Ampullary (AM-poo-la-ree) cancer is a rare cancer that forms in an area of your digestive system called the ampulla of Vater. The ampulla of Vater is located where your bile duct and pancreatic duct join and empty into your small intestine.

Ampullary cancer forms near many other parts of the digestive system, such as the liver, pancreas and small intestine. When ampullary cancer grows, it may affect these other organs.

Ampullary cancer treatment often involves extensive surgery to remove the cancer and a large margin of healthy tissue.

Ampullary cancer care at Mayo Clinic

Nov. 14, 2018
  1. Townsend CM Jr, et al. Tumors of the bile ducts, gallbladder and ampulla. In: Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice. 19th ed. Philadelphia, Pa.: Saunders Elsevier; 2012. https://www.clinicalkey.com. Accessed Oct. 27, 2016.
  2. Ryan DP, et al. Ampullary carcinoma: Treatment and prognosis. http://www.uptodate.com/home. Accessed Oct. 27, 2016.
  3. Riggin ER. Allscripts EPSi. Mayo Clinic, Rochester, Minn. July 29, 2016.