There's no specific test to diagnose MALS. Your doctor will carefully examine you and ask questions about your symptoms and health history. The physical exam is often normal in people with MALS. Bloodwork and imaging tests help your doctor rule out other causes of stomach pain.

Tests used to rule out other conditions and diagnose MALS may include:

  • Blood tests. Comprehensive blood tests are done to check for problems with your liver, pancreas, kidneys and other parts of the body. A complete blood cell count shows your level of white and red blood cells. A high white blood cell count can mean you have an infection.
  • Ultrasound of your abdomen. This noninvasive test uses high-frequency sound waves to determine how blood is flowing through your blood vessels. It can show if the celiac artery is compressed, especially when breathing in and out deeply.
  • Upper endoscopy. This procedure, also called esophagogastroduodenoscopy (EGD), is done to view the esophagus, stomach and upper part of the small intestine (duodenum). During an EGD, the doctor gently guides a long, flexible tube with a camera on the end (endoscope) down your throat after numbing medication is applied. If needed, the doctor can take tissue samples (biopsy) during this procedure.
  • Gastric emptying studies. Compression of the celiac artery can slow the rate of stomach emptying. Gastric emptying studies are done to determine how fast your stomach empties its contents. Slow or delayed gastric emptying may be from other medical conditions.
  • Magnetic resonance imaging (MRI). An MRI uses powerful magnets and radio waves to produce detailed images of the body area being studied. Sometimes, dye is injected into a blood vessel to more clearly show how blood moves through your arteries and veins (magnetic resonance angiogram).
  • Computerized tomography (CT) of the abdomen. CT uses X-rays to create 3D images of the body area examined. An abdominal CT scan can show if the celiac artery is narrowed or blocked. If the diagnosis is still unclear after other imaging tests are done, your doctor may inject a dye into a blood vessel to highlight blood flow in your arteries and veins (CT angiogram).


Surgery is the only treatment option for MALS. The most common procedure is called median arcuate ligament release, or median arcuate ligament decompression. It's usually done as an open surgery but sometimes can be done as a minimally invasive (laparoscopic or robotic) procedure.

While you're under general anesthesia, a surgeon divides the median arcuate ligament and network of nerves in the stomach area (celiac plexus). Doing so provides more room for the artery, restores blood flow and relieves pressure on the nerves.

Some people with MALS may need an open surgery to repair or replace a blocked celiac artery and fully restore blood flow (revascularization).

If you have MALS release surgery, you'll usually stay in the hospital for two to three days. You'll need an ultrasound about a month after surgery to confirm that blood flow through the celiac artery is fully restored. Several studies have shown that surgery to release the median arcuate ligament is safe, even in children with MALS. It often results in immediate pain relief and improves the person's quality of life.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.

Lifestyle and home remedies

Pain and stress often occur in a cycle. Pain can make you feel stressed, and stress can make pain worse. MALS pain may make it difficult to eat, exercise, sleep and do everyday tasks. Relaxation techniques, such as deep breathing and meditation, may ease pain and boost your mental health.

Coping and support

Living with MALS may make you feel sad, anxious or depressed. The challenge of getting an accurate diagnosis — and having so many medical tests — may be overwhelming. Sharing your thoughts and feelings with others who have similar experiences may be helpful. A support group can provide emotional support and help you learn about new coping skills. The National MALS Foundation provides information and connections for people with median arcuate ligament syndrome. Or, ask your doctor, clinic or hospital if they can recommend a support group in your area.

Preparing for your appointment

If you think you have stomach pain that doesn't go away, or think you may have median arcuate ligament syndrome, it's important that you make an appointment with your doctor. If median arcuate ligament syndrome is found early, treatment may be more effective.

A doctor's appointment can be brief, and there is often a lot to discuss. So it's a good idea to be properly prepared for your appointment. Writing down your list of questions or concerns is one of many steps you can take to get ready for your doctor's visit.

