皮肤 B 细胞淋巴瘤

预约门诊

概述

皮肤 B 细胞淋巴瘤是一种罕见癌症，始发于白细胞。这种癌症会侵袭皮肤。皮肤 B 细胞淋巴瘤会影响一种称为 B 细胞的抗病菌白细胞。这些细胞又称为 B 淋巴细胞。

皮肤 B 细胞淋巴瘤的类型包括：

  • 原发性皮肤滤泡中心淋巴瘤。
  • 原发性皮肤边缘区 B 细胞淋巴瘤。
  • 原发性皮肤弥漫性大 B 细胞淋巴瘤（腿部类型）。
  • 血管内弥漫性大 B 细胞淋巴瘤。

皮肤 B 细胞淋巴瘤的症状包括皮肤上有一个肿块或一组肿块。有时这种癌症会导致皮肤出现硬斑块。

皮肤 B 细胞淋巴瘤是一种非霍奇金淋巴瘤。影响皮肤的另一种非霍奇金淋巴瘤被称为皮肤 T 细胞淋巴瘤。皮肤 T 细胞淋巴瘤比皮肤 B 细胞淋巴瘤更常见。

Types

The types of cutaneous B-cell lymphoma include:

  • Primary cutaneous follicle center lymphoma. This is the most common type of cutaneous B-cell lymphoma. It appears mostly on the scalp, face, forehead and torso. Primary cutaneous follicle center lymphoma usually grows slowly and has an excellent prognosis.
  • Primary cutaneous marginal zone B-cell lymphoma. This is the second most common type of cutaneous B-cell lymphoma. It appears mostly on the torso, arms and head. Primary cutaneous marginal zone B-cell lymphoma usually grows slowly and has an excellent prognosis. However, this type comes back in about half the people.
  • Primary cutaneous diffuse large B-cell lymphoma, leg type. This is the rarest type of cutaneous B-cell lymphoma. It appears mostly on one or both legs but can be found elsewhere. Primary cutaneous diffuse large B-cell lymphoma, leg type usually grows fast and has a poor prognosis. This type has a high relapse rate and may spread beyond the skin when it comes back.
  • Intravascular diffuse large B-cell lymphoma. This type is different from the other types of cutaneous B-cell lymphoma. It is not limited to the skin but forms in small blood vessels of the skin and elsewhere in the body. Because of this, it can affect any organ. The skin and central nervous system are the most common sites. When in the skin, it appears most often on the legs or torso. Some people may have a fever or have symptoms in the brain before having skin symptoms. Intravascular diffuse large B-cell lymphoma usually grows fast and has a poor prognosis.
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诊断与治疗
May 14, 2026
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  1. Primary cutaneous lymphomas. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1491. Accessed Oct. 13, 2025.
  2. Jacobsen E, et al. Primary cutaneous diffuse large B-cell lymphoma, leg type. https://www.uptodate.com/contents/search. Accessed Oct. 13, 2025.
  3. Jacobsen E, et al. Primary cutaneous follicle center lymphoma. https://www.uptodate.com/contents/search. Accessed Oct. 13, 2025.
  4. Jacobsen E, et al. Primary cutaneous marginal zone lymphoma. https://www.uptodate.com/contents/search. Accessed Oct. 13, 2025.
  5. James WD. Cutaneous lymphoid hyperplasia, lymphoma, and other clonal lymphoid processes. In: Andrews' Diseases of the Skin: Clinical Dermatology. 14th ed. Elsevier; 2025. https://www.clinicalkey.com. Accessed Oct. 13, 2025.
  6. Fletcher CDM. Tumors of the skin. In: Diagnostic Histopathology of Tumors. 5th ed. Elsevier; 2021. https://www.clinicalkey.com. Accessed Oct. 13, 2025.
  7. Vitiello P, et al. Primary cutaneous B-cell lymphomas: An update. Frontiers in Oncology. 2020; doi:10.3389/fonc.2020.00651.
  8. Cancer staging. National Cancer Institute. https://www.cancer.gov/about-cancer/diagnosis-staging/staging. Accessed Oct. 20, 2025.
  9. Paulson CL. Allscripts EPSi. Mayo Clinic. July 15, 2025.

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