Research

Publications

Mayo Clinic doctors trained in brain conditions (neurologists), brain surgery (neurosurgeons), nonsurgical treatments (neurosurgeons and neuroradiologists), brain imaging (neuroradiologists) and other professionals research brain aneurysm development, diagnosis, monitoring, management and treatment.

Researchers study which brain aneurysms need to be treated and which can be monitored. Mayo Clinic researchers also study management of subarachnoid hemorrhages. Learn more about research in neurology and neurosurgery.

Mayo Clinic research of note includes:

  • Flow diverter research. Mayo Clinic researchers collaborated on the Pipeline for Uncoilable or Failed Aneurysms (PUFS) study and led the Aneurysm Study of Pipeline in an Observational Registry (ASPIRE) study, both of which assessed the feasibility, safety and efficacy of flow diverters for the treatment of unruptured brain aneurysms.

    Flow diverters are special devices which, when placed across the aneurysm, will redirect flow away from the aneurysm. In the vast majority of patients, placing flow diverters eventually leads to complete obliteration of the aneurysm. Such diverters are threaded to the aneurysm site through a catheter placed in the groin area.

    Mayo physicians also conduct related research into topics such as flow diverter effectiveness in recipients as well as the effectiveness of particular approaches, such as coiling followed by flow diversion to treat ruptured complex and large/giant ruptured cerebral aneurysms, or the potential efficacy of combined coiling and anti-inflammatory medications, to help prevent delayed aneurysm ruptures.

  • ISUIA study. The International Study of Unruptured Intracranial Aneurysms (ISUIA) indicated that aneurysm size and location were predictors of rupture in a cohort of people with an unruptured aneurysm. The research, led by Mayo Clinic and sponsored by the National Institutes of Health, helped doctors more reliably determine brain aneurysms needing immediate treatment.
  • Other large-scale studies. Mayo Clinic researchers examine questions such as the incidence and predictors of complications after surgical clipping of unruptured intracranial aneurysms. The aim in the post-surgical clipping study was to help recognize patients at greater risk of post-surgical complications, hopefully leading to appropriate treatment strategy changes for such patients.

    Mayo Clinic physicians have also examined the comparative effectiveness of endovascular coil embolization versus clipping for ruptured intracranial aneurysms. Additionally, Mayo researchers collaborated on a multicenter study on stent-assisted coiling versus coiling alone in poor-grade ruptured intracranial aneurysms.

  • Aneurysm genetics. Mayo Clinic researchers collaborated in the Familial Intracranial Aneurysm Study, which is clarifying the underlying genetic cause for brain aneurysms and frequency of aneurysm detection in the setting of a family history of aneurysm.
  • Aspirin study. Data from the International Study of Unruptured Intracranial Aneurysms, led by Mayo Clinic and funded by the National Institutes of Health, suggests that people who take aspirin in the setting of an unruptured intracranial aneurysm could possibly be at lower risk of aneurysm rupture. This research is ongoing.

Mayo Clinic publications

See a list of publications on brain aneurysms by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

Read more about intracranial aneurysm management.

