Hepatocellular carcinoma care at Mayo Clinic
The doctors at Mayo Clinic Comprehensive Cancer Center provide excellent care for people with hepatocellular carcinoma. Mayo Clinic Comprehensive Cancer Center is the only National Cancer Institute-designated comprehensive cancer center with three locations in Arizona, Florida and Minnesota.
Your Mayo Clinic care team
At Mayo Clinic, experts work in teams that bring together doctors from different specialties. Hepatocellular carcinoma care teams might include specialists in oncology, hepatology, surgery, radiology, pathology, radiation oncology, transplant and other specialties. Other professionals are included as needed.
Mayo Clinic offers an integrated clinical practice across its campuses in Arizona, Florida and Minnesota. Each campus offers the latest treatments for hepatocellular carcinoma.
Expertise in liver cancer surgery
The highly experienced team of surgical oncologists at Mayo Clinic uses advanced techniques such as robotic liver surgery to treat liver cancer. Advanced robotic surgery platforms offer unmatched visualization and surgical precision to help deliver optimal outcomes for complex procedures.
The volume of surgeries performed each year, combined with strong patient outcomes, reflects Mayo Clinic's deep expertise and commitment to excellence. Our team offers hope through surgical treatment options for those who have been told their cancer is inoperable.
For those whose liver cancer progresses to the point where a transplant becomes necessary, Mayo Clinic offers leading-edge liver transplant services through the Liver Transplant Program. With high transplant volumes and consistently excellent outcomes, we provide expert, compassionate care at every stage — from transplant evaluation through recovery.
Making liver surgery safer
Surgery to remove part of the liver can be lifesaving for people with liver cancer, but this procedure carries significant risks and needs careful planning. One major challenge is predicting how well the remaining liver will work after surgery. If the remaining liver doesn't work well enough, it could lead to liver failure. Mayo Clinic doctors and researchers have led pioneering studies that have shaped how healthcare professionals decide who is likely to do well after liver cancer surgery.
Mayo Clinic researchers, working with international partners, developed a better way to assess the risk of complications using simple blood tests that are widely available. Researchers also contributed to the development of a smartphone app that lets liver surgeons easily evaluate a patient's risk of liver failure after surgery. Mayo Clinic researchers continue to study new biomarkers to further improve risk assessment and make surgery safer for people with liver cancer.
Advanced diagnosis and treatment
Our specialists use advanced diagnostics to evaluate your tumor and your genetics and provide treatment options that will work best for you.
Mayo Clinic offers all the treatment options for hepatocellular carcinoma. This includes treatments that may only be available in clinical trials and those that aren't available at all medical centers, such as hepatic artery infusion pump (HAIP) chemotherapy.
The range of treatments offered to people with hepatocellular carcinoma includes surgery, such as liver transplant, and ablative therapies, such as radiofrequency ablation and cryoablation. Other treatments include radiation therapy, targeted therapy and immunotherapy.
The Mayo Clinic experience and patient stories
Our patients tell us that the quality of their interactions, our attention to detail and the efficiency of their visits mean health care like they've never experienced. See the stories of satisfied Mayo Clinic patients.
Expertise and rankings
Mayo Clinic doctors have the experience and resources to provide expert, comprehensive care to those with hepatocellular carcinoma. At Mayo Clinic, you can expect:
- Personalized care. At Mayo Clinic, experts in oncology, hepatology, surgery, radiology, pathology and transplant work as a multidisciplinary team to create a personalized treatment plan designed to meet all of your needs. Other professionals are included as needed.
- Experience you can trust. Mayo Clinic doctors have extensive experience caring for people with hepatocellular carcinoma and other, rarer types of liver cancer. Each year, Mayo Clinic doctors care for more than 2,000 people with primary liver cancer.
- Nationally recognized expertise. Mayo Clinic Comprehensive Cancer Center meets the strict standards for a National Cancer Institute-designated comprehensive cancer center. These standards recognize scientific excellence and a multispecialty approach focused on cancer prevention, diagnosis and treatment.
Mayo Clinic in Rochester, Minnesota, Mayo Clinic in Jacksonville, Florida, and Mayo Clinic in Phoenix/Scottsdale, Arizona, are ranked among the Best Hospitals for cancer by U.S. News & World Report. Mayo Clinic in Rochester, Minnesota, is ranked as the top hospital in Minnesota and Mayo Clinic in Phoenix/Scottsdale, Arizona, is ranked as the top hospital in Arizona.
Sept. 11, 2025