Overview

The prothrombin time, sometimes referred to as PT or pro time test, is a test to evaluate blood clotting.

Prothrombin is a protein produced by your liver. It is one of many factors in your blood that help it to clot appropriately.

Why it's done

Most often, the prothrombin time is monitored if you are taking the blood-thinning medication warfarin. In this situation, the prothrombin time is expressed as an international normalized ratio (INR).

Your doctor may recommend a prothrombin time test prior to surgery if there is any concern about your blood's ability to clot.

The prothrombin time test may also be performed to evaluate you for liver disease. It is one of several tests used to screen people waiting for liver transplants. That screening — known as the model for end-stage liver disease (MELD) — is a scoring system for assessing the severity of chronic liver disease.

If your doctor suspects you have other health issues, such as liver problems or a bleeding disorder, you might need additional testing to confirm your condition.

Risks

A prothrombin time test is similar to any other blood test. You might experience soreness or minor bruising at the site in the arm where your blood is drawn.

What you can expect

During the test

Obtaining the blood sample for prothrombin time testing usually takes just a few minutes, like any other blood test.

After the test

Your blood might be sent to a laboratory for analysis. If the laboratory analysis is done on-site, you could have your test results within hours. If your doctor sends your blood to an off-site laboratory, it may take several days to receive the results.

In some anticoagulation clinics, a nurse will take a sample of your blood with a finger stick, and give you the test result within minutes, while you are still in the exam room.

Home testing

Home testing kits are available for people who have to take blood thinners for long periods and who have been trained in taking blood samples and testing them.

Results

Prothrombin time test results can be presented in two ways.

In seconds

The average time range for blood to clot is about 10 to 13 seconds. A number higher than that range means it takes blood longer than usual to clot. A number lower than that range means blood clots more quickly than normal.

As INR

This ratio — which allows for easier comparisons of test results from different laboratories — is used if you take blood-thinning medications.

In healthy people an INR of 1.1 or below is considered normal. An INR range of 2.0 to 3.0 is generally an effective therapeutic range for people taking warfarin for disorders such as atrial fibrillation or a blood clot in the leg or lung. In certain situations, such as having a mechanical heart valve, you might need a slightly higher INR.

When the INR is higher than the recommended range, it means that your blood clots more slowly than desired, and a lower INR means your blood clots more quickly than desired.

What your results mean

Clotting too slowly

Blood that clots too slowly can be caused by:

  • Blood-thinning medications
  • Liver problems
  • Inadequate levels of proteins that cause blood to clot
  • Vitamin K deficiency
  • Other substances in your blood that hinder the work of clotting factors

Clotting too fast

Blood that clots too quickly can be caused by:

  • Supplements that contain vitamin K
  • High intake of foods that contain vitamin K, such as liver, broccoli, chickpeas, green tea, kale, turnip greens and products that contain soybeans
  • Estrogen-containing medications, such as birth control pills and hormone replacement therapy
Dec. 08, 2020
  1. Prothrombin time and international normalized ratio (PT/INR). Lab Tests Online. https://labtestsonline.org/tests/prothrombin-time-and-international-normalized-ratio-ptinr. Accessed Oct. 19, 2020.
  2. Feldman M, et al., eds. Liver chemistry and function tests. In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 11th ed. Elsevier; 2021.https://www.clinicalkey.com. Accessed Oct. 15, 2020.
  3. Gropper MA. Patient blood management: Coagulation. In: Miller's Anesthesia. 9th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed Oct. 15, 2020.
  4. Mayo Clinic Laboratories. Prothrombin time (PT). https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/602171. Accessed Oct. 16, 2020.
  5. Excessive bleeding. Merck Manual Professional Version. https://www.merckmanuals.com/professional/hematology-and-oncology/hemostasis/excessive-bleeding#. Accessed Oct. 16, 2020.

Prothrombin time test