Diagnosis

Tests and procedures used to diagnose floor of the mouth cancer may include:

  • Thorough physical examination. The process starts with a physical exam and a discussion of your symptoms and medical history.
  • Removing a sample of tissue for testing (biopsy). Your doctor may remove a sample of suspicious cells from the floor of your mouth using a scalpel. Then your doctor sends the sample to a laboratory where experts analyze the cells to determine whether they're cancerous.
  • Imaging tests. Imaging tests help your doctor determine the extent of your cancer and whether it may have spread. Tests may include a CT, MRI and positron emission tomography (PET). Which tests you undergo depend on your particular situation.
  • Nutrition, speech and swallowing evaluations. Some people may need to meet with specialists in nutrition, speech and swallowing to determine next steps.

Treatment

Treatments for floor of the mouth cancer include:

  • Surgery. The type of surgery used to treat floor of the mouth cancer depends on the size, type, location and depth of the tumor spread. If the tumor has spread beyond the floor of the mouth, nearby lymph nodes may need to be removed and examined to determine how far the cancer has spread.
  • Radiation therapy. Radiation therapy uses beams of intense energy, such as X-rays and protons, to kill cancer cells. Radiation may be used alone to treat small floor of the mouth cancers or it may be used after surgery to kill any cancer cells that might remain.
  • Chemotherapy. Chemotherapy uses drugs to destroy cancer cells. For people with floor of the mouth cancer, chemotherapy is often used after surgery to kill any cancer cells that might remain. Sometimes it's combined with radiation therapy.
  • Photodynamic therapy. In this therapy, your doctor will use a medication to make the cancer cells vulnerable to high-intensity light energy, such as from lasers. After the medication has been absorbed by the target tissue, your doctor will expose the cancer cells to a specific wavelength and energy of light that activates the drug and destroys the cancerous or precancerous cells.
  • Reconstructive surgery. Depending on the size, location and spread of the cancer, some people may need reconstructive surgery to restore mouth function.
  • Rehabilitation. Rehabilitation specialists in speech therapy, swallowing therapy, dietetics, physical therapy and occupational therapy help with rehabilitation that may be necessary after surgery or radiation therapy.
  • Palliative care. Palliative care is specialized medical care that focuses on providing relief from pain and other symptoms of a serious illness. Palliative care specialists work with you, your family and your other doctors to provide an extra layer of support that complements your ongoing care.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this disease.

Coping and support

A cancer diagnosis can be overwhelming and frightening. You can help yourself feel more in control by taking an active role in your health care. To help you cope, try to:

  • Learn enough about cancer to make decisions about your care. Ask your doctor about your cancer, including the extent of your cancer, your treatment options and, if you like, your prognosis. As you learn more about cancer, you may become more confident in making treatment decisions.
  • Keep friends and family close. Keeping your close relationships strong will help you deal with your cancer. Friends and family can provide the practical support you'll need, such as helping take care of your home if you're in the hospital. And they can serve as emotional support when you feel overwhelmed by cancer.
  • Find someone to talk with. Find a good listener with whom you can talk about your hopes and fears. This may be a friend or family member. The concern and understanding of a counselor, medical social worker, clergy member or cancer support group also may be helpful.

    Ask your doctor about support groups in your area or contact cancer organizations, such as the National Cancer Institute or the American Cancer Society.

Preparing for your appointment

Make an appointment with your doctor or dentist if you have any signs or symptoms that worry you.

If your doctor or dentist feels you may have mouth cancer, you may be referred to a doctor who specializes in diseases of the face, mouth, teeth, jaws, salivary glands and neck (oral and maxillofacial surgeon) or to a doctor who specializes in diseases that affect the ears, nose and throat (ENT specialist or otorhinolaryngologist).

Because appointments can be brief, and because there's often a lot of ground to cover, it's a good idea to be well prepared. Here's some information to help you get ready.

What you can do

  • Be aware of any pre-appointment restrictions. At the time you make the appointment, be sure to ask if there's anything you need to do in advance, such as restrict your diet.
  • Write down symptoms you're experiencing, including any that may seem unrelated to the reason for which you scheduled the appointment.
  • Write down key personal information, including major stresses or recent life changes.
  • Make a list of all medications, vitamins or supplements you're taking.
  • Take a family member or friend along. Sometimes it can be difficult to remember all the information provided during an appointment. Someone who accompanies you may remember something that you missed or forgot.
  • Write down questions to ask your doctor.

Your time with your doctor is limited, so preparing a list of questions can help you make the most of your time together. List your questions from most important to least important in case time runs out. For floor of the mouth cancer, some basic questions to ask your doctor include:

  • What is the stage of my cancer?
  • What other tests do I need?
  • What are my treatment options?
  • Is there one treatment that's best for my type and stage of cancer?
  • What are the potential side effects for each treatment?
  • Should I seek a second opinion? Can you give me the names of specialists you recommend?
  • Am I eligible for clinical trials?
  • Are there brochures or other printed material that I can take with me? What websites do you recommend?
  • What will determine whether I should plan for a follow-up visit?

What to expect from your doctor

Your doctor is likely to ask you a number of questions. Being ready to answer them may allow time later to cover points you want to address. Your doctor may ask:

  • When did you begin experiencing symptoms?
  • Have your symptoms been continuous or occasional?
  • How severe are your symptoms?
  • What, if anything, seems to improve your symptoms?
  • What, if anything, appears to worsen your symptoms?

Floor of the mouth cancer care at Mayo Clinic

Aug. 22, 2019
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  2. Flint PW, et al. Malignant neoplasms of the oral cavity. In: Cummings Otolaryngology: Head & Neck Surgery. 6th ed. Philadelphia, Pa.: Saunders Elsevier; 2015. https://www.clinicalkey.com. Accessed June 2, 2019.
  3. Head and neck cancers. Plymouth Meeting, Pa.: National Comprehensive Cancer Network. https://www.nccn.org/professionals/physician_gls/default.aspx. Accessed April 1, 2019.
  4. Warner KJ. Allscripts EPSi. Mayo Clinic, Rochester, Minn. May 3, 2019.
  5. Fonseca RJ, ed. Squamous cell carcinoma of the oral and maxillofacial region. In: Oral and Maxillofacial Surgery. 3rd ed. St. Louis, Mo.: Elsevier; 2018. https://www.clinicalkey.com. Accessed July 14, 2019.
  6. Oral cavity, pharyngeal, and laryngeal cancer prevention (PDQ) — Health professional version. National Cancer Institute. https://www.cancer.gov/types/head-and-neck/hp/oral-prevention-pdq. Accessed July 14, 2019.
  7. 2015–2020 Dietary Guidelines for Americans. U.S. Department of Health and Human Services and U.S. Department of Agriculture. https://health.gov/dietaryguidelines/2015/guidelines. Accessed Aug. 5, 2019.

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