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Obstetrics and Gynecology

Clinical trials

Below are current clinical trials.


36 studies in Obstetrics and Gynecology
(open studies only).

Filter this list of studies by location, status and more.

  1. Opportunistic Salpingectomy for Permanent Sterilization at the Time of Cesarean Delivery

    Rochester, Minn.

    The purpose of this study is to compare the safety of performing a bilateral tubal ligation vs. bilateral salpingectomy, two procedures performed for permanent sterilization, at the time of cesarean delivery. We want to determine if performing bilateral salpingectomy at the time of cesarean delivery poses any greater risk for blood loss, as compared to a bilateral tubal ligation.

  2. Metformin Hydrochloride and Combination Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

    Rochester, Minn.

    This randomized phase II trial studies how well metformin hydrochloride and combination chemotherapy works in treating patients with stage III-IV ovarian, fallopian tube, or primary peritoneal cancer. Drugs used in chemotherapy, such as carboplatin, paclitaxel and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Metformin hydrochloride may help carboplatin, paclitaxel and docetaxel work better by making tumor cells more sensitive to the drugs. Studying samples of blood and tissue in the laboratory from patients receiving metformin hydrochloride may help doctors learn more about the effects of metformin hydrochloride on cells. It may also help doctors understand how well patients respond to treatment. Giving metformin hydrochloride together with combination chemotherapy may kill more tumor cells.

  3. A Study of Ultrasound Imaging of Microscopic Blood Vessels as a Biomarker for Uterine Pathologies

    Rochester, Minn.

    The purpose of this study is to investigate the value of ultrasound imaging of microscopic blood vessels as a new biomarker for identifying the difference between benign and cancerous uterine pathologies, and to compare ultrasound imaging to the diagnostics of MRI and (if available), surgical pathology.

     

  4. Ovarian Tissue Freezing For Fertility Preservation In Women Facing A Fertility Threatening Medical Diagnosis Or Treatment Regimen

    Rochester, Minn.

    The primary objective of this study is to establish a tissue repository of research ovarian tissue that will subsequently be used to develop technologies enabling long-term preservation of ovarian function, including the production of viable oocytes, through cryopreservation of ovarian tissue prior to chemotherapy, radiation or treatment that is expected to reduce fertility.

  5. Evaluation of the Vaginal and Rectal Microbiome in Patients with Rectovaginal Fistula

    Rochester, Minn.

    The aim of this study is the characterization of the vaginal and rectal microbiome in women undergoing surgical repair of rectovaginal fistula.

  6. A Study of the Outcomes of Abdominal Pelvic Organ Prolapse Repair and the Introduction of the Enhanced Recovery Protocol

    Rochester, Minn.

    The purpose of this study is to compare pre and post-operative outcomes of undergoing open repair for pelvic organ prolapse with or without Enhanced Recovery Protocol , or also with the addition of liposomal Bupivacine, or compared to undergoing the procedure performed robotically.

  7. Understanding the Biology of Uterine Smooth Muscle

    Rochester, Minn.

    This study will investigate the biology of uterine smooth muscle cells and particularly explore the commonalities it has with smooth muscle cells of the airway.

  8. A Study of the Effect of Hip Arthroscopy on Female Pelvic Floor Symptoms

    Scottsdale/Phoenix, Ariz.

    The purpose of this study is to assess for improvement after recovering from hip surgery in the symptoms of pelvic floor disorders that existed prior to hip arthroscopy.

     

  9. Circulating Tumor DNA in Endometrial Cancer

    Rochester, Minn.

    The goal of this study is to identify circulating tumor DNA in the preoperative blood samples of endometrial cancer patients and detect changes in the quantity and tumor-specific mutations and chromosomal rearrangements in circulating tumor DNA of patients with endometrial cancer.

  10. Study of SC-003 in Subjects With Platinum-Resistant/Refractory Ovarian Cancer

    Rochester, Minn.

    This is a Phase 1a/1b study of SC-003 in patients with platinum-resistant/refractory ovarian cancer. SC-003 is an antibody-drug conjugate (ADC) comprised of a monoclonal antibody linked to a potent chemotherapy.

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May 25, 2018
References
  1. Congenital anomalies. World Health Organization. http://www.who.int/mediacentre/factsheets/fs370/en/. Accessed Feb. 8, 2018.
  2. Birth defects. Centers for Disease Control and Prevention. https://www.cdc.gov/ncbddd/birthdefects/data.html. Accessed Feb. 8, 2018.
  3. Srinivasan S, et al. Overview of fetal arrhythmias. Current Opinion in Pediatrics. 2008;20:522.
  4. Brennand J, et al. Fetal anaemia: Diagnosis and management. Best Practice & Research Clinical Obstetrics and Gynaecology. 2008;22:15.
  5. Kalyani R, et al. Twin reversed arterial perfusion syndrome (TRAP or acardiac twin): A case report. Journal of Clinical and Diagnostic Research. 2014;8:166.
  6. Djaafri F, et al. Twin-twin transfusion syndrome: What we have learned from clinical trials. Seminars in Fetal and Neonatal Medicine. 2017;22:367.
  7. D'Antonio F, et al. Prenatal risk factors and outcomes in gastroschisis: A meta-analysis. Pediatrics. 2015;136: e159. http://pediatrics.aappublications.org/content/136/1/e159. Accessed Feb. 8, 2018.
  8. Alpha-fetoprotein (AFP), single marker screen, maternal, serum. Mayo Medical Laboratories. https://www.mayomedicallaboratories.com/test-catalog/clinical+and+interpretive/81169. Accessed Feb. 8, 2018.
  9. AskMayoExpert. Prenatal screening and testing. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2017.
  10. Screening for fetal anomalies. National Institutes of Health. https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0009593/. Accessed Feb. 9, 2018.
  11. Baer RJ, et al. 311: Risk of preterm birth by subtype of infants with gastroschisis. American Journal of Obstetrics and Gynecology. 2017;216:S190.
  12. Wyllie R, et al., eds. Abnormal rotation and fixation of the intestine. In: Pediatric Gastrointestinal and Liver disease. 5th ed. Philadelphia, Pa.: Elsevier; 2016. https://www.clinicalkey.com. Accessed Feb. 12, 2018.
  13. Lee H, et al. Efficacy of radiofrequency ablation for twin-reversed arterial perfusion sequence. American Journal of Obstetrics and Gynecology. 2007;196:e1.
  14. Wee LY, et al. The twin-twin transfusion syndrome. Seminars in Neonatology. 2002;7:187.
  15. Ruano R (expert opinion). Mayo Clinic, Rochester, Minn. Feb. 13, 2018.
  16. Famuyide AO (expert opinion). Mayo Clinic, Rochester, Minn. March 1, 2018.
  17. Magtibay PM (expert opinion). Mayo Clinic, Phoenix/Scottsdale, Ariz. March 1, 2018.
  18. Amanda Ullom [contact for obstetrics and gynecology volumes]. MSS (Mayo Scheduling System). Mayo Clinic, Rochester, Minn. Feb. 27, 2018.

Mayo Clinic in Minnesota has been recognized as the best Gynecology hospital in the nation for 2017-2018 by U.S. News & World Report.

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