Print DiagnosisTo diagnose CGD, your health care provider will review your family and medical history and conduct a physical exam. Your provider may order several tests to diagnose CGD, including: Neutrophil function tests. Your provider may conduct a dihydrorhodamine 123 (DHR) test or other tests to see how well a type of white blood cell, called a neutrophil, is functioning. Providers usually use this test to diagnose CGD. Genetic testing. Your provider may request a genetic test to confirm the presence of a specific genetic alteration that results in chronic granulomatous disease. Prenatal testing. Providers may do prenatal testing to diagnose CGD if one of your children already has been diagnosed with CGD. Care at Mayo Clinic Our caring team of Mayo Clinic experts can help you with your chronic granulomatous disease-related health concerns Start Here TreatmentTreatment for CGD is aimed at helping you avoid infections and manage your condition. Treatments may include: Infection management. Your health care provider will work to prevent bacterial and fungal infections before they start. Treatment may include a trimethoprim and sulfamethoxazole combination (Bactrim, Sulfatrim Pediatric) or itraconazole (Sporanox, Tolsura). Additional antibiotics or antifungal medicines may be necessary should infection occur. Interferon-gamma. You may occasionally have interferon-gamma injections, which may help boost cells in your immune system to fight infections. Stem cell transplantation. In some cases, a stem cell transplant can provide a cure for CGD. Deciding to treat with stem cell transplantation depends on a number of factors, including prognosis, donor availability and personal preference. Potential future treatmentsGene therapy is currently being explored for CGD treatment, but further research is necessary. Researchers also are investigating repairing defective genes to treat CGD. Request an appointment Clinical trials Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition. By Mayo Clinic Staff Chronic granulomatous disease care at Mayo Clinic Request an appointment Symptoms & causesDoctors & departments March 23, 2023 Print Share on: FacebookTwitter Living with chronic granulomatous disease? Connect with others like you for support and answers to your questions in the Blood Cancers & Disorders support group on Mayo Clinic Connect, a patient community. Blood Cancers & Disorders Discussions Looking for other with Pulmonary embolisms 27 Replies Mon, May 29, 2023 chevron-right Anyone else have Low Grade B Cell Nodual Marginal Zone Lymphoma 8 Replies Sat, May 27, 2023 chevron-right Want to connect with others with Splenic B cell Marginal Zone Lymphoma 247 Replies Sun, May 28, 2023 chevron-right See more discussions Show references Zerbe CS, et al. Chronic granulomatous disease: Pathogenesis, clinical manifestations, and diagnosis. https://www.uptodate.com/contents/search. Accessed Feb. 8, 2023. Chronic granulomatous disease. Medline Plus. https://ghr.nlm.nih.gov/condition/chronic-granulomatous-disease?_ga=1.168947753.905232672.1468720729. Accessed Feb. 14, 2023. Chronic granulomatous disease. National Organization for Rare Disorders. https://rarediseases.org/rare-diseases/chronic-granulomatous-disease/?filter=ovr-ds-resources. Accessed Feb. 9, 2023. Marciano BE, et al. Chronic granulomatous disease: Treatment and prognosis. http://www.uptodate.com/contents/search. Accessed Feb. 9, 2023. Chronic granulomatous disease (CGD). Merck Manual Professional Version. https://www.merckmanuals.com/professional/immunology-allergic-disorders/immunodeficiency-disorders/chronic-granulomatous-disease-cgd. Accessed Feb. 9, 2023. Ami TR. Allscripts EPSi. Mayo Clinic. Nov. 23, 2022. Keller MD, et al. Future of care for patients with chronic granulomatous disease: Gene therapy and targeted molecular medicine. Journal of the Pediatric Infectious Diseases Society. 2018; doi:10.1093/jpids/piy011. Jeffrey Modell Foundation. https://info4pi.org/. Accessed Feb. 9, 2023. Related Products & Services Book: Mayo Clinic Family Health Book, 5th Edition Newsletter: Mayo Clinic Health Letter — Digital Edition Show more products and services from Mayo Clinic Chronic granulomatous diseaseSymptoms & causesDiagnosis & treatmentDoctors & departmentsCare at Mayo Clinic Advertisement Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Advertising & Sponsorship Policy Opportunities Ad Choices Mayo Clinic Press Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. 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