Overview

Deep vein thrombosis (DVT) occurs when a blood clot (thrombus) forms in one or more of the deep veins in your body, usually in your legs. Deep vein thrombosis can cause leg pain or swelling but also can occur with no symptoms.

You can get DVT if you have certain medical conditions that affect how your blood clots. A blood clot in your legs can also happen if you don't move for a long time, such as after you have surgery or an accident, when you're traveling a long distance, or when you're on bed rest.

Deep vein thrombosis can be very serious because blood clots in your veins can break loose, travel through your bloodstream and get stuck in your lungs, blocking blood flow (pulmonary embolism). However, pulmonary embolism can occur with no evidence of DVT.

When DVT and pulmonary embolism occur together, it's called venous thromboembolism (VTE).

Symptoms

DVT signs and symptoms can include:

  • Swelling in the affected leg. Rarely, there's swelling in both legs.
  • Pain in your leg. The pain often starts in your calf and can feel like cramping or soreness.
  • Red or discolored skin on the leg.
  • A feeling of warmth in the affected leg.

Deep vein thrombosis can occur without noticeable symptoms.

When to see a doctor

If you develop signs or symptoms of DVT, contact your doctor.

If you develop signs or symptoms of a pulmonary embolism (PE) — a life-threatening complication of deep vein thrombosis — seek emergency medical help.

The warning signs and symptoms of a pulmonary embolism include:

  • Sudden shortness of breath
  • Chest pain or discomfort that worsens when you take a deep breath or when you cough
  • Feeling lightheaded or dizzy, or fainting
  • Rapid pulse
  • Rapid breathing
  • Coughing up blood

Causes

Anything that prevents your blood from flowing or clotting normally can cause a blood clot.

The main causes of DVT are damage to a vein from surgery or trauma and inflammation due to infection or injury.

Risk factors

Many things can increase your risk of developing DVT. The more risk factors you have, the greater your risk of DVT. Risk factors for DVT include:

  • Age. Being older than 60 increases your risk of DVT, though it can occur at any age.
  • Sitting for long periods of time, such as when driving or flying. When your legs remain still for hours, your calf muscles don't contract. Muscle contractions normally help blood circulate.
  • Prolonged bed rest, such as during a long hospital stay, or paralysis. Blood clots can form in the calves of your legs if your calf muscles don't move for long periods.
  • Injury or surgery. Injury to your veins or surgery can increase the risk of blood clots.
  • Pregnancy. Pregnancy increases the pressure in the veins in your pelvis and legs. Women with an inherited clotting disorder are especially at risk. The risk of blood clots from pregnancy can continue for up to six weeks after you have your baby.
  • Birth control pills (oral contraceptives) or hormone replacement therapy. Both can increase your blood's ability to clot.
  • Being overweight or obese. Being overweight increases the pressure in the veins in your pelvis and legs.
  • Smoking. Smoking affects blood clotting and circulation, which can increase your risk of DVT.
  • Cancer. Some forms of cancer increase substances in your blood that cause your blood to clot. Some forms of cancer treatment also increase the risk of blood clots.
  • Heart failure. This increases your risk of DVT and pulmonary embolism. Because people with heart failure have limited heart and lung function, the symptoms caused by even a small pulmonary embolism are more noticeable.
  • Inflammatory bowel disease. Bowel diseases, such as Crohn's disease or ulcerative colitis, increase the risk of DVT.
  • A personal or family history of DVT or PE. If you or someone in your family has had one or both of these, you might be at greater risk of developing DVT.
  • Genetics. Some people inherit genetic risk factors or disorders, such as factor V Leiden, that make their blood clot more easily. An inherited disorder on its own might not cause blood clots unless combined with one or more other risk factors.
  • No known risk factor. Sometimes, a blood clot in a vein can occur with no apparent underlying risk factor. This is called an unprovoked VTE.

Complications

Complications of DVT can include:

  • Pulmonary embolism (PE). PE is a potentially life-threatening complication associated with DVT. It occurs when a blood vessel in your lung becomes blocked by a blood clot (thrombus) that travels to your lung from another part of your body, usually your leg.

    It's important to get immediate medical help if you have signs and symptoms of PE. Sudden shortness of breath, chest pain while inhaling or coughing, rapid breathing, rapid pulse, feeling faint or fainting, and coughing up blood may occur with a PE.

  • Postphlebitic syndrome. Damage to your veins from the blood clot reduces blood flow in the affected areas, causing leg pain and swelling, skin discoloration and skin sores.
  • Treatment complications. Complications may result from blood thinners used to treat DVTs. Bleeding (hemorrhage) is a worrisome side effect of blood thinners. It's important to have regular blood tests while taking such medications.

Prevention

Measures to prevent deep vein thrombosis include the following:

  • Avoid sitting still. If you have had surgery or have been on bed rest for other reasons, try to get moving as soon as possible. If you're sitting for a while, don't cross your legs, which can block blood flow. If you're traveling a long distance by car, stop every hour or so and walk around.
  • If you're on a plane, stand or walk occasionally. If you can't do that, exercise your lower legs. Try raising and lowering your heels while keeping your toes on the floor, then raising your toes with your heels on the floor.

  • Don't smoke. Smoking increases your risk of getting DVT.
  • Exercise and manage your weight. Obesity is a risk factor for DVT. Regular exercise lowers your risk of blood clots, which is especially important for people who sit a lot or travel frequently.

Dec. 22, 2020
  1. Venous thromboembolism. National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health-topics/venous-thromboembolism. Accessed Sept. 15, 2020.
  2. Bauer KA, et al. Clinical presentation and diagnosis of the nonpregnant adult with suspected deep vein thrombosis of the lower extremity. https://www.uptodate.com/contents/search. Accessed Sept. 16, 2020.
  3. Bonow RO, et al., eds. Cardiovascular disease in the elderly. In: Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 11th ed. Elsevier; 2019. https://www.clinicalkey.com. Accessed Sept. 16, 2020.
  4. Lip GYH, et al. Overview of the treatment of lower extremity deep vein thrombosis (DVT). https://www.uptodate.com/contents/search. Accessed Sept. 16, 2020.
  5. What is venous thromboembolism? Centers for Disease Control and Prevention. https://www.cdc.gov/ncbddd/dvt/facts.html. Accessed Sept. 16, 2020.
  6. Diagnosis and treatment of venous thromboembolism. Centers for Disease Control and Prevention. https://www.cdc.gov/ncbddd/dvt/diagnosis-treatment.html.Accessed Sept. 16, 2020.
  7. Jameson JL, et al., eds. Pulmonary thromboembolism and deep-vein thrombosis. In: Harrison's Manual of Medicine. 20th ed. McGraw Hill; 2020. https://accessmedicine.mhmedical.com. Accessed Sept. 16, 2020.
  8. Hull RD, et al. Biology of warfarin and modulators of INR control. https://www.uptodate.com/contents/search. Accessed Sept. 16, 2020.
  9. Blood thinner pills: Your guide to using them safely. Agency for Healthcare Research and Quality. https://www.ahrq.gov/patients-consumers/diagnosis-treatment/treatments/btpills/btpills.html. Accessed Sept. 16, 2020.
  10. Pruthi RK (expert opinion). Mayo Clinic. Sept. 22, 2020.

Related

Associated Procedures

Products & Services