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Melissa A. Lyle, M.D.

  1. Transplant Cardiologist


  1. Jacksonville, Florida



Melissa Lyle, M.D., FACC is a board certified cardiologist and echocardiographer with subspecialty training and board certification in advanced heart failure and transplantation. Her clinical focus includes:

  • Expertise in the diagnosis and management of cardiac amyloidosis
  • Management of chronic heart failure and implantation of guideline directed medical therapy
  • Inpatient care of acute cardiovascular diseases including acute decompensated heart failure and cardiogenic shock
  • Complex clinical decisions regarding treatment of advanced heart failure including cardiac transplantation or mechanical circulatory support, such as left ventricular assist device (LVAD) implantation
  • Treatment of cardiomyopathies including genetic cardiomyopathy, cardiac sarcoidosis, hypertrophic cardiomyopathy, and left ventricular noncompaction
  • Performance and interpretation of transthoracic and transesophogeal echocardiography

In addition to her clinical activities, Dr. Lyle is active in research and education, providing mentorship to both residents and fellows.

  1. Heart transplant
  2. Mechanical circulatory support device implantation
  3. Post-transplant long-term care
  4. Pre-transplant evaluation
  5. Transesophageal echocardiogram
  6. Transthoracic echocardiogram
  • Cardiac amyloidosis
  • Advanced heart failure
  • Heart transplantation
  1. 2020
    Advanced Fellowship - Advanced Heart Failure and Transplant FellowshipEmory University School of Medicine
  2. 2019
    FellowCardiovascular Disease, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  3. 2019
    FellowshipCardiovascular Diseases Fellowship Program, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  4. 2016
    Residency - Internal MedicineInternal Medicine Residency, Mayo School of Graduate Medical Education, Mayo Clinic in Rochester
  5. 2016
    ResidentInternal Medicine, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  6. 2013
    MDMercer University School of Medicine
  7. 2009
    BS - Biology (Minor in Chemistry)Wake Forest University


  1. 2020
    Advanced Heart Failure and Transplant CardiologyAmerican Board of Internal Medicine
  2. 2019
    Cardiovascular DiseasesAmerican Board of Internal Medicine
  3. 2019
    Adult Comp EchocardiographyNational Board of Echocardiography
  4. 2016
    Internal MedicineAmerican Board of Internal Medicine

Awards and honors

  1. 2022
    Fellow of the Heart Failure Society of America
  2. 2021
    Cardiology Teacher of the Year 2020-2021Mayo Clinic in Florida
  3. 2020
    Fellow of the American College of Cardiology ( FACC)
  4. 2019
    The Outstanding Clinical Fellow Award in the Cardiovascular Fellowship Training ProgramDepartment of Cardiovascular Medicine
  5. 2014
    Fellowship Scholarship Pulmonary Hypertension Association
  6. 2012
    Alpha Omega Alpha (AOA) Honor SocietyMercer University School of Medicine

Professional memberships

  1. 2022 - present
    MemberAmerican College of Cardiology, Florida Chapter, Education Committee
  2. 2022 - present
    MemberAmerican College of Cardiology, Women in Cardiology Committee
  3. 2022 - present
    MemberAmerican Society of Transplantation
  4. 2022 - present
    MemberWomen in Transplant and MCS
  5. 2021 - present
    MemberInternational Society of Heart and Lung Transplantation
  6. 2019 - present
    MemberAmerican Heart Association
  7. 2019 - present
    MemberHeart Failure Society of America
  8. 2018 - present
    MemberAmerican Society of Echocardiography
  9. 2016 - present
    MemberAmerican College of Cardiology
  10. 2013 - 2019
    MemberMayo Fellows Association