Aug. 09, 2019
  1. Williams LN, et al. Management of unruptured intracranial aneurysms. Neurology Clinical Practice. 2013;3:99.
  2. Thompson BG, et al. Guidelines for the management of patients with unruptured intracranial aneurysms: A guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2015;46:2368.
  3. Cerebral aneurysm fact sheet. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/cerebral_aneurysm/detail_cerebral_aneurysm.htm. Accessed April 11, 2017.
  4. Cerebral aneurysm. American Association of Neurological Surgeons. http://www.aans.org/en/Patients/Neurosurgical-Conditions-and-Treatments/Cerebral-Aneurysm. Accessed April 11, 2017.
  5. Daroff RB, et al. Intracranial Aneurysms and Subarachnoid Hemorrhage. In: Bradley's Neurology in Clinical Practice. 7th ed. Philadelphia, Pa.: Elsevier; 2016. https://www.clinicalkey.com. Accessed April 11, 2017.
  6. Singer RJ, et al. Unruptured intracranial aneurysms. https://www.uptodate.com/home. Accessed April 11, 2017.
  7. Maciel CB, et al. Seizures and epileptiform patterns in SAH and their relation to outcomes. Journal of Clinical Neurophysiology. 2016;33:183.
  8. Brown RD (expert opinion). Mayo Clinic, Rochester, Minn. April 27, 2017.
  9. Brown RD, et al. Screening for brain aneurysm in the Familial Intracranial Aneurysm study: Frequency and predictors of lesion detection. Journal of Neurosurgery. 2008;108:1132.
  10. Chalouhi N, et al. Differential sex response to aspirin in decreasing aneurysm rupture in humans and mice. Hypertension. 2016;68:411.
  11. Lanzino G (expert opinion). Mayo Clinic, Rochester, Minn. April 27, 2017.
  12. Brinjikji W, et al. Endovascular treatment of intracranial aneurysms with flow diverters: A meta-analysis. Stroke. 2013;44:442.
  13. Brinjikji W, et al. Estimating the proportion of intracranial aneurysms likely to be amenable to treatment with the pipeline embolization device. Journal of Neurointerventional Surgery. 2013;5:45.
  14. Stryker Neurovascular. Safety and Effectiveness of an Intracranial Aneurysm Embolization System for Treating Large or Giant Wide Neck Aneurysms (SCENT). ClinicalTrials.gov. http://www.clinicaltrials.gov/ct2/show/NCT01716117?term=aneurysm&rank=1.Accessed April 21, 2017.
  15. Theilen E, et al. Concomitant coiling reduces metalloproteinase levels in flow diverter-treated aneurysms but anti-inflammatory treatment has no effect. NeuroIntervental Surgery. 2017;9:307.
  16. Khurana VG, et al. The presence of tandem endothelial nitric oxide synthase gene polymorphisms identifying brain aneurysms more prone to rupture. Journal of Neurosurgery. 2005;102:526
  17. Mackey J, et al. Affected twins in the familial intracranial aneurysm study. Cerebrovascular Diseases. 2015;39:82
  18. Wiebers DO, et al. Unruptured intracranial aneurysms: Natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet. 2003;362:103.
  19. Kallmes DF, et al. Aneurysm study of pipeline in an observational registry (ASPIRe). Interventional Neurology. 2016;5:89.
  20. Becske T, et al. Long-term clinical and angiographic outcomes following pipeline embolization device treatment of complex internal carotid artery aneurysms: Five-year results of the pipeline for uncoilable or failed aneurysms trial. Neurosurgery. 2017;80:40.
  21. Brinjiki W, et al. Treatment of ruptured complex and large/giant ruptured cerebral aneurysms by acute coiling followed by staged flow diversion. Journal of Neurosurgery. 2016;125:120.
  22. Singer RJ, et al. Clinical manifestations and diagnosis of aneurysmal subarachnoid hemorrhage. https://www.uptodate.com/home. Accessed April 20, 2017.
  23. Singer RJ, et al. Treatment of aneurysmal subarachnoid hemorrhage. https://www.uptodate.com/home. Accessed April 20, 2017.
  24. Reynold MR, et al. The safety of vasopressor-induced hypertension in subarachnoid hemorrhage patients with coexisting unruptured, unprotected intracranial aneurysms. Journal of Neurosurgery. 2015;123:862.
  25.  Rinaldo L, et al. Elderly age associated with poor functional outcome after rupture of anterior communicating artery aneurysms. Journal of Clinical Neuroscience. 2016;34:108.
  26. Dai D, et al. Histopathological findings following pipeline embolization in a human cerebral aneurysm at the basilar tip. Interventional Neuroradiology. 2016;22:153.
  27. Kerezoudis P, et al. Predictors of 30-day perioperative morbidity and mortality of unruptured intracranial aneurysm surgery. Clinical Neurology and Neurosurgery. 2016;149:75.
  28. Zhao B, et al. Stent-assisted coiling versus coiling alone of poor-grade ruptured intracranial aneurysms: A multicenter study. Journal of NeuroInterventional Surgery. 2017;9:165.
  29. Sorenson T, et al. Trials and tribulations: An evidence-based approach to aneurysm treatment. Journal of Neurosurgical Sciences. 2016;60:22.
  30. Becske T, et al. Pipeline for uncoilable or failed aneurysms: Results from a multicenter clinical trial. Radiology. 2013;267:858.
  31. Wiebers DO, et al. Unruptured intracranial aneurysms — risk of rupture and risks of surgical intervention. The New England Journal of Medicine. 1998;339:1725.