
  • Radiofrequency ablation. Radiofrequency ablation involves applying energy waves to cancer cells, causing them to heat up and die.
  • Treatment for cancer that spreads to the liver. Pancreatic neuroendocrine tumors most often spread to the liver, and several treatments exist for this. Options include treatment to block blood flow to liver tumors (hepatic artery occlusion), treatment to deliver chemotherapy directly to the liver (chemoembolization), treatment to deliver radiation directly to the liver (radioembolization) and liver transplant.
  • Chemotherapy. In certain situations, your doctor may recommend chemotherapy. This drug treatment uses chemicals to kill cancer cells.

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Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.

Coping and support

With time, you'll find what helps you cope with the uncertainty and distress of a cancer diagnosis. Until then, you may find that it helps to:

  • Learn enough about cancer to make decisions about your care. Ask your doctor about your cancer, including your test results, treatment options and, if you like, your prognosis. As you learn more about cancer, you may become more confident in making treatment decisions.
  • Keep friends and family close. Keeping your close relationships strong will help you deal with your cancer. Friends and family can provide the practical support you'll need, such as helping take care of your home if you're in the hospital. And they can serve as emotional support when you feel overwhelmed by cancer.
  • Find someone to talk with. Find a good listener who is willing to hear you talk about your hopes and fears. This may be a friend or family member. The concern and understanding of a counselor, medical social worker, clergy member or cancer support group also may be helpful.

    Ask your doctor about support groups in your area. Other sources of information include the National Cancer Institute and the American Cancer Society.

Preparing for your appointment

Make an appointment with your doctor if you have any signs or symptoms that worry you. If your doctor suspects that you might have cancer, he or she may refer you to a specialist.

Here's some information to help you get ready for your appointment.

What you can do

When you make the appointment, ask if there's anything you need to do in advance, such as fasting before having a specific test.

Gather the medical records that pertain to your condition and bring them to your appointment. If you're seeing a new doctor, ask your previous doctor to forward files and other information, such as glass slides that contain tissue samples, to your new doctor.

Make a list of:

  • Your symptoms, including any that seem unrelated to the reason for your appointment
  • Key personal information, including major stresses, recent life changes and family medical history
  • All medications, vitamins or other supplements you take, including the doses
  • Questions to ask your doctor

Consider bringing a family member or friend to help you remember the information you're given.

For pancreatic neuroendocrine tumor, some basic questions to ask your doctor include:

  • What's likely causing my symptoms?
  • Other than the most likely cause, what are other possible causes for my symptoms?
  • What tests do I need?
  • What's the best course of action?
  • What are the alternatives to the primary approach you're suggesting?
  • What will happen if I don't have surgery or other medical treatments for my condition?
  • I have other health conditions. How can I best manage them together?
  • Are there restrictions I need to follow?
  • Should I see a specialist?
  • Are there brochures or other printed material I can have? What websites do you recommend?

Don't hesitate to ask other questions.

What to expect from your doctor

Your doctor is likely to ask you several questions, such as:

  • When did your symptoms begin?
  • Have your symptoms been continuous or occasional?
  • How severe are your symptoms?
  • What, if anything, seems to improve your symptoms?
  • What, if anything, appears to worsen your symptoms?
  • What else should I know about you that will help me make the right recommendations about your care?

Pancreatic neuroendocrine tumors care at Mayo Clinic

June 05, 2021
  1. Niederhuber JE, et al., eds. Cancer of the endocrine system. In: Abeloff's Clinical Oncology. 6th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed April 24, 2019.
  2. Neuroendocrine and adrenal tumors. National Comprehensive Cancer Network. https://www.nccn.org/professionals/physician_gls/default.aspx. Accessed Dec. 13, 2018.
  3. Pancreatic neuroendocrine tumors (islet cell tumors) treatment (PDQ) — Health professional version. National Cancer Institute. https://www.cancer.gov/types/pancreatic/hp/pnet-treatment-pdq. Accessed April 24, 2019.
  4. Goldman L, et al., eds. Pancreatic neuroendocrine tumors. In: Goldman-Cecil Medicine. 25th ed. Saunders Elsevier; 2016. https://www.clinicalkey.com. Accessed Dec. 13, 2018.
  5. Fact sheet: What is peptide receptor radionuclide therapy (PRRT)? Society of Nuclear Medicine and Molecular Imaging. http://www.snmmi.org/AboutSNMMI/Content.aspx?ItemNumber=29883. Accessed April 9, 2019.
  6. NPF pancreatic cancer centers. National Pancreas Foundation. https://pancreasfoundation.org/npf-centers-info/pancreatic-cancer-centers/. Accessed June 28, 2019.
  7. Warner KJ. Allscripts EPSi. Mayo Clinic. Sept. 23, 2019.
  8. About NCCN. National Comprehensive Cancer Network. https://www.nccn.org/about/default.aspx. Accessed Sept. 24, 2019.
  9. Panda A, et al. Molecular radionuclide imaging of pancreatic neoplasms. The Lancet Gastroenterology & Hepatology. 2019; doi:10.1016/S2468-1253(19)30081-0.
  10. Kendi AT, et al. Therapy with 177Lu-DOTATE: Clinical implication and impact on care of patients with neuroendocrine tumors. American Journal of Roentgenology. 2019; doi:10.2214/AJR.19.21123.
  11. Strosberg J, et al. Phase 3 trial of 177Lu-Dotate for midgut neuroendocrine tumors. The New England Journal of Medicine. 2017; doi:10.1056/NEJMoa1607427.


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