To diagnose myoclonus, your doctor will review your medical history and symptoms and conduct a physical examination.
To determine the cause of myoclonus and rule out other potential causes of your condition, your doctor may recommend several tests, including:
This procedure records the electrical activity of your brain and may help determine where in your brain the myoclonus originates. In this procedure, doctors attach small electrodes to your scalp. You may be asked to breathe deeply and steadily and look at bright lights or listen to sounds, as these actions may uncover abnormal electrical activity.
In this procedure, doctors put EMG surface electrodes on multiple muscles, especially on those muscles that are involved in the jerking.
An instrument records the electrical activity from your muscle at rest and as you contract the muscle, such as by bending your arm. These signals help determine the pattern and origin of the myoclonus.
Evoked potential studies
These tests measure the electrical activity of the brain, brainstem and spinal cord that is triggered by touch, sound, sight and other stimuli.
Magnetic resonance imaging (MRI)
An MRI scan may be used to check for structural problems or tumors inside your brain or spinal cord, which may cause your myoclonus symptoms. An MRI scan uses a magnetic field and radio waves to produce detailed images of your brain, spinal cord and other areas of your body.
Your doctor may suggest genetic testing to help identify possible causes of myoclonus. He or she may also test your blood or urine to check for:
- Metabolic disorders
- Autoimmune disease
- Kidney or liver disease
- Drugs or toxins
Treatment of myoclonus is most effective when a reversible underlying cause can be found that can be treated — such as another condition, a medication or a toxin.
Most of the time, however, the underlying cause can't be cured or eliminated, so treatment is aimed at easing myoclonus symptoms, especially when they're disabling. There are no drugs specifically designed to treat myoclonus, but doctors have borrowed from other disease treatment arsenals to relieve myoclonic symptoms. More than one drug may be needed to control your symptoms.
Medications that doctors commonly prescribe for myoclonus include:
- Tranquilizers. Clonazepam (Klonopin), a tranquilizer, is the most common drug used to combat myoclonus symptoms. Clonazepam may cause side effects such as loss of coordination and drowsiness.
Anticonvulsants. Drugs used to control epileptic seizures have proved helpful in reducing myoclonus symptoms. The most common anticonvulsants used for myoclonus are levetiracetam (Keppra, Elepsia XR, Spritam), valproic acid, zonisamide (Zonegran) and primidone (Mysoline). Piracetam is another anticonvulsant that's been found to be effective, but it's not available in the United States.
Valproic acid may cause side effects such as nausea. Levetiracetam may cause side effects such as fatigue and dizziness. Side effects from primidone may include sedation and nausea.
OnabotulinumtoxinA (Botox) injections may be helpful in treating various forms of myoclonus, particularly if only a single area is affected. Botulinum toxins block the release of a chemical messenger that triggers muscle contractions.
If your myoclonus symptoms are caused by a tumor or lesion in your brain or spinal cord, surgery may be an option. People with myoclonus affecting parts of the face or ear also may benefit from surgery.
Deep brain stimulation (DBS) has been tried in some people with myoclonus and other movement disorders. Researchers continue to study DBS for myoclonus.
Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.
Preparing for your appointment
You'll probably first discuss your concerns with your primary care doctor, who may then refer you to a doctor trained in nervous system conditions (neurologist).
Because appointments can be brief, and because there's often a lot to talk about, it's a good idea to arrive well prepared for your appointment. Here's some information to help you get ready for your appointment, and what to expect from your doctor.
What you can do
- Be aware of any pre-appointment restrictions, and ask if there's anything you need to do in advance.
- Write down a list of your symptoms, noting if there's anything that seems to trigger them or make them better.
- Take a list of all your medications, including any vitamins or supplements.
- Write down questions to ask your doctor, asking about possible causes, treatments and prognosis.
Your time with your doctor is limited, so preparing a list of questions ahead of time will help you make the most of your time together. For myoclonus, some basic questions to ask your doctor include:
- What's the most likely cause of my symptoms?
- Other than the most likely cause, what are other possible causes for my symptoms?
- What kinds of tests do I need?
- Is my condition likely temporary or chronic?
- What is the best course of action?
- What are the alternatives to the primary approach that you're suggesting?
- I have these other health conditions. How can I best manage them together?
- Are there any restrictions that I need to follow?
- Are there any brochures or other printed material that I can take home with me? What websites do you recommend visiting?
In addition to the questions that you've prepared to ask your doctor, don't hesitate to ask questions during your appointment at any time that you don't understand something.
What to expect from your doctor
Your doctor is likely to ask you a number of questions. Being ready to answer them may reserve time to go over any points you want to spend more time on. Your doctor may ask:
- When did you first start having symptoms?
- Do you have a history of seizures or other neurological conditions?
- Have you been exposed to drugs or chemicals?
- Do you have a family history of myoclonus or epilepsy?
- Have your symptoms been continuous or occasional?
- How severe are your symptoms?
- Does anything improve your symptoms?
- What, if anything, appears to worsen your symptoms?
Dec. 18, 2020