Obstetrics and Gynecology

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. A Study to Predict Post-Surgery Symptom Outcomes with the Use of a Preoperative Pessary

   Rochester, Minn.

   The goal of the study is to evaluate the change in pelvic floor symptoms with pessary use prior to reconstructive pelvic floor surgery for pelvic organ prolapse.  Additionally, we will assess the impact that preoperative pessary use has on patient self-reported preparedness for surgery.

2. Sequencing for Families with Hereditary Disorders

   Rochester, Minn.

   The purpose of this project will examine the feasibility of offering whole genome sequencing (WGS), and developing a Rapid WGS protocol, for a fetus or neonate with multiple anomalies.

3. A Study to Learn More About the Relationship between Fetal DNA and the Maternal Immune System

   Rochester, Minn.

   The purpose of this study is to learn about the ability of fetal DNA to activate the immune system.

4. OTL38 for Intra-operative Imaging of Folate Receptor Positive Ovarian Cancer

   Rochester, Minn., Scottsdale/Phoenix, Ariz.

   This is a phase 3, randomized, multi-center, single dose, open label, pivotal study in patients diagnosed with, or with high clinical suspicion of, ovarian cancer scheduled to undergo primary surgical cytoreduction, interval debulking, or recurrent ovarian cancer surgery.

5. A Study of Ovarian Tissue Freezing for the Preservation of Fertility in Children

   Rochester, Minn.

   The purpose of this study is to offer ovarian tissue cryopreservation to female pediatric patients (birth-17 years of age) with fertility threatening medical diagnoses or facing surgery, chemotherapy or radiation therapy that may cause loss of reproductive potential. Since this procedure is currently considered experimental, the establishment of an IRB protocol under which this opportunity can be offered is needed.

6. Study for Patient-Directed Postoperative Opioid Prescribing for Gynecologic Surgery

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to evaluate the impact of patient input on opioid prescribing and overall opioid use following gynecologic surgery.

7. A Study of MG1-E6E7 with Ad-E6E7 and Atezolizumab in Patients with HPV Associated Cancers

   Rochester, Minn., Scottsdale/Phoenix, Ariz., Jacksonville, Fla.

   The purpose of this study is to determine the safety, toxicity and maximum tolerated dose (MTD) / maximum feasible dose (MFD) of Ad/MG1-E6E7, and sequential treatment with atezolizumab in patients with HPV associated cancers.

    

    

8. A Study to Determine the Impact of Individualized Estrogen Therapy on Cardiovascular Disease Risk Parameters in Young Women after Bilateral Oophorectomy

   Rochester, Minn.

   The purpose of this study is to compare the cardiovascular function in young women (<46 years) following bilateral oophorectomy who are treated with either the standard dose of estradiol (100 mcg transdermal patch or equivalent oral dose) or titrated estradiol dosing to achieve average premenopausal estradiol level (80-120 pg/ml), to characterize the relationship between the serum estradiol level and cardiovascular function in young women (<46 years) on estradiol replacement after bilateral oophorectomy, and to compare the body composition in young women following bilateral oophorectomy who are treated with either the standard dose of estradiol (100 mcg transdermal patch or equivalent oral dose) or titrated estradiol dosing to achieve average premenopausal estradiol level (80-120 pg/ml).

9. Study to Assess the Ability of the MAKO 7 Device to Collect Cell Samples from the Fallopian Tube to Evaluate the Presence or Absence of Malignancy

   Jacksonville, Fla., Rochester, Minn.

   The purpose of this study is to assess the ability of the MAKO 7 device to collect cell samples from the fallopian tube that can be evaluated for the presence or absence of malignancy.

10. A Study of the Outcomes of Abdominal Pelvic Organ Prolapse Repair and the Introduction of the Enhanced Recovery Protocol

    Rochester, Minn.

    The purpose of this study is to compare pre and post-operative outcomes of undergoing open repair for pelvic organ prolapse with or without Enhanced Recovery Protocol , or also with the addition of liposomal Bupivacine, or compared to undergoing the procedure performed robotically.