Below are current clinical trials.33 studies in Obstetrics and Gynecology
(open studies only).
Filter this list of studies by location, status and more.
The purpose of this study is to compare the safety of performing a bilateral tubal ligation vs. bilateral salpingectomy, two procedures performed for permanent sterilization, at the time of cesarean delivery. We want to determine if performing bilateral salpingectomy at the time of cesarean delivery poses any greater risk for blood loss, as compared to a bilateral tubal ligation.
This randomized phase II trial studies how well metformin hydrochloride and combination chemotherapy works in treating patients with stage III-IV ovarian, fallopian tube, or primary peritoneal cancer. Drugs used in chemotherapy, such as carboplatin, paclitaxel and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Metformin hydrochloride may help carboplatin, paclitaxel and docetaxel work better by making tumor cells more sensitive to the drugs. Studying samples of blood and tissue in the laboratory from patients receiving metformin hydrochloride may help doctors learn more about the effects of metformin hydrochloride on cells. It may also help doctors understand how well patients respond to treatment. Giving metformin hydrochloride together with combination chemotherapy may kill more tumor cells.
The purpose of this study is to investigate the value of ultrasound imaging of microscopic blood vessels as a new biomarker for identifying the difference between benign and cancerous uterine pathologies, and to compare ultrasound imaging to the diagnostics of MRI and (if available), surgical pathology.
The aim of this study is the characterization of the vaginal and rectal microbiome in women undergoing surgical repair of rectovaginal fistula.
The purpose of this study is to compare pre and post-operative outcomes of undergoing open repair for pelvic organ prolapse with or without Enhanced Recovery Protocol , or also with the addition of liposomal Bupivacine, or compared to undergoing the procedure performed robotically.
This study will investigate the biology of uterine smooth muscle cells and particularly explore the commonalities it has with smooth muscle cells of the airway.
The purpose of this study is to assess for improvement after recovering from hip surgery in the symptoms of pelvic floor disorders that existed prior to hip arthroscopy.
The goal of this study is to identify circulating tumor DNA in the preoperative blood samples of endometrial cancer patients and detect changes in the quantity and tumor-specific mutations and chromosomal rearrangements in circulating tumor DNA of patients with endometrial cancer.
This is a Phase 1a/1b study of SC-003 in patients with platinum-resistant/refractory ovarian cancer. SC-003 is an antibody-drug conjugate (ADC) comprised of a monoclonal antibody linked to a potent chemotherapy.
Rochester, Minn., La Crosse, Wis., Eau Claire, Wis., Mankato, Minn.
The overall goal of this project is to better enable patients with uterine fibroids (UF) to make informed decisions about treatment options by leveraging the highest possible evidence of healthcare quality. The foundation of this project will be a multi-site, prospective registry of a diverse group of women who have undergone either medical or surgical treatment for UF.
Specifically, the investigators are interested in: comparing management options for symptom relief, preserving reproductive function and comparing effectiveness among different subpopulations, including consideration of patient needs and preferences of treatment options.
May 25, 2018
- Congenital anomalies. World Health Organization. http://www.who.int/mediacentre/factsheets/fs370/en/. Accessed Feb. 8, 2018.
- Birth defects. Centers for Disease Control and Prevention. https://www.cdc.gov/ncbddd/birthdefects/data.html. Accessed Feb. 8, 2018.
- Srinivasan S, et al. Overview of fetal arrhythmias. Current Opinion in Pediatrics. 2008;20:522.
- Brennand J, et al. Fetal anaemia: Diagnosis and management. Best Practice & Research Clinical Obstetrics and Gynaecology. 2008;22:15.
- Kalyani R, et al. Twin reversed arterial perfusion syndrome (TRAP or acardiac twin): A case report. Journal of Clinical and Diagnostic Research. 2014;8:166.
- Djaafri F, et al. Twin-twin transfusion syndrome: What we have learned from clinical trials. Seminars in Fetal and Neonatal Medicine. 2017;22:367.
- D'Antonio F, et al. Prenatal risk factors and outcomes in gastroschisis: A meta-analysis. Pediatrics. 2015;136: e159. http://pediatrics.aappublications.org/content/136/1/e159. Accessed Feb. 8, 2018.
- Alpha-fetoprotein (AFP), single marker screen, maternal, serum. Mayo Medical Laboratories. https://www.mayomedicallaboratories.com/test-catalog/clinical+and+interpretive/81169. Accessed Feb. 8, 2018.
- AskMayoExpert. Prenatal screening and testing. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2017.
- Screening for fetal anomalies. National Institutes of Health. https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0009593/. Accessed Feb. 9, 2018.
- Baer RJ, et al. 311: Risk of preterm birth by subtype of infants with gastroschisis. American Journal of Obstetrics and Gynecology. 2017;216:S190.
- Wyllie R, et al., eds. Abnormal rotation and fixation of the intestine. In: Pediatric Gastrointestinal and Liver disease. 5th ed. Philadelphia, Pa.: Elsevier; 2016. https://www.clinicalkey.com. Accessed Feb. 12, 2018.
- Lee H, et al. Efficacy of radiofrequency ablation for twin-reversed arterial perfusion sequence. American Journal of Obstetrics and Gynecology. 2007;196:e1.
- Wee LY, et al. The twin-twin transfusion syndrome. Seminars in Neonatology. 2002;7:187.
- Ruano R (expert opinion). Mayo Clinic, Rochester, Minn. Feb. 13, 2018.
- Famuyide AO (expert opinion). Mayo Clinic, Rochester, Minn. March 1, 2018.
- Magtibay PM (expert opinion). Mayo Clinic, Phoenix/Scottsdale, Ariz. March 1, 2018.
- Amanda Ullom [contact for obstetrics and gynecology volumes]. MSS (Mayo Scheduling System). Mayo Clinic, Rochester, Minn. Feb. 27, 2018.
Obstetrics and Gynecology