What you can do

  • Be aware of any pre-appointment restrictions. When you make the appointment, be sure to ask if there's anything you need to do in advance, such as not drinking or eating anything for a few hours. You may need to do this if your doctor orders blood or imaging tests.
  • Write down all your symptoms, including any that may seem unrelated to median arcuate ligament syndrome.
  • Write down key personal information, including any family history of heart disease, stroke, high blood pressure, blood clots, and any major stresses or recent life changes.
  • Make a list of all medications, vitamins or supplements that you're taking.
  • Bring a family member or friend with you, if possible. Sometimes it can be difficult to understand and remember all the information received during an appointment. The person who goes with you may remember something that you missed or forgot.
  • Write down questions to ask your doctor.

List your questions from most to least important, in case time runs out. For median arcuate ligament syndrome, some basic questions to ask your doctor include:

  • What is likely causing my symptoms or condition?
  • What are other possible causes for my symptoms or condition?
  • What kinds of tests will I need?
  • What's the most appropriate treatment?
  • What's an appropriate level of physical activity?
  • What are the alternatives to the primary approach that you're suggesting?
  • I have other health conditions. How can I best manage them together?
  • Are there any restrictions that I need to follow?
  • Are there any brochures or other printed material that I can take home with me? What websites do you recommend visiting?

Don't hesitate to ask your doctor additional questions during your appointment.

What to expect from your doctor

Your doctor is likely to ask you a number of questions. Being ready to answer them may save time to go over any concerns you want to spend more time on. Your doctor may ask:

  • When did you first start having symptoms?
  • Do you always have symptoms or do they come and go?
  • How severe is your pain?
  • What, if anything, seems to make your symptoms better?
  • What, if anything, makes your symptoms worse?

Median arcuate ligament syndrome (MALS) care at Mayo Clinic

Dec. 04, 2020
  1. AskMayoExpert. Median arcuate ligament syndrome. Mayo Clinic; 2020.
  2. Goodall R, et al. Median arcuate ligament syndrome. Journal of Vascular Surgery. 2020; doi:10.1016/j.jvs.2019.11.012.
  3. Kim EN, et al. Median arcuate ligament syndrome-review of this rare disease. JAMA Surgery. 2016; doi:10.1001/jamasurg.2016.0002.
  4. De'Ah HD, et al. The laparoscopic management of median arcuate ligament syndrome and its long-term outcomes. Journal of Laparoendoscopic & Advanced Surgical Techniques. 2018; doi:10.1089/lap.2018.0204.
  5. Joyce DD, et al. Pediatric median arcuate ligament syndrome: Surgical outcomes and quality of life. Journal of Laparoendoscopic & Advanced Surgical Techniques. 2014; doi:10.1089/lap.2013.0438.
  6. Sidawy AN, et al., eds. Median arcuate ligament syndrome: Pathophysiology, diagnosis, and management. In: Rutherford's Vascular Surgery and Endovascular Therapy. 9th ed. Elsevier; 2019. https://www.clinicalkey.com. Accessed Nov. 13, 2020.
  7. Celiac artery compression. Genetic and Rare Diseases Information Center (GARD). https://rarediseases.info.nih.gov/diseases/12308/celiac-artery-compression-syndrome. Accessed Nov. 12, 2020.
  8. Cienfuegos JA, et al. Laparoscopic treatment of median arcuate ligament syndrome: Analysis of long-term outcomes and predictive factors. Journal of Gastrointestinal Surgery. 2018; doi:10.1007/s11605-017-3635-3.
  9. Oderich GS, ed. Duplex ultrasound for evaluation and surveillance of fenestrated, branched, and parallel stent-grafts. In: Endovascular Aortic Repair: Current Techniques With Fenestrated Branched and Parallel Stent-Grafts. Springer; 2017.
  10. Moore WS, et al., eds. Diagnosis and surgical management of the visceral ischemic syndromes. In: Vascular and Endovascular Surgery: A Comprehensive Review. 9th ed. Elsevier; 2019.
  11. DeMartino RR (expert opinion). Mayo Clinic. Oct. 30, 2020.
  12. Scovell S, et al. Celiac artery compression syndrome. https://www.uptodate.com/contents/search. Accessed Nov. 30, 2020.