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Obstetrics and Gynecology

Clinical trials

Below are current clinical trials.


36 studies in Obstetrics and Gynecology
(open studies only).

Filter this list of studies by location, status and more.

  1. Sequencing for Families with Hereditary Disorders

    Rochester, Minn.

    The purpose of this project will examine the feasibility of offering whole genome sequencing (WGS), and developing a Rapid WGS protocol, for a fetus or neonate with multiple anomalies.

  2. A Study to Learn More About the Relationship between Fetal DNA and the Maternal Immune System

    Rochester, Minn.

    The purpose of this study is to learn about the ability of fetal DNA to activate the immune system.

  3. OTL38 for Intra-operative Imaging of Folate Receptor Positive Ovarian Cancer

    Rochester, Minn., Scottsdale/Phoenix, Ariz.

    This is a phase 3, randomized, multi-center, single dose, open label, pivotal study in patients diagnosed with, or with high clinical suspicion of, ovarian cancer scheduled to undergo primary surgical cytoreduction, interval debulking, or recurrent ovarian cancer surgery.

  4. A Study to Investigate FE 999049 in the Treatment of Infertility in Women Aged 18-34 Years Old with Assisted Reproductive Technology

    Rochester, Minn.

    The purpose of this study is to investigate the safety and effectiveness of FE 999049 compared to placebo in women aged 18-34 years old.

  5. A Study of Ovarian Tissue Freezing for the Preservation of Fertility in Children

    Rochester, Minn.

    The purpose of this study is to offer ovarian tissue cryopreservation to female pediatric patients (birth-17 years of age) with fertility threatening medical diagnoses or facing surgery, chemotherapy or radiation therapy that may cause loss of reproductive potential. Since this procedure is currently considered experimental, the establishment of an IRB protocol under which this opportunity can be offered is needed.

  6. A Study to Determine the Impact of Individualized Estrogen Therapy on Cardiovascular Disease Risk Parameters in Young Women after Bilateral Oophorectomy

    Rochester, Minn.

    The purpose of this study is to compare the cardiovascular function in young women (<46 years) following bilateral oophorectomy who are treated with either the standard dose of estradiol (100 mcg transdermal patch or equivalent oral dose) or titrated estradiol dosing to achieve average premenopausal estradiol level (80-120 pg/ml), to characterize the relationship between the serum estradiol level and cardiovascular function in young women (<46 years) on estradiol replacement after bilateral oophorectomy, and to compare the body composition in young women following bilateral oophorectomy who are treated with either the standard dose of estradiol (100 mcg transdermal patch or equivalent oral dose) or titrated estradiol dosing to achieve average premenopausal estradiol level (80-120 pg/ml).

  7. A Study to Evaluate Minimally Invasive Fetoscopic Regenerative Repair of Spina Bifida

    Rochester, Minn.

    The purpose of this study is to evaluate a new, minimally-invasive technique (fetoscopic repair) for repair of spina bifida (MMC) during the second trimester of pregnancy. Researchers are trying to determine if this less invasive surgical approach will have less risk to the mother and, at the same time, adequate closure of the fetal spina bifida defect.

  8. A Study of Automated Myocardial Performance Index Before, During and After Fetal Surgeries using Samsung HERA W10

    Rochester, Minn.

    The purpose of this study is to evaluate the cardiac function in fetuses with specific conditions before, during, and after fetal interventions using an automated myocardial performance index.

  9. Study for Patient-Directed Postoperative Opioid Prescribing for Gynecologic Surgery

    Scottsdale/Phoenix, Ariz.

    The purpose of this study is to evaluate the impact of patient input on opioid prescribing and overall opioid use following gynecologic surgery.

  10. A Study of the Outcomes of Abdominal Pelvic Organ Prolapse Repair and the Introduction of the Enhanced Recovery Protocol

    Rochester, Minn.

    The purpose of this study is to compare pre and post-operative outcomes of undergoing open repair for pelvic organ prolapse with or without Enhanced Recovery Protocol , or also with the addition of liposomal Bupivacine, or compared to undergoing the procedure performed robotically.

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References
  1. Congenital anomalies. World Health Organization. http://www.who.int/mediacentre/factsheets/fs370/en/. Accessed Feb. 8, 2018.
  2. Birth defects. Centers for Disease Control and Prevention. https://www.cdc.gov/ncbddd/birthdefects/data.html. Accessed Feb. 8, 2018.
  3. Srinivasan S, et al. Overview of fetal arrhythmias. Current Opinion in Pediatrics. 2008;20:522.
  4. Brennand J, et al. Fetal anaemia: Diagnosis and management. Best Practice & Research Clinical Obstetrics and Gynaecology. 2008;22:15.
  5. Kalyani R, et al. Twin reversed arterial perfusion syndrome (TRAP or acardiac twin): A case report. Journal of Clinical and Diagnostic Research. 2014;8:166.
  6. Djaafri F, et al. Twin-twin transfusion syndrome: What we have learned from clinical trials. Seminars in Fetal and Neonatal Medicine. 2017;22:367.
  7. D'Antonio F, et al. Prenatal risk factors and outcomes in gastroschisis: A meta-analysis. Pediatrics. 2015;136: e159. http://pediatrics.aappublications.org/content/136/1/e159. Accessed Feb. 8, 2018.
  8. Alpha-fetoprotein (AFP), single marker screen, maternal, serum. Mayo Medical Laboratories. https://www.mayomedicallaboratories.com/test-catalog/clinical+and+interpretive/81169. Accessed Feb. 8, 2018.
  9. AskMayoExpert. Prenatal screening and testing. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2017.
  10. Screening for fetal anomalies. National Institutes of Health. https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0009593/. Accessed Feb. 9, 2018.
  11. Baer RJ, et al. 311: Risk of preterm birth by subtype of infants with gastroschisis. American Journal of Obstetrics and Gynecology. 2017;216:S190.
  12. Wyllie R, et al., eds. Abnormal rotation and fixation of the intestine. In: Pediatric Gastrointestinal and Liver disease. 5th ed. Philadelphia, Pa.: Elsevier; 2016. https://www.clinicalkey.com. Accessed Feb. 12, 2018.
  13. Lee H, et al. Efficacy of radiofrequency ablation for twin-reversed arterial perfusion sequence. American Journal of Obstetrics and Gynecology. 2007;196:e1.
  14. Wee LY, et al. The twin-twin transfusion syndrome. Seminars in Neonatology. 2002;7:187.
  15. Ruano R (expert opinion). Mayo Clinic, Rochester, Minn. Feb. 13, 2018.
  16. Famuyide AO (expert opinion). Mayo Clinic, Rochester, Minn. March 1, 2018.
  17. Magtibay PM (expert opinion). Mayo Clinic, Phoenix/Scottsdale, Ariz. March 1, 2018.
  18. Amanda Ullom [contact for obstetrics and gynecology volumes]. MSS (Mayo Scheduling System). Mayo Clinic, Rochester, Minn. Feb. 27, 2018.

Mayo Clinic in Rochester, Minn., has been recognized as one of the best Gynecology hospitals in the nation for 2019-2020 by U.S. News & World Report.

Learn more about this top honor

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