Obstetrics and Gynecology

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. Opportunistic Salpingectomy for Permanent Sterilization at the Time of Cesarean Delivery

   Rochester, Minn.

   The purpose of this study is to compare the safety of performing a bilateral tubal ligation vs. bilateral salpingectomy, two procedures performed for permanent sterilization, at the time of cesarean delivery. We want to determine if performing bilateral salpingectomy at the time of cesarean delivery poses any greater risk for blood loss, as compared to a bilateral tubal ligation.

2. Metformin Hydrochloride and Combination Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

   Rochester, Minn.

   This randomized phase II trial studies how well metformin hydrochloride and combination chemotherapy works in treating patients with stage III-IV ovarian, fallopian tube, or primary peritoneal cancer. Drugs used in chemotherapy, such as carboplatin, paclitaxel and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Metformin hydrochloride may help carboplatin, paclitaxel and docetaxel work better by making tumor cells more sensitive to the drugs. Studying samples of blood and tissue in the laboratory from patients receiving metformin hydrochloride may help doctors learn more about the effects of metformin hydrochloride on cells. It may also help doctors understand how well patients respond to treatment. Giving metformin hydrochloride together with combination chemotherapy may kill more tumor cells.

3. A Study of Ultrasound Imaging of Microscopic Blood Vessels as a Biomarker for Uterine Pathologies

   Rochester, Minn.

   The purpose of this study is to investigate the value of ultrasound imaging of microscopic blood vessels as a new biomarker for identifying the difference between benign and cancerous uterine pathologies, and to compare ultrasound imaging to the diagnostics of MRI and (if available), surgical pathology.

    

4. Evaluation of the Vaginal and Rectal Microbiome in Patients with Rectovaginal Fistula

   Rochester, Minn.

   The aim of this study is the characterization of the vaginal and rectal microbiome in women undergoing surgical repair of rectovaginal fistula.

5. A Study of the Outcomes of Abdominal Pelvic Organ Prolapse Repair and the Introduction of the Enhanced Recovery Protocol

   Rochester, Minn.

   The purpose of this study is to compare pre and post-operative outcomes of undergoing open repair for pelvic organ prolapse with or without Enhanced Recovery Protocol , or also with the addition of liposomal Bupivacine, or compared to undergoing the procedure performed robotically.

6. Study to Assess the Ability of the MAKO 7 Device to Collect Cell Samples from the Fallopian Tube to Evaluate the Presence or Absence of Malignancy

   Jacksonville, Fla., Rochester, Minn.

   The purpose of this study is to assess the ability of the MAKO 7 device to collect cell samples from the fallopian tube that can be evaluated for the presence or absence of malignancy.

7. Understanding the Biology of Uterine Smooth Muscle

   Rochester, Minn.

   This study will investigate the biology of uterine smooth muscle cells and particularly explore the commonalities it has with smooth muscle cells of the airway.

8. A Study of the Effect of Hip Arthroscopy on Female Pelvic Floor Symptoms

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to assess for improvement after recovering from hip surgery in the symptoms of pelvic floor disorders that existed prior to hip arthroscopy.

    

9. Circulating Tumor DNA in Endometrial Cancer

   Rochester, Minn.

   The goal of this study is to identify circulating tumor DNA in the preoperative blood samples of endometrial cancer patients and detect changes in the quantity and tumor-specific mutations and chromosomal rearrangements in circulating tumor DNA of patients with endometrial cancer.

10. A Study to Compare Patient-Centered Options for the Management of Uterine Fibroids

    Rochester, Minn., Mankato, Minn., Eau Claire, Wis., La Crosse, Wis.

    The overall goal of this project is to better enable patients with uterine fibroids (UF) to make informed decisions about treatment options by leveraging the highest possible evidence of healthcare quality. The foundation of this project will be a multi-site, prospective registry of a diverse group of women who have undergone either medical or surgical treatment for UF.

    Specifically, the investigators are interested in: comparing management options for symptom relief, preserving reproductive function and comparing effectiveness among different subpopulations, including consideration of patient needs and preferences of treatment options.